Physiological Effects of Alloxan on Serum Glucose Levels and Liver Function Test in Male Rabbit DOI

Iftikhar Ahmed Pirzada,

Allah Bux Kachiwal,

Jameela Soomro

et al.

Futuristic Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 38 - 44

Published: June 30, 2024

Diabetes is a metabolic disorder characterized by elevated blood glucose levels that can lead to various complications. Exploring the physiological alterations in rabbits provide valuable insights for development of therapeutic interventions. This research delves into impact diabetes on and biochemical parameters male rabbits. Objectives: To compare like body temperature, heart rate, respiration oxygen saturation) weight parameters, including levels, alanine aminotransferase (ALT), aspartate (AST), creatinine, lactate dehydrogenase (LDH), total protein diabetic non-diabetic Methods: An experiment 30 divided control groups measured saturation. Body were tracked, samples taken ALT, AST, LDH, cholesterol, triglycerides levels. Statistical analysis was conducted between groups. Results: The results showed induced affects their significantly. Diabetic had lower saturation compared group. They also higher Biochemical increased creatinine decreased LDH Conclusions: These demonstrate extensive rabbit physiology biochemistry, offering future research.

Language: Английский

Aldehyde Dehydrogenase 2 rs671 Polymorphism is Associated with Susceptibility of Coronary Atherosclerosis in Patients with Hypertension DOI Creative Commons

Haisong Hou,

Sumei Huang, Wen‐Yi Huang

et al.

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 681 - 690

Published: Feb. 1, 2025

Objective: Predisposing factors for coronary atherosclerosis in hypertensive individuals are unclear. Atherosclerosis is a chronic inflammatory disease caused by lipid deposition the blood vessels, and aldehyde dehydrogenase 2 (ALDH2) involved this process. The aim of study was to assess relationship between ALDH2 rs671 polymorphism, serum lipids, peripheral inflammation indices (pan-immune value (PIV), systemic immune index (SII), system response (SIRI)) risk patients. Methods: A total 923 patients with hypertension (439 atherosclerosis, 484 without) who were admitted Meizhou People's Hospital January 2019 February 2024 retrospectively analyzed. levels, Results: There 532 (57.6%), 337 (36.5%), 54 (5.9%) G/G, G/A, A/A genotype, respectively. frequency G/A levels TC, LDL-C, PIV, SII, SIRI higher than those controls. Logistic analysis showed that body mass (BMI) ≥ 24.0 kg/m (odds ratio (OR): 1.670, 95% confidence interval (CI): 1.185– 2.352, p =0.003), history smoking (OR: 2.024, CI: 1.263– 3.243, genotype 1.821, 1.280– 2.589, =0.001), high TC 1.592, 1.021– 2.485, =0.040), SII 2.290, 1.386– 3.784, 1.727, 1.126– 2.650, =0.012) associated hypertension. Conclusion: Overweight (BMI ), smoking, Keywords: hypertension, , index,

Language: Английский

Citations

0
Exploring Diabetic Retinopathy: Pathogenesis, Therapeutic Advances, and Genetic Influences DOI

Lavanya B. Ramegowda,

Saurabh Maheshwari,

Shobha Chikkavaddaragudi Ramachandra

et al.

Current Ophthalmology Reports, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 11, 2025

Language: Английский

Citations

0
Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension DOI Creative Commons
Guoliang Wei, Bin Li, Hao Wang

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 12, 2024

Language: Английский

Citations

1
Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid‐β Aggregation in Cardiovascular Disease DOI

Komal Jabeen,

Kanwal Rehman, Muhammad Sajid Hamid Akash

et al.

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2024, Volume and Issue: 52(1)

Published: Nov. 24, 2024

Abstract This article investigates the intricate associations between apolipoprotein E (APOE) gene alleles variation, insulin resistance (IR) and amyloid‐β aggregation in cardiovascular disease (CVD) patients. A cohort of 250 patients exhibiting symptoms CVD 50 control subjects participated this study. After applying stringent inclusion exclusion criteria, diseased group was further stratified into three categories: CVD+ (Alzheimer's disease) AD, + (diabetes mellitus) DM AD. Blood samples were collected from all recruited participants for biochemical analyses lipid profile, glycaemic status, liver function enzymes, inflammatory oxidative stress biomarkers. Tetra amplification‐refractory mutation system‐polymerase chain reaction (ARMS‐PCR) employed APOE analysis. Biochemical evaluations revealed significant elevations serum levels glucose, interleukin‐6 (IL‐6), cholesterol, low‐density lipoproteins (LDL), triglycerides (TG) malondialdehyde (MDA) AD group. Conversely, insulin, HDL hexokinase decreased compared to controls other groups. ARMS‐PCR results indicated a higher percentage risk allele when with Our study elucidates multifaceted factors contributing IR Age‐related factors, prevalence impact statin use on incidences identified. These findings underscore need tailored preventive measures, particularly APOEε4 ε3/ε4 carriers CVD. Further studies should delve knowledge‐based protocols comprehend underlying mechanisms. Focusing therapeutic targets prevent or delay progression CVDs, especially carriers, is essential.

Language: Английский

Citations

1
Influence of apolipoprotein E gene polymorphisms on coronary artery disease in patients undergoing coronary angiography DOI Creative Commons

Azhi ShaMa,

Yingying Huang, Chunlan Ma

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33690 - e33690

Published: June 26, 2024

ObjectivePrevious studies have shown that apolipoprotein E (ApoE) gene polymorphisms an impact on coronary artery disease(CAD). However, many small sample sizes and different conclusions. The purpose was to retrospectively study the influence of ApoE CAD.MethodsThis assessed genotypes heart disease in patients who received angiography used multivariate logistic regression assess CAD.ResultsPatients with had no obvious differences incidence hypertension, diabetes or obesity(P > 0.05). Patients ε2/ε2 higher hypertriglyceridemia than other genotypes, while ε3/ε3 a lower those ε3/ε4,ε4/ε4, ε2/ε3 ε2/ε2(P < ε3/ε4, ε4/ε4, significant severity CAD (P ε2/ε4 reduced risk high LDL-C, heart(P premature disease(PCAD)(P age <45,age at 60–74 ≥74, ≥74(P 0.05).ConclusionPatients ε4/ε4,ε3/ε3 occurrence CAD. Compared isoform ε3 (ε3/ε3), ε4 did not increased LDL-C

Language: Английский

Citations

0
Apolipoprotein E E3/E4 genotype is associated with an increased risk of premature coronary artery disease DOI Creative Commons

Youqian Li,

Wei Zhong,

Changjing Huang

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 10, 2024

Dyslipidemia is one of the causes coronary heart disease (CAD), and apolipoprotein E (APOE) gene polymorphism affects lipid levels. However, relationship between APOE polymorphisms premature CAD (PCAD, male patients with ≤ 55 years old female 65 old) risk had different results in studies. The aim this study was to assess further evaluate PCAD Hakka population.

Language: Английский

Citations

0
Physiological Effects of Alloxan on Serum Glucose Levels and Liver Function Test in Male Rabbit DOI

Iftikhar Ahmed Pirzada,

Allah Bux Kachiwal,

Jameela Soomro

et al.

Futuristic Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 38 - 44

Published: June 30, 2024

Diabetes is a metabolic disorder characterized by elevated blood glucose levels that can lead to various complications. Exploring the physiological alterations in rabbits provide valuable insights for development of therapeutic interventions. This research delves into impact diabetes on and biochemical parameters male rabbits. Objectives: To compare like body temperature, heart rate, respiration oxygen saturation) weight parameters, including levels, alanine aminotransferase (ALT), aspartate (AST), creatinine, lactate dehydrogenase (LDH), total protein diabetic non-diabetic Methods: An experiment 30 divided control groups measured saturation. Body were tracked, samples taken ALT, AST, LDH, cholesterol, triglycerides levels. Statistical analysis was conducted between groups. Results: The results showed induced affects their significantly. Diabetic had lower saturation compared group. They also higher Biochemical increased creatinine decreased LDH Conclusions: These demonstrate extensive rabbit physiology biochemistry, offering future research.

Language: Английский

Citations

0