Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8611 - 8623
Published: Nov. 1, 2024
There is limited research on the long-term prognosis of percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) patients who have previously undergone artery bypass grafting (CABG). Additionally, prognostic value a novel systemic immune inflammation index (SII) this specific patient population remains unclear.
Language: Английский
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(8), P. e0307466 - e0307466
Published: Aug. 5, 2024
Introduction The neutrophil-percentage-to-albumin ratio (NPAR), a novel inflammatory biomarker, has been used to predict the prognosis of patients with cancer and cardiovascular disease. However, relationship between NPAR chronic kidney disease (CKD) remains unknown. purpose this study was investigate possible association CKD. Methods cross-sectional included participants complete information on NPAR, serum creatinine (Scr), or urinary albumin-to-creatinine (UACR) from 2009–2018 National Health Nutrition Examination Survey (NHANES). CKD defined as presence either low estimated glomerular filtration rate (eGFR) albuminuria. Univariate multivariate logistic regression restricted cubic spline were assess linear nonlinear associations renal function. Subgroup interactive analyses performed explore potential effects covariates. Missing values imputed using random forest. Results A total 25,236 enrolled in study, whom 4518 (17.9%) diagnosed After adjustment for covariates, odds ratios (ORs) prevalent 1.19 (95% CI = 1.07–1.31, p <0.05) Q2 group, 1.53 1.39–1.69, < 0.001) Q3 2.78 2.53–3.05, Q4 group. There significant interaction age diabetes mellitus (both 0.05). And there non-linear levels whole population ( 0.001). All sensitivity supported positive Conclusions positively correlated increased risk may serve an available cost-effective tool identifying intervening individuals at
Language: Английский
Citations
9
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 28, 2025
The neutrophil-to-albumin ratio (NPAR) is a relatively novel composite biomarker of inflammation, which has been used for prognostication in cardiovascular diseases and may also be associated with stroke. A cross-sectional analysis was conducted using data from the National Health Nutrition Examination Survey (NHANES) 1999–2018, including 48,734 individuals complete NPAR stroke data. association between prevalence values assessed through multivariate regression analysis. relationship these variables further visualized restricted cubic splines (RCS). Additionally, potential factors influencing this were explored subgroup model revealed significant prevalence, even after adjusting other covariates [1.06 (1.04, 1.08)]. Stroke 62% higher highest group compared to lowest [1.62 (1.40, 1.89)]. RCS confirmed positive correlation. Subgroup showed that not significantly influenced by factors. This study establishes strong prevalence. However, studies are needed clarify underlying mechanisms establish direct causal link.
Language: Английский
Citations
1
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: March 6, 2025
Background The neutrophil-percentage-to-albumin ratio (NPAR), as a low-cost and easily accessible inflammatory biomarker, has garnered considerable attention in various disease studies recent years. Specifically, existing research suggested significant correlation between NPAR diabetic retinopathy, indicating its potential relevance to complications. However, despite kidney (DKD) being complication that severely affects the quality of life patients, association prevalence DKD remains be elucidated. Therefore, this study aims explore link patients with type 2 diabetes mellitus. Methods We extracted complete data on neutrophil percentage, plasma albumin, serum creatinine, urine albumin-to-creatinine from National Health Nutrition Examination Survey database spanning 2009 2018. Multivariable logistic regression models were employed examine relationship levels DKD, conducted sensitivity tests, subsequently employing Generalized Additive Models combined smooth curve fitting methods relationships among variables. Then, subgroup analyses investigate changes across different subgroups. Finally, Receiver operating characteristic curves used assess predictive performance independent variable, NPAR, for dependent DKD. Results A total 2,263 participants enrolled cross-sectional study. After adjusting confounding factors, odds was 1.44 (95% CI: 1.08-1.90) second quartile group, 1.75 1.33-2.31) third 2.95 2.22-3.93) fourth group. Among mellitus, positive observed showed no differences populations. (ROC) analysis indicated had good Conclusion individuals T2DM. Additional large-scale prospective investigations may helpful corroborating these findings.
Language: Английский
Citations
0
Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 741 - 741
Published: March 16, 2025
Background/Objectives: Postoperative new-onset atrial fibrillation (AF) (PNOAF) is the most common complication after coronary artery bypass graft (CABG), and its incidence has been reported as up to 50% in studies. In this study, we investigated whether there was a relationship between PNOAF neutrophil percentage albumin ratio (NPAR) levels on-pump CABG. Methods: A total of 454 patients who underwent CABG were included study. NPAR calculated by dividing count value. Results: It determined that 93 developed (20.4%). When patient groups did not develop compared terms laboratory findings, C-reactive protein (CRP) values (4.0 mg/L (2.8–7.9) vs. 2.9 (1.1–6.7), <0.001), neutrophil/lymphocyte (NLR) (2.2 (1.2–4.2) 1.4 (0.7–3.1), platelets-to-lymphocyte (112 (72–177) 92 (69–122), <0.001) (2.29 (1.68–3.8) 1.09 (0.79–1.81), found be statistically significantly higher group PNOAF. ROC analysis showed cut-off value for development 1.86 with 78% sensitivity 72% specificity (area under curve = 0.778, 95% CI (0.728–0.828), p < 0.001). Conclusions: NPAR, which can detected simple venous blood test, shown strong predictive
Language: Английский
Citations
0
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: March 28, 2025
This study aimed to evaluate the associations between neutrophil percentage-to-albumin ratio (NPAR) and both all-cause cardiovascular mortality in diabetic kidney disease (DKD) patients. The data for this were sourced from National Health Nutrition Examination Survey (NHANES) 1999–2018. Weighted logistic regression, Cox proportional hazards model, Fine-Gray competing risk model used assess association NPAR DKD A total of 2,699 participants enrolled study. regression analysis revealed that elevated levels associated with a higher all (HR: 2.17, 95%CI: 1.83–2.58). Meanwhile, significant difference was observed males 1.83, 1.42–2.38) but not females. Finally, adjusted identified as an independent predictor (SHR: 1.86 1.28–2.72) In nationally representative sample US, detected increased mortality. addition, gender differences relationship also observed.
Language: Английский
Citations
0
Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)
Published: April 18, 2025
There is mounting evidence suggesting a direct connection between inflammatory responses and the pathophysiology of overactive bladder (OAB). However, conventional markers do not directly indicate correlation with OAB. Therefore, our goal was to investigate relationship OAB novel marker, neutrophil percentage-to-plasma-albumin ratio (NPAR). This study included 28,906 participants from 2005-2018 National Health Nutrition Examination Survey (NHANES). Weighted multivariate regression models multiple equations were applied evaluate NPAR Additionally, possibility linear OAB, smoothed curve fitting used. Sensitivity stratified analyses conducted assess robustness results. The final sample size consisted individuals, an overall prevalence 24.6%. Using weighted logistic model adjusting for covariates, we identified strong association (OR 1.074, 95% CI 1.06-1.08). Individuals in highest quartile had 32% greater compared those lowest quartile. Smoothed showed nonlinear effect sizes remained consistent across specific subgroups (P interaction < 0.05). incidence shown positively correlate higher levels this investigation. might be useful affordable biomarker determining who at risk facilitating timely intervention.
Language: Английский
Citations
0
Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 779 - 779
Published: April 23, 2025
Background and Objectives: The neutrophil-percentage-to-albumin ratio (NPAR) has been recognized as an independent risk factor for cardiovascular diseases. In our study, we investigated whether the NPAR is associated with formation of coronary collateral circulation (CCC) in patients chronic syndrome (CCS). Materials Methods: A total 681 CCS were included this study. Of these patients, 571 had occlusion at least one major vessel developed vessels. total, 110 control group, who but did not have complete a develop Patients vessels on angiography divided into two groups according to Rentrop score: poor CCC (Rentrop 0–1) good 2–3). Blood samples taken other biochemical parameters all during hospitalization. was calculated ratio. Results: group higher white blood count (WBC), neutrophil, C-reactive protein (CRP), neutrophil–lymphocyte (NLR), CRP/albumin (CAR), values than (p < 0.001, all). Multivariate logistic regression analysis showed that high levels predictor (OR: 2.79, 95% CI:1.7–4.6, p 0.001), accompanied by CRP, CAR, NLR levels. receiver operator characteristic curve (ROC analysis), cut-off value indicate 1.78 sensitivity 76.6% specificity 81.4% (area under ROC = 0.804 CI (0.753–0.854), 0.001). Conclusions: We demonstrated may be development clinical practice.
Language: Английский
Citations
0
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: May 7, 2025
Patients with chronic kidney disease (CKD) stages G3a to G5 frequently experience heightened systemic inflammation and nutritional loss. Identifying laboratory-accessible, cost-effective markers that can effectively predict the prognosis of CKD is crucial. This prospective cohort study included 3,331 patients who participated in National Health Nutrition Examination Survey (NHANES) from 2003 2018. Multivariable adjusted Cox proportional hazards regression models restricted cubic spline analyses were used assess associations neutrophil percentage-to-albumin ratio (NPAR) levels all-cause mortality, CVD, non-CVD mortality. The encompassed data participants for analysis. Nonlinear J-shaped observed between NPAR risk all-cause, mortality G5. High exhibited a significantly elevated both CVD fully model. respective hazard ratios (HRs) 1.23 [95% confidence interval (CI), 1.05-1.44], 1.513 (95% CI, 1.131-2.024). Elevated deaths advanced patients. Individuals high face an exhibit decreased survival rate context CKD. finding offers evidence supporting timely evaluation intervention status individuals
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Dec. 18, 2024
The neutrophil percentage to albumin ratio (NPAR) is an emerging, costimulatory indicator of inflammation that associated with a variety diseases, such as non-alcoholic fatty liver disease, fibrosis, stroke, and cardiovascular disease. However, the relationship between NPAR gallstones (GS) has not yet been explored. Therefore, this study aimed evaluate association odds GS age patients at time their first surgery. Participants were selected from National Health Nutrition Examination Survey (NHANES) in United States, nationally representative survey. Logistic regression analysis dose-response curve performed analyze prevalence GS. Multiple linear used Subgroup analyses further explored relationships age, sex, race, body mass index, hypertension, diabetes. In total, 7805 adults aged > 20 years included study, whom 838 had history After adjusting for all potential confounders, each 1-unit increase was found be 4% (odds (OR): 1.04, 95% confidence interval (CI): 1.02, 1.07) advancement patient surgery by 0.35 (β = − 0.35, CI: 0.68, 0.02). Dose-response curves confirmed positively negatively results subgroup suggested after positive more pronounced 40–59-year-old (OR: 1.07, 1.12), male non-Hispanic Black 1.06, 1.01, non-hypertensive 1.10), non-diabetic populations (OR=: 1.05, 1.08). higher NPAR, GS, earlier Due nature cross-sectional it possible determine causal them.
Language: Английский
Citations
1
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8611 - 8623
Published: Nov. 1, 2024
There is limited research on the long-term prognosis of percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) patients who have previously undergone artery bypass grafting (CABG). Additionally, prognostic value a novel systemic immune inflammation index (SII) this specific patient population remains unclear.
Language: Английский
Citations
0