Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs
Infection and Drug Resistance,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 887 - 902
Published: Feb. 1, 2025
The
inappropriate
prescribing
and
use
of
antibiotics
have
contributed
to
the
emergence
spread
antimicrobial
resistance
(AMR).
In
Zambia,
there
is
a
paucity
information
on
patterns
among
hospitalized
patients
in
level
1
hospitals.
This
study
investigated
antibiotic
five
hospitals
Lusaka,
Zambia.
cross-sectional
utilized
World
Health
Organization
(WHO)
Point
Prevalence
Survey
(PPS)
methodology
in-patients
admitted
before
08:00
a.m.
survey
day
August
2024.
Data
were
analysed
using
IBM
SPSS
version
23.0.
prevalence
inpatients
was
59.0%,
with
ceftriaxone
being
most
prescribed.
Antibiotics
prescribed
mainly
for
paediatrics
male
inpatients.
found
that
53.0%
from
Access
group
while
38.2%
Watch
Access,
Watch,
Reserve
(AWaRe)
classification.
Adherence
national
treatment
guidelines
36.0%,
empirically
without
evidence
culture
sensitivity
tests.
high
low
adherence
findings
this
demonstrate
need
establish
strengthen
stewardship
programs
laboratory
capacity
aid
clinicians
diagnosing,
treating,
managing
across
Language: Английский
Substandard antibiotics and their clinical outcomes among hospitalized patients in southern Malawi: a pilot study
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 18, 2025
The
burden
of
substandard
antibiotics
is
high
in
low-middle
income
countries
including
Malawi.
These
poor-quality
may
cause
deleterious
effects
on
patients
and
promote
drug
resistance.
We
assessed
the
quality
associated
clinical
outcomes
among
hospitalized
southern
A
cross-sectional
study
involving
review
retrospective
records
was
conducted
adult
at
Zomba
central,
Machinga
Nsanje
district
hospitals
October
2022
January
2024.
Trained
pharmacy
personnel
recorded
parenteral
that
were
issued
to
medical
wards.
used
these
for
matching
sampling
administered
medicine
batches
patient
files.
In
total,
we
reviewed
224
management
files
eligible
patients,
aiming
assess
recovery
occurrence
adverse
reactions
(ADRs)
using
a
global
trigger
tool.
collected
nine
samples
ceftriaxone
benzylpenicillin
which
subjected
them
tests
content
active
pharmaceutical
ingredients
methods
adapted
from
United
States
Pharmacopeia.
For
each
sample,
least
ten
dosage
units
Agilent®
1120
High
Performance
Liquid
Chromatography
analysis.
Of
files,
ADRs
occurred
18.3%
%
(n
=
41)
while
12.05%
27)
did
not
recover
their
illness.
One
sample
found
out
specifications
with
only
61.8%
declared
amount
ingredients.
Among
who
received
optimal
API
content,
15.8%
experienced
10.5%
failed
containing
lower
than
required
API,
7.1%
an
ADR
14.3%
differences
were,
however,
statistically
significant.
Patient
significantly
patient's
age
Charlson
comorbidity
index
(CCI),
p
<
0.05.
present
findings
reveal
significant
based
quality.
Therefore,
recommend
larger
prospective
further
validate
results
encourage
stakeholders
be
more
vigilant
antibiotic
medicines,
as
this
crucial
measure
improving
preventing
resistance
Language: Английский
Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey
Morelle Sèssiwèdé Gnimavo,
No information about this author
Bawa Boya,
No information about this author
Steward Mudenda
No information about this author
et al.
JAC-Antimicrobial Resistance,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Dec. 26, 2024
Abstract
Background
Antimicrobial
stewardship
promotes
the
appropriate
use
of
antibiotics
to
prevent
emergence
and
spread
antimicrobial
resistance.
This
study
evaluated
using
a
point
prevalence
survey
at
Centre
Hospitalier
Universitaire
de
Zone
d'Abomey
Calavi/Sô-Ava
(CHUZ/AS)
in
Benin.
Methods
cross-sectional
utilized
WHO
methodology
for
monitoring
antibiotic
among
inpatients
hospitals.
The
was
conducted
from
11
January
2022
19
hospitalized
patients
before
8:00
a.m.
on
day
survey.
Results
Of
111
inpatient
medical
files
reviewed,
82.9%.
number
received
per
patient
ranged
1
5,
with
mean
2.45
±
1.11
median
2.
most
commonly
prescribed
class
beta-lactams
(46.7%),
aminoglycosides
(20.6%)
nitroimidazoles
(19.7%).
According
AWaRe
classification,
30.4%
Access
group
44%
combination
Watch
antibiotics;
treatment
empiric
94.5%
encounters.
Only
22.7%
were
treated
based
microbiological
examination/culture
sensitivity
testing.
Conclusions
found
high
CHUZ/AS
Tertiary
Care
Hospital
ampicillin,
metronidazole
ceftriaxone.
Consequently,
low
culture
testing
guide
treatment,
particularly
paediatric
surgical
population,
preference
broad-spectrum
suggests
that
is
not
optimal.
Therefore,
programmes,
policies
guidelines
must
be
instigated
strengthened
address
these
gaps
promote
rational
antibiotics.
Language: Английский