State of Knowledge About Thyroid Cancers in the Era of COVID-19—A Narrative Review DOI Creative Commons
Agnieszka Bronowicka-Szydełko, Maciej Rabczyński, I. Dumas

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2829 - 2829

Published: Dec. 13, 2024

Thyroid cancer (TC), due to its heterogeneous nature, remains a clinical challenge. Many factors can initiate the carcinogenesis process of various types TC, which complicates diagnosis and treatment. The presented review gathers current information on specific taking into account effects COVID-19 pandemic. It is likely that has influenced continues influence function thyroid gland. A high percentage patients with showing simultaneous pathological changes in suggests SARS-CoV-2 may disrupt this gland pro-oxidative mechanisms, inflammatory states, autoimmune diseases, thereby promoting formation neoplastic changes. Furthermore, expression ACE2, TMPRSS2, CLEC4M DPP4 genes, observed also occur COVID-19. Therefore, it probable interaction cell receptors Additionally, some drugs used TC therapy (e.g., levothyroxine) increase affinity for cells, could contribute more severe course emergence long-term symptoms (post-COVID-19). Moreover, consequences sanitary restrictions (limited access medical services, reduction endocrinological oncological procedures) took place many countries during pandemic lead future an increased number missed diagnoses aggressive cancers.

Language: Английский

Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches DOI Creative Commons
Ali Attiq, Sheryar Afzal, Habibah A. Wahab

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 4215 - 4240

Published: Sept. 1, 2024

Angiotensin-converting enzyme 2 receptors (ACE2R) are requisite to enter the host cells for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). ACE2R is constitutive and functions as a type I transmembrane metallo-carboxypeptidase in renin-angiotensin system (RAS). On thyroid follicular cells, allows SARS-CoV-2 invade gland, impose cytopathic effects produce endocrine abnormalities, including stiff back, neck pain, muscle ache, lethargy, enlarged, inflamed gland COVID-19 patients. Further damage perpetuated by sudden bursts of pro-inflammatory cytokines, which suggestive life-threatening known "cytokine storm". IL-1β, IL-6, IFN-γ, TNF-α identified key orchestrators cytokine storm. These inflammatory mediators upregulate transcriptional turnover nuclear factor-kappa B (NF-κB), Janus kinase/signal transducer activator transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), paving pathway storm-induced dysfunctions euthyroid sick syndrome, autoimmune diseases, thyrotoxicosis Targeted therapies with corticosteroids (dexamethasone), JAK inhibitor (baricitinib), nucleotide analogue (remdesivir) N-acetyl-cysteine have demonstrated effectiveness terms attenuating severity frequency dysfunctions, morbidity mortality Here, we review pathogenesis storms mechanisms pathways that establish connection between disorder COVID-19. Moreover, cross-talk interactions signalling therapeutic strategies address COVID-19-associated diseases also discussed herein.

Language: Английский

Citations

8
The impact of COVID-19 infection on thyroid function DOI Creative Commons

Esraah Alharris,

Dina Saleh,

Thair Wali Ali

et al.

Cellular and Molecular Biology, Journal Year: 2025, Volume and Issue: 70(12), P. 142 - 146

Published: Jan. 12, 2025

Language: Английский

Citations

0
Comorbidities of hypothyroidism DOI Creative Commons
Gabriela Brenta, Ulrike Hostalek

Current Medical Research and Opinion, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 11, 2025

Hypothyroidism is a relatively common condition that may affect as many 10% of the population worldwide when its overt and subclinical presentations are considered. Important clinical comorbidities highly prevalent in people with hypothyroidism diminish quality life functional status manner proportional to number present their severity. This article reviews hypothyroidism, reported literature. The include conditions commonly associated such dyslipidaemia, hypertension, fatigue or (possibly) cardiovascular disease, can appear whether not intervention LT4 applied appropriately ensure biochemical euthyroidism. Other share some pathogenetic background including depression anxiety, autoimmune conditions. arise comorbidity other conditions, e.g. following application targeted cancer therapies alemtuzumab for multiple sclerosis. treatments, metformin, glucocorticoids proton pump inhibitors among others, alter levels thyrotropin, thus impacting on monitoring thyroid dysfunction diagnosis dysfunction. Ensuring good control necessary first step managing any patient hypothyroidism. Then, physicians should be aware possibility comorbid must addressed achieve an optimal outcome.

Language: Английский

Citations

0
Thyroid disorders and COVID-19: a comprehensive review of literature DOI Creative Commons

Narges Anbardar,

Sewell H. Dixon,

Samhitha Munugoti

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Background The literature is rapidly evolving with regards to the endocrine consequences of coronavirus disease 2019 (COVID-19), including diabetes, thyroid dysfunction, adrenal and pituitary disorders. There evidence suggesting that severe acute respiratory syndrome 2 (SARS-CoV-2) infection can lead dysfunction long-term sequelae. We aimed review current propose a preventive approach based on published data since beginning COVID-19 pandemic. Methods A comprehensive was conducted using electronic databases PubMed Google Scholar. Two authors independently used keywords “Thyroid, Hypothyroidism, Hyperthyroidism, Graves, Thyroid Eye Disease, or Thyroiditis” “Coronavirus, SARS-CoV-2 COVID-19” search these databases. screened titles abstracts for initial selection then reviewed full text relevant studies report outcomes data. Results selected 28 manuscripts. appears similar other viruses. It affects function resulting in non-thyroidal illness syndrome, which usually resolves spontaneously. also causes subacute thyroiditis. may trigger autoimmunity against leads autoimmune Autoimmune thyroiditis progress clinical subclinical hypothyroidism hyperthyroidism. Patients pre-existing probably have risks related adverse outcomes. Conclusions Evaluation important patients. Improving efficacy treatment reduce short-term complications. Systematic Review Registration https://www.crd.york.ac.uk/prospero , identifier CRD42023447994.

Language: Английский

Citations

0
Thyroid dysfunction in the wake of Omicron: understanding its role in COVID-19 severity and mortality DOI Creative Commons
Qingfeng Zhang, Ziyu Zhang, Xu Liu

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 16, 2024

SARS-CoV-2 can invade the thyroid gland. This study was to delineate risk of dysfunction amidst prevalence Omicron variant, and investigate correlation between function Coronavirus disease 2019 (COVID-19) outcomes. The also aimed ascertain whether persisted during COVID-19 recovery phase.

Language: Английский

Citations

2
Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors DOI Creative Commons
Moises Alberto Suarez-Zdunek, Nicoline Stender Arentoft,

Paul Suno Krohn

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 3, 2024

Abstract The prevalence of hyperthyroidism and hypothyroidism associated risk factors are unknown in liver transplant recipients. We aimed to determine the recipients compare it with controls from general population. As part Danish Comorbidity Liver Transplant Recipients (DACOLT) Study, all over age 20 were invited for measurements concentrations thyrotropin thyroid hormones. was compared age- sex-matched Copenhagen General Population Study. Using logistic regression adjusted age, sex, smoking, body-mass index, we investigated potential factors. recruited 489 1808 controls. Among recipients, 14 (2.9%) had 21 (1.2%) (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05–4.75, P = 0.04), while 42 (5.7%) 139 (7.7%) (aOR 0.68, CI 0.43–1.08, 0.10). Female autoimmune hepatitis primary sclerosing cholangitis as causes transplantation after adjustments. Age, female diseases cause DACOLT is registered ClinicalTrials.gov (NCT04777032).

Language: Английский

Citations

1
Thyroid status in patients with early stages of cancer of various localization DOI Creative Commons
В. А. Бандовкина, E. M. Frantsiyants, А. М. Салатова

et al.

Research and Practical Medicine Journal, Journal Year: 2024, Volume and Issue: 11(2), P. 46 - 56

Published: May 20, 2024

Purpose of the study . To determine thyroid status primary cancer patients in early stages uterine body cancer, kidney breast skin melanoma and lung without a history endocrine pathology. Patients methods The content levels thyroid-stimulating hormone (TSH), hormones (THs) T4 T3 total free forms were determined blood serum by RIA method 132 with (average age 55 years). comparison group consisted practically healthy donors. Results Only melanoma, TSH reduced 1.5 times ( p < 0.05). was 1.4–1.7 0.05) increased 16 % though A 1.3–1.5‑fold low (p level found while an 1.6‑fold increase cancer. revealed changes THs type clinical hyperthyroidism are 1.8 FT3 on background hyperthyroxinemia consisting concentrations FT3, as well FT4, patients, may be associated features malignant pathology, since it is known that proliferation stimulants can build up tumors. Conclusion. development tumor even disease perceived threat for homeostasis response to occurrence neoplasm reaction hypothalamicpituitary-thyroid regulatory axis. As outcome, develop euthyroid disorder syndrome.

Language: Английский

Citations

1
COVID-19 vaccination might be associated with asymmetric thyroid eye disease DOI Creative Commons
Kazuhiko Matsuzawa, Shoichiro Izawa, Hiroto Yunaga

et al.

Thyroid Science, Journal Year: 2024, Volume and Issue: 1(4), P. 100019 - 100019

Published: Aug. 7, 2024

The influence of COVID-19 vaccination on thyroid eye disease (TED) is unknown. We investigated the characteristics COVID-19-vaccinated TED. Sixty-two consecutive patients diagnosed with active TED were divided as follows. Patients from 2014 to 2019 defined pre-COVID-19 (n = 32). during pandemic (2020–2023) into 16) or without 14) before onset. Magnetic resonance images evaluated using number involved extraocular muscles (n-EOM), maximum signal intensity ratio (SIR max) and inferior rectus (IR) muscle area. Additionally, more enlarged IR area SIR max by that other side was calculated (IR ratio, ratio). symmetry also based ratios. Although, in affected orbit, n-EOM no significant difference, vaccinated showed fewer less orbit. significantly higher than others ratio; 1.07, 1.16, 1.42, 1.52, 1.38, 2.12, pre-COVID-19, non-vaccinated, vaccinated, respectively). When asymmetric 2 greater, proportion (50 %) (pre-COVID-19; 13 %, non-vaccinated; 14 %). In IR, regression line between Thyroid-stimulating antibody located lower those vaccination. After treatment, improved difference groups disappeared. asymmetry. Importantly, involvement reversible treatment.

Language: Английский

Citations

0
New-Onset Paroxysmal Atrial Fibrillation in a Healthy Male With Post-COVID-19 Painless Thyroiditis: A Case Report DOI Open Access

Valerie Chavez-Flores,

Andro Sharobiem,

Steven J. Kim

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Painless thyroiditis is a variant of without the typical neck pain and otherwise similar to subacute thyroiditis, which known post-viral condition has been associated with coronavirus disease 2019 (COVID-19) infections. While it usually self-limiting, can lead thyrotoxicosis that predispose individuals cardiac dysrhythmias, including atrial fibrillation. There clear association between COVID-19 few case reports describing We present healthy patient new-onset fibrillation secondary painless thyroiditis. This report highlights rare entity leading rapid ventricular response in who recently recovered from COVID-19. Physicians should consider potential patients

Language: Английский

Citations

0
Thyroid Function in the Time of COVID-19: A Systematic Review of Disease Progression and Vaccination Effect DOI Open Access
Maryam Zarkesh,

Maryam Sanoie,

Shabnam Heydarzadeh

et al.

International Journal of Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 22(3)

Published: Oct. 27, 2024

Objectives: This systematic review sought to address three key questions: (1) what differences in abnormal thyroid function test results are observed between COVID-19 patients and healthy individuals? (2) How does the severity of infection influence development dysfunction? (3) What impact do vaccines have on autoimmune processes? Methods: A literature search was conducted PubMed, Web Science, Scopus from December 2019 April 2023 identify studies dysfunction without pre-existing conditions. The focused observational case-control studies. Results: yielded 329 reports, which duplicates unrelated publications were excluded. Ultimately, 21 met inclusion criteria selected for review. second 605 5 Conclusions: findings suggest that SARS-CoV-2 can induce transient reversible dysfunction, possibly through direct viral effects gland or via indirect immune-mediated mechanisms. Clinicians should be mindful potential, albeit rare, thyroid-related adverse monitor function, particularly high-risk individuals.

Language: Английский

Citations

0