Impact of diabetes mellitus on mortality in pulmonary hypertension: A systematic review and meta-analysis DOI
Smitesh Padte, Priyal Mehta, V. Bansal

et al.

World Journal of Critical Care Medicine, Journal Year: 2024, Volume and Issue: 13(4)

Published: Oct. 31, 2024

BACKGROUND Pulmonary hypertension (PH) is a progressive disease characterized by endothelial dysfunction and vascular remodeling leading cause of mortality worldwide. Although it independently associated with multiple comorbidities, the impact diabetes mellitus (DM) on in patients PH remains uncertain. To address this issue, we conducted systematic review meta-analysis to investigate effect DM survival pulmonary hypertension. AIM patients. METHODS We comprehensive search four major electronic bibliographic databases like PubMed, Google Scholar, Scopus, Embase, identified 106 relevant studies, out 1561 articles, published since year 2000 for full-text review. Fourteen retrospective prospective cohort studies that compared between those without context were deemed eligible inclusion our meta-analysis. The study was registered PROSPERO identifier CRD42023390232. RESULTS A total 116455 included meta-analysis, whom 41228 suffered from 75227 did not. results indicate an elevated rate among comparison [odds ratio (OR) = 1.40, 95%CI: 1.15–1.70, P 0.0006]. meta-regression analysis unveiled statistically significant negative association mean age size (coefficient -0.036, value 0.018). Conversely, positive detected female proportion 0.000, < 0.001). CONCLUSION Our which approximately 116500 patients, revealed presence increased odds when non-diabetic indicates older participants lower proportions females tend exhibit smaller sizes. Clinically, these findings underscore importance incorporating status into risk stratification more aggressive monitoring early intervention improve prognosis potentially.

Language: Английский

Association between triglyceride-glucose related indices and mortality among individuals with non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Qingling Chen, Pingping Hu, Xiaoxue Hou

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 4, 2024

Abstract Background The prognostic value of triglyceride-glucose (TyG) related indices in non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic (MASLD) is still unclear. This study aimed to determine the associations between TyG-related and long-term mortality this population. Methods data came from National Health Nutrition Examination Survey (NHANES III) Death Index (NDI). Baseline TyG, TyG combining with body mass index (TyG-BMI), waist circumference (TyG-WC) were calculated, status was determined through 31 December 2019. Multivariate Cox restricted cubic spline (RCS) regression models performed evaluate relationship among participants NAFLD/MASLD. In addition, we examined association all-cause within subgroups defined by age, sex, race/ethnicity, fibrosis-4 (FIB-4). Results There 10,390 completed ultrasonography laboratory included study. NAFLD diagnosed 3672/10,390 (35.3%) participants, while MASLD 3556/10,390 (34.2%) amongst overall multivariate analyses showed high levels indices, particularly TyG-BMI TyG-WC significantly associated mortality, cardiovascular diabetes either MASLD. RCS curves a nonlinear trend three Subgroup that more suitable for predicting patients without advanced fibrosis. Conclusion Our highlights clinical survival NAFLD/MASLD would be surrogate biomarkers follow-up population

Language: Английский

Citations

26
Association of insulin resistance surrogates with disease severity and adverse outcomes in chronic thromboembolic pulmonary hypertension: a multicenter cohort study DOI Creative Commons
Luyang Gao, Sicheng Zhang, Sicong Li

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 19, 2025

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severely progressive disease that leads to right heart failure and death. Previous studies have shown diabetes insulin resistance (IR) are closely related hypertension, but the role of IR in patients with CTEPH remains unexplored. In this study, we investigated relationship between four indices severity, hemodynamic parameters, adverse outcomes CTEPH. We conducted multicenter, retrospective cohort study involving 516 diagnosed January 2013 December 2022. The metabolic score for (METS-IR), triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio, glucose (TyG) index, triglyceride-glucose-body mass (TyG-BMI) index were used quantify levels primary endpoint events clinical worsening. Multivariable Cox regression, restricted cubic splines, receiver operating characteristic analyses evaluate predictive value surrogates IR. Compared low intermediate-low risk patients, METS-IR (36.2 ± 6.7 vs. 37.7 8.7, p = 0.038) TyG-BMI (204.0 36.2 212.6 46.5, 0.022) significantly increased high intermediate-high patients. correlated markers such as World Health Organization functional class, 6-minute walk distance, N-terminal pro-brain natriuretic peptide levels. During mean 2.5 years' follow-up, 110 participants experienced all-cause death or worsening condition. independently predicted (hazard ratio: 1.27; 95% confidence interval 1.06–1.53 per 1.0-standard deviation increment, 0.009) after fully adjusting covariates. Adding COMPERA 2.0 improved its ability, reclassification discrimination ability. an independent predictor It offers convenient marker assessing severity long-term assessment.

Language: Английский

Citations

0
Association of Triglyceride-Glucose–Related Obesity Indices With All-Cause and Cardiovascular Mortality Among Individuals With Hyperuricemia: A Retrospective Cohort Study DOI
Yong Huang, Ziling Wei, Linfeng Wang

et al.

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: March 20, 2025

Objective This study sought to clarify the relationship between triglyceride-glucose (TyG)–related obesity indices and all-cause cardiovascular mortality in patients with hyperuricemia (HUA).

Language: Английский

Citations

0
Is pulmonary vascular remodeling an intermediate link between hyperglycemia and adverse outcomes in patients with idiopathic pulmonary arterial hypertension? Insights from a multi-center cohort study DOI Creative Commons
Sicheng Zhang, Luyang Gao, Sicong Li

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 28, 2024

Hyperglycemia upon admission is associated with poor prognosis of many cardiovascular diseases. However, the relationship stress hyperglycemia ratio (SHR), blood glucose (ABG), and hemoglobin A1c (HbA1c) pulmonary hypertension has not been reported. This study aimed to explore association indices disease severity long-term adverse outcomes in patients idiopathic arterial (IPAH). multi-center cohort included 625 consecutive diagnosed or treated for IPAH between January 2015 June 2023. SHR was calculated using followings: ABG (mmol/L)/(1.59 × HbA1c [%] − 2.59). The primary endpoint defined as clinical worsening events. Multivariable Cox regression restricted cubic spline analyses were employed evaluate SHR, ABG, mediating effect hemodynamics evaluated investigate potential mechanism outcomes. During a mean follow-up period 3.8 years, 219 (35.0%) experienced all-cause death correlated well-validated variables that reflected IPAH, such World Health Organization functional class, 6-min walk distance, N-terminal pro-brain natriuretic peptide levels. indicated (hazard [HR] 1.328, 95% confidence intervals [CI]: 1.185, 1.489 per 0.1-unit increment, P < 0.001) (HR 1.317, CI: 1.134, 1.529 1.0-unit independent predictors Mediation analysis vascular resistance mediated 5.65% 14.62% associations events, respectively. addition significantly improved reclassification, discrimination ability, model fit beyond risk prediction model. positively IPAH. appeared be partially through pathway remodeling, indicating may serve valuable indicator providing additional information.

Language: Английский

Citations

1
Pharmacological mechanisms of Taohe Chengqi decoction in diabetic cardiovascular complications: A systematic review, network pharmacology and molecular docking DOI Creative Commons

ZHANG Chun-peng,

Chunlian Tian,

YANG Xue

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33308 - e33308

Published: June 26, 2024

Diabetic cardiovascular complications are the leading cause of diabetes-related deaths. These place an enormous and growing burden on global health systems economies. The objective this study was to conduct a systematic review therapeutic mechanisms Taohe Chengqi Decoction (THCQD) in treatment diabetic complications. To predict potential action THCQD using network pharmacology, validate these predictions through molecular docking analysis.

Language: Английский

Citations

0
Impact of diabetes mellitus on mortality in pulmonary hypertension: A systematic review and meta-analysis DOI
Smitesh Padte, Priyal Mehta, V. Bansal

et al.

World Journal of Critical Care Medicine, Journal Year: 2024, Volume and Issue: 13(4)

Published: Oct. 31, 2024

BACKGROUND Pulmonary hypertension (PH) is a progressive disease characterized by endothelial dysfunction and vascular remodeling leading cause of mortality worldwide. Although it independently associated with multiple comorbidities, the impact diabetes mellitus (DM) on in patients PH remains uncertain. To address this issue, we conducted systematic review meta-analysis to investigate effect DM survival pulmonary hypertension. AIM patients. METHODS We comprehensive search four major electronic bibliographic databases like PubMed, Google Scholar, Scopus, Embase, identified 106 relevant studies, out 1561 articles, published since year 2000 for full-text review. Fourteen retrospective prospective cohort studies that compared between those without context were deemed eligible inclusion our meta-analysis. The study was registered PROSPERO identifier CRD42023390232. RESULTS A total 116455 included meta-analysis, whom 41228 suffered from 75227 did not. results indicate an elevated rate among comparison [odds ratio (OR) = 1.40, 95%CI: 1.15–1.70, P 0.0006]. meta-regression analysis unveiled statistically significant negative association mean age size (coefficient -0.036, value 0.018). Conversely, positive detected female proportion 0.000, < 0.001). CONCLUSION Our which approximately 116500 patients, revealed presence increased odds when non-diabetic indicates older participants lower proportions females tend exhibit smaller sizes. Clinically, these findings underscore importance incorporating status into risk stratification more aggressive monitoring early intervention improve prognosis potentially.

Language: Английский

Citations

0