European Polymer Journal, Journal Year: 2023, Volume and Issue: 196, P. 112215 - 112215
Published: June 10, 2023
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113956 - 113956
Published: Nov. 2, 2022
Language: Английский
Citations
72
OpenNano, Journal Year: 2023, Volume and Issue: 13, P. 100170 - 100170
Published: June 30, 2023
Thymol and carvacrol are aromatic compounds derived from plants that exhibit considerable broad-spectrum antimicrobial effects. They have also shown extensive biological effects, including antispasmodic, anti-inflammatory, anti-carcinogenic. Carvacrol thymol pleasant smells, tastes, potent antioxidant Therefore, along with their favorable toxicity, make an option as additive to inhibit microbial spoilage of foods agents against antibiotic-resistant bacteria. However, volatility, low stability, high hydrophobicity some the limitations thymol, which limit application. To increase efficacy carvacrol, especially properties, using a drug delivery system might be practical option. Encapsulation essential oils into appropriated nanocarriers may decrease potential limitations. thymol-encapsulated nanomaterials been more solubility increased antibacterial Here, we provide brief review effects nanoformulation give prospect on applications for future studies natural food additives.
Language: Английский
Citations
59
Industrial Crops and Products, Journal Year: 2023, Volume and Issue: 197, P. 116654 - 116654
Published: April 5, 2023
A pH-sensitive nanocomposite based on halloysite nanotubes (HNT) coated with polyacrylic acid (PAA)/carboxymethyl cellulose (CMC) hydrogel was synthesized for controlled delivery of curcumin (CUR) to MCF-7 cancer cells. Hazelnut oil added minimize the size and increase its uniformity via water/oil/water (W/O/W) double emulsion method. Likewise, Span 80 surfactant incorporated produce a nanoniosomal that increased stability retention CUR as an anticancer drug. The molecular interactions between components, crystalline structure, surface morphology, distribution charge were analyzed through Fourier transformed infrared (FT-IR) spectroscopy, field emission-scanning electron microscope (FE-SEM), X-ray diffraction (XRD), dynamic light scattering (DLS) zeta potential measurements, respectively. resulting drug system showed 45% loading 87% encapsulation efficiency, which are amongst highest values reported up date nanocarriers. about 36 mV, indicating good stability. sustained release observed, 61% 96% released at pH 7.4 5.4 after 96 h, respectively, confirms pH-sensitivity developed nanocarrier. MTT assay demonstrated strong toxicity nanocomposites against Also, 46% cell death rate in apoptotic phase observed by flow cytometry. results obtained herein support great PAA/CMC/HNT/CUR smart vehicles breast treatment.
Language: Английский
Citations
56
Food Chemistry X, Journal Year: 2024, Volume and Issue: 24, P. 101953 - 101953
Published: Nov. 2, 2024
Nanotechnology plays a pivotal role in food science, particularly the nanoencapsulation of bioactive compounds, to enhance their stability, bioavailability, and therapeutic potential. This review aims provide comprehensive analysis encapsulation emphasizing characteristics, applications, implications for human health. work offers detailed comparison polymers such as sodium alginate, gum Arabic, chitosan, cellulose, pectin, shellac, xanthan gum, while also examining both conventional emerging techniques, including freeze-drying, spray-drying, extrusion, coacervation, supercritical anti-solvent drying. The contribution this lies highlighting improving system controlling release rates, maintaining bioactivity under extreme conditions, reducing lipid oxidation. Furthermore, it explores recent technological advances aimed at optimizing processes targeted therapies functional foods. findings underline significant potential not only supplements foods but supportive medical treatments, showcasing its relevance health various contexts.
Language: Английский
Citations
22
Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3136 - 3136
Published: July 13, 2023
Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), resveratrol have been highlighted antiproliferative agents for cancer. Due their low solubility limited bioavailability, some alternative nanotechnologies applied encapsulate these compounds, aiming improve efficacy against In this comprehensive review, we evaluate the main nanotechnology approaches therapeutic potential of polyphenols cancer using in vitro studies vivo preclinical models, highlighting recent advancements field. It was found that polymeric nanomaterials, lipid-based inorganic carbon-based nanomaterials most used classes nanocarriers encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity pro-apoptotic effects, particularly breast, lung, prostate, cervical, colorectal cells, surpassing performance free compounds. Preclinical trials xenograft animal models revealed decreased tumor growth after treatment with polyphenol-loaded systems. Moreover, interaction polyphenol co-delivery polyphenol–drug is a promising approach increase anticancer decrease chemotherapy side effects. innovative hold significant implications advancement clinical research.
Language: Английский
Citations
41
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4275 - 4311
Published: July 1, 2023
Abstract: Breast cancer (BC) is the most prevalent type of in world and main reason women die from cancer. Due to significant side effects conventional treatments such as chemotherapy radiotherapy, search for supplemental alternative natural drugs with lower toxicity interest researchers. Curcumin (CUR) a polyphenol extracted turmeric. Numerous studies have demonstrated that CUR an effective anticancer drug works by modifying different intracellular signaling pathways. CUR's therapeutic utility severely constrained its short half-life vivo, low water solubility, poor stability, quick metabolism, oral bioavailability, potential gastrointestinal discomfort high doses. One practical solutions aforementioned issues development targeted delivery systems (TDDSs) based on nanomaterials. To improve targeting efficacy serve reference use TDDSs clinical setting, this review describes physicochemical properties bioavailability mechanism action BC, emphasis recent BC combination CUR, including passive TDDSs, active TDDSs. Keywords: breast cancer, curcumin, system, targeting,
Language: Английский
Citations
39
Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)
Published: Feb. 2, 2024
Abstract Hepatocellular carcinoma (HCC) is a form of malignancy with limited curative options available. To improve therapeutic outcomes, it imperative to develop novel, potent modalities. Ketoconazole (KET) has shown excellent efficacy against HCC by eliciting apoptosis. However, its water solubility hampers application in clinical treatment. Herein, mitochondria‐targeted chemo‐photodynamic nanoplatform, CS@KET/P780 NPs, designed using nanoprecipitation strategy integrating newly synthesized photosensitizer (P780) and chemotherapeutic agent KET coated chondroitin sulfate (CS) amplify therapy. In this CS confers tumor‐targeted subsequently pH‐responsive drug delivery behavior binding glycoprotein CD44, leading the release P780 KET. Mechanistically, following laser irradiation, targets destroys mitochondrial integrity, thus inducing apoptosis through enhancement reactive oxygen species (ROS) buildup. Meanwhile, KET‐induced synergistically enhances anticancer effect P780. addition, tumor cells undergoing can trigger immunogenic cell death (ICD) longer‐term antitumor response releasing tumor‐associated antigens (TAAs) damage‐associated molecular patterns (DAMPs), which together contribute improved outcomes HCC. Taken together, NPs bioavailability exhibit exerting chemophototherapy immunity.
Language: Английский
Citations
12
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7989 - 7989
Published: July 22, 2024
Chemical residues in food pose health risks such as cancer and liver issues. This has driven the search for safer natural alternatives to synthetic fungicides preservatives. The aim of this study was characterize chemical composition essential oils (EO), determine polyphenolic contents, evaluate vitro antioxidant antifungal activities methanol extracts (ME), powders from Rosmarinus officinalis L. (rosemary) Thymus ciliatus (Desf) Benth. (thyme) M'sila region, Algeria. EOs determined by GC-MS. R. EO composed 31 components, mainly camphor (41.22%), camphene (18.14%), α-pinene (17.49%); T. 58 mainly, percentage, (22.18), myrcene (13.13), β-pinene (7.73), β-caryophyllene (10.21), germacrene D (9.90). total phenols flavonoids were spectrophotometrically, rosemary ME found possess highest content (127.1 ± 2.40 µg GAE/mg), while thyme had flavonoid (48.01 0.99 QE/mg). activity assessed using three methods: most potent, followed DPPH (IC50 = 13.43 0.14 µg/mL), β-carotene/linoleic acid 39.01 2.16 μg/mL), reducing power (EC50 15.03 1.43 µg/mL). Antifungal 32 pathogenic foodborne fungi. Four methods applied solid medium. Incorporating powdered plant into culture medium (at 10%) reduced fungal growth greater than 50% 21.88% 6.25% all isolates, ciliatus, respectively. ME, well diffusion method (0.1 g/mL), less effective. Different concentrations tested. (1500 μL/L) inhibited molds levels 50 75% respectively, with complete inhibition four Fumigated (15 μL) 65% 65 81.25% five There little no sporulation conjunction inhibition. Our results revealed some potential studied plants fight presented their promising characteristics a source pesticides Further studies are needed find adequate application techniques safety area.
Language: Английский
Citations
8
Inorganic Chemistry Communications, Journal Year: 2022, Volume and Issue: 145, P. 110022 - 110022
Published: Oct. 2, 2022
Language: Английский
Citations
36
Nanomaterials, Journal Year: 2022, Volume and Issue: 12(18), P. 3201 - 3201
Published: Sept. 15, 2022
Cancer nanotherapeutics is an important field of research which utilizes nanomaterials as approach to cancer therapy. Nano-mediated therapeutic delivery systems overcome the adverse side effects traditional treatment methods. Nanoparticles (NPs) are considered excellent tumor-targeting vehicles due their compact and variable size, large surface area, ability load several genes drugs, mediation increased payload uptake. Despite rapid development nanotechnology, there growing concern regarding possible long-term NPs on environment human health. Green chemistry using plant materials, such curcumin, a sustainable alternative conventional reduction methods confers dual reducing capping properties. Curcumin bioactive compound isolated from rhizome Curcuma longa plant, exhibits various medicinal Curcumin-capped exhibit solubility, bioavailability, indices, antitumor This review highlights potential properties economical, simple, eco-friendly curcumin-synthesized capped for localized drugs tumor microenvironment with fewer effects.
Language: Английский
Citations
31