Composite dietary antioxidant index is inversely and nonlinearly associated with cardiovascular disease, atherosclerotic cardiovascular disease, and cardiovascular mortality in people with dyslipidemia: evidence from NHANES 2001–2018

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Dyslipidemia is a major risk factor for cardiovascular disease (CVD) and atherosclerotic CVD (ASCVD). The composite dietary antioxidant index (CDAI), an emerging measure of combined exposure, may provide insights into the relationship between diet CVD/ASCVD outcomes. We aimed to explore association CDAI prevalence CVD/ASCVD, as well mortality in individuals with dyslipidemia. was assessed by integrating vitamins A, C, E, zinc, selenium, carotenoids. diagnosed according widely established criteria. Data on were obtained through self-reports, while prospective matching participant records National Death Index database. Multivariate logistic regression analysis Cox proportional hazards used these associations calculate odds ratios [OR], hazard [HR], 95% confidence intervals [CI], respectively. A total 23,126 participants dyslipidemia from NHANES 2001-2018 included. After adjusting potential confounders, inversely associated both ASCVD populations (OR CI 0.979 (0.964, 0.995) 0.977 (0.961, 0.993), respectively). Similar observed specific types CVD. also (HR = 0.957, 0.939-0.976, p < 0.0001). Restricted cubic spline threshold effects analyses indicated that nonlinearly significant occurring only when CDAI≤0; however, > -2. Furthermore, age, sex, drinking found modify body mass influenced mortality. events dyslipidemic populations. These findings highlight patterns alleviate burden underscore importance personalized strategies.

Language: Английский

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Sex differences in the association between composite dietary antioxidant index and hyperlipidemia: Insights from NHANES

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0316130 - e0316130

Published: Jan. 10, 2025

Background Previous studies have shown that both the composite dietary antioxidant index (CDAI) and sex are strongly associated with a variety of cardiovascular diseases, but differences between CDAI hyperlipidemia unknown. Objective This study utilized data from National Health Nutrition Examination Survey (NHANES) to investigate hyperlipidemia. Method We calculated six antioxidants using NHANES, explored relationship prevalence multivariate logistic regression analysis, analyzed for potential nonlinear associations restricted cubic spline. Finally, association was further in different genders. Results The included total 34,754 participants mean age 47.04 years, whom 49.37% were man. In fully adjusted multivariable binary model, negatively (OR = 0.99, 95% CI:0.98–0.99). addition, highest quartile had lower risk hyperlipidaemia compared lowest 0.83, 95%CI: 0.76–0.92). also found non-linear (non-linear P 0.003, Inflection point -0.179). we significantly stronger female population than male (P interaction <0.05). Conclusion Our highlights L-shaped general adult population. this more significant

Language: Английский

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Association between composite dietary antioxidant indices and anemia: NHANES 2003–2018

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0316397 - e0316397

Published: Jan. 2, 2025

Background There is increasing acknowledgment of the potential role that diet rich in antioxidants may play prevention anemia. As a significant indicator antioxidant-rich diet, relationship between composite dietary antioxidant index (CDAI) and anemia has not been extensively studied. Therefore, this study aims to explore association CDAI Methods Utilizing datas from 2003–2018 National Health Nutrition Examination Survey (NHANES) database. The was calculated using six antioxidants, based on two 24-hour recall interviews, serving as comprehensive measure intake these antioxidants. Weighted multivariable logistic regression restricted cubic spline (RCS) analysis conducted investigate Furthermore, subgroup analyses were performed enhance reliability. Results A total 33914 participants included study, among which 3,416 (10.07%) diagnosed with unadjusted model showed negative (odds ratio [OR]: 0.94; 95% confidence interval [95%CI]: 0.93–0.96; P < 0.001). After adjusting for all covariates, each increase level linked 3% lower risk (OR: 0.97; 95%CI: 0.95–0.98; Moreover, when categorized into quartiles, observed trend persisted ( RCS revealed linear nonlinearity = 0.619). Except sex, smoking, diabetes hypertension, no statistically interactions found any 0.05 interaction). Conclusion Our findings suggest levels are inversely related prevalence Consequently, monitoring individuals low scores facilitate timely identification clinical decision-making.

Language: Английский

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Exploring the association between composite dietary antioxidant index and ocular diseases: a cross-sectional study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 14, 2025

Globally, approximately 2.2 billion people suffer from visual impairments or blindness. Dietary patterns are closely associated with the prevalence of multiple ocular diseases. This study aimed to explore association between Composite Antioxidant Index (CDAI) and disorders. The data were derived 1706 subjects aged 40 years older who participated in 2005–2008 National Health Nutrition Examination Survey (NHANES), which utilized undersampling techniques. Trained staff interviewed participants gather information about their dietary habits using 24-h diet recall method. CDAI, incorporating six antioxidants, was then computed a validated Eye diseases diagnosed through combination examinations questionnaires. Multinomial logistic regression used estimate odds ratios (ORs) 95% confidence intervals (CIs), adjusting for potential confounders. After confounders, higher CDAI quartiles (Q4) significantly reduced diabetic retinopathy (OR: 0.55, P = 0.041), cataracts 0.37, < 0.001), glaucoma 0.48, 0.003), macular degeneration 0.19, 0.001). Carotenoids showed significant negative correlation diseases, 0.57, 0.75, 0.014), 0.59, 0.001) Compared lowest quartile (Q1), zinc intake lower DR 0.32, 0.73, Similarly, Q4 vitamin C 0.70, 0.71, 0.003) compared Q1. Higher scores correlated decreased suggesting that an antioxidant-rich pattern may be better health. Understanding these correlations could contribute development preventive strategies intervention measures

Language: Английский

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Interactive association of the dietary oxidative balance score and cardiovascular disease with mortality in older adults: evidence from NHANES

Food & Function, Journal Year: 2024, Volume and Issue: 15(11), P. 6164 - 6173

Published: Jan. 1, 2024

: We conducted an assessment to explore potential associations of the dietary oxidative balance score (DOBS), cardiovascular disease (CVD), with all-cause mortality among older adults, while also exploring moderating effect DOBS on relationship between CVD and mortality.

Language: Английский

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Associations between Life’s Essential 8 and post-stroke depression and all-cause mortality among US adults

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: April 12, 2024

Abstract Background Depression is the common mental disease after stroke. Our objective was to investigate correlation of Life’s Essential 8 (LE8), recently updated evaluation cardiovascular health, with occurrence post-stroke depression (PSD) and all-cause mortality among United States (US) adults. Methods Participants stroke were chosen from National Health Nutrition Examination Survey (NHANES) between 2005 2018. The relationship LE8 risk PSD assessed through weighted multiple logistic models. A restricted cubic spline employed for examination correlations. To demonstrate stability results, sensitivity analysis subgroup carried out. Furthermore, Cox regression models used mortality. Results In this study, a total 1071 participants included analysis. It observed that score shared an inverse in per 10 points increase [OR = 0.62 (0.52–0.74, P < 0.001)] demonstrated approximately noticeable linear association risk. Sensitivity verified findings. Moreover, no statistically significant interactions identified reverse also 10-point [HR 0.85 (0.78–0.94, cox Conclusions negative discovered US We need conduct large-scale prospective studies further validate our results.

Language: Английский

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Association between composite dietary antioxidant index and hyperlipidemia: a cross-sectional study from NHANES (2005–2020)

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 10, 2024

Abstract The association between the composite dietary antioxidant index (CDAI) and hyperlipidemia remains unclear. Therefore, this study aimed to investigate relationship CDAI hyperlipidemia. data used in were obtained from National Health Nutrition Examination Survey (NHANES) dataset spanning 2005 2020. Based on 24-h recall interviews, was calculated using intake of six antioxidants. Univariate multivariate logistic regression models employed occurrence Additionally, restricted cubic spline (RCS) analysis utilized potential non-linear relationships risk final included 30,788 adults United States, among whom 25,525 (82.91%) diagnosed with A significant negative correlation observed unadjusted (Odds ratio [OR] 0.97 [95% CI 0.96, 0.98]) multi-variable adjusted (OR 0.98 0.97, 0.99]) models. When values analyzed as a categorical variable, individuals highest quartile 0.82 0.73, 0.92]) exhibited nearly one fifth decreased compared those lowest quartile. RCS revealed linear ( P for nonlinearity = 0.124). results remained consistent across subgroups except under age 60 or diabetes mellitus. There hyperlipidemia, indicating that maintaining an optimal level could effectively reduce incidence

Language: Английский

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Association between composite dietary antioxidant index and epilepsy in American population: a cross-sectional study from NHANES

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 17, 2024

Epilepsy is a major global health challenge, affecting approximately 50 million people across the globe and resulting in significant economic impacts on individuals society. Oxidative stress implicated pathogenesis of epilepsy, highlighting potential antioxidant-rich dietary patterns offering preventive protective benefits by mitigating oxidative stress. The Composite Dietary Antioxidant Index (CDAI) provides measure for assessing antioxidant intake, yet its link to epilepsy remains unexplored.

Language: Английский

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Association between the composite dietary antioxidant index and all-cause mortality in individuals with osteoarthritis via NHANES data

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 5, 2024

The impact of antioxidant intake on the prognosis osteoarthritis (OA) patients remains unclear. aim this study was to investigate relationship between composite dietary index (CDAI) and all-cause mortality in OA patients. A total 35,590 participants with from National Health Nutrition Examination Survey (1999–2020) were included study. We analysed associations CDAI risk via a multivariate Cox regression model. Restricted cubic spline used dose–response mortality. also conducted stratified analyses interaction tests explore underlying effect modification. After multivariable adjustment, each one-unit increase associated 2.1% reduction Compared those low group, multivariate-adjusted hazard ratios (HRs) for high group lower [Model 1 (HR 0.648, 95% CI 0.557–0.754), Model 2 0.739, 0.627–0.871), 3 0.788, 0.661–0.941)]. observed negative nonlinear (P < 0.05). Stratification confirmed robustness results. found higher significantly These results highlight potential advantages monitoring evaluating status preventing among OA.

Language: Английский

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Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 16, 2025

Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted adverse effects high reactive oxygen species (ROS) levels in progression chronic noncommunicable also during infections. On other hand, antioxidants play a crucial role preventing oxidative or postponing cell damage via direct scavenging free radicals indirectly Keap1/Nrf2/ARE pathway, among others. Dietary can be obtained from various sources, mainly through plant-based diet, including fruits vegetables. The dietary antioxidant index (DAI) has been developed assess total intake diet. This review delineated performance DAI risk assessment different diseases. It is suggested that score prevents obesity-related diseases, diabetes mellitus, hyperuricemia, dyslipidemia, metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, negatively associated with Helicobacter pylori Human papillomavirus infection, thus reducing gastric cervical cancer. Also, osteoporosis, miscarriage, infertility, mental illnesses. However, further prospective observations clinical trials are warranted confirm application studied.

Language: Английский

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