Aging and Disease,
Journal Year:
2013,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2013
Aging
is
characterized
by
progressive
multisystem
deterioration
driven
molecular
and
cellular
mechanisms
encapsulated
in
the
twelve
hallmarks
of
aging.
Green
tea
(GT),
derived
from
Camellia
sinensis,
has
garnered
significant
scientific
interest
due
to
its
rich
polyphenolic
composition,
particularly
epigallocatechin-3-gallate,
pleiotropic
health
benefits.
In
this
narrative
review,
we
explored
multifaceted
through
which
GT
may
mitigate
aging
hallmarks.
Evidence
vitro,
animal,
human
studies
shown
that
polyphenols
can
enhance
DNA
repair
pathways,
preserve
telomere
length,
modulate
epigenetic
markers,
improve
proteostasis
autophagic
flux,
regulate
nutrient-sensing
networks,
rejuvenate
mitochondrial
function.
Additionally,
exhibits
anti-inflammatory
properties
restore
a
physiological
gut
microbiota
composition.
Beyond
effects,
consumption
humans
been
associated
with
improved
cognitive
function,
cardiovascular
health,
muscle
preservation,
metabolic
regulation
populations.
Collectively,
these
findings
highlight
GT's
potential
as
naturally
occurring
geroscience
intervention
capable
addressing
interconnected
network
processes
more
comprehensively
than
single-target
pharmaceuticals.
Future
research
should
focus
on
optimizing
dosing
regimens,
exploring
synergies
other
anti-aging
strategies,
investigating
personalized
responses
interventions.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(8), P. 985 - 985
Published: Aug. 14, 2024
Gut
dysbiosis,
resulting
from
an
imbalance
in
the
gut
microbiome,
can
induce
excessive
production
of
reactive
oxygen
species
(ROS),
leading
to
inflammation,
DNA
damage,
activation
immune
system,
and
epigenetic
alterations
critical
genes
involved
metabolic
pathways.
dysbiosis-induced
inflammation
also
disrupt
barrier
integrity
increase
intestinal
permeability,
which
allows
gut-derived
toxic
products
enter
liver
systemic
circulation,
further
triggering
oxidative
stress,
associated
with
diseases.
However,
specific
metabolites,
such
as
short-chain
fatty
acids
(SCFAs),
lactate,
vitamins,
modulate
stress
system
through
mechanisms,
thereby
improving
function.
microbiota
diet-induced
diseases,
obesity,
insulin
resistance,
dyslipidemia,
hypertension,
transfer
next
generation,
involving
mechanisms.
In
this
review,
we
will
introduce
key
that,
along
dysbiosis
ROS,
are
engaged
developing
Finally,
discuss
potential
therapeutic
interventions
dietary
modifications,
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
may
reduce
syndrome
by
altering
alterations.
summary,
review
highlights
crucial
role
pathogenesis
a
particular
focus
on
(including
histone
methylomics,
RNA
interference)
that
prevent
or
improve
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2433 - 2433
Published: July 26, 2024
Existing
research
indicates
that
different
types
of
meat
have
varying
effects
on
health
and
aging,
but
the
specific
causal
relationships
remain
unclear.
This
study
aimed
to
explore
relationship
between
intake
aging-related
phenotypes.
employed
Mendelian
randomization
(MR)
select
genetic
variants
associated
with
from
large
genomic
databases,
ensuring
independence
pleiotropy-free
nature
these
instrumental
variables
(IVs),
calculated
F-statistic
evaluate
strength
IVs.
The
validity
estimates
was
assessed
through
sensitivity
analyses
various
MR
methods
(MR-Egger,
weighted
median,
inverse-variance
(IVW),
simple
mode,
mode),
MR-Egger
regression
intercept
used
test
for
pleiotropy
bias
Cochran's
Q
heterogeneity
results.
findings
reveal
a
positive
consumers
DNA
methylation
PhenoAge
acceleration,
suggesting
increased
may
accelerate
biological
aging
process.
Specifically,
lamb
is
found
effect
mitochondrial
copy
number,
while
processed
consumption
shows
negative
telomere
length.
No
significant
were
observed
other
intake.
highlights
impact
processing
cooking
meat's
role
in
enhancing
our
understanding
how
their
preparation
affect
process,
providing
theoretical
basis
dietary
strategies
at
delaying
quality
life.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(4), P. 616 - 616
Published: Feb. 8, 2025
Polyphenols
have
been
shown
to
be
utilized
as
an
effective
treatment
for
cancer
by
acting
a
DNMT
or
HDAC
inhibitor,
reducing
inflammatory
processes,
and
causing
cell
cycle
arrest.
While
there
many
studies
demonstrating
the
anti-cancerous
potential
of
individual
polyphenols,
are
limited
on
combinatorial
effects
polyphenols.
This
review
focuses
how
combinations
different
polyphenols
can
used
chemotherapeutic
option
patients.
Specifically,
we
examine
three
commonly
polyphenols:
curcumin,
resveratrol,
epigallocatechin
gallate.
These
induce
apoptosis,
prevent
colony
formation
migration,
increase
tumor
suppression,
reduce
viability
angiogenesis,
create
several
epigenetic
modifications.
In
addition,
these
were
synergistic
additive.
Thus,
findings
suggest
that
using
at
appropriate
concentrations
better
more
efficacious
against
compared
individually.
Journal of Aging Research and Lifestyle,
Journal Year:
2024,
Volume and Issue:
13, P. 88 - 92
Published: Jan. 1, 2024
Biological
age
is
a
concept
that
uses
bio-physiological
parameters
to
account
for
individual
heterogeneity
in
the
biological
processes
driving
aging
and
aims
enhance
prediction
of
age-related
clinical
conditions
compared
chronological
age.
Although
engaging
healthy
lifestyle
behaviors
has
been
linked
lower
mortality
risk
reduced
incidence
chronic
diseases,
it
remains
unclear
what
extent
these
health
benefits
result
from
slowing
pace
process.
This
short
review
summarized
how
modifiable
factors
-
including
diet,
physical
activity,
smoking,
alcohol
consumption,
aggregate
multiple
were
associated
with
established
estimates
based
on
or
cellular/molecular
markers,
Klemera-Doubal
Method
age,
homeostatic
dysregulation,
phenotypic
DNA
methylation
telomere
length.
In
brief,
available
studies
tend
show
consistent
association
physiological
measures
while
findings
regarding
molecular-based
metrics
vary.
The
limited
evidence
highlights
need
further
research
this
field,
particularly
life-course
approach.
