Phoenix dactylifera L. Pollen and Fluvoxamine Maleate Protect PC12 Cells Against H2O2-Induced Oxidative Stress by Involvement of Nrf2 and SIGMAR1 Gene Expression DOI Open Access
Elham Lak Mazaheri, Azadeh Niknejad, Elaheh Amini

et al.

Jundishapur Journal of Natural Pharmaceutical Products, Journal Year: 2023, Volume and Issue: 19(1)

Published: Dec. 28, 2023

Background: The association between oxidative stress and the pathogenesis of neurodegenerative diseases has been documented. Besides, there is evidence that antidepressant agents, such as fluvoxamine maleate (Flv), can ameliorate neurotoxicity. date palm (Phoenix dactylifera L.) pollen (DPP) contains various compounds with antioxidant capacity; however, its underlying mechanism function not fully understood. Objectives: present study aimed to compare neuroprotective effects DPP Flv on H2O2-induced damage their Nrf2, SIGMAR1, Bcl2 gene expression in PC12 cells. Methods: First, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay examined toxicities DPP, Flv, H2O2 at concentrations Real-time polymerase chain reaction (PCR) measured cells presence or absence after 4 h treatment 100 μM H2O2. Results: Based MTT results, 200 - 1000 µg/mL had no toxic effect IC50 was evaluated 57.26 109.5 under PCR analysis showed a decrease Nrf2 SIGMAR1 treated H2O2, an indicator recruitment Pretreatment (500 10 µM, respectively) for 24 resulted upregulation relative vehicle control. In addition, pretreatment increased level compared H2O2-exposed Considering role endoplasmic reticulum stress, should be translational level. Compared untreated cells, decreased all experimental cases, difference significant co-treatment cases. Conclusions: Taken together, have against Exposure 500 μg/mL protected morphology H2O-induced via regulating stress-involved genes.

Language: Английский

Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID DOI Creative Commons

Jun-Won Seo,

Seong Eun Kim, Yoonjung Kim

et al.

Infection and Chemotherapy, Journal Year: 2024, Volume and Issue: 56(1), P. 122 - 122

Published: Jan. 1, 2024

"Long COVID" is a term used to describe condition when the symptoms and signs associated with coronavirus disease 2019 (COVID-19) persist for more than three months among patients infected COVID-19; this has been reported globally poses serious public health issue. Long COVID can manifest in various forms, highlighting need appropriate evaluation management by experts from fields. However, due lack of clear clinical definitions, knowledge pathophysiology, diagnostic methods, treatment protocols, it necessary develop best standard guidelines based on scientific evidence date. We developed guideline diagnosing treating long analyzing latest research data collected start COVID-19 pandemic until June 2023, along consensus expert opinions. This provides recommendations diagnosis that be applied practice, total 32 key questions related COVID. The should comprehensive, including medical history, physical examination, blood tests, imaging studies, functional tests. To reduce risk developing COVID, vaccination antiviral during acute phase are recommended. will revised there reasonable updates availability new

Language: Английский

Citations

20
Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: The role of Epstein–Barr virus and the gut–brain axis DOI Creative Commons
Kenji Hashimoto

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(12), P. 4968 - 4976

Published: July 4, 2023

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection has resulted in a serious public health burden worldwide. In addition to respiratory, heart, and gastrointestinal symptoms, patients infected with SARS-CoV-2 experience number of persistent neurological psychiatric known as long COVID or "brain fog". Studies autopsy samples from who died COVID-19 detected the brain. Furthermore, increasing evidence shows that Epstein-Barr virus (EBV) reactivation after might play role symptoms. Moreover, alterations microbiome contribute this article, author reviews detrimental effects on brain, biological mechanisms (e.g., EBV reactivation, changes gut, nasal, oral, lung microbiomes) underlying COVID. addition, discusses potential therapeutic approaches based gut-brain axis, including plant-based diet, probiotics prebiotics, fecal microbiota transplantation, vagus nerve stimulation, sigma-1 receptor agonist fluvoxamine.

Language: Английский

Citations

35
Positionspapier zum Post-COVID-Syndrom DOI

Elisabeth Schieffer,

Denise Hilfiker‐Kleiner, Axel Schlitt

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Citations

0
Pharmacologic and Nonpharmacologic Treatment of Long COVID: A Meta-narrative Review DOI
Bala Munipalli, Nancy L. Dawson,

J. Calvo Rosales

et al.

SN Comprehensive Clinical Medicine, Journal Year: 2025, Volume and Issue: 7(1)

Published: April 14, 2025

Language: Английский

Citations

0
A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID complications DOI Creative Commons
Mani Iyer Prasanth, Dhammika Leshan Wannigama, Angela M. Reiersen

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 12, 2024

Abstract There have been 774,075,242 cases of COVID-19 and 7,012,986 deaths worldwide as January 2024. In the early stages pandemic, there was an urgent need to reduce severity disease prevent for hospitalization avoid stress on healthcare systems worldwide. The repurposing drugs clinical deterioration patients trialed in many studies using different drugs. Fluvoxamine (an SSRI sigma-1 receptor agonist) initially identified potentially provide beneficial effects COVID-19-infected patients, preventing hospitalization. Fourteen carried out date, with seven those being randomized placebo-controlled studies. This systematic review meta-analysis covers literature from outbreak SARS-CoV-2 late 2019 until Search terms related fluvoxamine, such its trade names chemical names, along words COVID-19, coronavirus, were used databases including PubMed, Google Scholar, Scopus, ClinicalTrials.gov database NIH, identify trials subsequent analysis. Clinical death data extracted these where available meta-analysis. A total 7153 studied across 14 (both open-label double-blind placebo-controlled). 681 3553 (19.17%) standard care group 255 3600 (7.08%) fluvoxamine-treated experienced deterioration. estimated average log odds ratio 1.087 (95% CI 0.200 1.973), which differed significantly zero (z = 2.402, p 0.016). resulted a 0.359 0.1111 0.5294), 3.103, 0.002). results this study fluvoxamine effective deterioration, subgrouping analysis suggests that earlier treatment dose 200 mg or above provides best outcomes. We hope outcomes can help design future into respiratory viral infections improve

Language: Английский

Citations

3
Tackling persistent neurological symptoms in patients following acute COVID-19 infection: an update of the literature DOI Creative Commons
Eder Cáceres, Afshin A. Divani, André Emilio Viñán Garcés

et al.

Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Dec. 23, 2024

Introduction The COVID-19 pandemic has taught myriad lessons and left several questions we are yet to comprehend. Initially, the scientific community was concerned with management of acute disease immunization. Once peak receded, it became clear that a proportion patients were far from fully recovered. Researchers started recognize those persisting symptoms as new entity termed 'Long COVID,' where neurological evident have major impact on quality life.

Language: Английский

Citations

3
Antidepressants for prevention of severe COVID-19, Long COVID and outlook for other viral diseases DOI Creative Commons
Udo Bonnet, Georg Juckel, Jens Kuhn

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 20, 2024

OPINION article Front. Med., 20 February 2024Sec. Infectious Diseases: Pathogenesis and Therapy Volume 11 - 2024 | https://doi.org/10.3389/fmed.2024.1305184

Language: Английский

Citations

2
The effect of Baduanjin Qigong combined with five-elements music on anxiety and quality of sleep in asymptomatic patients with COVID-19 infection: A randomised controlled trial DOI Creative Commons
Xian Wang,

Xuan Yin,

Ping Liu

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(8), P. e18962 - e18962

Published: Aug. 1, 2023

BackgroundInfections of Coronavirus Disease-2019 (COVID-19) and the subsequent quarantine can culminate in anxious mood sleep disturbances. The objective this clinical trial was to investigate effect traditional Qigong with music therapy on relieving anxiety improving quality Chinese adults COVID-19 infection.MethodsA total 200 asymptomatic infected patients were randomly assigned into two groups during their period Chongming Island, Shanghai. treatment group daily received Baduanjin Qigong, five-elements routine care, while control only took care. primary outcome levels measured by 7-item Generalized Anxiety Disorder scale (GAD-7). Secondary outcomes included Jenkins Sleep Scale (JSS), degree depression Patient Health Questionnaire (PHQ-9), as well self-efficacy Perceived Competence (PHCS). An online questionnaire given all participants day arrival determine baseline for then again discharge. A one-way analysis covariance used analyze differences between after intervention.ResultsAt end intervention, 177 (88.5%) finished questionnaire. Patients had clearly decreased GAD-7 scores (MD = 2.7, 95% CI 2.3, 3.2) exercise music. little changes −0.2, 95%CI −0.7, 0.3, P 0.07), PHQ-9 0.1, −0.5, 0.6, 0.66) when compared scores. There statistical between-group 2.9, 2.2, 3.6, < 0.001)and 4.4, 0.001) at post-treatment. Compared group, significantly lower JSS 2.0, 3.3, 0.001), higher PHCS −5.0, −6.1, −3.9, receiving therapy.ConclusionTraditional help relieve depression, improve infection.Trial registrationChinese Clinical Trial Registry ChiCTR2200059800.

Language: Английский

Citations

6
Randomized Controlled Trials for Post-COVID-19 Conditions: A Systematic Review DOI Open Access
Shastri Motilal,

Rebecca Rampersad,

Mercédes Adams

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

Post-coronavirus disease 2019 (COVID-19) syndrome or condition (PCS) is defined as new onset symptoms for at least three months following COVID-19 infection that has persisted two months. Given the global sequelae of COVID-19, there an urgent need effective PCS interventions. The aim this study was to systematically review all interventions tested in randomized controlled trials. In International Prospective Register Systematic Reviews (PROSPERO) registered (CRD42023415835) systematic review, PubMed, Google Scholar, and ClinicalTrials.gov databases were searched between 1st January 2020 30th April 2023. Inclusion criteria (1) trials (2) above. Studies independently reviewed, final decisions regarding extracted data risk bias made by consensus. Trial findings summarized qualitatively. included 23 with 1,916 subjects (mean age 44.9, 25.8% males) from 10 countries. predominant symptom function targeted general long (35%), fatigue (30%), breathlessness (17%), olfactory brain (9%). Overall, majority (74%) high bias. A range identified, including physical therapies, dietary regenerative treatments, electrical stimulation, digital wellness programs variable effects. While a diverse have been tested, their effectiveness varies, threats validity most studies. Trials focusing on mental health disorders, musculoskeletal complaints, children are needed. Well-designed RCTs needed establish definitive PCS.

Language: Английский

Citations

1
Die Bedeutung von Antidepressiva bei COVID-19 und Long-COVID – Ein Scoping-Review Update DOI
Udo Bonnet, Georg Juckel

Fortschritte der Neurologie · Psychiatrie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Introduction Preclinically, fluvoxamine and other antidepressants (AD) exerted antiviral anti-inflammatory properties also against SARS-COV-2. Therfore, It makes sense to test the clinical effect of AD COVID-19 Long COVID.

Language: Английский

Citations

1