Types of cell death in diabetic cardiomyopathy: insights from animal models DOI Creative Commons
Hongjiao Xu, Yu Zhuang, Jun Zhu

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Approximately one-tenth of the global population is affected by diabetes mellitus, and its incidence continues to rise each year. In China, 1.4 million patients die from diabetes-related complications every Additionally, approximately 26% with develop diabetic cardiomyopathy, heart failure being one main causes death in these patients. However, early detection cardiomyopathy has proven be difficult a clinical setting; furthermore, there are limited guidelines targeted means prevention treatment for this disease. recent years, several studies have provided evidence occurrence various forms regulated cell myocardial cells, including apoptosis, necroptosis, ferroptosis, cuproptosis, which closely linked pathological progression cardiomyopathy. Although most research on currently animal trial phase, inhibition regulatory processes can limit or slow down Therefore, review discusses appropriate experimental models available evaluates roles cuproptosis We hope provide new methods ideas future

Language: Английский

Bidirectional interplay of sleep apnea syndrome and cardio-vascular disorders in diabetes DOI Creative Commons

Paul Valensi,

K. Benmohammed, Mohamed Zerguine

et al.

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: 220, P. 111984 - 111984

Published: Jan. 5, 2025

Highlights•OSA and diabetes exert synergistic effects for the risk of CV complications.•The association OSA with CVD heart failure is bi-directional in diabetes.•Artery markers metrics hypoxia should be considered stratification.•Targeting weight loss (e.g. by incretin-based therapy) upmost importance obese patients OSA.•SGLT2 inhibitors seem to good candidates prevention management.AbstractAlthough often overlooked sleep apnea has emerged as a significant public health concern. Obstructive (OSA) commonly co-exist vicious cycle worsening incidence severity both conditions. many implications including cardiometabolic disorders impaired cardiovascular (CV) prognosis. combined generates cumulative effect on outcomes. The several comorbidities disease meaning that some them are likely contribute OSA. In diabetes, treatment integrated holistic strategy microvascular complications. This article provides clues advance understanding interplay between consider role like cardiac autonomic neuropathy artery stiffness novel hypoxic-related events stratification, offers discussion medical approaches strategies, GLP1-receptor agonists sodium–glucose cotransporter 2 inhibitors. It guidance improve screening diagnosis OSA, adherence diabetes.

Language: Английский

Citations

3
Personalized approach in the management of women with heart failure with preserved ejection fraction and carbohydrate metabolism disorders DOI Creative Commons
Lileia Petrovska, Iryna Kostitska,

Taras Petrovskyy

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 20(8), P. 622 - 632

Published: Jan. 4, 2025

Background. The progression of heart failure (HF) in individuals with carbohydrate metabolism disorders is one the many fatal complications among comorbid conditions. It found that risk developing HF women diabetes mellitus (DM) five times higher than those without it. Due to both heterogeneity and syntropy etiopathogenetic mechanisms occurrence, prevalence DM increasing world population, delayed treatment potentiates a poor prognosis. main task medical community undoubtedly early diagnosis preserved ejection fraction (HFpEF) prescription justified pathogenetic treatment, especially for prediabetes/type 2 (T2DM). Therefore, strategy patho­logy use patient-oriented approaches taking into account gender characteristics search alternative ways achieve glycemic goals safely HFpEF disorders. purpose study was examine results 12-week course metformin alone or combination dapagliflozin an emphasis on correction functional iron deficiency prediabetes/T2DM. Materials methods. Sixty female who met criteria were examined divided two groups: group I (n = 30) — prediabetes; II T2DM. Depen­ding therapy, patients groups randomized subgroup A (IA: n 15; IIA: 15), received (at daily dose 500–2000 mg) B (IB: IIB: 15) (500–2000 mg/day) (10 mg/day). According design scientific study, all at beginning after 12 weeks therapy underwent assessment basic anthropometric data, set laboratory examinations, clinical instrumental diagnosis. Results. In IB group, high effectiveness confirmed according indicators (glycated hemoglobin (HbA1C): ∆–10.67 %, p < 0.001) significant increase left ventricular (∆+7.73 compared receiving (∆–1.53 > 0.5). When using studied treatments prediabetes, it reliable normalization control chance (odds ratio 0.12, 95% confidence interval 0.011–1.339) preventing additional together confirms safe transferrin saturation (IB/IIB ∆+38.51 0.001/∆+ 29.59 0.001); content serum ∆+14.93 10.07 0.5) tendency towards compensatory hypoferritinemia. On background (daily 2000 mg, 10 mg), there comparable decrease IIB (IIA/IIB HbA1C treatment: ∆–1.75 %/∆–10.67 0.001, respectively) improvement parameters NT-pro-BNP content: ∆–5.96 0.05/∆–13.65 0.001; fraction: ∆+1.38 %/∆+9.00 respectively). Conclusions. proposed personalized approa­ches prediabetes have prognosis-modifying effect manifestations effective control. Timely contributes deficiency. As result combined compensation signs These conclusions contribute better understanding therapeutic potential prevention polypharmacy comorbidity.

Language: Английский

Citations

0
Association of triglyceride-glucose-body mass index with all-cause mortality among individuals with cardiovascular disease: results from NHANES DOI Creative Commons
Yulin Sun, Yuecheng Hu

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

The objective of this study was to explore the relationship between triglyceride-glucose-body mass index (TyG-BMI) and all-cause mortality rate determine valuable predictive factors for survival status patients with cardiovascular disease (CVD). Conduct a on CVD in NHANES database from 2007 2016. Patients were divided into four groups based weighted quartiles TyG-BMI. Kaplan-Meier curves, Cox regression, restricted cubic spline (RCS) used analyze correlation mortality. Receiver operating characteristic (ROC) curves evaluate its ability, sensitivity, specificity. This included 1085 patients, revealed significant differences rates among different TyG-BMI levels. higher group have lower risk, yet there is no evident non-linear relationship. ROC curve indicates that indicator can serve as value demonstrating good sensitivity found association CVD. be patients.

Language: Английский

Citations

0
Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway DOI Creative Commons

Weipin Niu,

Xin Liu, Bo Deng

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 20, 2025

Increasing evidence highlights the critical role of Piezo1 in cardiovascular diseases, with its expression upregulated diabetic heart. However, involvement pathogenesis cardiomyopathy (DCM) remains unclear. This study aims to elucidate regulatory mitochondrial dynamics within context DCM and investigate underlying mechanisms. We constructed cardiac-specific knockout (Piezo1∆Myh6) mice. Type 1 diabetes was induced using streptozotocin (STZ) injection while type 2 established through a high-fat diet combined STZ. Echocardiography assessed left ventricular function, histological evaluations used HE Masson staining examine cardiac pathology Piezo1fl/fl controls, Piezo1∆Myh6 Mitochondrial function including oxygen species level, morphology, respiration rate were also assessed. Our findings revealed that myocardium mice high-glucose-treated cells. Cardiac-specific improved dysfunction ameliorated fibrosis Moreover, deficiency attenuated impairment. exhibited increased calpain activity excessive fission mediated by Drp1 obvious reduced fusion; however, restored levels dysfunction. These observations corroborated H9C2 cells neonatal mouse cardiomyocytes. phosphorylation ERK1/2 vivo vitro. or treatment inhibitor function. provides first is elevated modulation dynamics, which reversed deficiency. Thus, inhibition may provide promising therapeutic strategy for DCM. In cardiomyocytes mice, Ca2+ entry upregulates activity, phosphorylated level Drp1. Therefore, shown hearts. Whereas, cardiomyocyte-specific alleviates

Language: Английский

Citations

0
Types of cell death in diabetic cardiomyopathy: insights from animal models DOI Creative Commons
Hongjiao Xu, Yu Zhuang, Jun Zhu

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Approximately one-tenth of the global population is affected by diabetes mellitus, and its incidence continues to rise each year. In China, 1.4 million patients die from diabetes-related complications every Additionally, approximately 26% with develop diabetic cardiomyopathy, heart failure being one main causes death in these patients. However, early detection cardiomyopathy has proven be difficult a clinical setting; furthermore, there are limited guidelines targeted means prevention treatment for this disease. recent years, several studies have provided evidence occurrence various forms regulated cell myocardial cells, including apoptosis, necroptosis, ferroptosis, cuproptosis, which closely linked pathological progression cardiomyopathy. Although most research on currently animal trial phase, inhibition regulatory processes can limit or slow down Therefore, review discusses appropriate experimental models available evaluates roles cuproptosis We hope provide new methods ideas future

Language: Английский

Citations

2