Correlation between Neutrophil-to-Lymphocyte Ratio, Platelets-to-Lymphocyte Ratio, C-Reactive Protein-to-Albumin Ratio and Clinical Picture of Elderly Chronic Heart Failure Patients

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 433 - 433

Published: Jan. 12, 2024

Neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte (PLR) and C-reactive protein-to-albumin (CAR) are believed to be potential inflammatory markers that closely related the prognosis course of cardiovascular diseases. The main goal this study was evaluation NLR, PLR CAR as factors reflecting clinical picture elderly chronic heart failure (CHF) patients. In 150 patients with newly diagnosed CHF, were correlated cardiac, laboratory nutritional parameters. Systemic ratios selected patient's associated an unfavorable CHF-a reduced EF (p = 0.007), elevated PASP 0.014), increased LVESD in both males females 0.032 0.024, respectively) a decreased TAPSE 0.023). allowed us distinguish between NYHA I-III IV classes AUC 0.830. By analyzing five-year mortality rate different values, greater death recorded for high values-one-year (40.3% vs. 17.2%) (80% 58.3%) 0.002). Both NLR only An analysis markers, mainly CAR, allows management because its value can reflect cardiac status prognostic value. serve supplementary examinations evaluation.

Language: Английский

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Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in general population: evidence from NHANES 1999–2010

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

Chronic inflammation is a recognized independent risk factor for cardiovascular disease (CVD), highlighting the need reliable inflammatory indicator to predict CVDs. As an which has been proved have predictive value prognosis of CVDs, neutrophil percentage-to-albumin ratio (NPAR) obtained increasing attention, but further research needed confirm relationship with mortality in general population. This prospective cohort study included 21,317 individuals who participated National Health and Nutrition Examination Survey (NHANES) from 1999 2010, where baseline characteristics NPAR level were extracted. Data CVD all-cause acquired by linking database Death Index through December 31, 2019. We employed restricted cubic spline analyses examine nonlinear association. Weighted Kaplan-Meier curves log-rank tests conducted access cumulative survival differences across different results. Multivariable Cox proportional hazards regression models used compute hazard ratios 95% CIs. Receiver Operating Characteristic (ROC) compare systemic immune index (SII) neutrophils percent. In this study, during 270,014 person-years follow-up, 4,074 deaths 1,116 CVD-cause documented. levels exhibited significant associations both (P = 0.018 nonlinearity) < 0.001 nonlinearity). Participants highest tertile had significantly increased (HR: 1.46, CI: 1.33-1.61) 1.54, 1.32-1.80) compared those lowest fully adjusted model, while no association was detected middle tertile. Further ROC analysis confirmed that higher than percent segment SII. Elevated associated The high NPAR, combined easy-to-calculate property, suggests its potential as novel worthy investigation.

Language: Английский

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Insights into the Neutrophil-to-Lymphocyte Ratio and the Platelet-to-Lymphocyte Ratio as Predictors for the Length of Stay and Readmission in Chronic Heart Failure Patients

Diagnostics, Journal Year: 2024, Volume and Issue: 14(18), P. 2102 - 2102

Published: Sept. 23, 2024

Background/Objectives: Chronic heart failure (CHF) is characterized by complex pathophysiology, leading to increased hospitalizations and mortality. Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) provide valuable diagnostic insights. Methods: This study evaluates prognostic relationship between NLR, PLR, and, in a specific subcohort, N-terminal pro B-type natriuretic peptide (NT-proBNP), alongside length of stay (LOS) 90-day readmission rates CHF patients, irrespective phenotype. A retrospective analysis 427 admissions (males = 57.84%) was conducted. Results: The mean age entire population 68.48 ± 11.53 years. average LOS 8.33 5.26 days, with rate 73 visits (17.09%) for 56 patients. NLR (3.79 3.32) showed low but positive correlation (r 0.222, p < 0.001). Conversely, PLR (144.84 83.08) did not demonstrate significant association LOS. presented negative days until next admission −0.023, 0.048). In prespecified subanalysis 323 admissions, NT-proBNP exhibited Pearson 0.241, 0.001) 0.151, 0.006). Conclusions: impact across phenotypes may suggest role systemic inflammation understanding managing CHF.

Language: Английский

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The neutrophil–lymphocyte ratio is associated with all-cause and cardiovascular mortality in cardiovascular patients

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 4, 2024

This study investigates the relationship of neutrophil–lymphocyte ratio (NLR) with risk all-cause and cardiovascular mortality in patients disease. The data for this analysis came from 2239 participants disease National Health Nutrition Examination Survey conducted between 1999–2018. optimal cutoff point NLR was determined using maximally selected rank statistics. Survival performed Cox regression models to assess impact on mortality. Restricted cubic spline used visualize association risk. Subgroup examine within subgroups based age, sex, diabetes hypertension. During a median follow-up period 6.7 (IQR, 3.3–10.9) years, 992 deaths occurred, including 381 deaths. Our revealed that is factor (HR: 1.15 95%Cl: 1.11 ~ 1.19) 1.14 1.08 1.2) among restricted showed non-linear (p < 0.05 nonlinearity) patients. remained robust subgroup analyses stratified by diabetes, Conclusion stands as significant both

Language: Английский

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Impact of neutrophil percentage-to-albumin ratio on mortality in iron-deficiency anemia patients: a retrospective study using MIMIC-IV database

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 4, 2025

In the intensive care unit (ICU), incidence of iron-deficiency anemia (IDA) is relatively high and associated with various adverse clinical outcomes. Therefore, it crucial to identify simple practical indicators assess mortality risk in ICU patients IDA. This study aims investigate relationship between Neutrophil Percentage-to-Albumin Ratio (NPAR) levels IDA their all-cause at 30 365 days. We analyzed data from Medical Information Mart for Intensive Care-IV (MIMIC-IV) 3.0 database spanning years 2008–2022 identified a cohort 817 who met our inclusion criteria. Through multivariate Cox regression analysis, NPAR 30-day 365-day risks was assessed, restricted cubic splines (RCS) models were used explore potential nonlinear relationships. Additionally, an inflection point analysis conducted evaluate predicting short- long-term risks. The found that significantly increased (hazard ratio [HR] range 1.49–2.23, p < 0.001 all). natural logarithmic transformation (ln) exhibited inverse "L" shaped pattern. Patient when ln-transformed exceeded 1.2 (HR 3.366–4.304, subgroup analyses did not reveal any significant interactions, indicating predictive effect on consistent across different subgroups. risks, particularly values exceed 1.2, which death within days patients.

Language: Английский

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Negative association between the neutrophil percentage-to-albumin ratio (NPAR) and psoriasis: a retrospective cross-sectional study

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 7, 2025

Language: Английский

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Antioxidant and Inflammatory Potential of Diet is Associated with Risk of Asthma-Chronic Obstructive Pulmonary Disease Overlap: Findings from NHANES (2003-2018)

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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CALLY Index as a Comprehensive Biomarker for Heart Failure Risk: Findings from NHANES 1999–2010

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Background Heart failure (HF) is a critical global health issue characterized by high morbidity, mortality, and economic burden. The interplay of chronic inflammation, malnutrition, immune dysregulation central to HF pathogenesis. C-reactive protein-Albumin-Lymphocyte (CALLY) index, composite biomarker that integrates inflammatory, nutritional, parameters, offers novel, holistic approach risk prediction. However, its association with prevalence potential clinical utility remains underexplored. Methods This study utilized data from the NHANES 1999–2010 cohort, encompassing 14,900 participants after stringent inclusion criteria. CALLY index was computed as albumin (g/L) × lymphocyte count (10⁹/L) / protein (CRP, mg/L). Logistic regression models were assess relationship between quartiles prevalence, adjustments made for demographic, socioeconomic, factors. Nonlinear associations examined using restricted cubic spline analysis, while subgroup analyses evaluated differences across age, gender, ethnicity. Results Participants (n = 659, 4.4%) exhibited significantly lower values compared those without HF. Multivariate revealed robust, dose-dependent higher (Q4 vs. Q1: adjusted OR 7.49, 95% CI: 5.89–9.52, P < 0.001). Restricted analysis identified threshold value 692, above which sharply increased. Subgroup highlighted significant heterogeneity, stronger observed among older adults (≥ 60 years), males, non-Hispanic Black populations, suggesting demographic-specific predictive utility. Conclusions serves low-cost, readily accessible stratification, integrating dimensions nutrition, function. Its nonlinear offer practical insights early detection intervention. Tailored strategies high-risk demographic groups, such individuals, could enhance application. Further longitudinal studies interventional trials are required confirm these findings evaluate broader applicability in cardiovascular management.

Language: Английский

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Association of neutrophil-to-lymphocyte ratio and monocyte-tolymphocyte ratio with all-cause mortality in patients with ischemia and non-obstructive coronary arteries

Revista română de medicină de laborator, Journal Year: 2025, Volume and Issue: 33(1), P. 21 - 28

Published: Jan. 1, 2025

Abstract Background Ischemia with non-obstructive coronary arteries (INOCA) is a frequent syndrome important impact on morbimortality. Systemic inflammation, key pathophysiological mechanism in its development, reflected diverse bio-markers, such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR) and platelet-to-lymphocyte (PLR). In this retrospective observational study, we aimed to assess value of NLR, MLR PLR predictors all-cause long-term mortality INOCA patients. Methods Acute/ chronic consecutive patients hospitalized from January 2014 December 2019 were included, after excluding pulmonary hypertension, acute non-cardiac pathology, in-hospital mortality. The primary endpoint was Results Our cohort included 238 (62.2% female, mean age 64.1±9.5 years). Of all patients, 14.3% reached during 5.8±1.1 years follow-up. Age (OR=1.10, p <0.001), diabetes mellitus (OR 2.54, =0.01), heart failure (OR=3.73, =0.003), atrial fibrillation (OR=3.52, =0.001), severe valve disease (OR=3.99, NT-proBNP (OR=3.28, 3rd tertile NLR (OR=4.33, <0.001) (OR=4.34, predictors, while not. multivariable analysis baseline prediction model (HR=1.12, (HR=3.78, <0.001). Adding NLR>2.99 (HR=4.58, MLR>0.36 (HR=4.74, or both increased power predictive chi-square 33.00 51.08 ( Conclusions INOCA, independently correlated most accurate NLR>2.99, MLR>0.36, diagnosis failure.

Language: Английский

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Proposed Novel Heart Failure Biomarkers and Their Association with Length of Hospital Stay and Mortality: A Retrospective Observational Pilot Study

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 589 - 589

Published: Feb. 28, 2025

Background/Objectives: Chronic heart failure (CHF) remains a significant global health burden, with high morbidity, prolonged hospitalizations, and increased mortality. Traditional biomarkers such as NT-proBNP provide prognostic value; however, novel biomarker ratios may enhance risk stratification. This study evaluated the predictive utility of NT-proBNP-to-albumin ratio (NTAR), red cell distribution width-to-eGFR (RGR), width-to-fibrinogen (RFR) for hospital length stay (LOS), extended hospitalization (ELOS), in-hospital mortality, 6-month all-cause Methods: A retrospective observational pilot was conducted on 382 CHF admissions (2022-2024) comprehensive laboratory assessment. Biomarker performance assessed through uni- multivariate logistic regression, receiver operating characteristic curve, Cox proportional hazards stepwise methods analyses refining models. Results: NTAR RGR emerged predictors outcomes. demonstrated moderate correlation LOS (r = 0.45, p < 0.001) an independent predictor ELOS (AUC 0.697, OR 2.438, 0.001), outperforming NT-proBNP. Additionally, significantly predicted mortality 0.768, 4.461, 0.766, 4.185, 0.001). strongest 0.785, HR 2.18, 0.005), highlighting its role in renal dysfunction erythropoietic alterations CHF. The RFR observed value minimal. Conclusions: In our study, offered valuable underscoring interplay cardiac stress, nutritional status, function prognosis. Further multicenter validation is warranted these biomarkers.

Language: Английский

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