Immunity and Coagulation in COVID-19

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11267 - 11267

Published: Oct. 19, 2024

Discovered in late 2019, the SARS-CoV-2 coronavirus has caused largest pandemic of 21st century, claiming more than seven million lives. In most cases, COVID-19 disease by virus is relatively mild and affects only upper respiratory tract; it often manifests itself with fever, chills, cough, sore throat, but also less-common symptoms. patients do not require hospitalization, fully recover. However, some infection leads to development a severe form COVID-19, which characterized life-threatening complications affecting lungs, other organs systems. particular, various forms thrombotic are common among COVID-19. The mechanisms for remain unclear. Accumulated data indicate that pathogenesis based on disruptions functioning innate immune key role primary response viral assigned two These pattern recognition receptors, primarily members toll-like receptor (TLR) family, complement system. Both systems first engage fight against launch whole range aimed at its rapid elimination. Normally, their joint activity destruction pathogen recovery. these can cause an excessive inflammatory dangerous body. turn, inflammation entails activation damage vascular endothelium, as well hypercoagulable state observed seriously ill Activation endothelium hypercoagulation lead thrombosis and, result, tissues. Immune-mediated termed "immunothrombosis". this review, we discuss detail features immunothrombosis associated potential underlying mechanisms.

Language: Английский

Incidence and predictors of clinical failure after early treatment for mild‐to‐moderate COVID‐19 in high‐risk individuals: A multicentric cohort study

Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

To estimate the risk of COVID-19-related hospitalization and death (CovH/D), among high-risk individuals early treated for COVID-19 to identify associated factors.

Language: Английский