Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports DOI Creative Commons
S. К. Zyryanov, I. L. Asetskaya, О. И. Бутранова

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 675 - 675

Published: May 24, 2024

(1) Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are extremely severe cutaneous adverse drug reactions which relatively rare in routine clinical practice. An analysis of a national pharmacovigilance database may be the most effective method obtaining information on SJS TEN. (2) Methods: Design—a retrospective descriptive pharmacoepidemiologic study spontaneous reports (SRs) with data TEN retrieved from Russian National Pharmacovigilance for period 1 April 2019 to 31 December 2023. Descriptive statistics was used assess demographic patients structure suspected drugs. (3) Results: A total 170 SRs were identified, 32.9% 67.1%—TEN. In total, 30% pediatric SRs, 21.2%—SRs elderly. There 12 lethal cases, all cases The leading culprit drugs anti-infectives systemic use nervous system agents. top 10 involved as follows: lamotrigine (23.5%), ibuprofen (12.9%), ceftriaxone (8.8%), amoxicillin beta-lactam inhibitors paracetamol (7.6%), carbamazepine (5.9%), azithromycin (4.1%), valproic acid omeprazole (3.5%), levetiracetam (3.5%). (4) Conclusions: Our first Russia aimed at assessment level.

Language: Английский

Labelling patients as allergic to beta-lactam antibiotics is associated with periprosthetic joint infection up to five years following knee arthroplasty DOI
Valerie Chiang, Hugo W.F. Mak, Amy Cheung

et al.

The Bone & Joint Journal, Journal Year: 2025, Volume and Issue: 107-B(5), P. 522 - 528

Published: May 1, 2025

Periprosthetic joint infections (PJIs) represent a significant complication of total knee arthroplasty (TKAs). However, the influence drug or beta-lactam (BL) antibiotic allergy labelling patients on PJI remains largely unknown. In this study, we examine association between labelled with BL and occurrence among undergoing TKA. We also assess prevalence incorrect patient explore feasibility multidisciplinary testing initiative to detect mislabelling. Longitudinal data from all who underwent TKA January 1993 December 2021 were analyzed. investigated different risk factors PJI, particular focus as having an allergy. The outcomes without compared. Additionally, had undergone scheduled for prospectively by formal assessment. Out 4,730 TKAs, overall incidence was 1.0% (47/4,730). Patients higher within first five years post-TKA compared those (3.0% (5/165) vs 0.7% (34/4,565); p = 0.001). presence label identified independent factor (hazard ratio 4.86 (95% CI 2.05 11.53); < Following negative provocation testing, majority (21/22)) evaluated labels successfully delabelled. longitudinal associated increased following TKA, particularly years. Given high rate being mislabelled, recommend that should be prioritized assessment evaluation. Further studies impact preoperative delabelling initiatives encouraged.

Language: Английский

Citations

1
Penicillin Allergy in China: Consequences of Inappropriate Skin Testing Practices and Policies DOI Creative Commons

Weihong Shi,

Ning Liu, Jinxian Huang

et al.

Clinical & Experimental Allergy, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

ABSTRACT Penicillins are the most frequently prescribed class of medications worldwide and first‐line antibiotic choice for bacterial infections. They also commonly labelled as culprit drug ‘allergy’; leading to obligatory use second‐line antibiotics, suboptimal therapy increased antimicrobial resistance. However, majority reported penicillin ‘allergy’ labels found be incorrect after allergy testing, emphasising importance proper testing evaluation. Penicillin skin (PST) remains an important component diagnosis; however, its practice policies significantly differ across world. Inappropriate non‐evidence‐based PST practices can lead consequences associated with mislabelling. Even within different regions China, a population exceeding 1.4 billion, there marked differences in implementation, execution interpretation PST. This review aims examine between Mainland Hong Kong rest We critically analyse current ‘pre‐emptive’ which has significant false‐positive rate high levels Non‐evidence‐based further compound rates indiscriminatory postulate that inappropriate may exacerbate mislabelling allergy, unnecessary overuse increasing resistance healthcare costs. advocate more collaborative research improve contemporary workflow diagnosis, reduce promote dissemination evidence‐based methods diagnosis.

Language: Английский

Citations

5
Impact of a drug allergy education course for non‐specialists: Findings from ADAPT—A randomized crossover trial DOI Creative Commons
Michaela Lucas, Hugo W.F. Mak,

Jasmine T. Y. Lee

et al.

Allergy, Journal Year: 2024, Volume and Issue: 80(2), P. 525 - 533

Published: Aug. 7, 2024

The consequences of drug allergy remain a global health concern. Drug is often neglected topic and many non-specialists lack sufficient knowledge or confidence in evaluating managing this common condition. Evidence-based interventions to better equip tackle are needed. aim the study evaluate effectiveness an intensive educational course on practice non-specialists. A randomized crossover trial (NCT06399601) was conducted among practicing physicians nurses participating course-Advances Allergy & Penicillin Testing (ADAPT). Participants' baseline self-reported practices were assessed with standardized questionnaires (scored from 0 100, "satisfactory" defined as ≥60/100). Participants into two cohorts attended ADAPT at different time points. Serial responses before after compared within between cohorts. Seventy participants (25 physicians, 45 nurses) groups completed course. Baseline (58.0 ± 19.9) (36.9 24.3) unsatisfactory non-specialists, significantly lower scores than both domains (knowledge: 49.0 17.4 vs. 74.0 12.7; practice: 32.1 21.3 53.3 23.1; all p < 0.001). Following completion ADAPT, demonstrated significant improvements 19.9 77.7 15.9, 0.001) 24.3 71.0 20.2, All (100%) 99% agreed that improved their clinical practice, respectively. effective improving for Further longitudinal studies required long-term impact.

Language: Английский

Citations

5
Leveraging COVID-19 vaccine allergy evaluations with coincident drug allergy delabelling: Effectiveness and impact on quality of life DOI Creative Commons
Andy Ka Chun Kan, Hugo W.F. Mak, Valerie Chiang

et al.

Vaccine, Journal Year: 2025, Volume and Issue: 50, P. 126849 - 126849

Published: Feb. 5, 2025

Concerns of potential drug/vaccine-associated allergies significantly impact vaccine safety and hesitancy. Delabelling incorrect drug allergy in the general public was previously impeded by limited access to allergist services, especially among less frequent healthcare utilisers community. COVID-19 evaluation services have enabled individuals (mis)labelled with receive vaccinations safely provided opportunities expand delabeling access. We investigated effectiveness this coincident delabelling its on health-related quality life (HRQoL). recruited labelled attending for Hong Kong between 2021 2022. Demographics, comorbidities, labels, vaccination infection outcomes, as well rates were analysed. HRQoL measured before after a subgroup individuals. Among 652 individuals, 1456 labels identified, anti-infectives being most common (606, 41.6 %). Beta-lactam antibiotics accounted 55.1 % (334). Almost all (99.4 %) proceeded vaccinations, an increased number doses conferring better protection. 228 (35.0 underwent investigations, successful 223 (97.8 %), removing 317 (21.8 which 173 (51.8 beta-lactams. Subgroup analysis showed improved serial following (DrHy-Q 45.0 vs 33.3, p < 0.001). Services evaluating not only empowered safely, but also enhanced public.

Language: Английский

Citations

0
Transparency, Reproducibility, and Accessibility of Clinical and Experimental Studies in Allergy (TRACES): Study design and protocol DOI Creative Commons
Hugo W.F. Mak, Chak Kwan Cheung,

Julio Lau

et al.

Journal of Allergy and Clinical Immunology Global, Journal Year: 2025, Volume and Issue: 4(2), P. 100447 - 100447

Published: March 6, 2025

Language: Английский

Citations

0
Bibliometric analysis of the trends and evolution in beta-lactam allergy research DOI Creative Commons
Hugo W.F. Mak, Jason A. Trubiano, Kimberly G. Blumenthal

et al.

Journal of Allergy and Clinical Immunology Global, Journal Year: 2024, Volume and Issue: 3(4), P. 100328 - 100328

Published: Aug. 24, 2024

β-Lactams remain the most reported drug allergy globally, with volume and diversity of related research continuing to accumulate. Recognizing evolving trends can help inform future directions encourage synergistic collaborations.

Language: Английский

Citations

2
NSAID Allergy Labels Associated With Mortality and Cardiovascular Outcomes in Stroke DOI
Clara Tsui, Hugo W.F. Mak, William Leung

et al.

Stroke, Journal Year: 2024, Volume and Issue: 56(1), P. 30 - 38

Published: Nov. 19, 2024

BACKGROUND: Mislabeled drug allergy can restrict future prescriptions and medication use, but its prevalence impact among patients with stroke remain unknown. This study investigated the of most commonly labeled allergies, their accuracy, stroke. METHODS: In this combined longitudinal cross-sectional study, we compared labels general population ischemic between 2008 2014 from electronic health care records in Hong Kong. Outcomes or without prevalent (ie, NSAID) were compared. Rate mislabeled NSAID was confirmed by provocation testing. RESULTS: Compared (n=702 966), had more (n=235) to cardiovascular hematopoietic system (prevalence, 19.5% versus 9.2%; odds ratio [OR], 2.4 [95% CI, 1.74–3.32]; P <0.001) radiographic diagnostic agents 4.2% 0.9%; OR, 4.82 2.56–9.08]; <0.001). The common 1.8%). Patients significantly less likely be prescribed aspirin after acute (OR, 0.24 0.09–0.60]; =0.003) on follow-up 0.22 0.08–0.56]; =0.002). median duration 6.7 years (6499±2.49 patient-years). also experienced higher mortality 7.44 2.44–23.18]; <0.001), peripheral vascular disease 9.35 1.95–44.86]; =0.005), major adverse events 6.09 2.00–18.58]; =0.001) poststroke period. (who remained alive could consent) referred for allergist assessment offered majority (80%; 4/5) negative tests delabeled. CONCLUSIONS: stroke, associated excessive mortality, disease, events. Given high rate multidisciplinary neuro-allergy interventions have potential improve patient outcomes.

Language: Английский

Citations

2
Global Differences and Risk Factors Influencing Drug Hypersensitivity Quality of Life: A Multi-Centre, Multi-ethnic Study of Drug Allergy Across Three Continents DOI Creative Commons
Ana Copaescu, Hugo W.F. Mak, Sara Vogrin

et al.

Journal of Allergy and Clinical Immunology Global, Journal Year: 2024, Volume and Issue: 4(1), P. 100354 - 100354

Published: Oct. 18, 2024

Language: Английский

Citations

1
Demographic characteristics associated with a penicillin allergy label during pregnancy DOI Creative Commons
Timothy M. Buckey, Patrick K. Gleeson,

Cara Curley

et al.

Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5

Published: Dec. 9, 2024

Penicillins and other beta-lactam antibiotics are used in greater than one-third of pregnant women as treatment for Group B Streptococcus colonization prophylaxis Caesarean sections. Penicillin allergy labels have been associated with increased morbidity the population, penicillin evaluation during pregnancy is now recognized safe effective. Yet, demographic characteristics having a label not studied. We aimed to evaluate factors diverse population patients.

Language: Английский

Citations

1
Non-Steroidal Anti-Inflammatory Drug Allergy Labels Associated with Mortality and Adverse Cardiovascular Outcomes Among Stroke Patients: High Rate of Mislabelled Allergy and Potential for Multi-Disciplinary Intervention DOI

Cheuk Wun Tsui,

Hugo W.F. Mak, William Leung

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0