APOPTOSIS, Journal Year: 2022, Volume and Issue: 27(5-6), P. 297 - 310
Published: March 21, 2022
Language: Английский
Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 189 - 213
Published: Oct. 25, 2021
Abstract Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. stimulates cell death, triggers cycle arrest, suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) DNA damage apoptosis chemotherapy. However, CP adverse effects on several organs of the body, drug resistance frequently observed. The purpose present review to show function curcumin decreasing CP's impacts improving its antitumor activity. administration reduces ROS levels prevent normal cells. Furthermore, can inhibit inflammation via down‐regulation NF‐κB maintain organs. nanoformulations reduce hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, cardiotoxicity caused by CP. Notably, potentiates cytotoxicity mediating death arrest. Besides, STAT3 NF‐ĸB as tumor‐promoting enhance sensitivity resistance. targeted delivery tumor cells be mediated nanostructures. In addition, derivatives are also able CP‐mediated side effects, increase against various types.
Language: Английский
Citations
151
Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 368, P. 110170 - 110170
Published: Oct. 3, 2022
Colon cancer affects both men and women is the world's second most significant cause of cancer-related mortality. death rates have risen worldwide due to current food habit lifestyle, which include a lot meat, alcohol, not enough physical exercise. As result, novel, less harmful pharmacological treatments for colon are needed now more than ever before. Colorectal (CRC) portion population. Chemotherapy's limits, as demonstrated by side effects resistance in CRC patients, being sought after despite recent breakthroughs that improved patient care survival. Numerous chemical compounds present medicinal herbs shown anti-tumor anti-apoptotic properties against various cancers, including CRC, animal experiments. These chemicals, come from several phytochemical families, activate signaling pathways. This article discusses research on anti-CRC benefits many plants conducted vitro, well components may play role study. Researchers also looking into impact these pathways involved signaling. According this review, be generated plants. That's why we're at how natural items can help treat while lowering risk developing it.
Language: Английский
Citations
146
Critical Reviews in Oncology/Hematology, Journal Year: 2022, Volume and Issue: 172, P. 103628 - 103628
Published: Feb. 18, 2022
In recent years, various drug nano-delivery platforms have emerged to enhance effectiveness in cancer treatment. However, their successful translation clinics been hampered by unwanted side effects, as well associated toxicity. Therefore, there is an imperative need for delivery vehicles capable of surpassing cellular barriers and also efficiently transfer therapeutic payloads tumor cells. Exosomes, a class small extracellular vesicles naturally released from all cells, exploited favorable vehicle due natural role intracellular communication biocompatibility. this review, information on exosome biogenesis, contents, forms isolation functions discussed, further complemented with the methodologies encapsulation, including distinct loading approaches. addition, grafting molecules improve pharmacokinetics, homing-ligands, stimuli-responsive elements cell specificity are debated. end, current status clinical-grade exosome-based therapies outlined.
Language: Английский
Citations
98
Acta Pharmacologica Sinica, Journal Year: 2022, Volume and Issue: 43(11), P. 2759 - 2776
Published: April 4, 2022
Language: Английский
Citations
86
Phytotherapy Research, Journal Year: 2022, Volume and Issue: 36(3), P. 1156 - 1181
Published: Feb. 7, 2022
Abstract Curcumin is a phytochemical achieved from the plant turmeric. It extensively utilized for treatment of several types diseases such as cancers. Nevertheless, its efficiency has been limited because rapid metabolism, low bioavailability, poor water solubility, and systemic elimination. Scientists have tried to solve these problems by exploring novel drug delivery systems lipid‐based nanoparticles (NPs) (e.g., solid lipid NPs, nanostructured carriers, liposomes), polymeric micelles, nanogels, cyclodextrin, gold, mesoporous silica NPs. Among these, liposomes most expansively studied. This review mainly focuses on different curcumin nanoformulations their use in cancer therapy vitro, vivo, clinical studies. Despite development curcumin‐containing NPs cancer, potentially serious side effects, including interactions with other drugs, some toxicity aspects may occur that require more high‐quality investigations firmly establish efficacy.
Language: Английский
Citations
82
Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5236 - 5236
Published: Aug. 16, 2022
Throughout the United States, cancer remains second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that specific have few consequences. Curcumin a polyphenol derivative found turmeric plant (Curcuma longa L.), provides chemopreventive, antitumor, chemo-, radio-sensitizing properties. In this paper, we summarize new nano-based formulations polyphenolic curcumin because growing interest its application against cancers tumors. According recent studies, use nanoparticles can overcome hydrophobic nature curcumin, as well improving stability cellular bioavailability vitro vivo. Several strategies nanocurcumin production been developed, each with own set advantages unique features. Because majority curcumin-based nanoformulation evidence still conceptual stage, numerous issues impeding provision possible therapeutic option. To support science, further work necessary develop viable anti-cancer adjuvant. review, cover various nanoformulations implications uses cancer, current state clinical studies patents. We address knowledge gaps future research orientations required feasible treatment candidate.
Language: Английский
Citations
74
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(10), P. 4375 - 4397
Published: July 11, 2023
Abstract Cancer is the most common cause of death worldwide, following cardiovascular diseases. a multifactorial disease and many reasons such as physical, chemical, biological, lifestyle‐related factors. Nutrition, which one various factors that play role in prevention, development, treatment types cancer, affects immune system, characterized by disproportionate pro‐inflammatory signaling cancer. Studies investigating molecular mechanisms this effect have shown foods rich bioactive compounds, green tea, olive oil, turmeric, soybean significant positively changing expression miRNAs involved regulation genes associated with oncogenic/tumor‐suppressing pathways. In addition to these foods, some diet models may change specific cancer‐related different ways. While Mediterranean has been anticancer effects, high‐fat diet, methyl‐restricted are considered negative effects. This review aims discuss effects called “immune foods,” models, components on cancer prevention
Language: Английский
Citations
58
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 232, P. 123283 - 123283
Published: Jan. 17, 2023
Hydrogels have emerged as a versatile platform for numerous biomedical application due to their ability absorb huge quantity of biofluids. In order design hydrogels, natural polymers are an attractive option owing biocompatibility and biodegradability. Due abundance in occurrence, cost effectiveness, facile crosslinking approaches, alginate has been extensively investigated fabricate hydrogel matrix. Management cancer chronic wounds always challenge pharmaceutical healthcare sector. both cases, curcumin shown significant improvement effectiveness. However, the innate restraints like poor bioavailability, hydrophobicity, rapid systemic clearance associated with restricted its clinical translations. The current review explores cascade research around encapsulated matrix wound healing therapy. focus is emphasize mechanistic effects fate inside cells. Further, discusses different approaches designed loaded hydrogels along parameters that regulates release behavior. Finally, concluded on some key aspect increasing efficacy these novel strategies further develop multifacet applications.
Language: Английский
Citations
54
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124566 - 124566
Published: April 24, 2023
Language: Английский
Citations
52
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 18166 - 18181
Published: March 9, 2023
Curcumin has been reported to exhibit free radical antioxidant, anti-inflammatory, and anticancer activities, which are beneficial for nutraceutical applications. However, its application this purpose is limited by poor water solubility, stability, bioavailability. These problems can be overcome using food-grade colloidal particles that encapsulate, protect, deliver curcumin. assembled from structure-forming food components may also protective effects, such as proteins, polysaccharides, polyphenols. In study, lactoferrin (LF), (-)-epigallocatechin gallate (EGCG), hyaluronic acid (HA) were used fabricate composite nanoparticles a simple pH-shift method. We showed curcumin could successfully loaded into these LF-EGCG-HA (d = 145 nm). The encapsulation efficiency (86%) loading capacity (5.8%) of within relatively high. Encapsulation improved the thermal, light, storage stabilities Moreover, curcumin-loaded exhibited good redispersibility after dehydration. in vitro digestion properties, cellular uptake, effects then explored. Compared curcumin, bioaccessibility uptake significantly nanoparticles. Furthermore, promoted apoptosis colorectal cancer cells. This study suggests biopolymer improve bioavailability bioactivity an important nutraceutical.
Language: Английский
Citations
50