Association between different insulin resistance surrogates and all-cause mortality in patients with coronary heart disease and hypertension: NHANES longitudinal cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 28, 2024

Abstract Background Studies on the relationship between insulin resistance (IR) surrogates and long-term all-cause mortality in patients with coronary heart disease (CHD) hypertension are lacking. This study aimed to explore different IR identify valuable predictors of survival status this population. Methods The data came from National Health Nutrition Examination Survey (NHANES 2001–2018) Death Index (NDI). Multivariate Cox regression restricted cubic splines (RCS) were performed evaluate homeostatic model assessment (HOMA-IR), triglyceride glucose index (TyG index), glucose-body mass (TyG-BMI index) mortality. recursive algorithm was conducted calculate inflection points when segmenting effects found. Then, segmented Kaplan–Meier analysis, LogRank tests, multivariable carried out. Receiver operating characteristic (ROC) calibration curves drawn differentiation accuracy predicting Stratified analysis interaction tests according age, gender, diabetes, cancer, hypoglycemic lipid-lowering drug use. Results 1126 participants included study. During median follow-up 76 months, 455 died. RCS showed that HOMA-IR had a effect 3.59 statistically significant point. When less than 3.59, it negatively associated [HR = 0.87,95%CI (0.78, 0.97)]. Conversely, greater positively 1.03,95%CI (1.00, 1.05)]. ROC indicated reliable predictor (area under curve 0,812). No interactions stratified variables Conclusion U-shaped CHD hypertension.

Language: Английский

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Association of the triglyceride-glucose index with all-cause and cardiovascular mortality in patients with cardiometabolic syndrome: a national cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 24, 2024

Abstract Objective This study aimed to evaluate the association of triglyceride-glucose (TyG) index with all-cause and cardiovascular mortality risk among patients cardiometabolic syndrome (CMS). Methods We performed a cohort 5754 individuals CMS from 2001–2018 National Health Nutrition Examination Survey. The TyG was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate Cox proportional hazards regression models assessed associations between . Non-linear correlations threshold effects were explored using restricted cubic splines two-piecewise model. Results Over median follow-up 107 months, 1201 deaths occurred, including 398 disease-related deaths. multivariate model showed positive mortality. Each one-unit increase in associated 16% (HR: 1.16, 95% CI 1.03, 1.31, P = 0.017) 39% 1.39, 1.14, 1.71, 0.001) after adjusting for confounders. revealed U-shaped ( nonlinear < 0.044), identifying values (all-cause mortality: 9.104; 8.758). A below these thresholds displayed negative 0.58, 0.38, 0.90, 0.015) but not 0.39, 0.12, 1.27, 0.119). Conversely, exceeding positively 1.35, 1.17, 1.55, 0.001; HR: 1.54, 1.25, 1.90, 0.001, respectively). Notably, higher (≥ values) significantly increased only aged under 55 compared those lower (< values). Conclusions demonstrated correlation CMS. 9.104 8.758 mortality, respectively, may be used intervention targets reduce premature death disease.

Language: Английский

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Association between estimated glucose disposal rate and cardiovascular diseases in patients with diabetes or prediabetes: a cross-sectional study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

Insulin resistance proxy indicators are significantly associated with cardiovascular disease (CVD) and diabetes. However, the correlations between estimated glucose disposal rate (eGDR) index CVD its subtypes have yet to be thoroughly researched. 10,690 respondents diabetes prediabetes from NHANES 1999-2016 were enrolled in study. Three machine learning methods (SVM-RFE, XGBoost, Boruta algorithms) employed select most critical variables. Logistic regression models established evaluate association eGDR CVD. We applied ROC curves, C-statistics, NRI, IDI, calibration DCA curves assess model performance. Subgroup analyses conducted investigate among different subgroups. Participants higher quartile showed a decreased prevalence of Multivariate logistic RCS demonstrated that had an independently negative linear correlation likelihood CVD[Q4 vs. Q1: OR 0.24(0.18,0.32)], CAD[OR 0.81(0.78,0.85)], CHF[OR 0.81(0.76,0.86)], stroke[0.85(0.80,0.90)]. Model evaluation better performance fully adjusted than basic models[C-statistics(Model 3 1): CVD(0.683 0.814), CAD(0.672 0.807), CHF(0.714 0.839) stroke(0.660 0.790)]. The AUCs values other IR surrogates unadjusted models, slightly models. indicated results robust. A lower was heightened diabetic prediabetic populations. And exhibited evaluating associations compared proxies encompassing TyG, HOMA-IR, QCUIKI, METS-IR, etc.

Language: Английский

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The triglyceride–glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 29, 2025

Language: Английский

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Association between triglyceride–glucose index trajectories and radiofrequency ablation outcomes in patients with stage 3D atrial fibrillation

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 5, 2024

Abstract Background This study investigates the relationship between triglyceride-glucose (TyG) index trajectories and results of ablation in patients with stage 3D atrial fibrillation (AF). Methods A retrospective cohort was carried out on who underwent AF Radiofrequency Catheter Ablation (RFCA) at Cardiology Department Fourth Affiliated Hospital Zhejiang University Taizhou Province from January 2016 to December 2022. The main clinical endpoint determined as occurrence arrhythmia for least 30 s following a 3-month period after ablation. Using latent class trajectory model, different groups were identified based TyG levels. outcome recurrence assessed through Kaplan-Meier survival curve analysis multivariable Cox proportional hazards regression model. Results included 997 participants, an average age 63.21 ± 9.84 years, whom 630 males (63.19%). mean follow-up participants 30.43 17.75 months, during which 200 individuals experienced recurrence. Utilizing minimum Bayesian Information Criterion (BIC) maximum Entropy principle, levels post-AF RFCA divided into three groups: Locus 1 low-low group ( n = 791), 2 low-high-low 14), 3 high-high 192). Significant differences rates among observed P < 0.001). Multivariate showed significant association baseline level outcomes (HR 1.255, 95% CI: 1.087–1.448). Patients above 9.37 had higher risk adverse compared those below 8.67 2.056, 1.335–3.166). Furthermore, incidence 1.580, 1.146-2). Conclusion are significantly linked Continuous monitoring may help identifying high recurrence, enabling early application effective interventions.

Language: Английский

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Triglyceride-Glucose Index as Predictor for Hypertension, CHD and STROKE Risk among Non-Diabetic Patients: A NHANES Cross-Sectional Study 2001–2020

Journal of Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: 14(3), P. 1152 - 1166

Published: July 2, 2024

Cardiovascular disease (CVD) is a leading cause of global mortality. Early intervention and prevention CVD depend on accurately predicting the risk CVD. This study aimed to investigate association between TyG index coronary heart (CHD), congestive failure (CHF), attack (HA), stroke, hypertension (HTN) among patients without diabetes in United States.

Language: Английский

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Association of the triglyceride-glucose index and its related parameters with frailty

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 21, 2024

Abstract Background Frailty is a dynamic geriatric condition. Limited studies have examined the association of triglyceride-glucose (TyG) index and its related indicators [TyG index, triglyceride glucose-waist to height ratio (TyG-WHtR), circumference (TyG-WC), glucose-body mass (TyG-BMI)] with frailty, potential links among them remain unclear. On basis data from National Health Nutrition Examination Survey (NHANES), this study investigated relationships TyG indices frailty. Methods This research included 7,965 participants NHANES 2003–2018. The relationship frailty was binary logistic regression analyses, restricted cubic spline (RCS), receiver operating characteristic (ROC) curve. Potential influences were further through stratified analyses interaction tests. Results prevalence in 25.59%, average 0.16 (0.00). In three analysis models, continuous associated positively addition, quartiles TyG, TyG-WC, TyG-WHtR, TyG-BMI significantly increased fully adjusted models (TyG Q4 vs. Q1, OR = 1.58, 95% CI: 1.19, 2.09, P 0.002; TyG-WC 2.40, 1.90, 3.04, < 0.001; TyG-WHtR 2.26, 1.82, 2.81, TyG- BMI 2.16, 1.76, 2.64, 0.001). According RCS analysis, linearly ROC curves revealed that (AUC: 0.654) had greater diagnostic value for than 0.604), 0.621), 0.629). All tests showed similar results. Conclusions Elevated associaed are an Reasonable control blood glucose lipids, avoidance obesity, may aid reducing occurrence middle-aged older adults.

Language: Английский

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The change of inflammatory markers may predict long-term major adverse cardiovascular events in elderly patients with coronary heart disease: a retrospective cohort study

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 13, 2025

At present, the relationship among inflammatory markers [monocytes/HDL-c (MHR), neutrophils/HDL-c (NHR) and lymphocytes/HDL-c (LHR)] long-term prognosis of coronary heart disease (CHD) is still unclear. Therefore, this study explores between indicators risk major adverse cardiovascular events (MACE) in elderly patients with CHD. A retrospective analysis was conducted on 208 who underwent angiography at Wuhan Fourth Hospital from August 2022 to 2023. They were divided into CHD group (N = 116) control 92). Patients followed up for 1 year MACE 36) non-MACE 80) according whether occurred. In patients, logistic regression shows that MHR an independent factor (OR 3.050, 95% CI 1.318-1.772). ROC curve found (AUC 0.865, 0.811-0.919, p < 0.001) higher than NHR LHR. CHD, spearman show positively correlated Gensini score (R 0.266, 0.004). The factors 6.048, 1.224-1.941, 0.002). showed critical value predict 0.651, sensitivity 58.3% specificity 90.0% could MACE, AUC 0.793 (95% 0.702-0.884, predictor severity artery lesions.

Language: Английский

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Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims establish relationship and direction insulin cognition, while also quantifying mediating role brain cortical structure in this association. The publicly available data sources for (fasting insulin, homeostasis model assessment beta-cell function resistance, proinsulin), structure, cognitive phenotypes (visual memory, reaction time) were obtained from MAGIC, ENIGMA, UK Biobank datasets, respectively. We first conducted bidirectional two-sample Mendelian randomization (MR) analysis examine susceptibility on phenotypes. Additionally, we applied two-step MR assess surficial area thickness pathway impairment. primary Inverse-variance weighted, accompanied by robust sensitivity analysis, was implemented explore verify our findings. reverse performed evaluate effect cognition structure. This study identified genetically determined elevated level proinsulin increased time (beta=0.03, 95% confidence interval [95%CI]=0.01 0.05, p=0.005), decreasing surface rostral middle frontal (beta=-49.28, 95%CI=-86.30 -12.27, p=0.009). mediated 20.97% (95%CI=1.44% 40.49%) total time. No evidence heterogeneity, pleiotropy, or causality observed. Briefly, noticed that adversely affected with partial mediation through alterations

Language: Английский

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Triglyceride-glucose index predicts adverse cardiovascular events in patients with H-type hypertension combined with coronary heart disease: a retrospective cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 29, 2025

Language: Английский

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