Adipokine levels and their association with clinical disease severity in patients with dengue DOI Creative Commons
Heshan Kuruppu, Rivindu Wickramanayake, Chandima Jeewandara

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 9, 2023

Adipokines have not been studied in acute dengue, despite their emerging role inducing and regulating inflammation. Therefore, we sought to identify adipokine levels patients with varying severities of dengue understand disease pathogenesis. We determined the leptin, resistin, omentin, adiponectin, as well IFNβ, NS1 using quantitative ELISA fever (DF=49) haemorrhagic (DHF=22) at admission (febrile phase) time discharge (recovery phase). The viral loads serotypes all samples were quantified real-time RT-PCR. Resistin (p =0.04) omentin (p=0.006) significantly higher who developed DHF. Omentin febrile phase also correlated AST (Spearman's r=0.38, p=0.001) ALT r=0.24, p=0.04); serum leptin both r=0.27, p=0.02) r=0.28, p=0.02). Serum adiponectin did correlate any other adipokines or liver enzymes, but inversely CRP r=-0.31, p=0.008). Although significant (p=0.14) IFNβ lower those progressed develop DHF (median 0, IQR 0 39.4 pg/ml), compared had DF 37.1, 65.6 pg.ml). data suggest that are likely play a pathogenesis which should be further explored for potential used prognostic markers therapeutic targets.

Language: Английский

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil DOI Creative Commons

Carlos Letacio Silveira Lessa,

Katharine Valéria Saraiva Hodel, Marilda de Souza Gonçalves

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2023, Volume and Issue: 8(5), P. 241 - 241

Published: April 23, 2023

Arboviruses constitute the largest known group of viruses. These viruses are etiological agents pathologies as arboviruses, with dengue being one most prevalent. Dengue has resulted in important socioeconomic burdens placed on different countries around world, including those Latin America, especially Brazil. Thus, this work intends to carry out a narrative-based review literature, conducted using study secondary data developed through survey scientific literature databases, and present situation dengue, particularly its distribution these localities. Our findings from demonstrate difficulties that managers face controlling spread planning response against pointing high cost disease for public coffers, rendering resources already limited even scarcer. This can be associated factors affect disease, ecological, environmental, social factors. order combat it is expected targeted properly coordinated policies need adopted not only specific localities, but also globally.

Language: Английский

Citations

39
Severe dengue in the intensive care unit DOI Creative Commons
Alexandre Mestre Tejo,

Débora Toshie Hamasaki,

Letícia Mattos Menezes

et al.

Journal of Intensive Medicine, Journal Year: 2023, Volume and Issue: 4(1), P. 16 - 33

Published: Sept. 28, 2023

Dengue fever is considered the most prolific vector-borne disease in world, with its transmission rate increasing more than eight times last two decades. While cases present mild to moderate symptoms, 5% of patients can develop severe disease. Although mechanisms are yet not fully comprehended, immune-mediated activation leading excessive cytokine expression suggested as a cause main findings critical patients: increased vascular permeability that may shock and thrombocytopenia, coagulopathy induce hemorrhage. The risk factors include previous infection by different serotype, specific genotypes associated efficient replication, certain genetic polymorphisms, comorbidities such diabetes, obesity, cardiovascular World Health Organization recommends careful monitoring prompt hospitalization warning signs or propensity for reduce mortality. This review aims update diagnosis management dengue intensive care unit.

Language: Английский

Citations

30
An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018–2023) DOI Creative Commons
Federica Frasca, Leonardo Sorrentino, Matteo Fracella

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(7), P. 166 - 166

Published: July 20, 2024

In recent decades, increases in temperature and tropical rainfall have facilitated the spread of mosquito species into temperate zones. Mosquitoes are vectors for many viruses, including West Nile virus (WNV) dengue (DENV), pose a serious threat to public health. This review covers most current knowledge on associated with transmission WNV DENV their geographical distribution discusses main vertebrate hosts involved cycles or DENV. It also describes virological pathogenic aspects infection, emerging concepts linking reproductive system. Furthermore, it provides an epidemiological analysis human cases reported Europe, from 1 January 2018 31 December 2023, particular focus Italy. The first autochthonous likely vector being

Language: Английский

Citations

10
Molecular mechanisms in the pathogenesis of dengue infections DOI
Gathsaurie Neelika Malavige, Graham S. Ogg

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(5), P. 484 - 498

Published: April 5, 2024

Language: Английский

Citations

9
A systematic analysis of the literature on the post-COVID-19 condition in Latin America focusing on epidemiology, clinical characteristics, and risk of bias DOI Creative Commons
Vivienne C. Bachelet, Belén Carroza, Bruno Morgado

et al.

Medwave, Journal Year: 2025, Volume and Issue: 25(01), P. e3014 - e3014

Published: Jan. 16, 2025

This analysis article aimed to identify and analyze all articles published on the post-COVID-19 condition in Latin America Caribbean, focusing epidemiology, clinical characteristics, risk of bias. We did a systematic survey literature with broad inclusion criteria. The only exclusion criteria were referring post-acute COVID-19 sequelae after an intensive care unit stay, which we distinguish from condition. searched MEDLINE/PubMed, LILACS, SciELO, Scopus, Web Science, Epistemonikos. included 55 records, 48 original (44 observational research, 29 had comparison group; four reviews). Various definitions for long COVID reported, or none, few used World Health Organization None studies reported prevalence rates region. extracted signs symptoms our Using Johanna Briggs Institute critical appraisal tools analytic found that most prone limitations biases. conclude more research should be done using rigorous study designs inform public health strategies.

Language: Английский

Citations

1
Cross‐reactivity of SARS‐CoV‐2 with other pathogens, especially dengue virus: A historical perspective DOI
Debrupa Dutta, A. C. GHOSH, Chiroshri Dutta

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(2)

Published: Feb. 1, 2023

Abstract Dengue is a vector‐borne viral disease caused by Flavivirus whereas the COVID‐19 pandemic was highly contagious virus, SARS‐CoV‐2 belonging to family Coronaviridae . However, severity observably less in dengue‐endemic countries and vice versa especially during active years of (2019–2021). We observed that dengue virus (DENV) antibodies (Abs) could cross‐react with spike antigen. This resulted false positivity rapid Ab test kits. DENV Abs binding receptor‐binding domain (and reverse scenario), as revealed docking studies further validated cross‐reactivity. Finally, were found cross‐neutralize DENV1 DENV2 neutralization (VNT). other pathogens like Plasmodium also cross‐reactive but non‐neutralizing for SARS‐CoV‐2. Here, we analyze existing data on cross‐reactivity pathogens, assess its impact health (cross‐protection?) differential sero‐diagnosis/surveillance.

Language: Английский

Citations

17
Incidence and co-infection with COVID-19 of dengue during the COVID-19 pandemic DOI Creative Commons
Yuan‐Pin Hung, Ching‐Chi Lee, Yingwen Chen

et al.

Journal of the Formosan Medical Association, Journal Year: 2024, Volume and Issue: 124(3), P. 206 - 211

Published: June 14, 2024

The co-infection of dengue and COVID-19 has been regarded as a public health issue for dengue-endemic countries during the pandemic. Travel restrictions might decrease chance mosquitoes biting and, thus, reduce risk transmission. However, spread was reported to increase with policies lockdowns social distancing in specific areas due delayed interventions Of cases experiencing co-infection, most recovered after receiving supportive care and/or steroid therapy. some episodes severe or fatal diseases individuals, such pregnant women, have reported, clinical course this is unrecognized unpredictable. Accordingly, it crucial promptly identify predictors developing viral among patients.

Language: Английский

Citations

6
COVID-19 and dengue coinfection in Latin America: A systematic review DOI Creative Commons
Darwin A. León‐Figueroa,

Sebastian Abanto-Urbano,

Mely Olarte-Durand

et al.

New Microbes and New Infections, Journal Year: 2022, Volume and Issue: 49-50, P. 101041 - 101041

Published: Oct. 28, 2022

Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) has spread globally, becoming a long-lasting pandemic. Dengue is the most common arboviral disease in tropical and subtropical regions worldwide. COVID-19 dengue coinfections have been reported, associated with worse outcomes significant morbidity mortality. Therefore, this study aims to determine epidemiological situation of coinfection Latin America. A systematic literature review was performed using PubMed, Scopus, Embase, Web Science, LILACS, BVS databases from January 1, 2020, September 4, 2021. The key search terms used were "dengue" "COVID-19". Nineteen published articles included. studies case reports detailed description coinfection's clinical, laboratory, diagnostic, treatment features. Coinfection SARS-CoV-2 virus similar clinical laboratory features each infection are challenge accurately diagnosing treating cases. Establishing an early diagnosis could be answer reducing estimated burden these conditions.

Language: Английский

Citations

21
Effective Preventative Measures are Essential to Lower Disease Burden From Dengue and COVID-19 Co-infection in Bangladesh DOI Creative Commons
Proma Rani Das, Sakif Ahamed Khan,

Jannatul Mabia Rahman

et al.

Environmental Health Insights, Journal Year: 2023, Volume and Issue: 17

Published: Jan. 1, 2023

Bangladesh is widely recognized as one of the dengue prone nations, and empirical evidence has consistently demonstrated an upward trend in severity disease over time. With persistent occurrence ongoing presence COVID-19, which not been fully eradicated may persist for uncertain period time, there a high probability co-infection between these 2 illnesses. Given circumstances, concurrent COVID-19 epidemics, along with potential co-infection, pose overwhelming burden on healthcare systems that are already grappling challenges meeting existing demand. Due to lack awareness, inadequate health infrastructure, ineffective prevention initiatives, country now more susceptible threat posed by found be associated severe outcomes, marked significant morbidity mortality. The objective this opinion piece explore gravity Bangladesh, well overcome preventative measures need implemented address severity. This proposes set modern strategies that, when integrated conventional methods, have mitigate severity, avert dengue, halt co-epidemics dengue.

Language: Английский

Citations

11
Functionalized cascaded tapered optical fiber sensor for simultaneous detection of dengue II E and SARS-CoV-2 S proteins DOI

Nurul Nadiah Zulkeflee,

Yasmin Mustapha Kamil, Syamsiah Mashohor

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117200 - 117200

Published: Feb. 1, 2025

Language: Английский

Citations

0