The Health Effects of Dietary Nitrate on Sarcopenia Development: Prospective Evidence from the UK Biobank DOI Creative Commons

Jigen Na,

Yuefeng Tan, Yanan Zhang

et al.

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 43 - 43

Published: Dec. 27, 2024

Nitrate is abundant in natural foods, especially plant-based having the potential to enhance muscle function. However, its relationship with sarcopenia context of daily diet remains unexplored. This cohort study investigated associations between dietary nitrate intake and sarcopenia, as well related symptoms, using data including 28,229 participants a mean follow-up 9.37 years from UK Biobank. Dietary was estimated comprehensive food database. Adjusted logistic regression models suggested inverse total risks plus pre-sarcopenia (Sarc-Presarc), low hand grip strength (HGS), walking pace. Similar results were primarily observed for foods. With higher intake, females appeared have HGS decreased risk Sarc-Presarc, while males exhibited reduced The association skeletal mass index more evident individuals aged 65 above. These seemed independent antioxidants, though antioxidants might augment protective effect against Mediation analyses indicated that protein homeostasis blood pressure mediate these associations. findings foods could contribute prevention, further research needed confirm observations.

Language: Английский

The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline DOI Open Access

Enzo Pereira de Lima,

Masaru Tanaka,

Caroline Barbalho Lamas

et al.

Published: Aug. 12, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

Citations

15
Exploring the global impact of obesity and diet on dementia burden: the role of national policies and sex differences DOI

Xueshan Cao,

Han-Guang Peng,

Ziyi Hu

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Language: Английский

Citations

14
Sarcopenic obesity and the risk of atrial fibrillation in non-diabetic older adults: a prospective cohort study DOI
Xinyi Yu, Jianying Chao, Xin Wang

et al.

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 47, P. 282 - 290

Published: March 4, 2025

Language: Английский

Citations

1
Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions DOI Creative Commons

Enzo Pereira de Lima,

Masaru Tanaka,

Caroline Barbalho Lamas

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2096 - 2096

Published: Sept. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Language: Английский

Citations

6
Sarcopenic obesity and brain health: A critical appraisal of the current evidence DOI Open Access
Uraiporn Booranasuksakul, Zhongyang Guan, Ian Macdonald

et al.

Nutrition Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 12, 2025

Abstract Sarcopenic obesity (SO) is a body composition phenotype derived from the simultaneous presence in same individual of an increase fat mass and decrease skeletal muscle and/or function. Several protocols for diagnosis SO have been proposed last two decades making prevalence disease risk estimates heterogeneous challenging to interpret. Dementia complex neurological disorder that significantly impacts patients, carers healthcare systems. The identification factors early cognitive impairment dementia key mitigating forecasted trends 2‐fold case numbers over next worldwide. Excess adiposity sarcopenia both independently associated with dementia. Whether greater currently uncertain. This review critically appraises current evidence on association between outcomes risk. It also discusses some putative biological mechanisms may link alteration brain functions.

Language: Английский

Citations

0
Metabolic dysfunction-associated steatotic liver disease, metabolic alcohol-related liver disease, and incident dementia: a nationwide cohort study DOI Creative Commons
Woo-Young Shin,

Eun Seok Kang,

Yun Hwan Oh

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 29, 2025

Language: Английский

Citations

0
The obesity paradox in cognitive decline: Impact of BMI dynamics and APOE genotypes across various cognitive status DOI Creative Commons

Weijie Zhai,

Guimei Zhang,

Chunxiao Wei

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract Aims To explore the relationship between body mass index (BMI) and its changes in relation to cognitive decline across different status, while also examining role of APOE genotype these associations. Materials Methods A total 23 255 individuals from National Alzheimer's Coordinating Center (NACC) were analysed using multivariable logistic Cox regression assess BMI variability decline. Subgroup analyses conducted how interacts with Results Compared normal cognition BMI, being underweight was associated a higher risk developing MCI (HR 3.065, 95% CI: [1.156–8.126]) dementia 4.057, [1.433–11.483]). Over 4.07‐year follow‐up, 9171 experienced Longitudinal analysis revealed that overweight or obese linked lower including impaired not MCI, dementia, but had no effect on those cognition. Additionally, compared stable hazard ratios (95% CI) for 2.336 (2.128–2.565) 2.338 (2.119–2.581) annual gain loss greater than 5%. However, genotypes may influence Conclusions This research supports ‘obesity paradox’ highlights critical modulating BMI's health.

Language: Английский

Citations

0
Healthy Cardiovascular Status Attenuates the Detrimental Association Between Osteosarcopenic Adiposity and Alzheimer's Disease‐Related Dementia: A UK Biobank Cohort Study DOI Creative Commons
Wen-Xu Wang, Rui Ren,

Honghao Yang

et al.

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Background Body composition abnormalities are associated with the risk of Alzheimer's disease‐related dementia (ADRD). However, specific link between osteosarcopenic adiposity (OSA), cardiovascular health (CVH), and ADRD is underexplored. This study examined association OSA to determine whether optimal CVH could modify this association. Methods We analyzed data from 152 028 UK Biobank participants. OSA‐related body include low bone mineral density, muscle mass/grip strength, high fat percentage. was assessed using Life's Essential 8 questionnaire. High corresponded lowest highest disease risks, respectively. The hazard ratios (HRs) 95% CIs for were estimated Cox proportional hazards models. A secondary analysis included 14 750 participants brain magnetic resonance imaging explore role structure in incidence ADRD. Results After a median follow‐up 14.1 years, 2628 (1.73%) developed Compared no abnormalities, adjusted HRs those 1, 2, 3 1.04 (95% CI, 0.95–1.14), 1.17 1.04–1.31), 1.46 1.11–1.92), found significant addictive interaction abnormal components, relative excess due CI) −1.34 −2.11 −0.57). Gray matter hippocampus mediate these associations, mediation proportion 17.3% ( P < 0.001). Conclusions components positively Maintaining status may mitigate individuals OSA.

Language: Английский

Citations

0
Association of waist circumference and BMI with premature death in young and middle-aged population DOI Creative Commons
Lin Hu, Xinyue Han,

Miaoshuang Chen

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 30, 2024

Premature death is a global health indicator, significantly impacted by obesity, especially in young and middle-aged population. Both body mass index (BMI) waist circumference (WC) assess with WC specifically indicating central obesity showing stronger relationship mortality. However, despite known associations between BMI premature death, as well the well-recognized correlation adverse outcomes, specific remains unclear. Therefore, focusing on individuals, this study aimed to reliably estimate independent combined WC, thereby providing causal evidence support strategies for management.

Language: Английский

Citations

2
The Health Effects of Dietary Nitrate on Sarcopenia Development: Prospective Evidence from the UK Biobank DOI Creative Commons

Jigen Na,

Yuefeng Tan, Yanan Zhang

et al.

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 43 - 43

Published: Dec. 27, 2024

Nitrate is abundant in natural foods, especially plant-based having the potential to enhance muscle function. However, its relationship with sarcopenia context of daily diet remains unexplored. This cohort study investigated associations between dietary nitrate intake and sarcopenia, as well related symptoms, using data including 28,229 participants a mean follow-up 9.37 years from UK Biobank. Dietary was estimated comprehensive food database. Adjusted logistic regression models suggested inverse total risks plus pre-sarcopenia (Sarc-Presarc), low hand grip strength (HGS), walking pace. Similar results were primarily observed for foods. With higher intake, females appeared have HGS decreased risk Sarc-Presarc, while males exhibited reduced The association skeletal mass index more evident individuals aged 65 above. These seemed independent antioxidants, though antioxidants might augment protective effect against Mediation analyses indicated that protein homeostasis blood pressure mediate these associations. findings foods could contribute prevention, further research needed confirm observations.

Language: Английский

Citations

0