Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care DOI Creative Commons
Florence Back, Alexandre Barras,

Ariunjargal Nyam‐Erdene

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Platelet extracellular vesicles (pEVs) isolated from clinical‐grade human platelet concentrates are attracting attention as a promising agent for wound healing therapies. Although pEVs have shown potential skin regeneration, their incorporation into bandages has remained limitedly explored. Herein, gelatine‐based hydrogel (PAH‐G) foams loading and release formulated by crosslinking gelatine with poly(allylamine) hydrochloride (PAH) in the presence of glutaraldehyde sodium bicarbonate. The optimized PAH‐G foam, PAH 0.24 G 37 , displayed an elastic modulus G’ = 8.5 kPa at °C retained rubbery state elevated temperatures. excellent swelling properties allowed to easily absorb high concentration (1 × 10 11 particles mL −1 ). therapeutic effect was evaluated vivo on chronic rat model. These studies demonstrated full closure after 14 days upon treatment @pEVs. maintenance reduced‐inflammatory environment onset promoted quicker transition remodeling. Promotion follicle activation angiogenesis well M1–M2 macrophage modulation evidenced. Altogether, multifunctional @pEVs addressed complex challenges associated diabetic wounds, representing significant advance toward personalized regimens these conditions.

Language: Английский

Platelet extracellular vesicles-loaded hydrogel bandages for personalized wound care DOI
Sabine Szunerits, Andrew E.‐Y. Chuang, Jen‐Chang Yang

et al.

Trends in biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Human platelet lysate: a potential therapeutic for intracerebral hemorrhage DOI Creative Commons

Dachang Qiu,

Lin Wang, Lanlan Wang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 15, 2025

Intracerebral hemorrhage (ICH) is a major public health challenge worldwide, and associated with elevated rates of mortality, disability, morbidity, especially in low- middle-income nations. However, our knowledge the detailed molecular processes involved ICH remains insufficient, particularly those secondary injury stage, resulting lack effective treatments for ICH. Human platelet lysates (HPL) are abundant bioactive factors, numerous studies have demonstrated their beneficial effects on neurological diseases, including anti-neuroinflammatory ability, anti-oxidant effects, maintenance blood-brain barrier integrity, promotion neurogenesis. In this review, we thoroughly explore potential HPL treating from three critical perspectives: rationale selecting as treatment ICH, mechanisms through which contributes to management, additional measures necessary We elucidate role platelets pathophysiology highlight limitations current options advancements preclinical research application disorders. Furthermore, historical developments preparation methods field biomedicine discussed. Additionally, summarize molecules present therapeutic Finally, outline issues that must be addressed regarding utilizing modality

Language: Английский

Citations

0
Intranasal delivery of epigallocatechin gallate-laden platelet extracellular vesicles for mitigating retinal glaucoma DOI

Wen-Yu Pan,

Pei-Wei Weng,

Shen-Han Wu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113596 - 113596

Published: March 1, 2025

Language: Английский

Citations

0
Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions DOI Creative Commons

Sam Dehghani,

Ozgecan Ocakcı,

Pars Tan Hatipoglu

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Neurodegenerative diseases (NDs) like Alzheimer’s, Parkinson’s, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability insufficient blood–brain barrier (BBB) permeability. Recently, exosomes—nanoscale vesicles packed with proteins, RNAs, lipids—have emerged as promising agents potential reshape therapeutic approaches these diseases. Unlike drug carriers, they naturally traverse BBB can deliver bioactive molecules affected neural cells. Their molecular cargo influence cell signaling, reduce neuroinflammation, potentially slow neurodegenerative progression. Moreover, exosomes serve non-invasive biomarkers, enabling precise while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded molecules, enhance this capability targeting diseased neurons overcoming barriers. By offering enhanced reduced immunogenicity, an ability bypass physiological limitations, exosome-based present a transformative advantage over existing approaches. This review examines multifaceted role of NDDs, emphasizing their capabilities, intrinsic functions, advanced vehicles.

Language: Английский

Citations

0
Unveiling exosomal biomarkers in neurodegenerative diseases: LC-MS-based profiling DOI
Yan-long Bi, Liang Wang, Chunyan Li

et al.

Extracellular Vesicle, Journal Year: 2025, Volume and Issue: 5, P. 100071 - 100071

Published: March 22, 2025

Language: Английский

Citations

0
Platelet Extracellular Vesicles as Natural Delivery Vehicles for Mitochondrial Dysfunction Therapy? DOI Creative Commons

Hsien Chang Yeh,

Kirti Gupta,

Ya-Hsuan Lu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care DOI Creative Commons
Florence Back, Alexandre Barras,

Ariunjargal Nyam‐Erdene

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Platelet extracellular vesicles (pEVs) isolated from clinical‐grade human platelet concentrates are attracting attention as a promising agent for wound healing therapies. Although pEVs have shown potential skin regeneration, their incorporation into bandages has remained limitedly explored. Herein, gelatine‐based hydrogel (PAH‐G) foams loading and release formulated by crosslinking gelatine with poly(allylamine) hydrochloride (PAH) in the presence of glutaraldehyde sodium bicarbonate. The optimized PAH‐G foam, PAH 0.24 G 37 , displayed an elastic modulus G’ = 8.5 kPa at °C retained rubbery state elevated temperatures. excellent swelling properties allowed to easily absorb high concentration (1 × 10 11 particles mL −1 ). therapeutic effect was evaluated vivo on chronic rat model. These studies demonstrated full closure after 14 days upon treatment @pEVs. maintenance reduced‐inflammatory environment onset promoted quicker transition remodeling. Promotion follicle activation angiogenesis well M1–M2 macrophage modulation evidenced. Altogether, multifunctional @pEVs addressed complex challenges associated diabetic wounds, representing significant advance toward personalized regimens these conditions.

Language: Английский

Citations

2