Intra‐pancreatic fat is associated with continuous glucose monitoring metrics

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(6), P. 2359 - 2367

Published: March 26, 2024

To investigate the relationship of fat in pancreas with time spent different glycaemic ranges.

Language: Английский

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Impact of acute glycemic variability on short-term outcomes in patients with ST-segment elevation myocardial infarction: a multicenter population-based study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 7, 2024

Abstract Background Given the increasing attention to glycemic variability (GV) and its potential implications for cardiovascular outcomes. This study aimed explore impact of acute GV on short-term outcomes in Chinese patients with ST-segment elevation myocardial infarction (STEMI). Methods enrolled 7510 consecutive diagnosed STEMI from 274 centers China. was assessed using coefficient variation blood glucose levels. Patients were categorized into three groups according tertiles (GV1, GV2, GV3). The primary outcome 30-day all-cause death, secondary major adverse events (MACEs). Cox regression analyses conducted determine independent correlation between Results A total 7136 included. During 30-days follow-up, there a significant increase incidence death MACEs higher tertiles. mortality rates 7.4% GV1, 8.7% GV2 9.4% GV3 ( p = 0.004), while 11.3%, 13.8% 15.8% respectively < 0.001). High levels during hospitalization significantly associated an increased risk MACEs. When analyzed as continuous variable, independently (hazard ratio [HR] 1.679, 95% confidence Interval [CI] 1.005–2.804) (HR 2.064, CI 1.386–3.074). Additionally, when categorical variables, group found predict MACEs, irrespective presence diabetes mellitus (DM). Conclusion Our findings indicate that high MACE STEMI. Moreover, emerged predictor risk, regardless DM status.

Language: Английский

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Acute Hyperglycemia-Induced Injury in Myocardial Infarction

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8504 - 8504

Published: Aug. 4, 2024

Acute hyperglycemia is a transient increase in plasma glucose level (PGL) frequently observed patients with ST-elevation myocardial infarction (STEMI). The aim of this review to clarify the molecular mechanisms whereby acute impacts coronary flow and perfusion (AMI) discuss consequent clinical prognostic implications. We conducted comprehensive literature on causes damage driven by context AMI. negative impact high PGL admission recognizes multifactorial etiology involving endothelial function, oxidative stress, production leukocyte adhesion molecules, platelet aggregation, activation coagulation cascade. current evidence suggests that all these pathophysiological compromise as whole not only culprit artery. admission, regardless whether or diabetes mellitus history, could be, thus, identified predictor worse reperfusion poorer prognosis In order reduce hyperglycemia-related complications, it seems rational pursue an adequate quick control PGL, despite best pharmacological treatment for still remaining matter debate.

Language: Английский

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Medical Genetics, Genomics and Bioinformatics Aid in Understanding Molecular Mechanisms of Human Diseases

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(18), P. 9962 - 9962

Published: Sept. 15, 2021

Molecular mechanisms of human disease progression often have complex genetic underpinnings, and sophisticated sequencing approaches coupled with advanced analytics [...].

Language: Английский

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The additive effect of essential hypertension on coronary artery plaques in type 2 diabetes mellitus patients: a coronary computed tomography angiography study

Cardiovascular Diabetology, Journal Year: 2022, Volume and Issue: 21(1)

Published: Jan. 4, 2022

Abstract Background The effect of comorbid hypertension and type 2 diabetes mellitus (T2DM) on coronary artery plaques examined by computed tomography angiography (CCTA) is not fully understood. We aimed to comprehensively assess whether T2DM influence using CCTA. Materials methods A total 1100 patients, namely, 277 normotensive [T2DM(HTN−)] 823 hypertensive [T2DM(HTN +)] individuals, 1048 patients without (control group) who had detected CCTA were retrospectively enrolled. Plaque type, stenosis, diseased vessels, the segment involvement score (SIS) stenosis (SSS) based data evaluated compared among groups. Results Compared with in control group, T2DM(HTN−) T2DM(HTN +) groups more partially calcified plaques, noncalcified segments obstructive a higher SIS SSS (all P values < 0.001). increased odds having any plaque [odds ratio (OR) = 1.669 1.278, respectively; both 0.001]; T2DM(HTN-) (OR 1.514 2.323; 0.005 0.001, respectively), disease (CAD) 1.629 1.992; 0.001 multivessel 1.892 3.372; P-values 0.001), an > 3 2.233 3.769; 0.001) 5 2.057 3.580; risk 1.561; 0.005), 1.867; 1.647; 1.625; Conclusion related presence CAD, extensive plaques. Comorbid further increase

Language: Английский

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Acute glycemic variability and risk of mortality in patients with sepsis: a meta-analysis

Diabetology & Metabolic Syndrome, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 23, 2022

Acute glycemic variability (GV) has been correlated with the severity of sepsis. The aim study was to evaluate potential association between acute GV and mortality risk in patients

Language: Английский

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Diabetic neuropathy: Pathogenesis and evolving principles of management

Disease-a-Month, Journal Year: 2023, Volume and Issue: 69(9), P. 101582 - 101582

Published: May 8, 2023

Language: Английский

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Noninvasive Blood Glucose Monitoring Using Spatiotemporal ECG and PPG Feature Fusion and Weight-Based Choquet Integral Multimodel Approach

IEEE Transactions on Neural Networks and Learning Systems, Journal Year: 2023, Volume and Issue: 35(10), P. 14491 - 14505

Published: June 8, 2023

change of blood glucose (BG) level stimulates the autonomic nervous system leading to variation in both human's electrocardiogram (ECG) and photoplethysmogram (PPG). In this article, we aimed construct a novel multimodal framework based on ECG PPG signal fusion establish universal BG monitoring model. This is proposed as spatiotemporal decision strategy that uses weight-based Choquet integral for monitoring. Specifically, performs three-level fusion. First, signals are collected coupled into different pools. Second, temporal statistical features spatial morphological extracted through numerical analysis residual networks, respectively. Furthermore, suitable determined with three feature selection techniques, compressed by deep neural networks (DNNs). Lastly, multimodel integrated coupling algorithms features. To verify feasibility model, total 103 days encompassing 21 participants were article. The levels ranged between 2.2 21.8 mmol/L. results obtained show model has excellent performance root-mean-square error (RMSE) 1.49 mmol/L, mean absolute relative difference (MARD) 13.42%, Zone A $+$ B 99.49% tenfold cross-validation. Therefore, conclude approach potentials practical applications diabetes management.

Language: Английский

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Serum Cytokines and Growth Factors in Subjects with Type 1 Diabetes: Associations with Time in Ranges and Glucose Variability

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2843 - 2843

Published: Oct. 19, 2023

The detrimental effect of hyperglycemia and glucose variability (GV) on target organs in diabetes can be implemented through a wide network regulatory peptides. In this study, we assessed broad panel serum cytokines growth factors subjects with type 1 (T1D) estimated associations between concentrations these molecules time ranges (TIRs) GV. One hundred thirty T1D twenty-seven individuals normal tolerance (control) were included. Serum levels 44 measured using multiplex bead array assay. TIRs GV parameters derived from continuous monitoring. Subjects compared to control demonstrated an increase IL-1β, IL-1Ra, IL-2Rα, IL-3, IL-6, IL-7, IL-12 p40, IL-16, IL-17A, LIF, M-CSF, IFN-α2, IFN-γ, MCP-1, MCP-3, TNF-α. Patients TIR ≤ 70% had higher IL-1α, p70, RANTES, TNF-α, TNF-β, b-NGF, lower IL-4, IL-10, GM-CSF, MIF than those > 70%. SCF, TNF-α correlated above range. IL-8, MIF, SDF-1α related at least one amplitude-dependent metric. logistic regression models, HGF, associated 70%, PDGF-BB coefficient variation values ≥ 36%. These results provide further insight into the pathophysiological effects people diabetes.

Language: Английский

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Glucose variability in subjects with normal glucose tolerance: Relations with body composition, insulin secretion and sensitivity

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2022, Volume and Issue: 16(1), P. 102387 - 102387

Published: Jan. 1, 2022

Language: Английский

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