Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102077 - 102077

Published: Sept. 24, 2023

Language: Английский

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Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

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Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson’s Disease

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(5), P. 1291 - 1305

Published: Feb. 29, 2024

Abstract Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons, with ferroptosis playing a significant role. Salidroside (SAL) has shown neuroprotective potential, this study aims to explore its capacity mitigate in PD, focusing on modulation Nuclear Factor E2-Related 2 (Nrf2)/ Glutathione Peroxidase 4 (GPX4) pathway. Male C57BL/6 mice were subjected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induce PD-like symptoms, followed SAL and Nrf2 inhibitor administration. Then behavioral tests, immunohistochemical staining, transmission electron microscopy, Western blot analysis conducted assess motor functions, pathological changes, ferroptosis, related protein expressions. In vitro, SH-SY5Y cells treated erastin protective effects SAL. Additionally, A53T-α-synuclein (α-syn) was used stimulate PD model, (ML385) utilized elucidate role Nrf2/GPX4 pathway mitigating PD. vivo , significantly improved functions reduced expression α-syn, while increasing tyrosine hydroxylase (TH) mice. treatment notably enhanced levels antioxidants MDA iron content substantia nigra vitro increased TH, GPX4, expression, mitochondrial membrane potential whereas alleviated through pathway, as evidenced erastin-induced α-syn overexpressing cells. While these reversed upon inhibition. demonstrates pathology positioning promising therapeutic target. However, future studies should focus long-term SAL, pharmacokinetics, addressing multifactorial nature pathogenesis.

Language: Английский

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The Role of Calcium and Iron Homeostasis in Parkinson’s Disease

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 17, 2024

Calcium and iron are essential elements that regulate many important processes of eukaryotic cells. Failure to maintain homeostasis calcium causes cell dysfunction or even death. PD (Parkinson’s disease) is the second most common neurological disorder in humans, for which there currently no viable treatment options effective strategies cure delay progression. Pathological hallmarks PD, such as dopaminergic neuronal death intracellular α-synuclein deposition, closely involved perturbations accumulation. Here, we summarize mechanisms by Ca2+ signaling influences promotes progression main ferroptosis Parkinson’s disease. Understanding imbalances contribute this disease critical developing treatments combat devastating disorder.

Language: Английский

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Ferroptosis in Parkinson's disease —— The iron-related degenerative disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102477 - 102477

Published: Aug. 31, 2024

Language: Английский

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Ferroptosis in senescence and age-related diseases: pathogenic mechanisms and potential intervention targets

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 17, 2025

Language: Английский

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Iridoids modulate inflammation in diabetic kidney disease: A review

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(3), P. 210 - 222

Published: March 28, 2024

Language: Английский

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Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Inhibition of IEC-6 Cell Proliferation and the Mechanism of Ulcerative Colitis in C57BL/6 Mice by Dandelion Root Polysaccharides

Foods, Journal Year: 2023, Volume and Issue: 12(20), P. 3800 - 3800

Published: Oct. 17, 2023

An exploration was conducted on the potential therapeutic properties of dandelion polysaccharide (DP) in addressing 3% dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) murine models. Subsequent assessments focused DP’s influence inflammation, oxidative stress, and ferroptosis IEC-6 cells damaged by H2O2. Results highlighted efficacy DP mitigating weight loss, improving disease activity index scores, normalizing colon length, alleviating histological abnormalities affected mice. repaired colonic mitochondrial damage enhancing iron transport inhibited death cells. Moreover, played a pivotal role antioxidant potential. This evident from increased expression levels Nrf2, HO-1, NQO-1, GSH, coupled with decrease MDA 4-HNE markers UC-afflicted Concurrently, manifested inhibitory effects MPO activation transcription inflammatory mediators such as IL-1β, IL-6, TNF-α, iNOS. upsurge occludin ZO-1 also observed. Restoration intestinal tightness resulted decreased serum LPS LDH levels. Thereafter, administration gavage fecal flora diversity relative abundance probiotics UC Analysis metabolites indicated that counteracted metabolic disturbances augmented short-chain fatty acids colitis-affected In vitro studies underscored triggering Nrf2 activation, which turn exhibited anti-inflammatory, antioxidant, anti-ferroptotic properties. Summarily, capacity to activate contributes suppression ferroptotic processes epithelial UC-affected mice, barrier’s integrity. Beyond that, possesses ability modulate gut microbiome, rectify imbalances, rejuvenate acid levels, bolster barrier approach UC.

Language: Английский

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Morroniside Protects C2C12 Myoblasts from Oxidative Damage Caused by ROS-Mediated Mitochondrial Damage and Induction of Endoplasmic Reticulum Stress

Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: 32(3), P. 349 - 360

Published: April 11, 2024

Oxidative stress contributes to the onset of chronic diseases in various organs, including muscles. Morroniside, a type iridoid glycoside contained

Language: Английский

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