The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases

Frontiers in Aging, Journal Year: 2023, Volume and Issue: 4

Published: Sept. 6, 2023

The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation microglia and macrophages. Traditional classifications macrophage phenotypes include pro-inflammatory M1 anti-inflammatory M2 phenotypes. Numerous studies demonstrated dynamic non-coding RNA modifications, which are catalyzed microglia-induced neuroinflammation. Different nutraceuticals focus on M1/M2 macrophages, offering a potent defense against neurodegeneration. Caeminaxin A, curcumin, aromatic-turmerone, myricetin, aurantiamide, 3,6'-disinapoylsucrose, resveratrol reduced microglial inflammatory markers while increased indicators in Alzheimer's disease. Amyloid beta-induced activation was suppressed andrographolide, sulforaphane, triptolide, xanthoceraside, piperlongumine, novel plant extracts also prevented microglia-mediated necroptosis apoptosis. Asarone, galangin, baicalein, a-mangostin oxidative stress cytokines, such as interleukin (IL)-1, IL-6, tumor necrosis factor-alpha M1-activated Parkinson's Additionally, myrcene, icariin, tenuigenin nod-like receptor family pyrin domain-containing 3 inflammasome neurotoxicity, a-cyperone, citronellol, nobiletin, taurine NADPH oxidase 2 nuclear factor kappa B activation. Furthermore, other like plantamajoside, swertiamarin, urolithin kurarinone, Daphne genkwa flower, Boswellia serrata showed promising neuroprotection treating In Huntington's disease, elderberry, iresine celosia, Schisandra chinensis, gintonin, pomiferin results improved patient symptoms. Meanwhile, linolenic acid, resveratrol, Huperzia serrata, baicalein protected activated macrophages experimental autoimmune encephalomyelitis multiple sclerosis. emodin, esters gallic rosmarinic acids, Agathisflavone, sinomenine offered sclerosis treatments. This review highlights therapeutic potential using to treat diseases involving microglial-related pathways.

Language: Английский

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Anticancer activity of thymoquinone against breast cancer cells: Mechanisms of action and delivery approaches

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 114972 - 114972

Published: July 21, 2023

The rising incidence of breast cancer has been a significant source concern in the medical community. Regarding adverse effects and consequences current treatments, cancers' health, socio-economical aspects have become more complicated, leaving research aimed at improved or new treatments on top priority. Medicinal herbs contain multitarget compounds that can control development advancement. Owing to Nigella Sativa's elements, it treat many disorders. Thymoquinone (TQ) is natural chemical derived from black seeds sativa Linn proved anti-cancer anti-inflammatory properties. TQ interferes broad spectrum tumorigenic procedures inhibits carcinogenesis, malignant development, invasion, migration, angiogenesis owing its multitargeting ability. It effectively facilitates miR-34a up-regulation, regulates p53-dependent pathway, suppresses Rac1 expression. promotes apoptosis controls expression pro- anti-apoptotic genes. also shown diminish phosphorylation NF-B IKK decrease metastasis ERK1/2 PI3K activity. We discuss TQ's cytotoxic for treatment with deep look relevant stimulatory inhibitory signaling pathways. This review discusses various forms polymeric non-polymeric nanocarriers (NC) encapsulation increasing oral bioavailability enhanced vitro vivo efficacy TQ-combined different chemotherapeutic agents against cell lines. study be useful scientific community, comprising pharmaceutical biological scientists, as well clinical investigators.

Language: Английский

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Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 396(11), P. 3087 - 3099

Published: May 9, 2023

Abstract Cancer cells can become resistant to existing treatments over time, so it is important develop new that target different pathways stay ahead of this resistance. Many cancer have severe side effects be debilitating and even life-threatening. Developing drugs effectively treat while minimizing the risks these essential for improving quality life patients. The study was designed explore whether combination dicinnamoyl-L-tartaric (CLT) sorafenib ((SOR), an anti-cancer drug)) could used hepatocellular carcinoma (HCC) in animal model assess would lead changes certain biomarkers associated with tumour. In study, 120 male mice were divided into 8 groups 15 each. A number biochemical parameters measured, including liver functions, oxidative stress (malondialdehyde, (MDA); nitric oxide (NO)), antioxidative activity (superoxide dismutase (SOD), glutathione peroxidase (GPx)). Furthermore, hepatic expressions Bax , Beclin1 TNF - α IL1β BCl-2 genes evaluated by qRT-PCR. SOR CLT found reduce levels enzymes, such as AST, ALT, ALP, GGT, pathological caused DAB PB. upregulation TNF-α Bcl-2 suggests able initiate inflammatory response combat tumor, downregulation indicates risk apoptosis liver. therapy led increased expression cytokines, resulting enhanced anti-tumor effect.

Language: Английский

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Probiotic-derived silver nanoparticles target mTOR/MMP-9/BCL-2/dependent AMPK activation for hepatic cancer treatment

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(5)

Published: April 4, 2024

Language: Английский

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Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line

Saudi Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 32(5), P. 102064 - 102064

Published: April 7, 2024

Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>90 %). Sorafenib (SORA) is a targeted therapy approved for treatment of HCC; however, reported response rate to such therapeutic suboptimal (<3%). Piperine (PIP) an alkaloid demonstrated exert direct tumoricidal activity HCC and improve pharmacokinetic profiles anticancer drugs including SORA. In this study, we developed strategy efficacy outcomes using PIP as add-on support first-line SORA biodegradable Poly (D, L-Lactide-co-glycolide, PLGA) nanoparticles (NPs). (both exhibit low aqueous solubility) were co-loaded into PLGA NPs (PNPs) stabilized with various concentrations polyvinyl alcohol (PVA). The PIP-loaded PNPs (SP-PNPs) characterized Fourier Transform Infrared (FTIR) Spectroscopy, X-ray Powder Diffraction (XRD), Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), Release these from SP-PNPs was investigated vitro at both physiological acidic pH, kinetic models employed assess mechanism drug release. against cells (HepG2) also evaluated. FTIR XRD analyses revealed that encapsulated amorphous state, no observed chemical interactions among or excipients. Assessment release pH 5 7.4 showed loaded 0.5 % PVA released sustained manner, unlike pure drugs, which exhibited relatively fast spherical, had average size 224 nm, encapsulation efficiency (SORA ∼ 82 %, 79 %), well superior cytotoxicity compared monotherapy vitro. These results suggest combining may be effective set comprehensive vivo study evaluate safety novel formulation murine model.

Language: Английский

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Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential

BioFactors, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Anticancer drug discovery needs serious attention to overcome the high mortality rate caused by cancer. There are still many obstacles treating this disease, such as cost of chemotherapeutic drugs, resulting side effects from drug, and occurrence multidrug resistance. Herbaceous plants a reservoir natural compounds that can be anticancer drugs with novel mechanisms action. Piperine, bioactive compound derived Piper species, is gaining due its unique dual role in directly inhibiting tumor growth enhancing bioavailability drugs. Unlike conventional treatments, Piperine exhibits mechanism action modulating multiple signaling pathways, including apoptosis autophagy, low toxicity. Additionally, acts bioenhancer improving absorption effectiveness other agents, reducing required dosage, minimizing effects. Therefore, review aims visualize summary sources, phytochemistry, chemical structure–anticancer activity relationship, activities semi‐synthetic derivatives, pharmacokinetic bioavailability, vitro vivo preclinical studies, antitumor action, human clinical trials, toxicity, effects, safety Piperine. References were collected Pubmed/MedLine database ( https://pubmed.ncbi.nlm.nih.gov/ ) following keywords: “Piperine anticancer,” derivatives,” mechanism” bioavailability,” after filter process inclusion exclusion criteria, 101 selected 444 articles. From 2013 2023, there numerous studies regarding various cell lines, breast cancer, prostate lung melanoma, cervical gastric osteosarcoma, colon hepatocellular carcinoma, ovarian leukemia, colorectal hypopharyngeal carcinoma. In vivo, study has also been conducted on some animal models, Ehrlich carcinoma‐bearing mice, ascites carcinoma cells‐bearing Balbc Wistar rat, A375SM A375P SNU‐16 BalbC HGC‐27‐bearing baby mice. Treatment leads proliferation inhibition induction apoptosis. used for trials diseases, but no cancer patient report exists. Various derivatives show efficacy an across lines. shows promise use either standalone treatment or bioenhancer. Its properties may enhance existing providing valuable foundation developing new therapies.

Language: Английский

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Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5587 - 5587

Published: July 22, 2023

Gastric cancer is one of the most frequent types neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise promising alternatives. In this scenario, piperine, an alkaloid Piper species, has received attention due to its biological activity, including attributes. present work proposes three heating-independent, reliable, low-cost, selective methods obtaining piperine from nigrum L. (Black pepper). Electronic (SEM) optical microscopies, X-ray diffraction, nuclear magnetic resonance spectroscopies (13C 1H NMR), (UV–Vis, photoluminescence, FTIR) confirm obtention crystals. MTT assay reveals that samples exhibit good cytotoxic activity against primary metastasis models gastric cell lines Brazilian Amazon. showed cytotoxicity on evaluated models, revealing higher effectiveness cells bearing degree aggressiveness. Moreover, investigated crystals demonstrated ability act enhancer when combined traditional chemotherapeutics (5-FU GEM), allowing drugs achieve same effect employing lower concentrations. These results establish molecule therapy investigations cancer, both isolated form or bioenhancer.

Language: Английский

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Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 12, 2023

Abstract Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide. Thymoquinone (TQ) is a natural compound Nigella sativa that has been used in traditional medicine against variety acute/chronic such as asthma, bronchitis, rheumatism, headache, back pain, anorexia, amenorrhea, paralysis, inflammation, mental disability, eczema, obesity, infections, depression, dysentery, hypertension, gastrointestinal, cardiovascular, hepatic, and renal disorders. This review aims to present detailed report on studies conducted anti-cancer properties TQ colorectal cancer, both vitro vivo. stands promising therapeutic agent can enhance efficacy existing cancer treatments while minimizing associated adverse effects. The combination with other anti-neoplastic agents promoted treatments. Further research needed acquire more comprehensive understanding its exact molecular targets pathways maximize clinical usefulness. These investigations may potentially aid development novel techniques combat drug resistance surmount obstacles presented by chemotherapy radiotherapy. Graphical

Language: Английский

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TQFL19, a Novel Derivative of Thymoquinone (TQ), Plays an Essential Role by Inhibiting Cell Growth, Metastasis, and Invasion in Triple-Negative Breast Cancer

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 773 - 773

Published: Feb. 7, 2025

Breast cancer (BC) is a significant public health concern globally. Triple-negative breast (TNBC) considered the most challenging type, as it defined by an absence of estrogen and progesterone receptor expression, along with lack HER2 overexpression. In current study, we developed novel thymoquinone (TQ), TQFL19, to control TNBC progression. Purpose: The study aimed investigate anticancer potential newly synthesized TQFL19 against TNBC. Study design: To achieve our research goals, meticulously both in vitro vivo studies focused on cell growth, metastasis, invasion. Results: Characterization ADMET properties prediction were first performed before treating cells. exhibited more potent cytotoxicity than TQ 4T1, BT-549, MDA-MB-231 cells induced apoptosis 4T1 MDA-MB-231, besides cycle arrest MDA-MB-231. mice allograft revealed ability hinder migration, metastasis Conclusions: results suggest that potentially inhibited conclude could be viable candidate for therapy.

Language: Английский

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Organ Targeting Drug Delivery Systems (OTDDS) of poly[(N-acryloylglycine)-co-(N-acryloyl-L-phenylalanine methyl ester)] Copolymer Library and Effective treatment of Triple Negative Breast Cancer

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The OTDDN library of amphiphilic copolymer [p(NAG- co -NAPA) ( x : y ) ] NPs with multiple drugs is effective for treating TNBC. Further, this has presented exciting treatment options specific organs such as liver, heart, lungs, and kidneys.

Language: Английский

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