Gut Microbiome Alteration in HIV/AIDS and the Role of Antiretroviral Therapy—A Scoping Review DOI Creative Commons
Zsófia Gáspár, Blin Nagavci, Bálint Gergely Szabó

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2221 - 2221

Published: Nov. 1, 2024

(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality among people living HIV (PLWH). effects of antiretroviral therapy on the microbiome remain underexplored. This study aims to map evidence impact integrase strand transfer inhibitors (INSTI) non-nucleoside reverse transcriptase (NNRTI) PLWH. (2) Methods: A scoping review was conducted using PubMed, Web Science, Embase, reports collected following PRISMA for Scoping Reviews (PRISMA-ScR). (3) Results: Evidence suggests that INSTI-based regimes generally promote restoration alpha diversity, bringing it closer seronegative controls, while beta diversity remains largely unchanged. therapies are suggested be improvements composition tendency toward reduced inflammatory markers. In contrast, NNRTI-based treatments demonstrate limited recovery linked an increase proinflammatory bacteria. (4) Conclusions: Based current literature, is indicated (ART) facilitates better microbiome.

Language: Английский

Effects of Vibrio alginolyticus on intestinal health and intestinal flora of sea urchin (Strongylocentrotus intermedius) DOI
Xiaochen Zhang, Wei Chen,

Haoyu Zhang

et al.

Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 111099 - 111099

Published: April 1, 2025

Language: Английский

Citations

0
Weight Gain in HIV Adults Receiving Antiretroviral Treatment: Current Knowledge and Future Perspectives DOI Creative Commons
Konstantinos Markakis, Οlga Tsachouridou,

Eleni Georgianou

et al.

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1367 - 1367

Published: Oct. 24, 2024

Body weight is impacted by several individual host and environmental factors. In a person living with HIV (PLWH), also influenced the disease stage. Wasting syndrome derived from progression, it can be reversed effective use of highly active antiretroviral therapy (HAART). alterations have been studied compared in clinical ART trials, they differ according to antiviral regimens. The newer integrase strand transfer inhibitors (INSTIs), such as bictegravir dolutegravir, especially when co-administered tenofovir alafenamide fumarate (TAF), seem lead greater increases regimens that include disoproxil (TDF), which an attenuating effect on gain. Nevertheless, despite established association between INSTI TAF negative impact weight, more recent data suggest cautious approach HAART treatment decisions are taken. this manuscript, we review changes among PLWH receiving relevant underlying pathogenic mechanisms described literature. We try provide critical appraisal available underline challenges assessing role both initiation setting switching.

Language: Английский

Citations

3
Gut Microbiome Alteration in HIV/AIDS and the Role of Antiretroviral Therapy—A Scoping Review DOI Creative Commons
Zsófia Gáspár, Blin Nagavci, Bálint Gergely Szabó

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2221 - 2221

Published: Nov. 1, 2024

(1) Background: The gut microbiota plays a crucial role in chronic immune activation associated with human immunodeficiency virus (HIV) infection, acquired deficiency syndrome (AIDS) pathogenesis, non-AIDS-related comorbidities, and mortality among people living HIV (PLWH). effects of antiretroviral therapy on the microbiome remain underexplored. This study aims to map evidence impact integrase strand transfer inhibitors (INSTI) non-nucleoside reverse transcriptase (NNRTI) PLWH. (2) Methods: A scoping review was conducted using PubMed, Web Science, Embase, reports collected following PRISMA for Scoping Reviews (PRISMA-ScR). (3) Results: Evidence suggests that INSTI-based regimes generally promote restoration alpha diversity, bringing it closer seronegative controls, while beta diversity remains largely unchanged. therapies are suggested be improvements composition tendency toward reduced inflammatory markers. In contrast, NNRTI-based treatments demonstrate limited recovery linked an increase proinflammatory bacteria. (4) Conclusions: Based current literature, is indicated (ART) facilitates better microbiome.

Language: Английский

Citations

1