Ferroptosis: a novel pathogenesis and therapeutic strategies for Parkinson disease: A review DOI Creative Commons

Di Jiao,

Yang Yang, Kejing Wang

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(3), P. e41218 - e41218

Published: Jan. 17, 2025

Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence climbing every year, but there still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays key role in progression PD. Most importantly, cellular animal trials episodes PD can be alleviated by inhibiting process, such as utilizing inhibitors, chelating agents, others. Here, we review ferroptosis, new form cell death, pathogenesis PD, summarize therapeutic strategies for targeting hoping to provide thinking study development strategies.

Language: Английский

The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders DOI Creative Commons

Yejia Xu,

Bowen Jia,

Jing Li

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 395 - 395

Published: March 26, 2024

Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain traumatic injury, epilepsy, depression, more. The involved pathogenesis is notably intricate diverse. Ferroptosis neuroinflammation play pivotal roles elucidating the causes of cognitive impairment stemming from these diseases. Given concurrent occurrence ferroptosis due metabolic shifts such as iron ROS, well their critical central nervous disorders, investigation into co-regulatory mechanism has emerged a prominent area research. This paper delves mechanisms along with interrelationship. It specifically emphasizes core molecules within shared pathways governing neuroinflammation, including SIRT1, Nrf2, NF-κB, Cox-2, iNOS/NO·, how different immune cells structures contribute dysfunction through mechanisms. Researchers’ findings suggest that mutually promote each other may represent key factors progression disorders. A deeper comprehension common pathway between cellular holds promise for improving symptoms prognosis related

Language: Английский

Citations

18
Ferroptosis inhibitors: past, present and future DOI Creative Commons
Lei Zhang, Yi Luo, Yang Xiang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Language: Английский

Citations

17
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors DOI Creative Commons

Carolina Punziano,

Silvia Trombetti, Elena Cesaro

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 298 - 298

Published: Feb. 28, 2024

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, ischemia–reperfusion injuries. linked iron accumulation, eliciting dysfunction antioxidant systems, which favor the production lipid peroxides, membrane damage, ultimately, death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against excess and/or lipid-derived ROS. Here, we discuss interaction between metabolic particular focus on transcription factors implicated in regulation ferroptosis, either as triggers peroxidation or defense pathways.

Language: Английский

Citations

16
The Role of Calcium and Iron Homeostasis in Parkinson’s Disease DOI Creative Commons
Ji Wang, Jindong Zhao,

Kunying Zhao

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 17, 2024

Calcium and iron are essential elements that regulate many important processes of eukaryotic cells. Failure to maintain homeostasis calcium causes cell dysfunction or even death. PD (Parkinson’s disease) is the second most common neurological disorder in humans, for which there currently no viable treatment options effective strategies cure delay progression. Pathological hallmarks PD, such as dopaminergic neuronal death intracellular α-synuclein deposition, closely involved perturbations accumulation. Here, we summarize mechanisms by Ca2+ signaling influences promotes progression main ferroptosis Parkinson’s disease. Understanding imbalances contribute this disease critical developing treatments combat devastating disorder.

Language: Английский

Citations

14
Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets DOI
Fernanda V. Carvalho,

Harold E. Landis,

Bruk Getachew

et al.

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 105 - 132

Published: Jan. 1, 2024

Language: Английский

Citations

9
Adiponectin ameliorates traumatic brain injury-induced ferroptosis through AMPK- ACC1 signaling pathway DOI Creative Commons
Yufeng Ge,

Tinghao Wang,

Qing Hu

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Various forms of neuronal death contribute to neurological injury after traumatic brain (TBI), leading irreversible deficits. Among these, ferroptosis is a form regulated cell characterized by the accumulation iron-dependent lipid hydroperoxides and induced incorporation polyunsaturated fatty acids (PUFAs) into cellular membranes. Adiponectin (APN), cytokine secreted adipocytes, have showed neuroprotective effects binding adiponectin receptors (AdipoRs), which are widely expressed in central nervous system. However, role TBI APN-AdipoRs signaling remains unexplored. Our clinical analysis revealed significant correlation between serum levels APN 6-month outcomes patients. Subsequent studies confirmed that TBI-induced was more pronounced knockout mice compared wild-type mice, while additional receptor agonist (AdipoRon) treatment significantly mitigated ferroptosis. Furthermore, AdipoR1 knockdown diminished protective AdipoRon against erastin-induced primary neurons. Correspondingly, neuron-specific conditional (AdipoR1CKO) neurons were susceptible TBI, increased edema lesion volume, exacerbated Mechanically, activation APN-AdipoR1 promoted adenosine monophosphate activated protein kinase (AMPK) -mediated phosphorylation acetyl-CoA carboxylase-1 (ACC1), thus suppressed PUFAs biosynthesis, determines theferroptosissensitivity Taken together, these findings provided compelling evidence for inhibiting AMPK-ACC1.

Language: Английский

Citations

1
Acteoside alleviates lipid peroxidation by enhancing Nrf2-mediated mitophagy to inhibit ferroptosis for neuroprotection in Parkinson's disease DOI
Han Zheng, Bao Wang, Yuqi Wen

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 493 - 505

Published: July 24, 2024

Language: Английский

Citations

8
Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson’s Disease DOI
Anand Thirupathi, Luis Felipe Marqueze, Tiago F. Outeiro

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(7), P. 1643 - 1654

Published: May 24, 2024

Language: Английский

Citations

7
The molecular mechanism of ferroptosis and its relationship with Parkinson's disease DOI Creative Commons

Yan Su,

Yue Jiao,

Sheng Cai

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 213, P. 110991 - 110991

Published: May 31, 2024

Neurodegenerative diseases such as Parkinson's disease (PD) have complex pathogenetic mechanisms. Genetic, age, and environmental factors are all related to PD. Due the unclear pathogenesis of PD lack effective cure methods, it is urgent find new targets for treating patients. Ferroptosis a form cell death that reliant on iron exhibits distinct morphological mechanistic characteristics compared other types death. It encompasses range biological processes, including iron/lipid metabolism oxidative stress. In recent years, research has found ferroptosis plays crucial role in pathophysiological processes neurodegenerative stroke. Therefore, also closely PD, This article reviews core mechanisms elucidates correlation between ferroptosis. addition, compounds emerged years exert anti effects by inhibiting signaling pathway were summarized. I hope further elaborate relationship through review this article, provide strategies developing treatments targeting

Language: Английский

Citations

7
Induction of ferroptosis by natural phenols: A promising strategy for cancer therapy DOI
Yiping Zhang, Xie Jun

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(4), P. 2041 - 2076

Published: Feb. 23, 2024

Abstract In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form regulated cell death characterized iron‐dependent lipid peroxidation. This review delves into roles key phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis their underlying mechanisms. Emphasizing significance amino acid, lipid, iron metabolism, study elucidates diverse pathways through which these regulate ferroptosis. Notably, well‐known polyphenol, exhibits multifaceted interactions with cellular components involved regulation, providing distinctive therapeutic avenue. Stilbenes, another class, demonstrate promising influencing metabolism processes, contributing to ferroptotic death. Understanding intricate interplay between not only illuminates complex regulatory networks but also unveils avenues novel therapies. Exploring compounds inducers presents strategy targeted treatment, capitalizing on delicate balance article synthesizes current knowledge, aiming stimulate further research context ferroptosis‐mediated therapy.

Language: Английский

Citations

6