Applications of Next-Generation Sequencing Technologies and Statistical Tools in Identifying Pathways and Biomarkers for Heat Tolerance in Livestock DOI Creative Commons
Gajendirane Kalaignazhal, Veerasamy Sejian, M. V. Silpa

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(12), P. 616 - 616

Published: Dec. 2, 2024

The climate change-associated abnormal weather patterns negatively influences the productivity and performance of farm animals. Heat stress is major detrimental factor hampering production, causing substantial economic loss to livestock industry. Therefore, it important identify heat-tolerant breeds that can survive produce optimally in any given environment. To achieve this goal, a clearer understanding genetic differences underlying molecular mechanisms associated with change impacts heat tolerance are prerequisite. Adopting next-generation biotechnological statistical tools like whole transcriptome analysis, metagenome sequencing, bisulphite genome-wide association studies (GWAS), selection signatures provides an opportunity goal. Through these techniques, possible permanent markers for tolerance, by incorporating those marker-assisted breeding selection, target livestock. This review gives overview recent advancements assessing using such ‘omics’ approaches models. salient findings from research highlighted several candidate biomarkers have potential be incorporated into future heat-tolerance studies. Such could revolutionise production changing scenario support food demands growing human population.

Language: Английский

Detecting the footprint of selection on the genome of Girgentana goat, a popular ancient breed DOI Creative Commons
Andrea Criscione, Slim Ben Jemaa, Gianni Chessari

et al.

animal, Journal Year: 2025, Volume and Issue: 19(4), P. 101466 - 101466

Published: Feb. 17, 2025

Language: Английский

Citations

0
Investigation of selection signatures of dairy goats using whole-genome sequencing data DOI Creative Commons

Weifeng Peng,

Yiyuan Zhang, Lei Gao

et al.

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 12, 2025

Dairy goats, a livestock species with long history of milk production, are essential for the economic advancement nations, particularly in regions experiencing growth. In this study, we gathered whole-genome resequencing data 58 including 34 dairy goats and 24 wild (Bezoar), to explore selection signatures linked production traits using ROH (Runs homozygosity), CLR (composite likelihood ratio), Fst (Fixation index), XP-EHH (Ex-tended haplotype homozygosity across populations) XP-CLR(Cross-population composite ratio test) methods. Analysis five tests revealed total 210 genes, genes consistently identified at least two approaches. These associated fat, protein, fat yield. Gene enrichment analysis highlighted important GO KEGG pathways related such as "acyl-CoA metabolic process", "glycerolipid biosynthetic "cellular response fatty ac-id", "hormone "Galactose metabolism". Additionally, repro-duction, immune response, environmental adaptation were goats. The findings from our study offer profound understanding into critical features practical guidance improvement development crossbreeding initiatives different goat breeds.

Language: Английский

Citations

0
Climate resilience in goats: a comprehensive review of the genetic basis for adaptation to varied climatic conditions DOI

Ram Parsad,

Sonika Ahlawat,

Meena Bagiyal

et al.

Mammalian Genome, Journal Year: 2024, Volume and Issue: 36(1), P. 151 - 161

Published: Dec. 30, 2024

Language: Английский

Citations

3
Examination of homozygosity runs and selection signatures in native goat breeds of Henan, China DOI Creative Commons

Weifeng Peng,

Yiyuan Zhang, Lei Gao

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 6, 2024

Language: Английский

Citations

1
Discovery of Potential Candidate Genes for Coat Colour in Wuzhishan Pigs by Integrating SNPs and mRNA Expression Analysis DOI Creative Commons
Qiao Xu,

Yabiao Luo,

Zhe Chao

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(23), P. 3493 - 3493

Published: Dec. 3, 2024

Despite identifying genes regulating the coat colour in Western pig breeds, genetic basis of Chinese indigenous pigs is still not understood due to diversity breeds and their differences from exotic pigs. In this study, 215 Wuzhishan with three patterns (white, black, black-back/white-belly) were used conduct a genome-wide association analysis. We found that responsible for breed are located on chromosome 8. Ninety-seven significant SNPs related animal's colour. Using haplotype-sharing analysis, we narrowed potential candidate region 10.1 Mb interval encompassing only one gene,

Language: Английский

Citations

0
Applications of Next-Generation Sequencing Technologies and Statistical Tools in Identifying Pathways and Biomarkers for Heat Tolerance in Livestock DOI Creative Commons
Gajendirane Kalaignazhal, Veerasamy Sejian, M. V. Silpa

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(12), P. 616 - 616

Published: Dec. 2, 2024

The climate change-associated abnormal weather patterns negatively influences the productivity and performance of farm animals. Heat stress is major detrimental factor hampering production, causing substantial economic loss to livestock industry. Therefore, it important identify heat-tolerant breeds that can survive produce optimally in any given environment. To achieve this goal, a clearer understanding genetic differences underlying molecular mechanisms associated with change impacts heat tolerance are prerequisite. Adopting next-generation biotechnological statistical tools like whole transcriptome analysis, metagenome sequencing, bisulphite genome-wide association studies (GWAS), selection signatures provides an opportunity goal. Through these techniques, possible permanent markers for tolerance, by incorporating those marker-assisted breeding selection, target livestock. This review gives overview recent advancements assessing using such ‘omics’ approaches models. salient findings from research highlighted several candidate biomarkers have potential be incorporated into future heat-tolerance studies. Such could revolutionise production changing scenario support food demands growing human population.

Language: Английский

Citations

0