Association between neutrophil-to-lymphocyte ratio and all-cause and cardiovascular mortality among adults with cancer from NHANES 2005-2018: a retrospective cohort study DOI Creative Commons
Gangping Li, Yuewen Fu, Di Zhang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 18, 2025

Evidence on the association between neutrophil-to-lymphocyte ratio (NLR) and all-cause cardiovascular disease (CVD) mortality in adults with cancer is limited. This study aimed to examine relationship NLR CVD cancer. A retrospective cohort included 2,639 patients U.S. from NHANES dataset (2005-2018), collecting demographic, laboratory, data. Multivariable Cox regression analysis, subgroup analysis restricted cubic spline analyses assessed associations outcomes. During a median follow-up of 77 months, 713 (27.0%) deaths occurred, including 149 (5.6%) CVD. revealed that high NLR, treated as continuous variable, was significantly correlated increased (HR, 1.09; 95% CI, 1.05-1.12; p < 0.001) 1.12; 1.05-1.19; 0.001). Meanwhile, when evaluating categorical adjusted hazard ratios (HR) for quartiles Q2 (1.6-2.2), Q3 (2.2-3), Q4 (>3) were 1.06 (95% CI: 0.83-1.34, = 0.062), 1.12 0.89-1.42, 0.334), 1.30 1.04-1.63, 0.021), respectively, compared individuals lower quartile Q1 (≤1.6). In terms mortality, HR values Q2, Q3, 0.92 0.50-1.69, 1.24 0.71-12.19, 1.76 1.04-2.97, 0.034), those Subgroup showed similar patterns (all p-values interaction > 0.05). Kaplan-Meier indicated survival rates higher RCS suggested positive linear mortality. Elevated linked risks among

Language: Английский

The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension DOI Creative Commons
Xuexue Zhang, Rui Wei, Xujie Wang

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 2, 2024

Abstract Background Identifying reliable prognostic markers is crucial for the effective management of hypertension. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential inflammatory marker linked to cardiovascular outcomes. This study aims investigate association NLR with all-cause and mortality among patients Methods analyzed data from 3067 hypertensive adults in National Health Nutritional Examination Surveys (NHANES) 2009 2014. Mortality details were obtained Death Index (NDI). Restricted cubic spline (RCS) was deployed visualize risk. Weighted Cox proportional hazards models employed assess independent Time-dependent receiver operating characteristic curve (ROC) analysis conducted access predictive ability survival. Mediation used explore indirect impact on mediated through eGFR. Results Over median 92.0-months follow-up, 538 deaths occurred, including 114 deaths. RCS revealed positive between both mortality. Participants stratified into higher (> 3.5) lower (≤ groups. demonstrated that individuals had significantly increased risk (HR 1.96, 95% confidence interval (CI) 1.52–2.52, p < 0.0001) 2.33, CI 1.54–3.51, 0.0001). Stratified interaction confirmed stability core results. Notably, eGFR partially by 5.4% 4.7% proportion, respectively. Additionally, areas under (AUC) 3-, 5- 10- year survival 0.68, 0.65 0.64 0.70 0.69 mortality, Conclusion Elevated independently confers an

Language: Английский

Citations

53
The naples prognostic score as a new predictor for heart failure: A cross-sectional study DOI

Ziyan Guo,

Futao Zhang, Siang Chew Chai

et al.

Heart & Lung, Journal Year: 2025, Volume and Issue: 70, P. 360 - 367

Published: Jan. 28, 2025

Language: Английский

Citations

2
Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population DOI Creative Commons
Geng Shen, Yuting Liu, Can Zhou

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 31, 2025

The prevalence of type 2 diabetes mellitus (T2DM) remains high and biomarkers related to T2DM are needed be investigated. This study aimed investigate the association between neutrophil percentage-to-albumin ratio (NPAR) with all-cause mortality risk cardiovascular disease (CVD) in community-dwelling individuals T2DM. prospective cohort included 3602 adults aged 20 or above who were diagnosed by American Diabetes Association criteria US National Health Nutrition Examination Survey (NHANES) database from 1999 2016, followed up until 2019. Multivariable Cox proportional hazards regression models utilized determine relationship NPAR mortality. Restricted cubic spline analyses employed explore nonlinear assessment nonlinearity was conducted using likelihood test. After adjustment, for highest group (≥ 15.40) compared lowest serum reference (< 13.30) 1.62 (95% CI, 1.36, 1.94) P values < 0.001. Nevertheless, versus 1.41 0.99, 2.00) a value 0.06. Among patients T2DM, levels exhibited correlation both CVD risk, 0.001 both. identified significant elevated an increased among (T2DM). Conversely, no found

Language: Английский

Citations

2
Neutrophil to lymphocyte ratio (NLR) prognostic effects on heart failure; a systematic review and meta-analysis DOI Creative Commons
Mehrbod Vakhshoori,

Sepehr Nemati,

Sadeq Sabouhi

et al.

BMC Cardiovascular Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 14, 2023

Abstract Background Neutrophil to lymphocyte ratio (NLR), as a recent inflammatory index, has been reported be prognostic tool in different diseases. However, implication of this heart failure (HF) is less investigated. In systematic review and meta-analysis, we aimed assess the potential impact NLR on HF clinical outcomes. Methods Relevant English published records PubMed, Scopus, Embase, Web Science were screened up July 2023. Articles reporting outcomes (follow-up or in-hospital mortality, readmission, prediction, extended hospital stay length, pulmonary vascular resistance, atrial fibrillation, renal disease functional capacity) sufferers collected for further analysis with addition difference stratified by death/survived status. Results Thirty-six articles ( n = 18231) finally selected which (mean: 4.38, 95% confidence interval (CI): 4.02–4.73). We found 25 total mortality (either follow-up death N 19): 4.52 (95% CI: 4.03–5.01) 10): 5.33 4.08–6.57)) mean 4.74 4.28–5.20). was higher among deceased patients compared survived ones (standard difference: 0.67 0.48–0.87), P < 0.001)). related risk (continuous variable: hazard (HR): 1.12, 1.02–1.23, 0.013), categorical HR: 1.77, 1.27–2.46, 0.001, T2 vs. T1: HR:1.56, 95%CI: 1.21–2.00, T3 HR:2.49, 1.85–3.35, 0.001). Other aforementioned variables not feasible analyze due presence few studies. Conclusions simple acceptable stratification prioritizing high settings, especially resource limited nations.

Language: Английский

Citations

26
Diagnostic and prognostic performance of the neutrophil-to-lymphocyte ratio in acute coronary syndromes: A meta-analysis of 90 studies including 45 990 patients DOI Open Access
Michał Pruc, Jacek Kubica, Maciej Banach

et al.

Kardiologia Polska, Journal Year: 2024, Volume and Issue: 82(3), P. 276 - 284

Published: March 20, 2024

Cardiovascular disease is a leading cause of mortality worldwide and likely to rise. Acute coronary syndrome (ACS) consequent on inflammation. As common cost-effective inflammatory biomarker, the neutrophil-to-lymphocyte ratio (NLR) may be beneficial in cardiovascular medicine.

Language: Английский

Citations

15
Associations of neutrophil-percentage-to-albumin ratio level with all-cause mortality and cardiovascular disease-cause mortality among patients with hypertension: evidence from NHANES 1999–2010 DOI Creative Commons

Zhihao Liu,

Lei Dong,

Geng Shen

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 17, 2024

The associations of neutrophil-percentage-to-albumin ratio (NPAR) level with all-cause and cardiovascular disease (CVD)-cause mortality among patients hypertension remain unclear. This study aims to investigate the NPAR CVD-cause hypertension.

Language: Английский

Citations

12
Predictive value of the neutrophil percentage-to-albumin ratio for coronary atherosclerosis severity in patients with CKD DOI Creative Commons

Zhao Mengqi,

Xin Huang,

Yang Zhang

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 28, 2024

The neutrophil percentage-to-albumin ratio (NPAR), which is defined as the percentage of neutrophils divided by concentration albumin, a cost-effective and readily available biomarker inflammation. This study aimed to evaluate association between NPAR severity coronary atherosclerosis in patients with chronic kidney disease (CKD).

Language: Английский

Citations

10
The impact of platelet-to-lymphocyte ratio on clinical outcomes in heart failure: a systematic review and meta-analysis DOI Creative Commons
Mehrbod Vakhshoori, Niloofar Bondariyan,

Sadeq Sabouhi

et al.

Therapeutic Advances in Cardiovascular Disease, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

Background: Inflammation has been suggested to play a role in heart failure (HF) pathogenesis. However, the of platelet-to-lymphocyte ratio (PLR), as novel biomarker, assess HF prognosis needs be investigated. We sought evaluate impact PLR on clinical outcomes. Methods: English-published records PubMed/Medline, Scopus, and Web-of-science databases were screened until December 2023. Relevant articles evaluated with outcomes (including mortality, rehospitalization, worsening, detection) recruited, difference analysis based death/survival status total reduced ejection fraction (HFrEF) patients. Results: In total, 21 ( n = 13,924) selected. The mean age was 70.36 ± 12.88 years (males: 61.72%). Mean 165.54 [95% confidence interval (CI): 154.69–176.38]. 18 10,084) reported mortality [either follow-up (PLR: 162.55, 95% CI: 149.35–175.75) or in-hospital 192.83, 150.06–235.61) death rate] 166.68 (95% 154.87–178.50). Further revealed significantly lower survived patients rather than deceased group (152.34, 134.01–170.68 versus 194.73, 175.60–213.85, standard difference: −0.592, −0.857 −0.326, p < 0.001). A similar trend observed for HFrEF failed show any association risk (hazard ratio: 1.02, 0.99–1.05, 0.289). Analysis other aforementioned not possible due presence few studies interest. Conclusion: should used caution assessment sufferers are necessary explore exact association.

Language: Английский

Citations

8
The Prognostic Role of the Neutrophil-to-Lymphocytes Ratio in the Most Frequent Cardiovascular Diseases: An Update DOI Creative Commons
Evelina Maria Gosav, Daniela Maria Tănase, Oana Nicoleta Buliga-Finiș

et al.

Life, Journal Year: 2024, Volume and Issue: 14(8), P. 985 - 985

Published: Aug. 7, 2024

Given the continuous changes in world, with an increasing trend of unhealthy lifestyles, metabolic comorbidities, and increased susceptibility to cardiovascular diseases (CVDs), researchers change their attention improve not only therapeutic platform but also current CVD predictive prognostic tools disease outcomes. As is characterized by inflammatory paradigm involving, some degree, innate adaptative immune systems, neutrophil-to-lymphocyte ratio (NLR) emerged as a potential low-cost, rapidly available, reliable marker, substantial recent evidence showing its utility clinical practice. Thus, this literature review, we will present up-to-date discussion role NLR most frequent CVDs, such acute chronic coronary disease, atherosclerotic heart failure, cardiac valvopathies, arrhythmias predilection atrial fibrillation.

Language: Английский

Citations

8
Association of systemic immune biomarkers with metabolic dysfunction-associated steatotic liver disease: a cross-sectional study of NHANES 2007–2018 DOI Creative Commons
Yong Wang,

Shude Chen,

Chen Tian

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 4, 2024

Numerous studies emphasize the pivotal role of inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD) development. Some link specific systemic immune biomarkers (e.g., immuno-inflammatory index [SII], neutrophil-to-albumin ratio [NPAR] and neutrophil-to-lymphocyte [NLR]) to hepatic steatosis risk. However, relevance other markers like immune-inflammation [SIRI], platelet-to-lymphocyte [PLR] lymphocyte/monocyte [LMR] MASLD remains unclear. Limited literature covers all six together. This study aims investigate association between SII, SIRI, LMR, NLR, PLR, NPAR MASLD, assessing their predictive value.

Language: Английский

Citations

7