Association Between COVID-19 and Osteoporosis: A Bidirectional Mendelian Randomization Study

Deleted Journal, Journal Year: 2024, Volume and Issue: 1, P. 8 - 8

Published: Aug. 6, 2024

Objective: The prevalence and severity of covid-19 infection were higher in patients with osteoporosis than healthy controls, the mean BMD was lower COVID-19 low vitamin D levels associated development COVID-19. objective this study is to understand whether there indeed a bidirectional causal relationship between Methods: Analysis two through two-way Mendelian pathway. Finding disease-related Single nucleotide Polymorphism as working variables Genome-wide association database. primary analysis for randomization (MR) inverse variance weighting (IVW) method. pleiotropy estimated intercept from MR-Egger regression, heterogeneity assessed Cochran’s Q test IVW approach. Results: In forward MR analysis, neither exposure infection, hospitalization or severe significantly drug-induced outcome (P>0.05); reverse exposures not outcomes (infection, hospitalization, case) (P>0.05). Conclusion: There no significant by genetic prediction.

Language: Английский

Prevalence of lymphopenia in the American population: Insights from demographic, BMI, and lifestyle factors

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0312540 - e0312540

Published: Nov. 4, 2024

Objective To determine the difference in prevalence of lymphopenia American population according to demographic characteristics, body mass index (BMI) and living habits. Methods A total 33,365 participants aged over 1 were included 2009–2018 National Health Nutrition Survey (NHANES). All analyses used weighted samples considered layering clustering design. Results Using white as a reference, Mexican-American was significantly lower than that ( P = 0.018). There no significant between black 0.376) participants. The 1.81% (95%CI, 1.53%-2.10%) for participants, 1.08% 0.78%-1.39%) 0.42% 0.17%-0.68%) increases with age, reaching peak 6.84% among elderly 75 above. In terms gender difference, men is higher women <0.001). Individuals who smoke <0.001), consume alcohol 0.032), engage regular exercise 0.031), have sleep disorders <0.001) those classified having an unhealthy weight had average lymphocyte count. without 0.014). However, differences observed classification variables smoking, drinking, exercise, BMI. Conclusion diagnosis treatment lymphopenia, clinicians should consider influence factors such race, gender, disorders, other lifestyle habits improve accuracy treatment, thereby reducing high mortality risk associated lymphopenia. Consequently, we propose novel perspective be tailored levels specific subpopulations, rather applying generalized approach.

Language: Английский

Mast Cells and Basophils in Major Viral Diseases: What Are the Correlations with SARS-CoV-2, Influenza A Viruses, HIV, and Dengue?

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2044 - 2044

Published: Dec. 11, 2024

The SARS-CoV-2 pandemic has significantly impacted global health and led the population scientific community to live in fear of a future pandemic. Based on viral infectious diseases, innate immunity cells such as mast basophils play fundamental role pathogenesis diseases. Understanding these mechanisms could be essential better study practical therapeutic approaches not only COVID-19 but also other infections widely spread worldwide, influenza A, HIV, dengue. In this literature review, we want concepts. Mast intervene bridge between acquired seem have damage during infection stimulation humoral cellular immunity. some cases, can act reservoirs favor replication virus body. useful diagnostic prognostic perspectives. prospects applying artificial intelligence machine learning algorithms for creation very accurate diagnostic/prognostic tools are interesting.

Language: Английский