Red blood cell distribution width to albumin ratio is associated with increased depression: the mediating role of atherogenic index of plasma

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Background Recent studies have identified a correlation between inflammation and depression. This study aims to explore the red blood cell distribution width (RDW) albumin ratio (RAR), practical measure for assessing inflammation, depression in general population. Methods In this population-based cross-sectional study, data from 28932 adults aged≥18 years old NHANES during period of 1999–2018 were analyzed. To examine RAR depression, multivariate logistic regression analyses, subgroup restricted cubic spline interaction tests conducted. Furthermore, mediation analysis was performed elucidate role atherogenic index plasma (AIP) mediating effect on Results Multivariate analyses splines indicated that can exhibit linearly with (OR = 1.335; 95% CI: 1.222, 1.458). Subjects Q2, Q3, Q4 groups had an increased risk as 22.8%, 22.9% 51.9% than those Q1 group. positive more pronounced history cancers. The ROC area under curve (AUC) (AUC=0.593) significantly greater RDW individually. Mediation AIP mediated 7.8% Conclusions findings significant linear prevalence serving mediator.

Language: Английский

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The association between remnant cholesterol and rheumatoid arthritis: insights from a large population study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 7, 2024

Abstract Objectives While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates metabolism, and rheumatoid arthritis (RA) has not been investigated. Accordingly, this study evaluated whether RC associated with RA disease events. Methods Data were collected specifically extracted from National Health Nutrition Examination Survey (NHANES) 1999–2008 database. The value was derived by subtracting combined amount of low-density lipoprotein (LDL-C) high-density (HDL-C) total (TC). using multivariate regression analysis subgroup analysis. Results analyzed 7777 patients, 581 patients (7.47%) diagnosed RA. After accounting for different covariates, logistic revealed notable correlation increased levels an likelihood (odds ratio OR = 1.54; 95% confidence interval CI: 1.11–2.13; P 0.0092). interaction test did yield statistically significant effects on association. linear observed within restricted cubic spline model limitations. Conclusion results suggest that higher are odds RA, indicating can serve novel convenient index forecasting in United States. Additionally, these findings offer insights into early intervention strategies susceptible populations at risk developing

Language: Английский

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Association of cardiovascular health using Life's Essential 8 with depression: Findings from NHANES 2007–2018

General Hospital Psychiatry, Journal Year: 2024, Volume and Issue: 87, P. 60 - 67

Published: Jan. 30, 2024

Language: Английский

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Association between depressive status and mild cognitive impairment in middle-aged and elderly Chinese adults from CHARLS study

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Background The potential association between depressive status and the risk of mild cognitive impairment (MCI) remains unclear, especially in absence prospective evidence. This study aims to elucidate impact either depression score or on MCI using longitudinal data from China Health Retirement Longitudinal Study (CHARLS). Methods included 5,766 participants CHARLS followed 2011 2015. We calculated baseline 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) after 3 years follow-up through four dimensions: orientation, memory, calculation, draw. collected sociological characteristics health-related factors as covariates, multivariate-adjusted logistics regression models (odds ratios (OR) 95% confidence intervals (CI)) restricted cubic splines (RCS) estimate effect risk. Results observed 724 new cases at follow-up. Logistics analysis showed that with had a 58% higher developing than those without (OR = 1.58, 95%CI: 1.35-1.85), positive persisted adjusting covariates such population 1.24, 1.04-1.48). also dose-response relationship risk, 11~20 21~30 scores having progressively compared 0~10 (p trend < 0.05), 3% increase each 1-point 1.03, 1.01-1.04). RCS nonlinear non-linearity 0.001), increasing score. In addition, stratified analyses based sex, age, marital status, residence, BMI, nighttime sleep, smoking alcohol drinking serological indicators, comorbidities no interaction > 0.05) other serum total cholesterol levels 0.008). Conclusions Among middle-aged elderly adults CHARLS, is an independent factor MCI, indicating individuals more severe symptoms are likely suffer MCI. Early screening CESD-10 may help identify high early intervention reduce incidence Alzheimer’s disease, thereby reducing social care burden ageing population.

Language: Английский

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Association between depression and infertility risk among American women aged 18–45 years: the mediating effect of the NHHR

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 10, 2024

Depression and infertility are major medical social problems. The non-high-density lipoprotein cholesterol to high-density ratio (NHHR) serves as an innovative reliable lipid marker for cardiovascular disease risk assessment. Previous research has indicated a potential correlation among metabolism, depression, infertility. Nonetheless, the exact involvement of metabolism in modulating pathological mechanisms associated with depression-induced remains be fully elucidated. aim this study was explore connection between depression assess whether NHHR mediates association.

Language: Английский

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Association between remnant cholesterol and depression in middle-aged and older Chinese adults: a population-based cohort study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Background The focus on remnant cholesterol (RC) has intensified because of its association with various diseases. In this study, we investigated the between RC and depression in middle-aged older adults. Methods study involved 7,305 participants from 2015 2018 waves China Health Retirement Longitudinal Study. Based 10-item Center for Epidemiological Studies Depression Scale (CESD-10), was indicated by scores ≥ 12. To assess correlation levels depression, a logistic regression model that incorporated restricted cubic spline techniques used. Results Of population, (mean age: 60.0 ± 9.5 years), 50.3% were female. From to 2018, mean CESD-10 score increased 6.31 3.56 7.85 5.23. Following adjustment confounding factors, individuals higher level quartile exhibited risk (Q3: odds ratio [OR]: 1.75, 95% confidence intervals [CI]: 1.29–2.39; Q4: OR: 2.68, CI: 1.96–3.68, P trend < 0.001), linear (P nonlinearity = 0.108). And subgroup analysis yielded results consistent primary findings. Conclusion This revealed China, individuals, elevated associated risk, suggesting is promising target prevention treatment.

Language: Английский

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Association between Remnant Cholesterol and All-Cause and Cardiovascular Mortality Risk in Chronic Kidney Disease Patients Over 60: A Cohort Study Based on NHANES 2001-2018

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract Objective Chronic kidney disease (CKD) patients face significant mortality risks, and remnant cholesterol (RC) may be a critical prognostic indicator. This study aimed to explore the association between RC all-cause cardiovascular risks in CKD patients. Methods prospective cohort utilized data from National Health Nutrition Examination Survey (NHANES) 2001-2018, including 1,606 aged over 60. Cox proportional hazards models were employed assess mortality, with multi-model adjustments subgroup analyses. Results During 93.9 months of follow-up, 932 events (58.0%) 283 (17.6%) observed. Each logarithmic unit increase was associated 41% reduction risk (adjusted HR: 0.59, 95% CI: 0.40-0.87, P=0.0079). Subgroup analyses revealed significantly reduced women (HR=0.71), hypertensive (HR=0.75), type 2 diabetes (HR=0.66). Conclusion In patients, is risk, providing new perspective for individualized assessment.

Language: Английский

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Remnant cholesterol and suicide attempts in untreated first-episode major depressive disorder

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Objective The objective of this research was to investigate the relationship between remnant cholesterol (RC) levels and suicide attempts (SA) made by Chinese patients with untreated first-episode major depressive disorder (UFE MDD). Methods This study included 1718 UFE MDD. Demographic, clinical characteristics, blood lipid parameters were collected. 17-item Hamilton Depression Rating Scale (HAMD), 14-item Anxiety (HAMA), positive subscale Positive Negative Syndrome (PANSS) used assess their depression, anxiety, psychotic symptoms, respectively. Multivariable binary logistic regression analysis estimate association RC risk SA. A two-piecewise linear model threshold effects if non-linear associations existed. Results Univariate showed a significant correlation SA, but after controlling for confounding factors, them not statistically significant. After dividing into quartiles, only in Q4 group significantly positively correlated (OR = 1.73, 95% CI: 1.13-2.65, P 0.012, vs. Q1) fully adjusted model. Curve fitting also nonlinear an inflection point at 1.99 mmol/L RC. On left point, observed SA (OR: 1.36, 1.09-1.69, p=0.006). However, on right no found 0.79, 0.55-1.14, p=0.214). Conclusion demonstrates disorder. When less than mmol/L, they correlation.

Language: Английский

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Association between cardiometabolic index (CMI) and suicidal ideation: The mediating role of depression and cardiovascular disease

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 380, P. 487 - 495

Published: March 28, 2025

Language: Английский

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Effects of remnant cholesterol on adverse renal outcomes in lupus nephritis

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 10, 2025

Remnant cholesterol (RC) causes inflammation and promotes kidney diseases development. However, its role in lupus nephritis (LN) remains unclear. The purpose of this study was to investigate the association between RC LN. This observational conducted among patients enrolled 2000 2018 High Quality Evidence Guangzhou Lupus Nephritis Cohort. outcomes were defined as adverse renal outcomes, including serum creatinine doubled end-stage disease. Patients stratified into lower higher groups based on optimal cutoff value (86.88 mg/dL) for outcomes. To explore RC, survival analyses, multivariate Cox regression subgroup analyses conducted. Overall, 909 individuals enrolled. Over a median follow-up 8.33 (interquartile range, 3.08-12.83) years, 134(14.74%) them reached endpoints. Kaplan-Meier indicated that with levels more susceptible LN (P < 0.001). After adjusting confounding factors, exhibited significant correlations [hazard ratio (HR):1.98, 95% confidence interval (CI):1.16-3.39; P = 0.012]. Subgroup revealed strong relationship particularly aged 40 an estimated glomerular filtration rate 60 ml/min/1.73m2 or proliferative pathological changes nephrotic syndrome 0.05). Higher significantly associated poor LN, indicating may become non-invasive prognostic tool clinical assessment

Language: Английский

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