Effects of Combined Visual-Motor Response Training on Cognitive Function and Brain Plasticity Mechanisms in Various Populations: Protocol for a Single-Center, Open-Label, Controlled Clinical Trial DOI Creative Commons
Wenlong Yu, Jiamin Gao, Ping Zhu

et al.

JMIR Research Protocols, Journal Year: 2024, Volume and Issue: 13, P. e56424 - e56424

Published: Oct. 7, 2024

Background Cognitive impairment is one of the major diseases facing aging population. The progressive decline cognitive function can lead to declining health or even loss life, work, and social ability. Exercise behavioral stimulation increase neurotransmitters in brain improve overall function. Reactivity training mobilize neuromuscular induce changes plasticity, which may effectively dysfunction delay occurrence development Alzheimer disease; however, evidence supporting its effectiveness still limited. Objective This study aims explore reliability visual-motor reaction improving function, thereby promoting application novel nonpharmacological therapies. Methods a single-center, open-label, controlled clinical trial. A total 78 participants will be recruited for study, including an equal number athletes, ordinary healthy college students, older adults community. Participants receive 2 weeks response training. primary outcome this assess differences functional magnetic resonance imaging (fMRI) at weeks. secondary outcomes were following: acousto-optic time, Hamilton Depression Rating Scale (HAM-D), Anxiety (HAM-A), Mini Mental State Examination (MMSE), Activity Daily Living (ADL) Scale, Subjective Decline Questionnaire–9 (SCD-Q9), 10-word memory test, safety. Results was approved by Shanghai Clinical Research Ethics Committee on January 2, 2024 (SECCR/2023-162-01). As September 11, 2024, we have completed recruitment all 3 groups volunteers. We expect complete data collection analysis February 2025. Conclusions purpose compare improvements perceptual motor functions levels across different populations through ability efficacy safety exercise-based therapies Other potential benefits include understanding characteristics brain’s perceptual-motor system between athletes general population exploring adaptability acquiring skills during competitive sports could provide base early talent broader youth development. Trial Registration Chinese Registry ChiCTR2400079602; https://tinyurl.com/23fbbndw International Registered Report Identifier (IRRID) DERR1-10.2196/56424

Language: Английский

Physical activity and neuroplasticity in neurodegenerative disorders: a comprehensive review of exercise interventions, cognitive training, and AI applications DOI Creative Commons

Lamia Ben Ezzdine,

Wissem Dhahbi, Ismail Dergaa

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 28, 2025

This review aimed to elucidate the mechanisms through which (i) physical activity (PA) enhances neuroplasticity and cognitive function in neurodegenerative disorders, (ii) identify specific PA interventions for improving rehabilitation programs. We conducted a literature search PubMed, Medline, Scopus, Web of Science, PsycINFO, covering publications from January 1990 August 2024. The strategy employed key terms related neuroplasticity, exercise, function, personalized activity. Inclusion criteria included original research on relationship between while exclusion eliminated studies focusing solely pharmacological interventions. identified multiple pathways may enhance including releasing neurotrophic factors, modulation neuroinflammation, reduction oxidative stress, enhancement synaptic connectivity neurogenesis. Aerobic exercise was found increase hippocampal volume by 1–2% improve executive scores 5–10% older adults. Resistance training enhanced control memory performance 12–18% elderly individuals. Mind–body exercises, such as yoga tai-chi, improved gray matter density memory-related brain regions 3–5% emotional regulation 15–20%. Dual-task attention processing speed 8–14% individuals with disorders. also discuss potential role AI-based AI preventing rehabilitating illnesses, highlighting innovative approaches patient outcomes. significantly disorders various mechanisms. resistance training, mind–body practices, dual-task exercises each offer unique benefits. Implementing these activities clinical settings can Future should focus creating tailored conditions, incorporating programs optimize rehabilitation.

Language: Английский

Citations

1
Effects of traditional Thai folk dance combined with cognitive stimulation program on behavior and cognition among older adults with cognitive decline: A randomized controlled trial DOI Creative Commons
Panawat Sanprakhon, Wachira Suriyawong,

Natsala Longphasuk

et al.

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100066 - 100066

Published: Jan. 1, 2025

Language: Английский

Citations

0
Examining the Impact of 28-Week Multicomponent and Strength Exercises on Brain Health, Salivary Stress, and Mental Well-Being in Frail Older Women: A Controlled Trial analysis DOI
Guilherme Eustáquio Furtado, Marcelo P. Barros, Rafael Nogueira Rodrigues

et al.

Physiology & Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 114868 - 114868

Published: Feb. 1, 2025

Language: Английский

Citations

0
CSL-CTEA: a systematic method for evaluating novel intelligent cognitive assessment tools DOI
Aihua Li, Sifan Chen, Jianbing Liu

et al.

Health Information Science and Systems, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 11, 2025

Language: Английский

Citations

0
Effectiveness of Combined Cognitive Stimulation and Physical Activity Interventions on Activities of Daily Living, Cognitive Function, and Physical Function in Older People with Mild Cognitive Impairment: A Systematic Review with Meta-Analysis DOI Open Access
Edgar Vásquez-Carrasco, Celia Sánchez Gómez, Pablo Valdés-Badilla

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2261 - 2261

Published: March 26, 2025

Background/Objectives: This systematic review with meta-analysis aimed to evaluate and synthesize scientific evidence about the combined cognitive stimulation physical activity interventions on Activities of Daily Living (ADL), function, function in older people Mild Cognitive Impairment (MCI). Methods: A literature search was conducted between August 2024 October using core collection six generic databases: PubMed, EBSCOhost, CINAHL Complete, Cochrane, Scopus, Web Science. The PRISMA, RoB 2, GRADEpro tools assessed evidence's methodological quality certainty. protocol registered PROSPERO, CRD42024577229. Results: Of 270 records identified databases, 9 studies were analyzed PICOS format. MMSE showed significant improvements favor experimental groups (p = 0.010). In contrast, no found for TMT-A 0.51) TMT-B 0.37). No differences reported other variables studied. Conclusions: as measured by MMSE, improvements, while did not produce ADL or among MCI. Individual suggest that programs integrate both components may provide some benefits.

Language: Английский

Citations

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Effects of Drumming-Based Cognitive and Physical Training on Cognitive Performance and Brain Activity in Older Adults: A Randomized Controlled Trial DOI Creative Commons
Yeon-Gyo Nam, Bum Sun Kwon

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(9), P. 5062 - 5062

Published: May 2, 2025

Aging is associated with cognitive decline, significantly impacting quality of life. Drumming-based and physical training, a novel intervention, engages motor circuits simultaneously, potentially improving executive functions emotional regulation in older adults. A randomized controlled trial (RCT) was conducted 40 participants aged 55 years older, assigned to either an experimental group receiving drumming-based training or control undergoing conventional memory exercises. The intervention lasted four weeks, consisting 30-min sessions three times per week. Functional near-infrared spectroscopy (fNIRS) employed measure brain activity, while outcomes were assessed through standardized tests, including the Mini-Mental State Examination (MMSE) Geriatric Depression Scale (GDS). Task performance metrics, such as accuracy success rates, also recorded. Experimental exhibited significant improvements performance, greater number correct answers (p = 0.0004) higher task rate 0.0001) compared group. fNIRS data revealed increased oxygenated hemoglobin levels left orbitofrontal cortex (OFC) 0.028). This study provides compelling evidence that program can lead benefits

Language: Английский

Citations

0
Shrimp peptide QMDDQ improves scopolamine-induced memory impairments by activating the Notch1 signaling pathway DOI

Peng-Fei Yan,

Junchao Wang,

Xiyu Zhao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106041 - 106041

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Effect of Aerobic or Strength Training in Elderly with Cognitive Decline: The Fit4Alz Project DOI
Ana Filipa Silva, Filipe Manuel Clemente,

Mafalda Sofia Roriz

et al.

Journal of Sports Science and Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 172 - 186

Published: Feb. 24, 2025

This study aimed to examine the effects of aerobic and strength training methodologies, either combined with or without cognitive training, on mitigating decline. A total 154 subjects were recruited (72.8 ± 6.1 years, 69% females) divided into four groups: i) plus (STCT, n = 56); ii) (ST, 23); iii) (AT, 41); iv) (ATCT, 34). Subjects previously cognitively assessed showed decline (less than 26 points Montreal Cognitive Assessment, MoCA). For 12 weeks, all groups performed 3 times a week, for 60 minutes, program corresponding their attributed group. The MoCA test Senior Fitness applied at beginning end intervention. repeated-measures ANCOVA revealed significant time-by-group interactions physical performance measures, including 2-minute step-in-place (p 0.026), arm curl < 0.001), chair sit-and-reach back-scratch 8-foot up-and-go 6-minute walk tests 0.001). However, no improvements observed function (MoCA, p 0.242) lower body (chair stand, 0.411). AT group greater in upper compared STCT ST 0.001; d 0.698; 0.004; 0.598), while significantly improved flexibility ATCT 1.049). had greatest endurance 0.133; 0.350). It was demonstrated that overall elderly individuals. performance. Although these findings suggest both exercise, improve fitness, further research is needed determine its impact

Language: Английский

Citations

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Effects of exercise on older adults with mild cognitive impairment: A systematic review and network meta-analysis DOI Creative Commons
M. Jia,

Fengting Hu,

Yifeng Hui

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Background: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and Alzheimer's disease (AD), with significantly elevated risk of progressing to AD. In recent years, accumulating evidence has indicated that exercise interventions may mitigate decline in individuals MCI reduce the conversion AD, potentially through mechanisms such as enhancing cerebral blood flow promoting neuroplasticity. Objective: To explore which type is most effective improving global cognition older adults investigate whether can enhance their balance abilities. Methods: Randomized controlled trials were retrieved from four databases. Stata software was used for Network Meta-Analysis traditional meta-analysis. Results: A total 33 studies included, 28 determine best modality. The results multicomponent (SUCRA = 76.5%) moderate-intensity aerobic 73.6%) are two modalities. meta-analysis showed combined training, exercise, resistance land-based kayaking training improve ability. Conclusions: Multicomponent be optimal modality MCI, various modalities However, more larger sample sizes higher quality needed provide further evidence.

Language: Английский

Citations

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Combined Physical–Cognitive Therapies for the Health of Older Adults with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis DOI Open Access
Juan Miguel Muñoz-Perete, María del Carmen Carcelén‐Fraile,

Javier Cano-Sánchez

et al.

Healthcare, Journal Year: 2025, Volume and Issue: 13(6), P. 591 - 591

Published: March 8, 2025

Background: Mild cognitive impairment (MCI) represents an early stage of loss that significantly increases the risk dementia. The aim this study was to comprehensively synthesize current evidence on effect combined physical and therapies in older adults with MCI. Methods: A systematic review meta-analysis conducted by searching for specific keywords PubMed, Scopus, Cinhal, Web Science databases. This included a total 2256 participants distributed across 21 studies evaluated benefits combining exercise stimulation. Results: revealed these types present significant improvement memory, attention, executive functions. Participants showed notable improvements areas, highlighting synergistic effects stimulation, which exceeded each therapy separately. These results contribute understanding how can improve health population, offering robust supporting their application clinical practice. Conclusions: shows stimulation interventions may be effective strategy improving findings offer valuable contribution field, potential prevent decline quality life population. interest professionals guide future research applications.

Language: Английский

Citations

0