Beneficial Role of Antioxidant Secondary Metabolites from Medicinal Plants in Maintaining Oral Health

Antioxidants, Journal Year: 2021, Volume and Issue: 10(7), P. 1061 - 1061

Published: June 30, 2021

Plant-derived phytochemicals have been touted as viable substitutes in a variety of diseases. All over the world, dentists turned to natural remedies for dental cure due negative possessions certain antibacterial mediators used dentistry. Antimicrobial and other drugs are currently use, but they show some side effects. Since ancient times, antioxidant EOs different ailments grown popularity time. Several vitro, vivo, clinical trials shown safety effectiveness essential oils (EOs) oral health obtained from medicinal plants. The current review literature provides summary secondary metabolites, more specifically 20 most commonly plants their applications maintaining health. Dental caries periodontal diseases common preventable global infectious diseases, with cavity being considered major affecting person's studies connection between microbiota. This discusses role metabolites inhibiting growth pathogens reducing formation plaque, well symptoms article contributes basic outline healing actions.

Language: Английский

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Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health—A systematic review of randomized controlled trials

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 24, 2023

Introduction: Leaves of the Australian tea tree plant Melaleuca alternifolia were used traditionally by First Nations Australians for treating wounds, burns, and insect bites. Tea oil, essential oil steam-distilled from M. alternifolia, is well-known its medicinal properties, evidence most applications however limited. This review aimed to critically appraise clinical trials examining therapeutic efficacy safety on outcomes. Methods: Randomized controlled with participants any age, gender, or health status, comparing control included, without limit publication date. Electronic databases searched 12 August 2022 additional records sourced article reference sections, reviews, industry white papers. Risk bias was assessed two authors independently using Cochrane risk-of-bias 1.0 tool. Results summarized synthesized thematically. Results: Forty-six articles eligible following medical fields (Dentistry n = 18, Dermatology 9, Infectious disease Ophthalmology 6, Podiatry 3; Other 1). indicate that oral mouthwashes 0.2%-0.5% may accumulation dental plaque. Gels containing 5% applied directly periodontium aid treatment periodontitis as an adjunctive therapy scaling root planing. More needed confirm benefits reducing acne lesions severity. Local anti-inflammatory effects skin, if any, also require further elucidation. Topical regimens show similar standard treatments decolonizing body methicillin-resistant Staphylococcus aureus, although intra-nasal use cause irritation mucous membranes. added iodine provide effective molluscum contagiosum in young children. oil-based eyelid wipes Demodex mite are needed. Side reported 60% included studies minor, except where topically concentrations ≥ 25%. Discussion: Overall, quality research poor modest higher larger samples better reporting required substantiate potential oil. Systematic Review Registration: PROSPERO, identifier [CRD42021285168].

Language: Английский

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Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review

Life, Journal Year: 2024, Volume and Issue: 14(4), P. 468 - 468

Published: April 3, 2024

Periodontitis, a prevalent oral condition, is facing difficulties in therapeutic approaches, sometimes leading to failure. This literature review was conducted investigate the diversity of other approaches and their potential contributions successful management disease. research scrutinized alterations microbial imbalances crucial species, which contribute significantly pathogenesis periodontitis. Within limitations this study, we highlight importance understanding treatment plan’s role periodontitis disease, opening way for further innovative plans mitigate impact on health. will aid both healthcare professionals patients preventing effectively treating periodontitis, ultimately improving health outcomes overall systemic well-being.

Language: Английский

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Adjunctive Antimicrobials in Nonsurgical Periodontitis Treatment: A Review of Recent Trials and Indications

Open Access Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

This review collected the latest evidence from clinical trials on antimicrobials used as adjunctive medications for mechanical management of periodontitis, a common condition affecting teeth that leads to tooth loosening and loss. A search was conducted PubMed in May 2024 identify human trial reports published last five years English with follow-up time at least six months. included 29 randomized trials. Nine studied use systemic antibiotics, investigated topical agents, fifteen applied various antimicrobial photodynamic therapy (aPDT) protocols. The results studies are discussed context evidencebased guidelines treatment periodontitis. Adjunctive antibiotics may benefit patients selected severe periodontitis cases, providing subgingival microbiological improvements lasting more than months when instrumentation. Localized these demonstrated aPDT new locally delivered like ozone, 1% melatonin 5% tea tree oil gel provide benefits. Further research is needed ensure efficient uses local delivery clinically significant improvement outcome instrumentation

Language: Английский

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Advances of multifunctional hydrogels for periodontal disease

Smart Materials in Medicine, Journal Year: 2023, Volume and Issue: 4, P. 460 - 467

Published: Jan. 1, 2023

Periodontal disease is a chronic inflammatory that develops from dental plaque affects periodontal supporting tissues. The control of by mechanical therapy has always been the mainstream clinical practice. However, studies have shown both bacteria and oxidative stress are associated with disease, which means blocking one them alone may not acquire better curative effect. excellent physicochemical properties biological functions hydrogels made as kinds ideal biomaterials for in recent years. For these reasons, antimicrobials antioxidants considered an effective treatment modality disease. Among them, chitosan, cellulose, other biopolymers performed their desirable characteristics form hydrogel materials to treat Here we systematically summarize current related research applications multifunctional hope offering new idea approaches damage.

Language: Английский

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Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(30)

Published: April 27, 2023

Abstract Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on pathophysiology essential for enhancing their therapeutic effects periodontitis treatment. As promising localized drug delivery systems and engineering scaffolds, hydrogels have gained significant interest controlled sustained release bioactive agents applications. rational can facilitate bacterial control modulate destructive host inflammation, thereby preventing the progression periodontitis. In this review, pathophysiological mechanisms underlying as fundamental principles hydrogel are first introduced. following part, an overview systematically provided types functions loaded with anti‐bacterial anti‐inflammatory delivery. Finally, remaining challenges future perspectives applications proposed. It believed review will inspire development innovative toward therapy.

Language: Английский

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Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1787 - 1787

Published: Sept. 21, 2023

Diabetes mellitus (DM) is associated with periodontal disease. Clinically, treatment less effective for patients DM. Oxidative stress one of the mechanisms that link DM to periodontitis. The production reactive oxygen species (ROS) increased in tissues and involved development insulin resistance tissues. Insulin decreases Akt activation inhibits cell proliferation angiogenesis. This results deterioration wound healing tissue repair Antioxidants ameliorants may inhibit ROS improve healing, which worsened by manuscript provides a comprehensive review most recent basic clinical evidence regarding generation resulting from microbial challenge study also delves into impact oxidative on context dental implant therapies. Furthermore, it discusses potential benefits administering antioxidants anti-insulin medications, have been shown counteract inflammation. approach potentially enhance especially cases exacerbated hyperglycemic conditions.

Language: Английский

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Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 566 - 566

Published: May 3, 2024

Periodontal disease is an inflammatory condition characterized by aberrant immune response against a dysbiotic dental biofilm, with oxidative stress performing essential role in its pathogenesis. This paper presents patent mining, performed the Orbit Intelligence database, related to antioxidant phytochemicals technological developments that are working prevent and treat periodontal disease. To access documents, descriptors “PERIODONTAL” “ANTIOXIDANT” were typed title, abstract, claim search fields. A total of 322 patents demonstrate growing interest researching natural antioxidants for scientific purposes. The top ten countries regarding number family produced United States, European Office, Japan, South Korea, China, India, Mexico, Denmark, Canada, Great Britain. most cited compounds vitamin C, green tea, quercetin, melatonin, lycopene, resveratrol, curcumin. These have been used development gels, membranes, dentifrices, chewing gum, orally disintegrating film, mouthwash, mouth spray, massage cream exhibit ability neutralize free radicals reduce stress, critical factor progression diseases. documents shown using conjunction traditional treatments promising area therapy.

Language: Английский

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Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis.

PubMed, Journal Year: 2024, Volume and Issue: 14(4), P. 430 - 454

Published: July 2, 2024

Periodontitis is a type of prevalent chronic inflammatory disorder resulting in failure the function tissues supporting tooth, like gingiva, alveolar bone, and periodontal ligament. Although antibiotic therapy common for periodontitis cases, this approach can cause some adverse effects these patients. Thus, finding an effective curative option with low side still puzzle.

Language: Английский

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Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis

Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 14

Published: Sept. 6, 2022

For various ailments, natural remedies have been traditionally used. To defend against common disorders, medicinal plants are progressively used as nutritional supplements. Gingivitis and periodontitis widespread can affect most of the world’s population. is a very common, nondestructive inflammatory disease gums that causes redness irritation gingiva (gums), but permanent damage to teeth’ subsidiary structures. Herbal medicines getting popular for treatment such types disorders due being economical with their effectiveness, compatibility, nontoxicity. Traditional chemical therapies cause cell toxicity along disease-curing effects. In this article, we discussed be an alternative gingivitis (early-stage gum disease) (chronic-stage disease).

Language: Английский

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