Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114504 - 114504

Published: Aug. 23, 2022

Language: Английский

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Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing

Cancers, Journal Year: 2021, Volume and Issue: 13(5), P. 1102 - 1102

Published: March 4, 2021

Within aggressive malignancies, there usually are the “hypoxic zones”—poorly vascularized regions where tumor cells undergo oxygen deficiency through inadequate blood supply. Besides, hypoxia may arise in tumors as a result of antiangiogenic therapy or transarterial embolization. Adapting to hypoxia, acquire hypoxia-resistant phenotype with characteristic alterations signaling, gene expression and metabolism. Both lack by itself hypoxia-responsive phenotypic modulations render more radioresistant, so that hypoxic serious challenge for radiotherapy. An understanding causes radioresistance would help develop novel ways overcoming this challenge. Molecular targets various approaches radiosensitizing considered present review. It is here analyzed how hypoxia-induced cellular responses involving hypoxia-inducible factor-1, heat shock transcription factor 1, proteins, glucose-regulated epigenetic regulators, autophagy, energy metabolism reprogramming, epithelial–mesenchymal transition exosome generation contribute be inhibited attenuating radioresistance. The pretreatments multitarget inhibition cancer cell adaptation seem promising approach sensitizing carcinomas, gliomas, lymphomas, sarcomas radiotherapy and, also, liver radioembolization.

Language: Английский

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PI3K/Akt/mTOR signaling pathway in cancer stem cells

Pathology - Research and Practice, Journal Year: 2022, Volume and Issue: 237, P. 154010 - 154010

Published: July 3, 2022

Language: Английский

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Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 976 - 976

Published: Feb. 15, 2022

Emerging evidence suggests that a small subpopulation of cancer stem cells (CSCs) is responsible for initiation, progression, and metastasis cascade in tumors. CSCs share characteristics with normal cells, i.e., self-renewal differentiation potential, suggesting they can drive progression. Consequently, targeting to prevent tumor growth or regrowth might offer chance lead the fight against cancer. create their niche, specific area within tissue unique microenvironment sustains vital functions. Interactions between niches play critical role regulating CSCs' tumorigenesis. Differences observed frequency CSCs, due phenotypic plasticity many remain challenge therapeutics, since modulate transcriptional activities into more stem-like state protect themselves from destruction. This represents an essential step future therapeutic approaches. Regarding self-renewal, are modulated by same molecular pathways found such as Wnt/β-catenin signaling, Notch Hedgehog signaling. Another key characteristic resistance standard chemotherapy radiotherapy treatments, capacity rest quiescent state. review will analyze primary mechanisms involved CSC tumorigenesis, particular attention roles progression benign malignant diseases; examine perspectives on identification new markers better control well dissecting process.

Language: Английский

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VEGF signaling: Role in angiogenesis and beyond

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(2), P. 189079 - 189079

Published: Jan. 26, 2024

Language: Английский

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