Current insights into transcriptional role(s) for the nutraceutical Withania somnifera in inflammation and aging

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 3, 2024

The health-beneficial effects of nutraceuticals in various diseases have received enhanced attention recent years. Aging is a continuous process wherein physiological activity an individual declines over time and characterized by indefinite hallmarks which contribute toward aging-related comorbidities include many neurodegenerative diseases, cardiac problems, diabetes, bone-degeneration, cancer. Cellular senescence homeostatic biological that has important function driving aging. Currently, growing body evidence substantiates the connection between epigenetic modifications aging process, along with diseases. These are now being recognized as promising targets for emerging therapeutic interventions. Considering almost all processes modulated RNAs, numerous RNA-binding proteins been found to be linked age-related complexities. studies shed light on ability nutraceutical Withania somnifera (Ashwagandha) influence RNA expression, stability, processing, offering insights into its mechanisms action. By targeting RNA-related pathways, may exhibit ameliorating age-associated molecular changes, gene expression signaling networks. This review summarizes potential role modulating RNA-level changes associated aging, encompassing both vitro vivo studies. Taken together, putative role(s) modulation key RNAs will provide understanding facilitate development preventive strategies employing healthy

Language: Английский

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Molecular Mechanisms of Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5452 - 5452

Published: May 17, 2024

Metabolic syndrome represents a cluster of conditions, such as abdominal obesity, hypertension, dyslipidemia, and hyperglycemia, that are highly prevalent in developed countries because unhealthy lifestyles [...]

Language: Английский

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The Role of PTP1B in Cardiometabolic Disorders and Endothelial Dysfunction

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 39

Published: Feb. 25, 2025

Cardiovascular diseases (CVD) are a global health concern that accounts for large share of annual mortality. Endothelial dysfunction is the main underlying factor eventually leads to cardiovascular events. Recent studies have underscored critical function Protein Tyrosine Phosphatase 1B (PTP1B) in onset endothelial dysfunction, chiefly through its involvement metabolic such as diabetes, obesity, and leptin resistance. PTP1B attenuates insulin signaling by dephosphorylating their respective receptors at key tyrosine residues, resulting resistance-both which significant mechanisms underpinning development dysfunction. also contributes disruption endoplasmic reticulum, causing reticulum stress, another molecular driver Efforts inhibit activity hold promise advancing prevention management CVD disorders, these conditions common risk factors cellular mechanisms. Numerous small molecules been reported inhibitors; however, progression advanced clinical trials has hindered major challenges low selectivity undesirable side effects. This review provides an in-depth analysis PTP1B's interaction with examines strategies related inhibiting this enzyme.

Language: Английский

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Circadian biology in obstructive sleep apnea associated cardiovascular disease

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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The effect of Chromium Supplementation on cardio-metabolic risk factors in overweight and obese patients. A systematic review and meta-analysis of randomized controlled trial

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 89, P. 127645 - 127645

Published: April 12, 2025

Language: Английский

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Discover the Power of Lithospermic Acid as Human Carbonic Anhydrase VA and Pancreatic Lipase Inhibitor Through In Silico and In Vitro Studies

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(4)

Published: April 1, 2025

ABSTRACT Obesity remains a significant global health concern, with limited pharmacological options that balance efficacy and safety. In this study, we identified lithospermic acid (LTS0059529) from Salvia miltiorrhiza as potential dual inhibitor of pancreatic lipase (PL) human carbonic anhydrase VA ( h CA VA), two key enzymes in lipid metabolism. Using molecular docking dynamics simulations, observed interacts Zn²⁺ via its benzofuran carboxylate moiety forms stable complexes PL through hydrogen bonding ASP 205 π–stacking interactions PHE 77 215. Experimental validation confirmed inhibitory activity, K i values 33.1 ± 1.6 μM for 0.69 0.01 VA. While inhibition is not isoform‐specific, demonstrates inhibitor, targeting complementary pathways obesity management. This study the first to explore action on VA, highlighting promising strategy future antiobesity therapies. Further research will focus optimizing selectivity potency develop safer more effective treatments.

Language: Английский

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The impact of Intermittent Fasting and Mediterranean Diet on older adults physical health and quality of life: A Randomized Clinical Trial

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 104132 - 104132

Published: May 1, 2025

Language: Английский

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Transcriptomic Analysis of Arachidonic Acid Pathway Genes Provides Mechanistic Insight into Multi-Organ Inflammatory and Vascular Diseases

Genes, Journal Year: 2024, Volume and Issue: 15(7), P. 954 - 954

Published: July 20, 2024

Arachidonic acid (AA) metabolites have been associated with several diseases across various organ systems, including the cardiovascular, pulmonary, and renal systems. Lipid mediators generated from AA oxidation studied to control macrophages, T-cells, cytokines, fibroblasts, regulate inflammatory that induce vascular remodeling dysfunction. is metabolized by cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP) generate anti-inflammatory, pro-inflammatory, pro-resolutory oxidized lipids. As comorbid states such as diabetes, hypertension, obesity become more prevalent in cardiovascular disease, studying expression of pathway genes their association these can provide unique pathophysiological insights. In addition, lipids exhibits diverse functions different where a lipid be both anti-inflammatory pro-inflammatory depending on location metabolic activity. Therefore, we aimed characterize gene enzymes receptors throughout multi-organ via transcriptomic meta-analysis using Gene Expression Omnibus (GEO) Database. our study, found distinct pathways were expressed conditions, especially those prominent risk factors. Comorbidities, appeared contribute elevated mediator genes. Our results demonstrate may potentiate attenuate disease; therefore, suggest further exploration therapeutic targets improve outcomes.

Language: Английский

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Multimorbidity patterns and the association with health status of the oldest-old in long-term care facilities in China: a two-step analysis

BMC Geriatrics, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 13, 2023

Abstract Background The increasing prevalence of multimorbidity has created a serious global public health problem in aging populations. Certain patterns across different age ranges and their association with status remain unclear. main aim this study is to identify discrepancies associated between younger-old oldest-old. Methods Ethics Committee Nanjing Medical University approved the protocol (No.2019–473). Convenience sampling method was used recruit older adults aged ≥ 60 years from July December 2021 38 Landsea long-term care facilities China. were analyzed using network analysis two-step cluster analysis. One-Way ANOVA utilized explore including body function, activity daily living, social participation. A Sankey diagram visualized flow within patterns. This reported following STROBE guidelines. Results total 214 (60–84 years) 173 oldest-old (≥ 85 included. Leading coexisting diseases cardiovascular disease (CD), metabolic endocrine (MED), neurological (ND), orthopedic (OD). Cluster 1 (53, 24.8%) CD-ND (50, 94.3%; 31, 58.8%), 2 (39, 18.2%) MED-ND-CD 100%; 39, 37, 94.9%), 3 (37, 17.3%) OD-CD-MED-ND 33, 89.2%; 27, 73.0%; 16, 43.2%), 4 (34, 15.9%) CD-MED 34, 100%) identified younger-old. In oldest-old, primary were: (33, 19.1%) CD-respiratory disease-digestive disease-urogenital (CD-RD-DSD-UD) (32, 97.0%; 9, 27.3%; 8, 24.2%; 7, 21.2%), (42, 24.3%) ND-CD-MED 35, 83.3%; 14, 33.3%), (28, 16.2%) OD-CD-MED 25, 89.3%; 18, 64.3%), (35, 20.2%) 100%). Younger-old or MED-ND-CD, have worse compared other (e.g., OD-CD-MED). Conclusion Discrepancies common groups suggest that caregivers should consider changes ageing when developing prevention plans for individualized management. Neurological concurrent major determinant status, especially Interventions targeting need be focused, yet generic. It essential assess complex needs outcomes arise manage them through an interdisciplinary approach priorities gain high-quality living facilities.

Language: Английский

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Food addiction and the physical and mental health status of adults with overweight and obesity

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17639 - e17639

Published: June 28, 2024

Background Overweight and obesity now affect more than a third of the world’s population. They are strongly associated with somatic diseases, in particular increasing risk many metabolic cardiovascular but also mental disorders. In particular, there is strong association between depression. As result, attention paid to neurobiological, behavioural, psychological mechanisms involved eating. One these food addiction (FA). Research comparing lifestyle elements, physical health problems excess body weight individuals FA limited has focused on younger people, mainly students. There lack studies that relate actual parameters FA. To better understand problem older adults, it important specific relationships variables. Methods A cross-sectional survey was conducted 172 adults overweight (82% female) aged 23–85 years. The mean age all subjects M = 59.97 years ( SD 11.93), BMI 32.05 kg/m 2 4.84), fat 39.12% 6.48). following questionnaires were used: Food Frequency Questionnaire-6 (FFQ-6), Global Physical Activity Questionnaire (GPAQ), Three Factor Eating Questionnaire-R18 (TFEQ-R18), Yale Addiction Scale 2. 0 (YFAS 2.0), Zung Self-Rating Depression (SDS). Body composition, anthropometry, fasting glucose, lipid profile, blood pressure measured. Results total 22.7% participants had symptoms depression according SDS, 18.6% met criteria for YFAS 2.0. statistically significantly common among people up 50 BMI, mass, diastolic sedentary behaviour higher symptoms. Those who 301–450 min per day likely have depressive symptoms, those 450 Conclusions Our findings complement current literature FA, particularly parameters, suggest further research directions. Although our study design does not allow causal interpretations, activity appears be management or This may even alone, future needed explore further.

Language: Английский

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