Reactions Weekly, Journal Year: 2023, Volume and Issue: 1948(1), P. 401 - 401
Published: March 18, 2023
Language: Английский
Pituitary, Journal Year: 2024, Volume and Issue: unknown
Published: May 18, 2024
Abstract Purpose This systematic review aims to examine the latest research findings and assess impact of COVID-19 vaccination on pituitary gland. Method PubMed Tripdatabase were searched from January 1st, 2020 February 12th, 2024. Case reports, case series reviews related post disease included. Eligible articles tabulated analysed in attempt provide an overview epidemiology, clinical presentation, imaging, treatment, outcomes pathophysiological background disease. Results Among 23 reports included this review, hypophysitis was reported 9 patients, apoplexy (PA) 6 cases, SIADH 5 cases Isolated ACTH deficiency 2 cases. Additionally, precipitating adrenal crisis registered 7 patients tumor enlargement 1 patient after receiving vaccination. Conclusion Despite rarity these events, our suggest association between subsequent development diseases. The most common manifestations include with ADH deficiency, PA SIADH, symptoms typically emerging shortly vaccine administration. Potential pathogenetic mechanisms molecular mimicry, adjuvants vaccine-induced thrombotic thrombocytopenia (VITT), presence ACE2 receptors hypothalamus-pituitary system contributing process. These can aid diagnostic treatment decisions for presenting syndromes. Nevertheless, given safety efficacy currently available vaccines remain robust we strongly advocate continuing pursuing efforts.
Language: Английский
Citations
8
Endocrine Journal, Journal Year: 2024, Volume and Issue: 71(8), P. 799 - 807
Published: Jan. 1, 2024
COVID-19 vaccines have resulted in a remarkable reduction both the morbidity and mortality associated with COVID-19. However, there are reports of endocrine rare clinical conditions linked to vaccination. In this report, we present case hypophysitis following vaccination review literature on condition. This involved 72-year-old male type 1 diabetes who experienced symptoms such as vomiting, appetite loss, headaches his fifth vaccine dose. He was diagnosed secondary adrenal insufficiency; subsequent assessment revealed an enlarged pituitary gland. Unlike previous cases, our patient has partial recovery from insufficiency, function gradually improved over time. Anti-pituitary antibodies (APAs) against corticotrophs, thyrotrophs, gonadotrophs, folliculo stellate cells (FSCs) were detected serum samples taken 3 months after onset. Hypophysitis is condition, only eight cases reported by end 2023, most occurring initial or second Symptoms similar those classic dysfunction. Pituitary insufficiency persistent, five above patients presenting posterior dysfunction three anterior Two had autoimmune diseases. Our suggests potential link between acquired immunity, APA production, damage. To elucidate etiology vaccination, detailed investigation nonspecific necessary.
Language: Английский
Citations
3
BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 20, 2024
Although vaccination against coronavirus disease (COVID-19) has several side effects, hypopituitarism due to hypophysitis rarely been reported.
Language: Английский
Citations
2
Published: March 6, 2024
Abstract: The emergence of the COVID-19 pandemic has led to rapid and worldwide devel-opment investigation multiple vaccines. While most side effects these vaccines are mild transient, potentially severe adverse events may occur involve endocrine system. This narrative review aims explore current knowledge on potential following vaccination, with thyroid disorders being common. Data about pi-tuitary, adrenal, diabetes, gonadal will also be reviewed. provides a comprehensive understanding pathogenesis associated SARS-CoV-2 A PubMed/MEDLINE, Embase database (Elsevier), Google Scholar research were performed. Case reports case series, original studies, reviews written in English published online up 31 August 2023 selected is accumulating. However, their causal relationship not strong enough make definite conclusion, further studies needed clarify mechanisms linked vac-cines.
Language: Английский
Citations
1
Vaccines, Journal Year: 2024, Volume and Issue: 12(7), P. 750 - 750
Published: July 8, 2024
The emergence of the COVID-19 pandemic has led to rapid and worldwide development investigation multiple vaccines. While most side effects these vaccines are mild transient, potentially severe adverse events may occur involve endocrine system. This narrative review aimed explore current knowledge on potential following vaccination, with thyroid disorders being common. Data about pituitary, adrenal, diabetes, gonadal also reviewed. provides a comprehensive understanding pathogenesis associated SARS-CoV-2 PubMed/MEDLINE, Embase database (Elsevier), Google Scholar searches were performed. Case reports, case series, original studies, reviews written in English published online up 31 August 2023 selected accumulating. However, their causal relationship is not strong enough make definite conclusion, further studies needed clarify mechanisms linked
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 9, 2024
Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), long COVID (LC) and post-COVID-19 vaccine show similarities in their pathophysiology clinical manifestations. These disorders are related to viral adjuvant persistence, immunological alterations, autoimmune diseases hormonal imbalances. A developmental model is postulated that involves the interaction between immune hyperactivation, hypophysitis pituitary hypophysitis, depletion. This process might begin with a deficient CD4 T-cell response infections genetically predisposed individuals (HLA-DRB1), followed by an uncontrolled CD8 hyperactivation elevated antibody production, some of which may be directed against autoantigens, can trigger direct damage pituitary, resulting decreased production hormones, such as ACTH. As disease progresses, prolonged exposure antigens lead exhaustion system, exacerbating symptoms pathology. It suggested these could included autoimmune/adjuvant-induced inflammatory (ASIA) because similar manifestations possible relationship genetic factors, polymorphisms HLA-DRB1 gene. In addition, it proposed treatment antivirals, corticosteroids/ginseng, antioxidants, metabolic precursors improve modulating response, function, inflammation oxidative stress. Therefore, purpose this review suggest origin adenohypophysis improvement after corticosteroid replacement therapy.
Language: Английский
Citations
1
BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 6, 2024
Arginine vasopressin deficiency (AVP-D) can occur due to various conditions, so clarifying its cause is important for deciding treatment strategy. Although several cases of AVP-D following coronavirus disease 2019(COVID-19) infection or COVID-19 vaccination have been reported, the diagnosis underlying has not reported in most cases.
Language: Английский
Citations
1
Endocrine Journal, Journal Year: 2024, Volume and Issue: 71(12), P. 1165 - 1173
Published: Jan. 1, 2024
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2, and various complications have been reported. Furthermore, there increasing reports of endocrinopathy related to COVID-19 following the pandemic. We report a 49-year-old healthy woman who developed rapid onset polydipsia polyuria three weeks after COVID-19. Laboratory tests indicated low urine osmolarity increased serum osmolarity, antidiuretic hormone (ADH) was undetectable. Urine osmolality remained with water deprivation. Similarly, plasma ADH responses hypertonic-saline infusion were blunted in response desmopressin. There no clear evidence anterior pituitary dysfunction. T1-weighted magnetic resonance imaging (MRI) showed stalk thickening absence posterior bright signal spots, suggesting presence hypophysitis. Based on these results, we made probable diagnosis lymphocytic infundibulo-neurohypophysitis (LINH) which central diabetes insipidus. Positive findings for anti-rabphilin-3A antibodies, reported as potential diagnostic marker LINH, also noted. Following oral desmopressin administration, quickly improved, though treatment still required over four months. This first patient LINH tested positive antibodies. those antibodies suggest that dysfunction associated hypophysitis involving an abnormal immune mechanism. The may be useful non-invasive potentially serve valuable aid cases
Language: Английский
Citations
1
Journal of Neuroanaesthesiology and Critical Care, Journal Year: 2024, Volume and Issue: 11(01), P. 010 - 017
Published: March 1, 2024
Abstract Adverse reactions to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine depict a tropism for neural structures. This narrative review was aimed discuss published data on spectrum of neurological side effects SARS-CoV-2 vaccines, which were accorded emergency use authorization. The majority manifestations vaccination are usually mild, brief, self-limiting, and easily manageable. Rarely, these can be serious nature require hospitalization. High vigilance helps in early identification treatment complications leading good outcomes. reported incidence vaccinated population is miniscule, overall benefits outweigh risks effects. However, it crucial conduct larger collaborative multicenter studies prove or reject causal association between vaccines postvaccination Herein, we have tried summarize various related literature from 2021 mid-2023.
Language: Английский
Citations
0
Pituitary, Journal Year: 2024, Volume and Issue: 27(6), P. 874 - 888
Published: Oct. 15, 2024
Language: Английский
Citations
0