Hyaluronic acid-silybin conjugate for the preparation of multifunctional, biomimetic, vancomycin-loaded self-assembled polymersomes against bacterial sepsis DOI
Mohammed A. Gafar, Calvin A. Omolo, Usri H. Ibrahim

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140152 - 140152

Published: Jan. 22, 2025

Language: Английский

Stimuli‐Responsive NO Delivery Platforms for Bacterial Infection Treatment DOI
Yanling Hu, Meng Ding, Xinyi Lv

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)

Published: Aug. 22, 2024

The prevalence of drug-resistant bacterial infections has emerged as a grave threat to clinical treatment and global human health, presenting one the foremost challenges in medical care. Thus, there is an urgent imperative develop safe efficacious novel antimicrobial strategies. Nitric oxide (NO) recognized endogenous signaling molecule, which plays pivotal role numerous pathological processes. Currently, NO garnered significant interest antibacterial agent due its capability eradicate bacteria, disrupt biofilms, facilitate wound healing, all while circumventing emergence drug resistance. However, inherently unstable characteristic therapeutic gas renders controlled administration gases exceedingly challenging. Hence, this review, current challenge infection discussed; then it briefly elucidated mechanism comprehensively delineate recent advancements stimulus-responsive delivery platforms, along with their merits, obstacles, prospective avenues for application. This review offers guidance future NO-medicated anti-infection therapy hoped.

Language: Английский

Citations

8
Antimicrobial peptide-fucoidan nanoplexes: A novel multifunctional biomimetic nanocarrier for enhanced vancomycin delivery against bacterial infections and sepsis DOI
Mohammed A. Gafar, Calvin A. Omolo, Usri H. Ibrahim

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125344 - 125344

Published: Feb. 1, 2025

Language: Английский

Citations

1
Engineering dynamic covalent bond-based nanosystems for delivery of antimicrobials against bacterial infections DOI

Abdelrahman Tageldin,

Calvin A. Omolo, Vincent O. Nyandoro

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 237 - 257

Published: May 31, 2024

Language: Английский

Citations

6
Hyaluronic acid-silybin conjugate for the preparation of multifunctional, biomimetic, vancomycin-loaded self-assembled polymersomes against bacterial sepsis DOI
Mohammed A. Gafar, Calvin A. Omolo, Usri H. Ibrahim

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140152 - 140152

Published: Jan. 22, 2025

Language: Английский

Citations

0