Increased serum EGF but not SDF-1 levels are associated with the pathophysiology and development of generalized anxiety disorder DOI Creative Commons
A. S. M. Roknuzzaman, MMA Shalahuddin Qusar, Hasan Shahriar

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 9, 2024

Generalized anxiety disorder (GAD) is a common and persistent mental illness accompanied by uncontrollable worries for daily staff. Physiological, environmental, genetic, stress from surroundings involved in developing GAD. Here, we aimed to assess the association of stromal cell-derived factor-1 (SDF-1) epidermal growth factor (EGF) pathophysiology GAD their role as diagnostic tools. This case-control study recruited 50 patients psychiatry department tertiary care teaching hospital Dhaka city 38 age-sex-matched healthy controls (HCs) surrounding areas. A qualified psychiatrist conducted standardized psychiatric interview diagnose evaluate HCs applying statistical manual disorders, 5th edition (DSM-5) used GAD-7 scale severity symptoms. After confirming inclusion exclusion criteria, collected 5 ml blood samples each participant. We measured serum SDF-1 EGF levels using ELISA techniques. observed increased compared (5.91 ± 3.90 ng/ml vs. 1.59 1.08 ng/ml; p < 0.001). Also, this increment positively associated with (r = 0.479, 0.002). The receiver operating characteristic analysis showed good performance (AUC 0.869, 0.001) high sensitivity (82.5%), specificity (81.1%) at cut off value 2.31 ng/ml. However, didn't find significant differences between (11.96 4.50 12.70 11.76 0.337). present suggests that have but not are symptoms well. Moreover, could serve biomarker further interventional studies larger homogeneous suggested confirm establish these findings.

Language: Английский

The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets DOI Creative Commons
Anupam Sah, Nicolas Singewald

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108825 - 108825

Published: Feb. 1, 2025

Language: Английский

Citations

2
From bite to brain: Neuro‐immune interactions in food allergy DOI Creative Commons
Vikki Houghton, Thomas Eiwegger, Esther Florsheim

et al.

Allergy, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

Abstract Immunoglobulin E (IgE)‐mediated food allergies are reported to affect around 3.5% of children and 2.4% adults, with symptoms varying in range severity. While being the gold standard for diagnosis, oral challenges burdensome, diagnostic tools based on specific IgE can be flawed. Furthering our understanding mechanisms behind allergy onset, severity persistence could help reveal immune profiles associated disease, ultimately aid diagnosis. Alterations cytokine levels cell ratios have been identified, though further research is needed fully capture heterogenous nature allergy. Moreover, existence such alterations also raises question potential wider systemic effects. For example, recent has emphasised impact neuro‐immune interactions implicated behavioural neurological changes This review will provide an overview allergy‐driven interactions, aim emphasising importance furthering underlying IgE‐mediated

Language: Английский

Citations

0
Increased serum EGF but not SDF-1 levels are associated with the pathophysiology and development of generalized anxiety disorder DOI Creative Commons
A. S. M. Roknuzzaman, MMA Shalahuddin Qusar, Hasan Shahriar

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 9, 2024

Generalized anxiety disorder (GAD) is a common and persistent mental illness accompanied by uncontrollable worries for daily staff. Physiological, environmental, genetic, stress from surroundings involved in developing GAD. Here, we aimed to assess the association of stromal cell-derived factor-1 (SDF-1) epidermal growth factor (EGF) pathophysiology GAD their role as diagnostic tools. This case-control study recruited 50 patients psychiatry department tertiary care teaching hospital Dhaka city 38 age-sex-matched healthy controls (HCs) surrounding areas. A qualified psychiatrist conducted standardized psychiatric interview diagnose evaluate HCs applying statistical manual disorders, 5th edition (DSM-5) used GAD-7 scale severity symptoms. After confirming inclusion exclusion criteria, collected 5 ml blood samples each participant. We measured serum SDF-1 EGF levels using ELISA techniques. observed increased compared (5.91 ± 3.90 ng/ml vs. 1.59 1.08 ng/ml; p < 0.001). Also, this increment positively associated with (r = 0.479, 0.002). The receiver operating characteristic analysis showed good performance (AUC 0.869, 0.001) high sensitivity (82.5%), specificity (81.1%) at cut off value 2.31 ng/ml. However, didn't find significant differences between (11.96 4.50 12.70 11.76 0.337). present suggests that have but not are symptoms well. Moreover, could serve biomarker further interventional studies larger homogeneous suggested confirm establish these findings.

Language: Английский

Citations

0