Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 856 - 870
Published: Nov. 1, 2024
Language: Английский
Circulation Research, Journal Year: 2025, Volume and Issue: 136(5), P. 524 - 550
Published: Feb. 27, 2025
Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.
Language: Английский
Citations
3
Cardiovascular Research, Journal Year: 2024, Volume and Issue: 120(11), P. 1265 - 1278
Published: May 13, 2024
Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular (CV) diseases. Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycaemic states that may manifest as T2D. Pro-apoptotic ceramides modulate sensitivity glucose tolerance while being linked to poor CV outcomes. Sirtuin-1 (SIRT1) is a NAD + -dependent deacetylase protects against pancreatic dysfunction; however, systemic levels decreased in obese-T2D mice promote hyperglycaemia. Herein, we aimed assess the effects of restoring circulating SIRT1 prevent metabolic imbalance obese diabetic mice.
Language: Английский
Citations
5
Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: April 21, 2025
Epigenomics is a rapidly emerging field that has gathered significant attention as "non-genetic determinant" implicated in the manifestation of non-communicable diseases. Exploring epigenetic modifications provides novel insights into management cardiometabolic disease (CMD). Epigenetics signatures are influenced by environmental stressors such air pollution, toxins, and urban noises well established cardiovascular risk factors including smoking, sedentary lifestyle, obesity, diabetes. Understanding how alterations lead to CMD inter-individual differences makeup could unveil new molecular targets epi-drugs be employed for precision medicine approaches growing population patients with reduce risk. Herein, we provide an overview latest advancements mechanisms possible therapeutic opportunities.
Language: Английский
Citations
0
Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown
Published: May 5, 2025
Language: Английский
Citations
0
AJP Heart and Circulatory Physiology, Journal Year: 2024, Volume and Issue: 326(6), P. H1498 - H1514
Published: April 19, 2024
Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common cause of pulmonary hypertension (PH) worldwide and strongly associated adverse clinical outcomes. The American Association recently highlighted a call to action regarding distinct lack evidence-based treatments for PH due poorly understood pathophysiology attributable HFpEF (PH-HFpEF). Prior studies have described cardiophysiological mechanisms explain development isolated postcapillary (ipc-PH); however, consequent increase in vascular (PV) resistance (PVR) may lead less more fatal combined pre- (cpc-PH). Metabolic disease inflammatory dysregulation been suggested predispose PH, yet molecular are unknown. Although PH-HFpEF has studied partly share vasoactive neurohormonal mediators primary arterial (PAH), trials that targeted these pathways unsuccessful. increased mortality patients necessitates further study into viable mechanistic targets involved progression. We aim summarize current pathophysiological understanding PH-HFpEF, highlight role known progression PV disease, introduce novel concept lipid metabolism be attenuating propagating PH-HFpEF.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7740 - 7740
Published: July 15, 2024
With increasing research, the sirtuin (SIRT) protein family has become increasingly understood. Studies have demonstrated that SIRTs can aid in metabolism and affect various physiological processes, such as atherosclerosis, heart failure (HF), hypertension, type 2 diabetes, other related disorders. Although pathogenesis of HF with preserved ejection fraction (HFpEF) not yet been clarified, a role its development. Therefore, may offer fresh approach to diagnosis, treatment, prevention HFpEF novel therapeutic intervention target.
Language: Английский
Citations
2
JACC Basic to Translational Science, Journal Year: 2024, Volume and Issue: 9(10), P. 1211 - 1230
Published: July 31, 2024
Dilated cardiomyopathy (DCM) is associated with high mortality despite advanced therapies. The
Language: Английский
Citations
2
Cardiovascular Research, Journal Year: 2024, Volume and Issue: 120(15), P. 1835 - 1850
Published: Oct. 1, 2024
Whilst metabolic inflexibility and substrate constraint have been observed in heart failure for many years, their exact causal role remains controversial. In parallel, of our fundamental assumptions about cardiac fuel use are now being challenged like never before. For example, the emergence sodium-glucose cotransporter 2 inhibitor therapy as one four 'pillars' is causing a revisit metabolism key mechanism therapeutic target failure. Improvements field metabolomics will lead to far more granular understanding mechanisms underpinning normal abnormal human use, an appreciation drug action, novel strategies. Technological advances expanding biorepositories offer exciting opportunities elucidate aspects these mechanisms. Methodologic include comprehensive accurate quantitation such stable-isotope fluxomics, improved access arterio-venous blood samples across determine consumption energy conversion, high quality tissue biopsies, biochemical analytics, informatics. Pairing technologies with recent discoveries epigenetic regulation, mitochondrial dynamics, organ-microbiome crosstalk garner critical mechanistic insights this state-of-the-art review, we focus on new insights, eye emerging strategies Our synthesis be valuable diverse audience interest metabolism.
Language: Английский
Citations
2
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2883 - 2883
Published: May 14, 2024
Cardiometabolic diseases (CMDs) are interrelated and multifactorial conditions, including arterial hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke. Due to the burden of cardiovascular morbidity mortality associated with CMDs' increasing prevalence, there is a critical need for novel diagnostic therapeutic strategies in their management. In clinical practice, innovative methods such as epicardial adipose tissue evaluation, ventricular-arterial coupling, exercise tolerance studies could help elucidate multifaceted mechanisms CMDs. Similarly, epigenetic changes involving noncoding RNAs, chromatin modulation, cellular senescence represent both biomarkers targets Despite promising data available, significant challenges remain translating basic research findings into highlighting further investigation complex pathophysiology underlying
Language: Английский
Citations
0
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 10, 2024
Language: Английский
Citations
0