Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID DOI Creative Commons

Shreya Mukherjee,

Tracey Singer,

Aditi Venkatesh

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 7(1)

Published: Dec. 11, 2024

Abstract Persistent symptoms after COVID-19 constitute the long COVID syndrome, also called post-acute sequelae of SARS-CoV-2 infection (PASC). vaccines reduce gravity ensuing infections. However, whether have an impact on PASC remain unknown. We investigated vaccination prior to alters subsequent neurologic (Neuro-PASC). studied prospectively first consecutive 200 post-hospitalization Neuro-PASC (PNP) and 1100 non-hospitalized (NNP) patients evaluated at our neuro-COVID-19 clinic between May 2020 January 2023. Among PNP patients, 87% had a pre-vaccination 13% breakthrough post-vaccination. NNP 70.7% 29.3% infection. Both more frequent pre-existing depression/anxiety than their respective groups, comorbidities headache, lung gastrointestinal diseases group. An average 10 months symptom onset, three most common neurological for were brain fog (86.5%), numbness/tingling (56.5%) headache (56.5%). Of all symptoms, frequently reported anosmia compared (69.2 versus 37.9%; P = 0.005). For (83.9%), (70.9%) dizziness (53.8%). (56.6 39.1%; < 0.0001) dysgeusia (53.3 37.3%; patients. (61.5 50.6%; 0.001). impaired quality-of-life in cognitive, fatigue, sleep, anxiety depression domains with no differences groups. performed worse National Institutes Health Toolbox tests processing speed, attention, executive function working memory US normative population whereas lower results processing, attention memory, without These indicate that does not affect manifestations either or Minor groups may be caused by strains evolution. Patients developing higher burden comorbidities, highlighting different risk factors warranting targeted management.

Language: Английский

Variability in COVID-19 symptom presentation during pregnancy and its impact on maternal and infant outcomes across the pandemic DOI Creative Commons

Julia Günther,

Yvonne Ziert,

Kristin Andresen

et al.

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 146, P. 107157 - 107157

Published: July 5, 2024

Language: Английский

Citations

8
COVID-19 booster vaccine uptake and reduced risks for long-COVID: A cross-sectional study of a U.S. adult population DOI
Zhigang Xie, Sericea Stallings‐Smith, Shraddha Patel

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(16), P. 3529 - 3535

Published: April 26, 2024

Language: Английский

Citations

6
Characteristics of Children Hospitalized for Acute COVID-19 in France From February 2020 to December 2023 DOI
Alexis Rybak, Naïm Ouldali, A. Werner

et al.

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

We describe the characteristics of children hospitalized for coronavirus disease 2019 in France with a focus on post-BA.1 Omicron period (February 2022–December 2023). identified 3 main groups children: those ≤90 days old (44.8%), older comorbidities (22.1%) and multisystem inflammatory syndrome (5.2%). Low vaccination coverage these suggests that this burden could be alleviated immunization.

Language: Английский

Citations

0
Neurobiological Alterations Induced by SARS-CoV-2: Insights from Variant-Specific Host Gene Expression Patterns in hACE2-Expressing Mice DOI Creative Commons
Hamid Reza Jahantigh, Amany Elsharkawy, Anchala Guglani

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 329 - 329

Published: Feb. 27, 2025

Since the onset of COVID-19 pandemic, various severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants have emerged. Although primary site SARS-CoV-2 infection is lungs, it can also affect brain and induce neurological symptoms. However, specific effects different on remain unclear. In this study, a whole-transcriptome analysis was conducted using tissues K18-hACE2 mice infected with ancestral B.1 (Wuhan) variant major concern, including B.1.1.7 (Alpha), B.1.351 (Beta), B.1.617.2 (Delta) B.1.529 (Omicron). After sequencing, differential gene expression, ontology (GO) genome pathway enrichment analyses were performed. An Immune Cell Abundance Identifier (ImmuCellAI) used to identify abundance cell populations. Additionally, RT-qPCR validate RNA-seq data. The viral load hierarchical clustering divided samples into two clusters notable differences in expression at day 6 post-infection for all compared control group. GO Kyoto Encyclopedia genes genomes revealed similar patterns variants. ImmuCellAI changes immune populations, decrease CD4+ T B proportions increase CD8+ dendritic proportions. A co-expression network that some genes, such as STAT1, interleukin-6 (IL-6) tumor necrosis factor alpha (TNF-α), dysregulated IL-6, CXCL10 IRF7 further validated analysis. conclusion, study provides, first time, an extensive transcriptome mouse after

Language: Английский

Citations

0
Extrarespiratory, Digestive, and Hepatic Manifestations of COVID‐19 in a Moroccan Series DOI Creative Commons
H. Abid, Safae Karim, Nada Lahmidani

et al.

Scientifica, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Coronavirus disease 2019 (COVID-19) has emerged as a global human health threat. While SARS-CoV-2 infection exhibits fever and respiratory symptoms, extrarespiratory manifestations were also reported in many cases. Objectives: This study aimed to determine the prevalence of digestive hepatic symptoms at onset assess whether are associated with severe progression. Patients Methods: Prospective was conducted during first COVID-19 wave (from April October 2020). It included consenting Moroccan patients diagnosed based on PCR test chest computed tomography. Results: A total 211 participated study. The mean age 42.3 years, sex ratio (F/M) 1.7. Digestive present 28% cases, most common being nausea or vomiting (12.8%), diarrhea (11.4%), abdominal pain (5.2%), anorexia (16.6%). These significantly diabetes hypertension. higher frequency anosmia headache. Hepatic 21.3%, liver function disturbances, particularly cholestasis. Nearly half (49.2%) experienced moderate COVID-19, percentage observed (61.8%) among those aged 42 years older. However, this association not statistically significant. Conclusion: Healthcare professionals need recognize range gastrointestinal ensure timely diagnosis effective patient management.

Language: Английский

Citations

0
The use of wastewater surveillance to estimate SARS-CoV-2 fecal viral shedding pattern and identify time periods with intensified transmission DOI Creative Commons
Wan Yang,

Enoma Omoregie,

Aaron L. Olsen

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 24, 2025

Wastewater-based surveillance is an important tool for monitoring the COVID-19 pandemic. However, it remains challenging to translate wastewater SARS-CoV-2 viral load infection number, due unclear shedding patterns in and potential differences between variants. We utilized comprehensive data estimates of prevalence (i.e., source shedding) available New York City (NYC) characterize fecal pattern over multiple waves. collected measurements NYC during August 31, 2020 – 29, 2023 (N = 3794 samples). Combining with (number infectious individuals including those not detected as cases), we estimated time-lag, duration, per-infection rate ancestral/Iota, Delta, Omicron variants, separately. also developed a procedure identify occasions intensified transmission. Models suggested likely starts around same time lasts slightly longer than respiratory tract shedding. Estimated was highest ancestral/Iota variant wave, at 1.44 (95% CI: 1.35 1.53) billion RNA copies per day (measured by RT-qPCR), decreased 20% 50-60% Delta wave period, respectively. identified 200 which exceeded expected level any city's 14 sewersheds. These anomalies disproportionally occurred late January, April—early May, early August, from late-November late-December, frequencies exceeding expectation assuming random occurrence (P < 0.05; bootstrapping test). may be useful understanding changes underlying help quantify transmission severity time. have demonstrated that can support identification periods potentially

Language: Английский

Citations

0
CLINICAL CHARACTERISTICS OF PATIENTS WITH COMMUNITY-ACQUIRED CORONAVIRUS ASSOCIATED PNEUMONIA DOI Open Access
S. Ya. Dotsenko, O. S. Kulbachuk,

O.V. Soloviov

et al.

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2025, Volume and Issue: 25(1), P. 24 - 28

Published: March 31, 2025

Introduction. In late 2019, a novel coronavirus (COVID-19) emerged in Wuhan, China. Initial reports suggested that the infection caused clinical manifestations similar to severe acute respiratory syndrome (SARS-CoV). This condition was later renamed SARS-CoV-2 after series of studies. Coronaviruses were not previously considered highly pathogenic humans until 2002 and 2003 outbreaks Guangdong Province, The COVID-19 pandemic has had devastating impact on global community, causing significant morbidity. addition, patients with pneumonia have high incidence thrombotic events, which can lead morbidity mortality. main objective this study evaluate characteristics community-acquired associated between 2020 2023. Subjects methods. included 104 aged 46 75 years who tested positive for SARS-CoV-2. Two groups formed: first group 54 2020-2021; second involved 50 treated 2022-2023. group, there 11 (20.4%) vaccinated individuals, all vaccinated. All determined by during history taking examined. Results. revealed changed period, particular, showed lower certain symptoms, such as anosmia, cough, shortness breath. Statistical analysis patient complaints frequency symptoms weakness, breath, wheezing, nausea did differences (p > 0.05) both groups. anosmia significantly more common 10 (18.5%) versus 2 (4.0%) < 0.05). Clinical cough 45 (83.3%), breath 48 (88.9%), chest tightness 17 (31.5%), chills 8 (14.8%), muscle pain 7 (13.0%) higher proportion Statistics shown decreased due vaccination, although antigen test results remain important rapid detection infection. authors emphasize further studies course are needed optimize treatment identify at risk disease. Conclusions. community–acquired changing; vaccination reduces symptoms; use tests contributes timely

Language: Английский

Citations

0
Persistent Health and Cognitive Impairments Up to Four Years Post-COVID-19 in Young Students: The Impact of Virus Variants and Vaccination Timing DOI Creative Commons
Ashkan Latifi, Jaroslav Flegr

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract The long-term consequences of COVID-19 infection are becoming increasingly evident in recent studies. This repeated cross-sectional study aimed to explore the health and cognitive effects COVID-19, focusing on how virus variants, vaccination, illness severity, time since impact post-COVID-19 outcomes. We examined three cohorts university students (N=584) used non-parametric methods assess correlations various variables with SARS-CoV-2 infection, vaccination status, variants. Our results show that some impairments persist, even progressively worsening especially fatigue women memory men, up four years post-infection, Wuhan variant having most significant Omicron least. Interestingly, severity acute was not correlated SARS-CoV-2. analysis also revealed individuals who contracted after had better outcomes compared those infected before vaccination. discusses limitations inherent studies, particularly arising from stronger tendency poorer health, healthier individuals, avoid prioritize To mitigate potential bias, proposes factors such as or when analyzing persistent symptoms.

Language: Английский

Citations

1
Genomic surveillance and serological profile of SARS-CoV-2 variants circulating in Macaé and nearby cities, southeastern Brazil DOI Creative Commons

Amanda Cristina Veiga Fernandes da Silva,

Carina Azevedo Oliveira Silva,

Graziele Fonseca de Sousa

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 30, 2024

Introduction A characteristic of the COVID-19 pandemic has been sequential emergence and global dissemination SARS-CoV-2 variants, noted for their enhanced transmission efficiency. These variants with mutations in Spike glycoprotein (S-glycoprotein), which interacts ACE2 receptors human cells is critical infection, affects transmissibility virus, a matter great concern public health. Objective This research analyses effects these on cohort vaccinated naturally infected individuals from cities Macaé-RJ, Rio das Ostras-RJ, Campos dos Goytacazes-RJ, Brazil, March 2021 to 2023. Methods investigation encompasses Alpha (B.1.1.7), Gamma (P.1), Delta (B.1.617.2, B.1.671.3), Omicron (BQ.1, BQ.1.1 sublines, BF.7) focusing genomic surveillance implications disease’s epidemiology. The experimental analysis included control group (vaccinated uninfected subjects), an (post-vaccinated subjects). Samples nasopharyngeal swabs underwent viral detection via RT-qPCR diagnosis confirmation. RNase H-dependent (rhAmp-PCR) third-generation sequencing were used detect variants. Anti-S-glycoprotein immunoglobulins also evaluated noninfected volunteers. Symptoms compiled order reveal patterns clinical signs associated infection. Results study 289 participants, infections identified by ( n = 44), 189), 56) prevalent symptoms among participants cough, fever, sore throat, headache, runny nose. For Omicron, cognitive such as memory loss concentration issues reported. Interestingly, had higher anti-S-glycoprotein IgM production 28, 0.2833 ± 0.09768 OD) compared 14, 0.1035 0.03625 OD). Conversely, IgG was 12, 1.770 0.1393 than 26, 1.391 0.1563 Conclusion comprehensive enables monitoring predominant correlation cases, providing valuable insights Our continues survey circulating contributing understanding pandemic.

Language: Английский

Citations

0
The effect ofCitrus reticulatapeel extract containing hesperidin on inhibition of SARS-CoV-2 infection based on pseudovirus entry assays DOI Open Access
Endah Puji Septisetyani,

Hayfa Salsabila Harsan,

Dennaya Kumara

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 5, 2024

ABSTRACT Orange ( Citrus reticulata Blanco) peel contains a flavonoid glycoside hesperidin (HSD) as the primary component. HSD, upon enzymatic hydrolysis, forms hesperetin (HST) aglycone derivate. These two flavonoids have been predicted to in-silico affinities for ACE2 and SARS-CoV-2 spike, crucial proteins in infection mechanisms. However, vitro antiviral testing of orange extract, HST has not reported. This study presents first time pseudovirus entry assay approach test anti-SARS-CoV-2 effect HST, extract prepared by hydrodynamic cavitation (HCV). We used non-virulent model an alternative original virus target point enable research be conducted outside BSL-3 facility. Based on HPLC analysis, results showed that HCV contained HSD at about 4% w/w. Moreover, 1 10 μM, μg/ml inhibition 293/hACE2 cells with percentages 25.92, 37.40, 27.32, 38.97 %, respectively. Despite showing 6 % lower inhibitory activity than μM assay, it holds potential supplement or source raw material antiviral.

Language: Английский

Citations

0