Regulation of ubiquitination in sepsis: from PAMP versus DAMP to peripheral inflammation and cell death DOI Creative Commons
Yueying Li, Jian Yu, Zhiwen Zeng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Sepsis (sepsis) is a systemic inflammatory response triggered by infection, and its pathologic features include overproduction of peripheral factors (e.g., IL-1β, IL-6, TNF-α), which ultimately leads to cytokine storm multiple organ dysfunction syndrome (MODS). Pathogen-associated molecular patterns (PAMP) damage-associated (DAMP) induce strong immune responses exacerbate inflammation activating pattern recognition receptors (PRRs) in the host. Ubiquitination, as key protein post-translational modification, dynamically regulates activity several inflammation-associated proteins RIPK1, NLRP3) through coordinated action E1, E2, E3 enzymes, affects cell death pathways such necroptosis pyroptosis, release factors. Deubiquitinating enzymes (DUBs), on other hand, influence intensity sepsis counter-regulating ubiquitination process balancing pro- anti-inflammatory signals. This review focuses how PAMP DAMP activate via PRRs, central role deubiquitination development sepsis, especially mechanisms regulating secretion death. By deeply dissecting impact balance regulation, we further envision potential therapeutic target sepsis.

Language: Английский

Cycloastragenol Reduces Inflammation in CLP-induced Septic Mice by Suppressing TLR4 Signaling Pathways DOI
Guang‐Hong Chen, Weihong Wang, Baoyi Guan

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156645 - 156645

Published: March 13, 2025

Language: Английский

Citations

0
Exploring the Potential Role of the Cholinergic Anti-Inflammatory Pathway from the Perspective of Sepsis Pathophysiology DOI

Ziyi Zhu,

Lixia Liu

Journal of Intensive Care Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Sepsis is one of the most prevalent conditions in critical care medicine and characterized by a high incidence, mortality, poor prognosis, with no specific treatment currently available. The pathogenesis sepsis complex dysregulated inflammatory response at its core. If initial not promptly controlled, patients often develop multiple organ dysfunction syndrome or die, whereas survivors may experience post-sepsis syndrome. Regulation central autonomic nervous systems essential for maintaining homeostasis. Among these, cholinergic anti-inflammatory pathway (CAP) has been extensively studied owing to significant role modulating responses. Recent advancements CAP-related interventions include minimally invasive vagus nerve stimulation, novel α7nAchR-targeting drugs, serum choline acetyltransferase cholinesterase, acupuncture, focused ultrasound stimulation therapy. This review primarily discusses advantages, limitations, therapeutic prospects these approaches. Additionally, heart rate variability, which reflects changes system function, can serve as an indicator assessing functional status nerve. In summary, modulation responses through nerve-mediated CAP represents potential strategy achieving precision sepsis. Future research should focus on conducting high-quality clinical studies CAP-based therapies context sepsis-induced dysregulation. Incorporating indicators evaluate function further elucidate impact dysregulation body.

Language: Английский

Citations

0
Systemic and Pulmonary Microcirculation, Double Microcirculation: From Basic Concepts to Treatment Key Points DOI
Guangjian Wang,

Qingyu Deng,

Jie Wang

et al.

Journal of Intensive Care Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

It seems logical to divide the macrocirculation into systemic and pulmonary circulation, but it is rare in clinical practice further subdivide microcirculation microcirculation. Both microcirculations play important roles development progression of critical illness. Therefore, targeting overall status for treatment may overlook heterogeneity different critically ill patients. unavoidable microcirculation, so this review explains differences structure, function, blood flow regulation, other aspects between systematically presenting concept "double microcirculation." At same time, refine care even improve prognosis patients, we propose explain key points based on protection."

Language: Английский

Citations

0
The role of natural killer T cells in sepsis-associated acute kidney injury DOI

Cheng Li,

Xi Gao, Yuan Liu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 159, P. 114953 - 114953

Published: May 25, 2025

Language: Английский

Citations

0
Traumatic brain injury: Symptoms to systems in the 21st century DOI Creative Commons
Geoffrey P. Dobson, Jodie L. Morris, Hayley L. Letson

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149271 - 149271

Published: Oct. 11, 2024

Language: Английский

Citations

3
Acute Kidney Injury During Sepsis and Prognostic Role of Coexistent Chronic Heart Failure DOI Open Access

Jens Soukup,

Rainer U. Pliquett

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 964 - 964

Published: Feb. 3, 2025

Background: The recently updated definition of sepsis considers pathophysiologic mechanisms to guide initial therapy. Clearly, generalized recommendations for therapy may be limited by pre-existing multimorbidity in addition sepsis-related multi-organ failure. In particular, a recommendation regarding fluid rescue require adequate cardiac function and/or the absence sepsis-induced cardiomyopathy. all patients with compromised or cardiomyopathy, patient-specific regimen is required prevent pulmonary edema and early death. Similarly, sepsis, acute kidney injury without chronic disease requires attention paid excretory renal avoid hypervolemia-mediated heart addition, hyponatremia related intravascular hypovolemia explained vasopressin stimulation. However, hypothetically, hyporesponsiveness contribute injury. this review, relevant cardiorenal pathomechanisms will assessed context Conclusions: conclusion, has take comorbidity, if present, into account. extent which aggravates sepsis-mediated insufficiency should remain subject further study.

Language: Английский

Citations

0
Machine Learning-Based Mortality Risk Prediction Model in Patients with Sepsis DOI Creative Commons
Ye Zhang, Chen Li, Yilin Ji

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 6427 - 6437

Published: May 1, 2025

The aim of our study was to establish and validate a machine learning-based predictive model for mortality risk in elderly patients with sepsis. By integrating traditional biomarkers, novel clinical data, established scoring systems, the seeks enhance accuracy thereby improve outcomes high-risk patient population. Conducted at Beijing Chao-Yang Hospital from August 2021 2023, included 180 emergency department meeting Sepsis 3.0 diagnostic criteria. Data collected demographics, vital signs, laboratory parameters, disease-related scores, major comorbidities, 28-day mortality. Variables were analyzed using univariate analysis LASSO regression, learning constructed R statistical software validated internally via bootstrap resampling calibration curves. identified seven significant variables: SOFA, APACHE II, MAP, ALB, PCT, LTB, VEGF. These variables constituted final prediction model, which achieved an AUC 0.845 (95% CI: 0.786, 0.905), sensitivity 75.9% specificity 85.0%. Internal validation yielded bootstrap-corrected 0.857 0.799, 0.912), confirming model's robustness. nomogram provided visual tool predicting risk, decision curve demonstrated strong potential utility. incorporates VEGF, shows sepsis patients. It provides convenient rapid use. Further research larger sample sizes external is warranted confirm these findings applicability.

Language: Английский

Citations

0
Ubiquitination in Pyroptosis Pathway: A Potential Therapeutic Target for Sepsis DOI

Yan Liao,

Wangzheqi Zhang,

Miao Zhou

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
Regulation of ubiquitination in sepsis: from PAMP versus DAMP to peripheral inflammation and cell death DOI Creative Commons
Yueying Li, Jian Yu, Zhiwen Zeng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Sepsis (sepsis) is a systemic inflammatory response triggered by infection, and its pathologic features include overproduction of peripheral factors (e.g., IL-1β, IL-6, TNF-α), which ultimately leads to cytokine storm multiple organ dysfunction syndrome (MODS). Pathogen-associated molecular patterns (PAMP) damage-associated (DAMP) induce strong immune responses exacerbate inflammation activating pattern recognition receptors (PRRs) in the host. Ubiquitination, as key protein post-translational modification, dynamically regulates activity several inflammation-associated proteins RIPK1, NLRP3) through coordinated action E1, E2, E3 enzymes, affects cell death pathways such necroptosis pyroptosis, release factors. Deubiquitinating enzymes (DUBs), on other hand, influence intensity sepsis counter-regulating ubiquitination process balancing pro- anti-inflammatory signals. This review focuses how PAMP DAMP activate via PRRs, central role deubiquitination development sepsis, especially mechanisms regulating secretion death. By deeply dissecting impact balance regulation, we further envision potential therapeutic target sepsis.

Language: Английский

Citations

0