Impact of migraine on changes in cardiovascular health profile among Hong Kong Chinese women: insights from the MECH-HK cohort study DOI Creative Commons
Jingbo Liang, Jiajun Ma, Haoxiang Wang

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 27, 2024

Previous research has shown an association between migraine and cardiovascular diseases (CVDs). However, limited studies have explored the progression of health (CVH) among individuals with migraine. This cohort study aimed to explore relationship changes in CVH women Chinese descent Hong Kong. Data from a titled "Migraine Exposures Cardiovascular Health Kong Women (MECH-HK)" were analysed. A total 2,603 women, averaging 56.5 ± 8.5 years age, selected, all complete data at baseline follow-up occurring on average 1.27 later. profile was assessed by adapted Life's Essential 8, comprising dietary habits, physical activity, nicotine exposure, sleep duration, body mass index (BMI), lipid levels, blood pressure, stress. Each component scored 0 100, overall as average. levels categorized low (0–49), moderate (50–79), high (80–100), representing poor excellent health. Changes defined shifts these categories subsequent follow-up. Migraine cases identified utilizing International Classification Headache Disorders 3. 275 (10.6%) having By follow-up, both without experienced significant declines profiles (all p-value < 0.05). In fully adjusted model, had 1.36 times higher risk (OR 95% CI: 1.33, 1.39) decline compared non-migraineurs. They also likelihood shifting worse several individual components, including activity (OR: 1.09), exposure 4.27), quality 1.80), 1.03), stress 1.23) Among migraine, those experiencing aura poorer greater BMI, increased than exhibited Targeted monitoring management CVH-related factors this population are crucial reducing their elevated CVDs.

Language: Английский

Association between serum carotenoids levels and severe headache or migraine in adults: a cross-sectional study from NHANES DOI Creative Commons
Hu Tian, Yufei Chen, Siyu Chen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Carotenoids are well-established for their potent antioxidant properties; however, potential association with severe headaches or migraines remains largely unexamined. This study was conducted to explore the relationship between serum carotenoid levels and prevalence of within US population. We utilized data from 2001-2004 National Health Nutrition Examination Survey (NHANES), which comprised a total 8,910 participants. Serum levels-specifically α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene-were quantified using high-performance liquid chromatography. Migraine status determined based on questionnaire. The research methodologies employed included multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) models. in population 22.37%. Multivariate regression analysis indicated that concentrations α-carotene (OR = 0.91, 95% CI: 0.85-0.97), β-carotene 0.88, 0.81-0.94), β-cryptoxanthin 0.83, 0.76-0.90), lutein/zeaxanthin 0.75, 0.67-0.85), carotenoids 0.79, 0.70-0.90) were significantly inversely correlated migraines; no significant found lycopene levels. RCS showed had an L-shaped non-linear migraine at threshold approximately 9.392 μg/dL, while analyses confirmed consistent inverse across various groups. incidence adults. evidence indicates may provide protective effect against further investigation is warranted substantiate these associations elucidate underlying mechanisms.

Language: Английский

Citations

1
Neuropsychiatric adverse events associated with Glucagon-like peptide-1 receptor agonists: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database DOI Creative Commons
Wenchao Lu, Shihan Wang, Huilin Tang

et al.

European Psychiatry, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 1, 2025

Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used due to their profound efficacy in glycemic control and weight management. Real-world observations have revealed potential neuropsychiatric adverse events (AEs) associated with GLP-1RAs. This study aimed comprehensively investigate characterize these AEs Methods We analyzed GLP-1RA reaction reports using the FDA Adverse Event Reporting System database. Disproportionality analysis reporting odds ratio (ROR) identified eight categories of conducted descriptive time-to-onset (TTO) analyses explored AE signals among individual GLP-1RAs for loss diabetes mellitus (DM) indications. Results 25,110 cases GLP-1RA-related AEs. showed an association headache (ROR 1.74, 95% confidence interval [CI] 1.65–1.84), migraine 1.28, 95%CI 1.06–1.55), olfactory sensory nerve abnormalities 2.44, 1.83–3.25; ROR 1.69, 1.54–1.85). Semaglutide a moderate suicide-related signal population 2.55, 1.97–3.31). The median TTO was 16 days (interquartile range: 3–66 days). Conclusions In this study, we and, first time, detected positive migraine, abnormalities, abnormalities. also observed semaglutide, population. provides reliable basis further investigation However, as exploratory our findings require confirmation through large-scale prospective studies.

Language: Английский

Citations

1
Tryptophan metabolism in migraine: a review of experimental and clinical studies and a need to enhance research strategies DOI
Michał Fila, Jan Chojnacki,

Marcin Derwich

et al.

Reviews in the Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Tryptophan (TRP) metabolism produces various neuroactive substances in the gastrointestinal tract, as well central and peripheral nervous systems intestinal microbiota. Initially centered on serotonin pathway TRP itself, many studies are now focusing kynurenine pathway, with an increasing interest indole pathway. Several metabolites have been associated migraines, suggesting that may serve a potential therapeutic target. However, these significant limitations, including small number of participants, lack standardized diets prior to and/or during clinical trials, insufficient information regarding transformation after its intake. Furthermore, no thorough study encompasses all essential components metabolism: products, enzymes, receptors, transporters. Different mechanisms explain involvement glutamate signaling neurovasodilatory, immune, oxidative, inflammatory processes. The results role migraine be helpful for making dietary recommendations prevention management; however, individual characteristics metabolizing should considered. aim this narrative perspective review is critically present explore their implications therapy. Unlike other reviews focus solely either or our paper addresses three primary pathways.

Language: Английский

Citations

0
Neutrophil percentage-to-albumin ratio and the risk of all-cause and cardiovascular mortality: a 20-year follow-up cohort study of 36,428 US adults DOI Creative Commons

Dunzheng Han,

Lanlan Wu,

Haobin Zhou

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 22, 2025

Language: Английский

Citations

0
Association between the Composite Dietary Antioxidant Index and severe headache or migraine: results from the National Health and Nutrition Examination Survey DOI Creative Commons

Zhiru Zhang,

Xushan Chen,

Haotao Fang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 1, 2024

Severe headache or migraine is a neurological disease that seriously affects the quality of human life. Oxidative stress considered main factor in pathogenesis severe migraine. The Composite Dietary Antioxidant Index (CDAI) score calculated using six dietary antioxidant components (including vitamins A, C, E, selenium, zinc, and carotenoid), which represents person's level ingredients. Based on theory oxidative stress, we speculated CDAIs may be relevant to risk migraine, as relationship between CDAI unclear. Hence, purpose this study was explore participants.

Language: Английский

Citations

2
A U-shaped association between composite dietary antioxidant index and migraine in US adults: a nationwide cross-sectional study DOI

Teng Zuo,

Jingya Yang,

Yiyan Sun

et al.

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Nov. 5, 2024

Background: The field of dietary therapies for migraine has grown in popularity. Less research been conducted to establish the relationship between and composite antioxidant index (CDAI), a crucial indicator evaluating overall combined effects multiple antioxidants. Therefore, this study addressed gap based on National Health Nutrition Examination Survey (NHANES) database.

Language: Английский

Citations

0
Impact of migraine on changes in cardiovascular health profile among Hong Kong Chinese women: insights from the MECH-HK cohort study DOI Creative Commons
Jingbo Liang, Jiajun Ma, Haoxiang Wang

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 27, 2024

Previous research has shown an association between migraine and cardiovascular diseases (CVDs). However, limited studies have explored the progression of health (CVH) among individuals with migraine. This cohort study aimed to explore relationship changes in CVH women Chinese descent Hong Kong. Data from a titled "Migraine Exposures Cardiovascular Health Kong Women (MECH-HK)" were analysed. A total 2,603 women, averaging 56.5 ± 8.5 years age, selected, all complete data at baseline follow-up occurring on average 1.27 later. profile was assessed by adapted Life's Essential 8, comprising dietary habits, physical activity, nicotine exposure, sleep duration, body mass index (BMI), lipid levels, blood pressure, stress. Each component scored 0 100, overall as average. levels categorized low (0–49), moderate (50–79), high (80–100), representing poor excellent health. Changes defined shifts these categories subsequent follow-up. Migraine cases identified utilizing International Classification Headache Disorders 3. 275 (10.6%) having By follow-up, both without experienced significant declines profiles (all p-value < 0.05). In fully adjusted model, had 1.36 times higher risk (OR 95% CI: 1.33, 1.39) decline compared non-migraineurs. They also likelihood shifting worse several individual components, including activity (OR: 1.09), exposure 4.27), quality 1.80), 1.03), stress 1.23) Among migraine, those experiencing aura poorer greater BMI, increased than exhibited Targeted monitoring management CVH-related factors this population are crucial reducing their elevated CVDs.

Language: Английский

Citations

0