Post hepatectomy liver failure (PHLF) – Recent advances in prevention and clinical management

European Journal of Surgical Oncology, Journal Year: 2020, Volume and Issue: 47(2), P. 216 - 224

Published: Sept. 10, 2020

Language: Английский

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HGF/c-Met: A Key Promoter in Liver Regeneration

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: March 17, 2022

Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on various epithelial cells to regulate cell growth, movement and morphogenesis, tissue regeneration of injured organs. HGF sequestered by heparin-like protein in its inactive form widespread the extracellular matrix most tissues. When liver loses average mass, volume, or physiological biochemical functions due reasons, binds specific receptor c-Met (cellular mesenchymal-epithelial transition) transmits signals into cells, triggers intrinsic kinase activity c-Met. The downstream cascades HGF/c-Met include JAK/STAT3, PI3K/Akt/NF-κB, Ras/Raf pathways, affecting proliferation, survival. has important clinical significance for fibrosis, hepatocyte after inflammation, transplantation. And development as biological drug regenerative therapy diseases, is, using recombinant human treat disorders trials, underway. This review summarizes recent findings signaling regeneration.

Language: Английский

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Current Surgical Management Strategies for Colorectal Cancer Liver Metastases

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 1063 - 1063

Published: Feb. 20, 2022

Colorectal cancer is the third most common diagnosis in world, and second cause of cancer-related deaths. Despite significant progress management strategies for colorectal over last several decades, metastatic disease remains difficult to treat often considered incurable. However, patients with liver metastases (CRLM), surgical resection offers best opportunity survival, can be curative, gold standard. Unfortunately, treatment options are underutilized. Misperceptions regarding resectable unresectable CRLM likely play a role this. The assessment factors that impact resectability status like medical fitness, technical considerations, biology difficult, necessitating careful multidisciplinary input discussion. identification ideal operative time windows align multimodal these also perplexing. For all it may therefore advantageous obtain evaluation at discovering mitigate challenges minimize risk undertreatment. In this review we summarize current discuss when determining resectability.

Language: Английский

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Critical Roles of the Sphingolipid Metabolic Pathway in Liver Regeneration, Hepatocellular Carcinoma Progression and Therapy

Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 850 - 850

Published: Feb. 20, 2024

The sphingolipid metabolic pathway, an important signaling plays a crucial role in various physiological processes including cell proliferation, survival, apoptosis, and immune regulation. liver has the unique ability to regenerate using bioactive lipid mediators involving multiple sphingolipids, ceramide sphingosine 1-phosphate (S1P). Dysregulation of balance between sphingomyelin, ceramide, S1P been implicated regulation regeneration diseases, fibrosis hepatocellular carcinoma (HCC). Understanding modulating this may have therapeutic implications for tumor progression, metastasis HCC. For cancer therapy, several inhibitors activators signaling, ABC294640, SKI-II, FTY720, discussed. Here, we elucidate critical roles pathway regeneration, fibrosis, Regulation sphingolipids their corresponding enzymes considerably influence new insights into therapies disorders diseases.

Language: Английский

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Value of Liver Function Tests in Cirrhosis

Journal of Clinical and Experimental Hepatology, Journal Year: 2021, Volume and Issue: 12(3), P. 948 - 964

Published: Nov. 14, 2021

Language: Английский

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Liver Regeneration and Immunity: A Tale to Tell

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1176 - 1176

Published: Jan. 7, 2023

The physiological importance of the liver is demonstrated by its unique and essential ability to regenerate following extensive injuries affecting function. By regenerating, reacts hepatic damage thus enables homeostasis be restored. aim this review add new findings that integrate regenerative pathway current knowledge. An optimal regeneration achieved through integration two main pathways: IL-6/JAK/STAT3, which promotes hepatocyte proliferation, PI3K/PDK1/Akt, in turn enhances cell growth. Proliferation growth are events must balanced during three phases process: initiation, proliferation termination. Achieving correct liver/body weight ratio ensured several pathways as extracellular matrix signalling, apoptosis caspase-3 activation, molecules including transforming factor-beta, cyclic adenosine monophosphate. actors involved process numerous many them also pivotal players both immune non-immune inflammatory process, observed early stages regeneration. Balance Th17/Treg important outcomes. Knowledge will allow a more detailed characterisation molecular mechanisms crucial interplay between inflammation.

Language: Английский

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Influence of cytokines, circulating markers and growth factors on liver regeneration and post-hepatectomy liver failure: a systematic review and meta-analysis

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: July 2, 2021

The pathophysiology of post-hepatectomy liver failure is not entirely understood but rooted in the disruption normal hepatocyte regeneration and homeostasis. Current investigations are focused on evaluation circulating hepatic function parameters (transaminases, cholestasis, coagulation parameters), volumetry hemodynamics. However, identification biochemical factors associated with post hepatectomy crucial for understanding patients at risk. objective present systematic review was to identify undergoing hepatectomy. quantitative analysis intended if studies provided sufficient data. Electronic databases (MEDLINE via PubMed, Web Knowledge, Cochrane Library WHO International Clinical Trials Registry Platform) were searched publications cell signaling following resection clinical setting. No date restriction given. language used. Studies assessed using MINORS. This study registered PROSPERO (CRD42020165384) prior data extraction. In total 1953 evaluated titles abstracts after exclusion duplicates. Full texts 167 further inclusion. 26 articles included 6 meta-analyses. High levels serum hyaluronic acid even preoperatively PHLF especially increased early predictive high sensitivity specificity. Postoperative elevation HA between 100 500 ng/ml risk ([OR] = 246.28, 95% [CI]: 11.82 5131.83; p 0.0004) Inteleukin-6 show contradicting result association organ dysfunction. HGF positively correlates regeneration. Overall, due heterogeneity, scarcity, observational design largely retrospective analysis, certainty evidence, GRADE, very low. a strong specificity, POD1. Interleukin-6 need be studied contradictive results For HGF, no could made. Yet, most find positive correlation Prospective investigating other growth factors, interleukins 1 measured sequentially through e.g. volumetry, parameters, preferably expanding include dynamic tests, needed sufficiently illustrate connection biomolecule outcomes.

Language: Английский

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Signaling pathways of liver regeneration: Biological mechanisms and implications

iScience, Journal Year: 2023, Volume and Issue: 27(1), P. 108683 - 108683

Published: Dec. 7, 2023

SummaryThe liver possesses a unique regenerative ability to restore its original mass, in this regard, partial hepatectomy (PHx) and transplantation (PLTx) can be executed smoothly safely, which has important implications for the treatment of disease. Liver regeneration (LR) very complicated procedure that involves multiple cytokines transcription factors interact with each other activate different signaling pathways. Activation these pathways drive LR process, divided into three stages, namely, initiation, progression, termination stages. Therefore, it is investigate involved elucidate mechanism LR. This study reviews latest research on key stages LR.Graphical abstract

Language: Английский

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Lactiplantibacillus plantarum AR113 Exhibit Accelerated Liver Regeneration by Regulating Gut Microbiota and Plasma Glycerophospholipid

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 13, 2022

Emerging evidence indicates that probiotics have been proved to influence liver injury and regeneration. In the present study, effects of Lactiplantibacillus plantarum AR113 on regeneration were investigated in 70% partial hepatectomy (PHx) rats. Sprague-Dawley (SD) rats gavaged with L. suspensions (1 × 1010 CFU/mL) both before after hepatectomy. The results showed administration 2 weeks can accelerate by increased hepatocyte proliferation tumor necrosis factor-α (TNF-α), growth factor (HGF), transforming factor-β (TGF-β) expression. Probiotic enriched Lactobacillus Bacteroides depleted Flavonifractor Acetatifactor gut microbiome. Meanwhile, decline phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidyl serine (PS), lysophosphatidyl choline (LysoPC) levels serum administration. Moreover, treated exhibited higher concentrations L-leucine, L-isoleucine, mevalonic acid, lower 7-oxo-8-amino-nonanoic acid plasma than PHx. Spearman correlation analysis revealed a significant between changes microbiota composition glycerophospholipid. These indicate is promising for accelerating provide new insights regarding correlations among microbiome, metabolome,

Language: Английский

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Myokines in Appetite Control and Energy Balance

Muscles, Journal Year: 2022, Volume and Issue: 1(1), P. 26 - 47

Published: Jan. 30, 2022

Efficacy of obesity treatments varies between individuals, highlighting the presence responders and non-responders. Whilst exercise alone or combined with diet leads to underwhelming weight loss for most, there exist super losing significant weight. Furthermore, in response loss, majority but not all patients tend regain Within biopsychosocial model, biology as a determinant has been underappreciated. The understanding role that organs beyond adipose tissue gastrointestinal tract play appetite control body regulation developed recent years. aim this review is highlight potential myokines may be important physiology overall energy balance. A number attractive targets are described warrant further investigation. deeper how these drive feeding behaviours improve measures prevent treat through precision medicine approach.

Language: Английский

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