Potential Regulation of the Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript1 by Estrogen in Parkinson’s Disease DOI Creative Commons

Eman Adel,

Maya Nicolas

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1662 - 1662

Published: Dec. 16, 2024

Parkinson’s disease (PD) is the second-leading cause of death among neurodegenerative after Alzheimer’s (AD), affecting around 2% population. It expected that incidence PD will exceed 12 million by 2040. Meanwhile, there a recognized difference in phenotypical expression and response to treatment between men women. Men have twice compared women, who late onset worse prognosis usually associated with menopause. In addition, women cumulative estrogen levels their bodies. These differences are suggested be due protective effect on brain, which cannot given clinical practice improve symptoms because its peripheral side effects, causing cancer both males females addition feminizing it has males. As pathophysiology involves alteration multiple LncRNAs, including metastatic-associated lung adenocarcinoma transcript 1 (MALAT1), as been illustrated control MALAT1 conditions, worth investigating estrogen–MALAT1 interaction mimic brain while avoiding effects. The following literature review suggests potential regulation PD, would enhance our understanding disease, improving development more tailored effective treatments.

Language: Английский

Burden of Parkinson’s disease in Iran: disparities, trends, and the impact of social development indicators DOI
Mohammad Sarmadi, Mina Rezaei, Mohsen Poursadeghiyan

et al.

Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Language: Английский

Citations

0
Assessing the perception of Parkinson’s disease in Al-Ahsa, Saudi Arabia among the visitors of a public campaign: before and after survey DOI Creative Commons
Alia Ali Alokley, Fatimah Alhubail,

Abdullah M. Al Omair

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: April 3, 2024

Introduction Insufficient knowledge and beliefs hinder the early diagnosis provision of adequate treatment care for PD patients, causing socio-economic burdens. Raising public awareness understanding gap is crucial effective educational programs detection. This study aims to assess perception Parkinson’s disease (PD) among visitors a campaign conducted raise facilitate detection management. Methods A before-and-after was from May June 2023, in Al-Ahsa, Saudi Arabia. The included booths discussing symptoms, causes, diagnosis, management, support. Participants completed self-administered online questionnaire before after campaign. data were analyzed using SPSS. Results 48 eligible individuals. mean score significantly enhanced following campaign, rising 12 17.77 points ( p < 0.05). symptoms that showed significant difference slow movement, tremors, depression, memory problems, sleep problems. had beneficial effect on participants’ general PD. Discussion campaigns successfully raised community Participants’ improved highlighting its positive effect. Further research could explore measuring continuity over longer period impact improving patients’ lives expand sample size.

Language: Английский

Citations

3
Predict the prevalence and incidence of Parkinson’s disease using fractal interpolation-LSTM model DOI Creative Commons
Zhong Dai, Shutang Liu, Changan Liu

et al.

Chaos An Interdisciplinary Journal of Nonlinear Science, Journal Year: 2024, Volume and Issue: 34(5)

Published: May 1, 2024

The investigation of the prediction disease population is a noticeable exploration topic in field sciences. As type neurological disease, incidence and prevalence Parkinson’s are still difficult to accurately study. In this paper, method proposed forecast number incident cases (NumIn), rate (InRa), prevalent (NumPr), (PrRa) ten countries selected. Using past data on rate, cases, from 1990 2019, three types fractal interpolations with different dimensions constructed for reconstructing data, where vertical scaling factors determined by article. Then, Long Short-Term Memory (LSTM) model employed values NumIn, InRa, NumPr, PrRa 2020. Meanwhile, autoregressive integrated moving average used predict compared LSTM model. evaluation metrics error calculation include root mean square coefficient determination (R2). According optimal criteria, best predicted results based analyzing comparing eight results.

Language: Английский

Citations

3
The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson’s disease DOI Creative Commons

Martina B. William,

Sherifa A. Hamed, Ali Shalash

et al.

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 6, 2024

The impact of LRRK2 variants on the risk Parkinson's disease in Egyptians remains unknown. We examined 1210 (611 PD patients and 599 controls) from 16 governorates across Egypt for 12 pathogenic variants. p.Gly2019Ser was only variant detected, with a prevalence 4.1% sporadic cases, 6.5% familial 0.68% controls. Among carriers, all were heterozygous bar one homozygous patient, shared common haplotype 1. Demographics UPDRS scores did not differ between carriers non-carriers, most being males developed their fifties. Young Early-onset 37.5% 33% non-carriers. Familial cases 16.6% 11.5% This study affirms that like other Mediterranean populations, have higher compared to global average. inhibitors could be promising therapeutic options further exploration this population.

Language: Английский

Citations

2
Global, Regional, and National Burden of Parkinson's Disease 1990–2021: A Systematic Analysis of the Global Burden of Disease Study 2021 DOI
Jiacheng Wang, Shuhao Zhang,

Linna Yuan

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

2
Dementia and Multimorbidity Trends in Al-Baha, Saudi Arabia: An Analytical Retrospective Study Using Records-Based Data DOI Open Access

Saba Beigh,

Remas Adnan,

Al-Johrah Abdulaziz

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 18, 2024

Background: The prevalence of dementia is escalating significantly, posing a substantial societal burden. Currently, there exists dearth comprehensive health data about patients in Saudi Arabia, particularly within Al-Baha City. Methods: A retrospective case-series study was undertaken to ascertain the populace region, Kingdom Arabia. This investigation utilized hospital-based records encompassing individuals exhibiting symptoms or diagnosed with and its related forms across region. Furthermore, aimed evaluate burden comorbidities among document pharmacological therapeutic interventions administered manage associated concurrent conditions. Results: Our explored rates various accompanying affected individuals. spanned from August 2020 2023. encompassed 407 Alzheimer's disease (AD), Parkinson's disease, vascular (VaD), other who were either admitted attended tertiary hospitals Al-Baha. Assessment comorbidity conducted using Charlson Comorbidity Index (CCI). findings revealed that these patients, 13.3% presented AD, 23.6% VaD, 33.4% 15.75% amnesia, 14.0% types dementia. spectrum observed conditions, diabetes mellitus emerging as predominant (19.1%), followed by hypertension (16.4%). Additionally, manifestations depression noted 14% while 9.82% suffered paralysis. Chronic conditions such cancer, chronic obstructive pulmonary disorder (COPD), cervical spondylosis also afflicted varied forms. Statistically significant correlations established between gender, age, nationality, comorbidities, Therapeutic form treatments prescribed for comorbidities. Commonly medications included Amlod (6.3%), Amlodipine (6.6%), Amlor (5.8%), Aspirin (10.5%), chemotherapeutic drugs (4.4%), Glipizide (8.5%), Lantus (11.3%), Levodopa (23.5%), Metformin (7.8%), acetylcholinesterase inhibitors (6.8%), Pulmicort (7.86%). These alleviate Conclusions: underscores experienced patients. offer crucial insights into overall status grappling dementia, serving catalyst increased awareness clinicians policymakers. Such can drive improvements medical care support frameworks tailored specific needs

Language: Английский

Citations

1
Psychometric properties of Arabic-translated-related quality of life scales for people with parkinson disease: a scoping review DOI Creative Commons

Chiraz Azaiez,

Naser Chalghaf,

Amayra Tannoubi

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 14, 2024

Language: Английский

Citations

1
Measuring public attitudes towards people living with chronic diseases in Arabic-speaking populations: adaptation and development of the Social Stigma Scale of Chronic Diseases (SSS-CD) DOI Creative Commons
Feten Fekih‐Romdhane, Sahar Obeïd, Georgio Chidiac

et al.

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 18, 2023

A large proportion of the population in Arab countries suffer from chronic diseases. According to statistics by Global Health Estimates, illnesses contribute 71% total deaths region. While have been demonstrated carry high levels social stigma, it is only recently that little research attention has given this topic world. It well-established stigma construct culturally-dependent. Therefore, lack an Arabic measure highlighted urgent need for developing a culturally adapted and valid instrument assess toward people living with In study, we aimed examine psychometric properties translation, adaptation development "the Social Stigma Scale Chronic Diseases" (SSS-CD).

Language: Английский

Citations

1
Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features DOI Creative Commons
Arash Yaghoobi, Homa Seyedmirzaei, Moein Ala

et al.

Parkinson s Disease, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 13

Published: Aug. 23, 2023

Despite remarkable progress in identifying Parkinson's disease (PD) genetic risk loci, the basis of PD remains largely unknown. With help endophenotype approach and using data from dopamine transporter single-photon emission computerized tomography (DaTscan), we identified potentially involved genes PD.We conducted an imaging study by performing exome-wide association (EWAS) genome-wide (GWAS) on specific binding ratio (SBR) six DaTscan anatomical areas between 489 559 subjects progression markers initiative (PPMI) cohort 83,623 36,845 single-nucleotide polymorphisms (SNPs)/insertion-deletion mutations (INDELs). We also investigated cerebrospinal fluid (CSF) protein concentration our significant with PPMI CSF proteome data.Among SNPs/INDELs EWAS, one SNP (rs201465075) 1 q32.1 locus was significantly (P value = 4.03 × 10-7) associated left caudate SBR, 33 SNPs were suggestive. Among GWAS, (rs12450112) 17 p.12 1.34 10-6) right anterior putamen 39 suggestive among which 8 intergenic. found that rs201465075 rs12450112 are most likely related to IGFN1 MAP2K4 genes. The level cohort; however, proteomic not available for gene.We have shown particular variants may be PD. Since could positive other Parkinsonian syndromes, caution should taken when interpreting results. Future experimental studies needed verify these findings.

Language: Английский

Citations

1
We are living in the Parkinson's pandemic DOI
Roongroj Bhidayasiri, Soania Mathur, Walter Maetzler

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 9

Published: Jan. 1, 2024

Language: Английский

Citations

0