Inflammatory burden index (IBI) and body roundness index (BRI) in gallstone risk prediction: insights from NHANES 2017–2020

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 21, 2025

The Inflammatory Load Index (IBI) and Body Roundness (BRI) were employed to evaluate the systemic inflammatory status body fat. This study aims elucidate association between IBI prevalence of gallstones, as well analyze mediating role BRI in this association. Data from National Health Nutrition Examination Survey (NHANES) (2017–2020) utilized our cross-sectional study. A total 2598 participants aged ≥ 20 years enrolled. Boruta algorithm, a supervised classification feature selection method, is leveraged identify confounding variables most strongly associated with gallstones. Weighted multivariate logistic regression, restricted cubic splines (RCS), subgroup analyses investigate assess presence linear association, effect on gallstone risk across different populations. Finally, was examined. In fully adjusted model, when highest tertile, each unit increase (corresponding an 1 natural logarithm IBI) linked 110.8% higher gallstones (OR = 2.108, 95% CI: 1.109–4.005; P 0.028). odds ratio for increased levels unadjusted, partially adjusted, models (P trend < 0.05). positive confirmed be by RCS curve nonlinear 0.887). Subgroup analysis indicated that significantly elevated individuals 60, females, those Poverty-to-Income Ratio (PIR) 2 Mediation revealed had significant indirect through BRI, size 0.0129 (95% 0.0121–0.0136; 0.001), mediation contributed 33.24% effect. demonstrates relation prevalence. Furthermore, mediates risk. These findings provide more precise marker prevention treatment. Not applicable.

Language: Английский

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Association between life's essential 8 and Parkinson's disease: a case–control study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 1, 2025

Abstract Objectives Life's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) still unclear. This study aimed to elucidate association between LE8 metrics PD in US adults. Methods Data of 26,975 participants were extracted from last 7 National Health Nutrition Examination Survey (NHANES) cycles (2005–2018). The calculated according American Heart Association criterion, divided into 3 groups using tertile range. Multivariate logistic regression models constructed explore PD. Sensitivity analysis was conducted verify robustness. A nonlinear linkage evaluated via restricted cubic spline (RCS). stability this validated by subgroup interaction test. Results total eligible (including 271 cases 26,704 non-PD cases) included study. multivariate revealed a reverse continuous with ORs 0.97 (unadjusted model [95% CI: 0.96–0.98, P < 0.01], partially adjusted 0.97–0.98, fully 0.95–0.98, 0.01]). Compared those low group, high group 0.37 (95% 0.27–0.50, 0.01) unadjusted model, 0.51 0.36–0.72, 0.32–0.81, model. sensitivity ensured robustness observed LE8-PD association. relationship ( nonlinearity RCS analysis. showed that participants'gender might impact strength metrics-PD = 0.029). Conclusions CVH, as delineated metrics, reversely associated dose–response pattern, more pronounced female compared male. These findings highlight potential guide targeted strategies addressing gender-based CVH disparities, offering beneficial insights tertiary prevention

Language: Английский

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Association of the inflammatory burden index with the risk of pre-diabetes and diabetes mellitus: a cross-sectional study

BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

This study aims to investigate the association between Inflammatory Burden Index (IBI) and prevalence of pre-diabetes (pre-DM) diabetes mellitus (DM) in U.S. population from 1999 2010. By analyzing relevant data collected during this period, seeks understand IBI's role onset pre-DM DM its potential implications for public health. A cross-sectional analysis was conducted using National Health Nutrition Examination Survey (NHANES) total 29,554 participants were included, with status determined by self-reported diagnoses clinical indicators (such as glycosylated hemoglobin fasting blood glucose). The calculated C-reactive protein (CRP) multiplied neutrophil-to-lymphocyte ratio. generalized additive model (GAM) employed examine relationship increasing IBI incidence DM. included participants, 14,290 (48.4%) men 15,264 (51.6%) women, a mean age 48.3 years (SD = 19.1). findings revealed significant risk In fully adjusted model, stronger observed pre-DM, DM, IBI. significantly higher fourth quartile (Q4) compared first (Q1), 26% an 18% when greater than 1.04. Our demonstrates correlation population. Given these findings, we recommend that be considered key indicator management treatment settings.

Language: Английский

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Inflammatory burden index as a predictor of mortality in septic patients: a retrospective study using the MIMIC-IV database

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 17, 2025

Previous studies have identified the Inflammatory Burden Index (IBI) as a potential predictor of mortality risk in inflammatory diseases. However, its relationship with rates specifically septic patients has not been thoroughly investigated. This study aimed to explore association between IBI and sepsis. We sourced clinical records 1,828 from Multiparameter Intelligent Monitoring Intensive Care IV (MIMIC-IV 3.0) dataset, covering period 2008 2022. The primary endpoint was within 28 days, secondary endpoints including during intensive care unit (ICU) stays throughout hospitalization. Patients were categorized into quartiles based on their log-transformed (LnIBI) levels. Binary logistic regression utilized examine independent influence outcomes, adjusting for confounders. Additionally, these outcomes explored using restricted cubic splines Kaplan-Meier analysis. Further comparison receiver operating characteristic (ROC) curves conducted investigate predictive performance. involved patients, 1,047 males. all-cause 17.78% (325/1828) 17.34% (317/1828) ICU stays, 18.22% (333/1828) over course In adjusted model, positive correlation found LnIBI at days (OR 1.093[1.014, 1.179], P = 0.021), stay 1.106[1.025, 1.195], 0.01), hospitalization 1.1[1.022, 1.187], 0.012). analysis showed linear risks. areas under curve (AUC) larger than that CRP (P < 0.05), there no significant differences Neutrophil counts or Lymphocyte > 0.05). plots revealed significantly lower survival highest quartile 0.001). Elevated values are linked higher risks ICU, patients.

Language: Английский

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Association of weight-adjusted waist index with all-cause and cardiovascular mortality in individuals with osteoarthritis

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 21, 2025

The Weight-Adjusted waist index (WWI) is a novel obesity assessment parameter that has been shown to be associated with mortality in various chronic disease populations and also linked the onset of osteoarthritis (OA). aim this study investigate whether WWI all-cause cardiovascular OA population. analyzed cohort 3,554 patients drawn from National Health Nutrition Examination Survey (NHANES) conducted between 2005 2018. Kaplan-Meier survival curves, Cox proportional hazards regression models, subgroup analyses were utilized assess association outcomes. dose-response relationship was examined using restricted cubic spline (RCS) model. Among individuals, 611 participants determined as deceased (13%), 26% deaths due causes. fully adjusted model revealed elevated values significantly higher risk (HR = 1.28, 95% CI 1.07‒1.52). only observed minimally 1.43, 1.12‒1.81). A similar conclusion when grouped according tertiles. curves demonstrated rates among individuals WWI. analysis indicated linear positive rates. above associations remained consistent across all subgroups. Elevated levels independently. Not applicable.

Language: Английский

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Inflammatory Burden Index as a predictor of mortality in septic patients: A retrospective study using the MIMIC-IV Database

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Purpose Previous studies have identified the Inflammatory Burden Index (IBI) as a potential predictor of mortality risk in inflammatory diseases. However, its relationship with rates specifically septic patients has not been thoroughly investigated. This study aimed to explore association between IBI and sepsis. Patients methods: We sourced clinical records 1,828 from MIMIC-IV (3.0) dataset. The primary endpoint was within 28 days, secondary endpoints including during ICU stays throughout hospitalization. were categorized into quartiles based on their LnIBI levels. Binary logistic regression utilized examine independent influence outcomes, adjusting for confounders. Additionally, these outcomes explored using restricted cubic splines Kaplan-Meier analysis. Results involved patients, 1,047 males. all-cause 17.78% (325/1828) 17.34% (317/1828) stays, 18.22% (333/1828) over course In adjusted model, positive correlation found Ln at days (OR 1.093[1.014, 1.179], P = 0.021), stay 1.106[1.025, 1.195], 0.01), hospitalization 1.1[1.022, 1.187], 0.012). analysis showed linear risks. plots revealed significantly lower survival highest quartile (P < 0.001). Conclusion Elevated values are linked higher risks ICU, period patients.

Language: Английский

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Letter to the editor for the article “associations between inflammatory burden index, prostate cancer, and mortality among middle-aged and elderly individuals”

World Journal of Urology, Journal Year: 2024, Volume and Issue: 43(1)

Published: Dec. 3, 2024

Language: Английский

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Gender-specific inflammatory burden and headache risk in youth: a NHANES analysis

Head & Face Medicine, Journal Year: 2024, Volume and Issue: 20(1)

Published: Dec. 5, 2024

Headaches are a common and often debilitating condition among youth. The Inflammatory Burden Index (IBI), simple surrogate marker of systemic inflammation, has been linked to various diseases. However, evidence for its relationship with headaches, particularly in youth, is lacking. This study aimed investigate the association between IBI persistent headache focus on evaluating gender-specific responses exposure. We analyzed data from 2,210 young people 2001–2004 National Health Nutrition Examination Survey (NHANES). frequent or severe headaches past year was investigated using weighted logistic regression models. Odds ratios (ORs) 95% confidence intervals (95% CIs) were calculated, threshold effect analyses performed. Youths highest quartile (Q4) had 46% higher risk compared lowest (Q1) (OR: 1.46, CI: 1.12–1.91, P = 0.0051). Gender-stratified analysis revealed significant high females 1.48; 1.03–2.11, 0.0324), but not males. Threshold identified an breakpoint 3.78, below which increased significantly under 18 years 1.12, 1.01–1.25, 0.0385). Our findings demonstrate elevated females. suggests that inflammatory processes may play more prominent role pathophysiology female These results underscore importance considering markers early identification prevention youth especially

Language: Английский

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