The HOXC‐AS2/miR‐876‐5p/HKDC1 axis regulates endometrial cancer progression in a high glucose‐related tumor microenvironment DOI Creative Commons
Jing Guo, Feng Ye, Wenli Xie

et al.

Cancer Science, Journal Year: 2022, Volume and Issue: 113(7), P. 2297 - 2310

Published: April 29, 2022

Abstract The tumor microenvironment (TME) is related to chronic inflammation and currently identified as a risk factor for the occurrence development of endometrial cancer (EC). Pyroptosis new proinflammatory form programmed cell death that plays critical role in progression multiple diseases. However, important pyroptosis high‐glucose (HG)‐related EC underlying molecular mechanisms remain elusive. In present study, transcriptome high‐throughput sequencing revealed significantly higher hexokinase domain‐containing 1 (HKDC1) expression patients with diabetes than normal glucose. Mechanistically, HKDC1 regulates HG‐induced by modulating production reactive oxygen species pyroptosis‐induced cytokine release EC. addition, TME formation enhancing glycolysis, promoting metabolic advantage lactate‐rich environments further accelerate progression. Subsequently, miR‐876‐5p was predicted target mRNA, HOXC‐AS2 potentially inhibit miR‐876‐5p/HKDC1 axis regulating HG‐related Collectively, we elucidated regulatory HOXC‐AS2/miR‐876‐5p/HKDC1 signal transduction at level, which may provide an effective therapeutic who are diagnosed

Language: Английский

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives DOI Creative Commons
Shun Wang, Yan Zheng, Yang Feng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: July 5, 2021

Abstract Pancreatic cancer is an increasingly common cause of mortality with a tight correspondence between disease and incidence. Furthermore, it usually diagnosed at advanced stage very dismal prognosis. Due to the high heterogeneity, metabolic reprogramming, dense stromal environment associated pancreatic cancer, patients benefit little from current conventional therapy. Recent insight into biology genetics has supported its molecular classification, thus expanding clinical therapeutic options. In this review, we summarize how biological features reprogramming as well tumor microenvironment regulate development progression. We further discuss potential biomarkers for diagnosis, prediction, surveillance based on novel liquid biopsies. also outline recent advances in defining subtypes subtype-specific responses preclinical models. Finally, prospects challenges therapeutics.

Language: Английский

Citations

237
A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies DOI
Riya Thapa, Gaurav Gupta, Asif Ahmad Bhat

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127375 - 127375

Published: Oct. 13, 2023

Language: Английский

Citations

88
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine DOI Creative Commons
Yanhong Duo, Lei Han, Yaoqiang Yang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11242 - 11347

Published: Oct. 9, 2024

Biopsy, including tissue and liquid biopsy, offers comprehensive real-time physiological pathological information for disease detection, diagnosis, monitoring. Fluorescent probes are frequently selected to obtain adequate on processes in a rapid minimally invasive manner based their advantages biopsy. However, conventional fluorescent have been found show aggregation-caused quenching (ACQ) properties, impeding greater progresses this area. Since the discovery of aggregation-induced emission luminogen (AIEgen) promoted advancements molecular bionanomaterials owing unique high quantum yield (QY) signal-to-noise ratio (SNR),

Language: Английский

Citations

18
A new era of cancer immunotherapy: vaccines and miRNAs DOI Creative Commons

Gitika Sareen,

Maneesh Mohan, Ashi Mannan

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(5)

Published: April 1, 2025

Language: Английский

Citations

2
An electrochemical biosensor for simultaneous detection of breast cancer clinically related microRNAs based on a gold nanoparticles/graphene quantum dots/graphene oxide film DOI
Chammari Pothipor, Jaroon Jakmunee, Suwussa Bamrungsap

et al.

The Analyst, Journal Year: 2021, Volume and Issue: 146(12), P. 4000 - 4009

Published: Jan. 1, 2021

An electrochemical biosensor employing a gold nanoparticles/graphene quantum dots/graphene oxide composite modified electrode is developed for the multiplex detection of miRNA breast cancer biomarkers.

Language: Английский

Citations

99
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers DOI Creative Commons
Yi‐Ting Chen,

Jieling Ning,

Wenjie Cao

et al.

Frontiers in Oncology, Journal Year: 2020, Volume and Issue: 10

Published: Oct. 21, 2020

TXNIP, also known as thioredoxin interacting protein, is a kind of (TRX) binding which can mediate oxidative stress, inhibit cell proliferation and induce apoptosis by inhibiting the function system. In recent years, TXNIP has attracted attention because its wide range functions in cardiovascular diseases, neurodegenerative cancer, diabetes other diseases. Accumulating evidence demonstrated that abnormally expressed variety malignant tumors, tumor suppressor malignancies such hepatoma, breast pancreatic ductal adenocarcinoma lung cancer. We know cancer cells affecting metabolic reprogramming, affect invasion metastasis through TXNIP-HIF1α-TWIST signal axis, negatively regulate bladder carcinogenesis via activation ERK induced stromal cell-derived factor-1/C-X-C chemokine receptor type 4 signal, cells. this review, we summarized be regulated to transcription factors or proteins, down-regulated epigenetic changes miRNA, summarise emerging insights on expression functional role different kinds cancers, clarify it participate reprogramming stress gene proliferation, promote cells, important basic clinical significance for finding new molecular targets treatment methods diagnosis tumors.

Language: Английский

Citations

88
Emerging role of exosomes as biomarkers in cancer treatment and diagnosis DOI

Niloofar Asadi Hanjani,

Nazanin Esmaelizad, Saba Zanganeh

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2021, Volume and Issue: 169, P. 103565 - 103565

Published: Dec. 3, 2021

Language: Английский

Citations

84
An Enzyme‐Activatable Aggregation‐Induced‐Emission Probe: Intraoperative Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E DOI
Zhirong Zhu, Qi Wang, Xiaohong Chen

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(3)

Published: Oct. 25, 2021

Pancreatic cancer (PC) is one of the most devastating malignant tumors. However, fluorescence probes for early clinical diagnosis PC often encounter difficulties in accuracy and penetrability. In this work, an enzyme-activated aggregation-induced-emission (AIE) probe, QM-HSP-CPP, high-contrast developed by monitoring specific overexpressed enzyme Cathepsin E (CTSE). The probe composed AIE fluorophore QM-COOH (QM = quinoline-malononitrile), CTSE-triggered hydrophobic peptide (HSP), hydrophilic biocompatible cell penetrating (CPP). CPP unit can well-modulate molecular dispersion properties, giving initial fluorescence-off state aqueous biosystem, thus endowing high signal-to-noise ratio, finally overcoming poor targeting selectivity traditional probes. ensure cell/tissue ability, allowing on-site endogenous CTSE cells, tissues, living animal models. When QM-HSP-CPP specifically cleaved CTSE, it generate signals situ with high-specificity long-term tracking successfully achieve intraoperative human sections, heterotopic nude mice CTSE-enzyme-triggered AIEgens' liberation strategy improves addresses penetration problem simultaneously, which expand database multitudinous AIE-active probes, especially establishing pathological fluorescent diagnosis.

Language: Английский

Citations

67
Nanoparticle-based therapeutic strategies targeting major clinical challenges in pancreatic cancer treatment DOI Creative Commons
Mubin Tarannum, Juan L. Vivero‐Escoto

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 187, P. 114357 - 114357

Published: May 21, 2022

Language: Английский

Citations

40
Circulating microRNAs as Potential Biomarkers in Pancreatic Cancer—Advances and Challenges DOI Open Access
Attila A. Seyhan

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13340 - 13340

Published: Aug. 28, 2023

There is an urgent unmet need for robust and reliable biomarkers early diagnosis, prognosis, prediction of response to specific treatments many aggressive deadly cancers, such as pancreatic cancer, liquid biopsy-based miRNA profiling has the potential this. MiRNAs are a subset non-coding RNAs that regulate expression multitude genes post-transcriptionally thus diagnostic, prognostic, predictive have also emerged therapeutics. Because miRNAs involved in post-transcriptional regulation their target mRNAs via repressing gene expression, defects biogenesis pathway perturb oncogenic or tumor-suppressive pathogenesis various cancers. As such, numerous been identified be downregulated upregulated functioning either oncomes oncosuppressor miRs. Moreover, dysregulation pathways can change function cancer. Profiling dysregulated cancer shown correlate with disease indicate optimal treatment options predict therapy. Specific signatures track stages hold markers, well therapeutics mimics inhibitors (antagomirs). Furthermore, they along downstream used therapeutic targets. However, limited understanding validation roles miRNAs, lack tissue specificity, methodological, technical, analytical reproducibility, harmonization isolation quantification methods, use standard operating procedures, availability automated standardized assays improve reproducibility between independent studies limit bench-to-bedside translation clinical applications. Here I review recent findings on markers.

Language: Английский

Citations

31