A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 13, 2024

As a traditional Chinese medicinal herb with long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes research progress of CP field past 5 By searching and analyzing literature, combining Cytoscape software, we comprehensively examined role mechanism action individual application, combination drug codonopsis pilosula’s active ingredients variety diseases. It also analyzes use its application value medicine. found that mainly manifests important roles several diseases, such as cardiovascular system, nervous digestive immune etc., regulates development many diseases through mechanisms inflammation regulation, oxidative stress, immunomodulation apoptosis. Its rich pharmacological activities diverse effects endow broad prospects values. provides valuable reference guidance for further

Language: Английский

Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

Objective This study aims to elucidate the role of SB in inhibiting CRC progression by targeting CAFs and elucidating underlying mechanisms. Methods In this study, a spontaneous model induced AOM/DSS was used evaluate effects on CAFs. Mice were treated with SB, tumor burden assessed colon length. isolated post-treatment for transcriptomic analysis identify differentially expressed genes, molecular docking providing silico evidence SB’s binding target proteins. changes further examined through HE staining, IHC, assays cell viability, colony formation, migration. Integrated bioinformatic elucidated mechanistic CAFs-mediated progression. Results vivo studies showed that effectively reduced POSTN α-SMA protein levels AOM/DSS-induced mice. Consistently, vitro experiments demonstrated significantly decreased both mRNA fibroblasts (colonic myofibroblast CCD-18Co lines.) co-cultured lines (human colorectal adenocarcinoma SW480 RKO lines). also inhibited proliferation, migration cells. Transcriptomic integrated analyses suggested exerts therapeutic modulating key pathways. Conclusion These results holds promise as agent CRC. advances our understanding mechanisms, particularly its inhibitory

Language: Английский

Shenqi Fuzheng Injection Reduces Cisplatin-Induced Kidney Injury via cGAS/STING Signaling Pathway in Breast Cancer Mice Model

Breast Cancer Targets and Therapy, Journal Year: 2024, Volume and Issue: Volume 16, P. 451 - 469

Published: Aug. 1, 2024

Shenqi Fuzheng Injection (SQFZ) is a traditional Chinese medicine injection consists of extracts

Language: Английский