Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: April 6, 2022

In recent decades, probiotic bacteria have become increasingly popular as a result of mounting scientific evidence to indicate their beneficial role in modulating human health. Although there is strong associating various Lactobacillus probiotics health benefits, further research needed, particular determine the mechanisms by which may exert these effects and indeed gauge inter-individual value one can expect from consuming products. One must take into consideration differences individual combination strains, conditions create difficulty making direct comparisons. The aim this paper review current understanding means species stand benefit our gastrointestinal

Language: Английский

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Postbiotics: Current Trends in Food and Pharmaceutical Industry

Foods, Journal Year: 2022, Volume and Issue: 11(19), P. 3094 - 3094

Published: Oct. 5, 2022

Postbiotics are non-viable bacterial products or metabolic byproducts produced by probiotic microorganisms that have biologic activity in the host. functional bioactive compounds, generated a matrix during anaerobic fermentation of organic nutrients like prebiotics, for generation energy form adenosine triphosphate. The this sequence called postbiotics, these low molecular weight soluble compounds either secreted live microflora released after microbial cell lysis. A few examples widely studied postbiotics short-chain fatty acids, fragments, extracellular polysaccharides, lysates, teichoic acid, vitamins, etc. Presently, prebiotics and probiotics on market; however, also gaining great deal attention. numerous health advantages postbiotic components may soon lead to an increase consumer demand supplements. most recent research aspects food pharmaceutical industries included review. review encompasses brief introduction, classification, production technologies, characterization, biological activities, potential applications postbiotics.

Language: Английский

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Exopolysaccharides as Antimicrobial Agents: Mechanism and Spectrum of Activity

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: May 19, 2021

Exopolysaccharides (EPSs) are metabolites synthesized and excreted by a variety of microorganisms, including lactic acid bacteria (LAB). EPS serve several biological functions such as interactions between their environments, protection against hostile conditions dehydration, the alleviation action toxic compounds (bile salts, hydrolyzing enzymes, lysozyme, gastric, pancreatic metal ions, antibiotics), stresses (changing pH, osmolarity), evasion immune response phage attack. Bacterial EPSs considered valuable food, pharmaceutical, nutraceutical industries, owing to health-promoting benefits rheological impacts. Numerous studies have reported unusual antimicrobial activities various wide pathogenic microbes (bacteria, virus, fungi). This review aims provide comprehensive examination in vitro vivo different EPSs, mainly foodborne bacterial, fungal, viral pathogens. The mechanism these pathogens well methods used measure critically reviewed.

Language: Английский

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Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1225 - 1225

Published: April 8, 2021

Probiotics are live microorganisms that confer health benefits on the host. However, in recent years, several concerns their use have been raised. In particular, industrial processing and storage of probiotic products still technological challenges as these could severely impair cell viability. On other hand, safety should be taken into account, especially when administered to vulnerable people, such elderly immunodeficient individuals. These drawbacks enhanced interest toward new based non-viable probiotics paraprobiotics postbiotics. paraprobiotics, defined “inactivated microbial cells (non-viable) a benefit consumer,” hold ability regulate adaptive innate immune systems, exhibit anti-inflammatory, antiproliferative antioxidant properties exert antagonistic effect against pathogens. Moreover, can safety, assure practical also used suitable for people with weak immunity elderly. features offer an important opportunity prompt market novel functional foods or nutraceuticals safer more stable. This review provides overview central issues highlights urgent need further studies aimed at assessing efficacy mechanisms action order support decisions regulatory authorities. Finally, definition is proposed unambiguously distinguishes from

Language: Английский

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Shrimp vibriosis and possible control measures using probiotics, postbiotics, prebiotics, and synbiotics: A review

Aquaculture, Journal Year: 2022, Volume and Issue: 551, P. 737951 - 737951

Published: Jan. 21, 2022

Language: Английский

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Postbiotics as potential new therapeutic agents for metabolic disorders management

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113138 - 113138

Published: June 16, 2022

The prevalence of obesity, diabetes, non-alcoholic fatty liver disease, and related metabolic disorders has been steadily increasing in the past few decades. Apart from establishment caloric restrictions combination with improved physical activity, there are no effective pharmacological treatments for most disorders. Many scientific-studies have described various beneficial effects probiotics regulating metabolism but others questioned their effectiveness safety. Postbiotics defined as preparation inanimate microorganisms, and/or components, which determine safety use confers a health benefit to host. Additionally, unlike postbiotics do not require stringent production/storage conditions. Recently, many lines evidence demonstrated that may be management via several potential including anti-inflammatory, antibacterial, immunomodulatory, anti-carcinogenic, antioxidant, antihypertensive, anti-proliferative, hypocholesterolaemia properties enhance both immune system intestinal barrier functions by acting directly on specific tissues epithelium, also organs or tissues. In view reports high biological activity postbiotics, we summarized present review current findings reporting derivatives alterations.

Language: Английский

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Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens

Antibiotics, Journal Year: 2023, Volume and Issue: 12(2), P. 274 - 274

Published: Jan. 30, 2023

Antimicrobial resistance (AMR) is one of the most important global public health problems. The imprudent use antibiotics in humans and animals has resulted emergence antibiotic-resistant bacteria. dissemination these strains their resistant determinants could endanger antibiotic efficacy. Therefore, there an urgent need to identify develop novel strategies combat resistance. This review provides insights into evolution mechanisms AMR. Additionally, it discusses alternative approaches that might be used control AMR, including probiotics, prebiotics, antimicrobial peptides, small molecules, organic acids, essential oils, bacteriophage, fecal transplants, nanoparticles.

Language: Английский

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Postbiotics in Human Health: A Narrative Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 291 - 291

Published: Jan. 6, 2023

In the 21st century, compressive health and functional foods are advocated by increasingly more people in order to eliminate sub-health conditions. Probiotics postbiotics have gradually become focus of scientific nutrition communities. With maturity wide application probiotics, safety concerns other disadvantages non-negligible as we review here. As new-era products, continue considerable potential well plentiful drawbacks optimize. “Postbiotic” has been defined a “preparation inanimate microorganisms and/or their components that confers benefit on host”. Here, evolution concept “postbiotics” is reviewed. The underlying mechanisms postbiotic action discussed. Current insight suggests exert efficacy through protective modulation, fortifying epithelial barrier modulation immune responses. Finally, provide an overview comparative advantages current food industry at pharmaceutical biomedical levels.

Language: Английский

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The Current and Future Perspectives of Postbiotics

Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 15(6), P. 1626 - 1643

Published: Feb. 10, 2023

With the emphasis on intestinal health, probiotics have exploded into a vast market potential. However, new scientific evidence points out that beneficial health benefits of are not necessarily directly related to viable bacteria. metabolites or bacterial components live bacteria driving force behind promotion. Therefore, scientists gradually noticed effects based itself, metabolites, cell lysates, and these factors officially named "postbiotics" by ISAPP. Postbiotic diverse outperform in terms technology, safety, cost due their good absorption, metabolism, organismal distribution. Postbiotics been shown bioactivities such as antimicrobial, antioxidant, anti-inflammatory, anti-proliferative, immunomodulation. Moreover, numerous studies revealed significant potential postbiotics for disease treatment. This paper first presents production classification with examples from lactic acid (LAB), followed mechanisms action most recent pre-clinical clinical wide range non-clinical applications postbiotics. Furthermore, current future prospects postbiotic commercial available products discussed. Finally, we comment knowledge gaps several examples.

Language: Английский

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Postbiotics and Their Health Modulatory Biomolecules

Biomolecules, Journal Year: 2022, Volume and Issue: 12(11), P. 1640 - 1640

Published: Nov. 4, 2022

Postbiotics are a new category of biotics that have the potential to confer health benefits but, unlike probiotics, do not require living cells induce effects and thus subject food safety requirements apply live microorganisms. defined as “preparation inanimate microorganisms and/or their components confers benefit on host”. Postbiotic include short-chain fatty acids, exopolysaccharides, vitamins, teichoic bacteriocins, enzymes peptides in non-purified inactivated cell preparation. While research into postbiotics is its infancy, there increasing evidence modulate human health. Specifically, number been shown improve gut by strengthening barrier, reducing inflammation promoting antimicrobial activity against pathogens. Additionally, being conducted application other areas body, including skin, vagina oral cavity. The purpose this review set out current postbiotics, demonstrate how currently used commercial products identify knowledge gaps where further needed for future applications postbiotics.

Language: Английский

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