Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 14, 2023

Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection prevention those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study plasma levels low-molecular-weight metabolites (LMWMs) a cohort 307 patients with assess their relationships type-2 diabetes (T2D) incident atherosclerotic disease (ASCVD).We conducted cross-sectional prospective study. We included attending Lipid Unit our University Hospital for treatment following disturbances associated disorders: T2D (73.9%), obesity (58.7%), hypertension (55.1%). 1H-NMR was used 13 LMWMs. LMWM serum concentrations were evaluated without T2D. correlations several parameters associations analyzed. The association between at baseline development ASCVD after 10 years follow-up also evaluated.Among LMWMs measured, branched-chain amino acids (BCAAs) valine, leucine isoleucine showed positive clinical lipid-related biochemical inflammatory markers (p < 0.05). Likewise, these three BCAAS even adjusting covariates During period years, 29 185 (15.68%) developed ASCVD. After covariates, valine alanine 0.05).Overall, results indicated that measured by could be potential Moreover, risk this disease.

Language: Английский

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Clinical and social characterization of patients hospitalized for COPD exacerbation using Machine Learning tools

Archivos de Bronconeumología, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Triglyceride-glucose index is associated with recurrent revascularization in patients with type 2 diabetes mellitus after percutaneous coronary intervention

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 21, 2023

Abstract Background The Triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, is independently associated with the severity coronary artery lesions and prognosis heart disease. investigation aimed to explore relationship between TyG index recurrent revascularization in individuals type 2 diabetes mellitus (T2DM) resulting from progression or in-stent restenosis (ISR) after percutaneous intervention (PCI). Method A total 633 patients who met inclusion exclusion criteria were enrolled divided into three groups based on tertiles index. primary endpoint was ISR. All-cause death considered competing risk event. Competing analysis Cox regression for predicting PCI conducted stepwise. Variables standardized make hazard ratio (HR), subdistribution (SHR) corresponding 95% CI more consistent prior being used fitting multivariate model. predictive ability evaluated using several measures, including ROC curve, likelihood test, Akaike’s information criteria, category-free continuous net reclassification improvement (cNRI > 0), integrated discrimination (IDI). Internal validation through bootstrapping 1000 resamples. Results During median follow-up period 18.33 months, 64 (10.11%) experienced revascularization, 55 cases lesion 9 restenosis. After controlling competitive events, higher [SHR:1.4345, (95% 1.1458–1.7959), P = 0.002]. test showed that significantly improves prognostic ability. Additionally, adding improved established model indicated by C-index 0.759 0.724–0.792, < 0.01), cNRI 0 0.170 0.023–0.287, 0.05), an IDI 0.024 0.009–0.039, 0.002). These results remained when models containing confirmed internal bootstrap method. Conclusion findings highlight potential predictor revascularization. Lesion emerged contributor instead incorporation prediction likely be beneficial accurate stratification order improve prognosis.

Language: Английский

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Effect of systolic blood pressure status on coronary inflammation and high-risk plaque characteristics

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(4)

Published: Feb. 28, 2025

Inadequately controlled hypertension often leads to an increased cardiovascular death rate in type 2 diabetes mellitus (T2DM). It remains unclear whether systolic blood pressure (SBP) status of is related coronary inflammation and plaques T2DM. To evaluate SBP variability (SBPV) levels are T2DM patients using computed tomography angiography (CCTA). This retrospective study involved 881 with CCTA images, including 668 213 normotension patients. Hypertension were subgroup based on status: (1) SBPV: Low (< 8.96 mmHg) high (≥ groups; (2) levels: Controlled 140 uncontrolled groups. Pericoronary adipose tissue (PCAT) attenuation, high-risk (HRPs) obstructive stenosis (OS) evaluated by CCTA. Propensity score matching was utilized compare these findings for The impact SBPV multivariate logistic regression multivariable linear regression. PCAT attenuation the left anterior descending artery (LAD), any low plaque (LAP), spotty calcification (SC), positive remodeling (PR), OS had significant differences between group group, as well or (all P < 0.05). independently positively correlated LAD-PCAT (β = 1.815, 0.010), LAP (OR 1.612, 0.019), SC 1.665, 0.013), PR 1.549, 0.033), 1.928, 0.036) all Additionally, (high β 1.673, 0.048; SBP: 2.370, 0.004) OR 1.903, 2.230, 0.013) hypertension. hypertension, and/or levels, may be inflammation, HRPs, T2DM, leading risk. Achieving both simultaneously, especially individuals warrants clinical attention.

Language: Английский

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Sex-Specific Association between Systolic Blood Pressure Time in Target Range and Cardiovascular Outcomes: A Post-Hoc Analysis of the SPRINT Trial

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 18, 2025

Systolic blood pressure time in target range (SBP TTR) is a novel metric for control. Previous studies have demonstrated an inverse association between SBP TTR and risks of cardiovascular events, but sex differences never been reported. This study aims to investigate the sex-specific relationship using data from Blood Pressure Intervention Trial (SPRINT). post hoc analysis included 8822 SPRINT participants with at least three follow-up systolic (SBP) measurements within first months. was calculated Rosendaal method linear interpolation. The primary endpoint major adverse cerebrovascular events (MACCE). Cox proportional hazards models restricted cubic splines (RCS) were used assess events. Women accounted 35.3% mean age 68.6 ± 9.5 years, having higher body mass index (p = 0.007) lower compared men < 0.001). In overall population women, each standard deviation (SD) increase associated reduced risk MACCE (adjusted hazard ratio (HR) 0.89; 95% confidence interval (CI) 0.82-0.97; p 0.007, adjusted HR 0.85; CI 0.74-0.99; 0.039, respectively) acute decompensated heart failure 0.86; 0.73-0.99; 0.047, 0.68; 0.51-0.92; 0.011, respectively), while this not observed men. RCS indicated similar trend only when exceeded 39%. Additional adjustments variability yielded outcomes. demonstrates that failure, men, higher, underscoring necessity considering personalized management strategies. NCT01206062, https://www.clinicaltrials.gov/expert-search?term=NCT01206062.

Language: Английский

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Effect of atherogenic index of plasma and triglyceride-glucose index on early neurological deterioration of patients with large artery atherosclerotic ischemic stroke

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 9, 2025

Abstract Background Stroke due to large artery atherosclerosis (LAA-stroke) has a poor early prognosis despite appropriate medical treatment. Recently, various parameters reflecting pathological conditions such as insulin resistance or atherogenic dyslipidemia have been proposed using triglyceride (TG) and other biomarkers. In this study, we evaluated the association between TG andTG-related neurological deterioration (END) in patients with acute LAA stroke. Methods We consecutive LAA-stroke January 2010 December 2020. TG-related were calculated following formulas: index of plasma (AIP) = log 10 (TG level/high-density lipoprotein level) TG-glucose (TyG) Ln level x glucose level/2). END was defined an increase ≥ 2 total National Institutes Health Scale (NIHSS) score 1 motor NIHSS within first 72 h admission. Results Six hundred forty evaluated. multivariable analyses, AIP (adjusted odds ratio [aOR]: 1.93, 95% confidence interval: 1.32–2.82) closely associated after adjustment for confounders. The TyG (aOR: 2.22, 1.51–3.27) also showed close END. significant differences no groups only caused by intracranial atherosclerosis. addition, related artery-to-artery embolism branch atheromatous disease mechanisms. Conclusions found that occurrence LAA-stroke. This appeared differently depending on location mechanism relevant vessel

Language: Английский

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Machine learning profiles of cardiovascular risk in patients with diabetes mellitus: the Silesia Diabetes-Heart Project

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 24, 2023

As cardiovascular disease (CVD) is a leading cause of death for patients with diabetes mellitus (DM), we aimed to find important factors that predict (CV) risk using machine learning (ML) approach.We performed single center, observational study in cohort 238 DM (mean age ± SD 52.15 17.27 years, 54% female) as part the Silesia Diabetes-Heart Project. Having gathered patients' medical history, demographic data, laboratory test results, results from Michigan Neuropathy Screening Instrument (assessing diabetic peripheral neuropathy) and Ewing's battery examination (determining presence autonomic neuropathy), managed use ML approach occurrence overt CVD on basis five most discriminative predictors area under receiver operating characteristic curve 0.86 (95% CI 0.80-0.91). Those features included past or current foot ulceration, age, treatment beta-blocker (BB) angiotensin converting enzyme inhibitor (ACEi). On aforementioned parameters, unsupervised clustering identified different CV groups. The highest was determined eldest treated large extent ACEi but not BB having slightly younger individuals extensively both above-mentioned drugs, relatively small percentage ulceration.Using prospective DM, predicted risk. If patient BB, older has/had ulcer, this strongly predicts he/she at high CVD.

Language: Английский

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Metabolomics signature of cardiovascular disease in patients with diabetes, a narrative review

Journal of Diabetes & Metabolic Disorders, Journal Year: 2023, Volume and Issue: 22(2), P. 985 - 994

Published: July 14, 2023

Language: Английский

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The prognostic significance of insulin resistance in COVID-19: a review

Journal of Diabetes & Metabolic Disorders, Journal Year: 2024, Volume and Issue: 23(1), P. 305 - 322

Published: Jan. 20, 2024

Language: Английский

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Vascular Risk Factors and Brain Health in Aging: Insights from a Community-Based Cohort Study

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(4), P. 1361 - 1374

Published: May 21, 2024

Background: The aging population and high rates of Alzheimer’s disease (AD) create significant medical burdens, prompting a need for early prevention. Targeting modifiable risk factors like vascular (VRFs), closely linked to AD, may provide promising strategy intervention. Objective: This study investigates how VRFs influence cognitive performance brain structures in community-based cohort. Methods: In this cross-sectional study, 4,667 participants over 50 years old, drawn from the Beijing Ageing Brain Rejuvenation Initiative project, were meticulously examined. Cognitive function (diabetes mellitus, hypertension, hyperlipidemia, obesity, smoking), comprehensively assessed through one-to-one interviews. Additionally, subset ( n = 719) underwent MRI, encompassing T1-weighted diffusion-weighted scans, elucidate gray matter volume white structural network organization. Results: findings unveil diabetes as potent detriment memory, manifesting atrophy within right supramarginal gyrus diminished nodal efficiency degree centrality inferior parietal lobe. Hypertension solely impaired memory without changes. Intriguingly, individuals with comorbid hypertension exhibited most pronounced deficits both structure performance. Remarkably, hyperlipidemia emerged factor associated enhanced cognition, preservation structure. Conclusions: illuminates intricate associations between varied patterns damage. Notably, synergistic effect emerges particularly deleterious. These underscore imperative tailor interventions patients distinct VRF comorbidities, especially when addressing decline

Language: Английский

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