Pathogens,
Journal Year:
2023,
Volume and Issue:
12(3), P. 397 - 397
Published: March 1, 2023
The
purpose
of
this
study
was
to
evaluate
the
relationship
between
human
papillomavirus
(HPV16/18),
Epstein-Barr
virus
(EBV),
and
cytomegalovirus
(HCMV)
infections
occurrence
ovarian
cancer
in
48
women,
whom
36
underwent
surgery
chemotherapy
(group
A),
12
sufficient
B),
60
with
endometroid
endometrial
stage
G1-G3
C),
compared
patients
uterus
its
appendages
were
removed
for
nononcological
reasons
(control
group).
detection
HPV,
EBV,
HCMV
tumor
tissue
normal
performed
using
real-time
polymerase
chain
reaction
(RT-PCR)
technique.
A
statistically
significantly
higher
risk
noted
infected
only
(OR
>
1;
p
<
0.05).
In
contrast,
a
group
associated
HPV16,
HPV18,
EBV
0.05);
B
HPV18
HMCV
obtained
results
suggest
that
infection
is
development
when
treatment
can
be
completed
alone.
Meanwhile,
appears
responsible
more
advanced
stages.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: May 20, 2023
Abstract
Histones
are
DNA‐binding
basic
proteins
found
in
chromosomes.
After
the
histone
translation,
its
amino
tail
undergoes
various
modifications,
such
as
methylation,
acetylation,
phosphorylation,
ubiquitination,
malonylation,
propionylation,
butyrylation,
crotonylation,
and
lactylation,
which
together
constitute
“histone
code.”
The
relationship
between
their
combination
biological
function
can
be
used
an
important
epigenetic
marker.
Methylation
demethylation
of
same
residue,
acetylation
deacetylation,
phosphorylation
dephosphorylation,
even
methylation
different
residues
cooperate
or
antagonize
with
each
other,
forming
a
complex
network.
Histone‐modifying
enzymes,
cause
numerous
codes,
have
become
hot
topic
research
on
cancer
therapeutic
targets.
Therefore,
thorough
understanding
role
post‐translational
modifications
(PTMs)
cell
life
activities
is
very
for
preventing
treating
human
diseases.
In
this
review,
several
most
thoroughly
studied
newly
discovered
PTMs
introduced.
Furthermore,
we
focus
histone‐modifying
enzymes
carcinogenic
potential,
abnormal
modification
sites
tumors,
multiple
essential
molecular
regulation
mechanism.
Finally,
summarize
missing
areas
current
point
out
direction
future
research.
We
hope
to
provide
comprehensive
promote
further
field.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 30, 2024
Drug
resistance
in
cancer
cells
significantly
diminishes
treatment
efficacy,
leading
to
recurrence
and
metastasis.
A
critical
factor
contributing
this
is
the
epigenetic
alteration
of
gene
expression
via
RNA
modifications,
such
as
N6-methyladenosine
(m6A),
N1-methyladenosine
(m1A),
5-methylcytosine
(m5C),
7-methylguanosine
(m7G),
pseudouridine
(Ψ),
adenosine-to-inosine
(A-to-I)
editing.
These
modifications
are
pivotal
regulating
splicing,
translation,
transport,
degradation,
stability.
Governed
by
"writers,"
"readers,"
"erasers,"
impact
numerous
biological
processes
progression,
including
cell
proliferation,
stemness,
autophagy,
invasion,
apoptosis.
Aberrant
can
lead
drug
adverse
outcomes
various
cancers.
Thus,
targeting
modification
regulators
offers
a
promising
strategy
for
overcoming
enhancing
efficacy.
This
review
consolidates
recent
research
on
role
prevalent
resistance,
with
focus
m6A,
m1A,
m5C,
m7G,
Ψ,
A-to-I
Additionally,
it
examines
regulatory
mechanisms
linked
underscores
existing
limitations
field.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(4), P. 2170 - 2170
Published: Feb. 16, 2022
Ovarian
cancer
is
the
most
malignant
gynecological
tumor.
Previous
studies
have
reported
that
metabolic
alterations
resulting
from
deregulated
lipid
metabolism
promote
ovarian
aggressiveness.
Lipid
involves
oxidation
of
fatty
acids,
which
leads
to
energy
generation
or
new
metabolite
synthesis.
The
upregulation
acid
synthesis
and
related
signaling
tumor
cell
proliferation
migration,
and,
consequently,
lead
poor
prognosis.
Fatty
acid-mediated
in
microenvironment
(TME)
modulates
immunity
by
regulating
immune
cells,
including
T
B
macrophages,
natural
killer
play
essential
roles
survival.
Here,
types
sources
acids
their
interactions
with
TME
been
reviewed.
Additionally,
this
review
focuses
on
role
suggests
pathways
are
potential
therapeutic
targets
for
cancer.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 9, 2024
Abstract
Ovarian
cancer
is
the
most
lethal
malignancy
among
gynecologic
cancers,
and
primary
secondary
chemotherapy
resistance
one
of
important
reasons
for
poor
prognosis
ovarian
patients.
However,
specifics
to
in
remain
unclear.
Herein,
we
find
that
expression
level
cellular
retinoic
acid
binding
protein
2
(CRABP2)
up-regulated
drug-resistant
tissues
cell
lines,
levels
CRABP2
epithelial
are
closely
related
tumor
clinical
stage
patients’
prognosis,
suggesting
plays
an
role
progression
corresponding
ability
chemotherapy.
With
in-depth
study,
demonstrates
high
metabolic
activity
cells,
all-trans
exacerbates
this
activity.
Further
molecular
mechanism
exploration
experiments
show
not
only
up-regulates
HIF1α,
but
also
increases
localization
HIF1α
nucleus.
In
knocking
down
can
block
drugs
cells.
Taken
together,
our
findings
suggest
first
time
affects
by
regulating
HIF1α.
This
study
provides
a
possible
drug
target
treatment
cancer.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 24, 2025
Epithelial-mesenchymal
transition
(EMT)
is
designated
as
one
of
the
prime
causes
chemoresistance
in
many
cancers.
In
our
previous
study
we
established
that
cisplatin
resistance
ovarian
cancer
(OC)
associated
with
EMT
using
sensitive
OV90
cells
and
its
resistant
counterparts
OV90CisR1
OV90CisR2.
this
study,
revealed
through
RNAseq
analysis
ITGA1
can
play
essential
part
mediated
OC.
We
found
large
number
related
terms
predominant
top
gene
ontologies
(GO).
also
Extracellular
matrix
(ECM)
actin
cytoskeleton
genes
highly
altered
cells.
This
was
further
confirmed
by
protein-protein
interaction
(PPI)
where
identified
core
ECM
components
e.g.,
collagen,
fibronectin,
metalloproteases
integrins
possessed
most
interactions.
The
pathway
Wnt
signaling
leading
pathway.
Since
have
significant
signaling,
focused
on
among
which,
ITGA1,
ITGA6,
ITGA11
ITGAV
were
primarily
altered.
validated
results
western
blotting
expressed
Additionally,
high
ABCA5
(efflux
transporter)
expression
supports
proposition.
β-catenin
confirming
activity.
Further,
induced
xenograft
tumors
nude
mice.
histopathological
aggressive
nature
showed
presence
necrotic
which
could
be
implicated
to
EMT.
Finally,
immunohistochemical
staining
protein
tumor.
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 25, 2024
Abstract
Ovarian
cancer
accounts
for
more
deaths
than
any
other
female
reproductive
tract
cancer.
The
major
reasons
the
high
mortality
rates
include
delayed
diagnoses
and
drug
resistance.
Hence,
improved
diagnostic
therapeutic
options
ovarian
are
a
pressing
need.
Extracellular
vesicles
(EVs),
that
exosomes
provide
hope
in
both
aspects.
They
natural
lipid
nanovesicles
secreted
by
all
cell
types
carry
molecules
reflect
status
of
parent
cell.
This
facilitates
their
potential
use
as
biomarkers
an
early
diagnosis.
Additionally,
EVs
can
be
loaded
with
exogenous
cargo,
have
features
such
stability
favorable
pharmacokinetic
properties.
makes
them
ideal
tumor-targeted
delivery
biological
moieties.
International
Society
Vesicles
(ISEV)
based
on
Minimal
Information
Studies
(MISEV)
recommends
usage
term
“small
extracellular
(sEVs)”
includes
particles
30–200
nm
size.
However,
majority
studies
reported
literature
relevant
to
this
review
used
“exosomes”.
Therefore,
will
“exosomes”
interchangeably
sEVs
consistency
avoid
confusion
readers.
review,
initially
summarizes
different
isolation
detection
techniques
developed
study
cancer-derived
these
diagnosis
devastating
disease.
It
addresses
role
exosome
contents
pathogenesis
cancer,
discusses
strategies
limit
exosome-mediated
progression,
provides
therapy
Finally,
it
states
future
research
directions
essential
needed
successfully
transition
from
laboratory
gynecologic-oncology
clinic.
Small,
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 8, 2023
Various
female
reproductive
disorders
affect
millions
of
women
worldwide
and
bring
many
troubles
to
women's
daily
life.
Let
alone,
gynecological
cancer
(such
as
ovarian
cervical
cancer)
is
a
severe
threat
most
lives.
Endometriosis,
pelvic
inflammatory
disease,
other
chronic
diseases-induced
pain
have
significantly
harmed
physical
mental
health.
Despite
recent
advances
in
the
field,
existing
challenges
are
still
enormous
such
personalization
difficulty
diagnosing
early
cancers,
antibiotic
resistance
infectious
diseases,
etc.
To
confront
challenges,
nanoparticle-based
imaging
tools
phototherapies
that
offer
minimally
invasive
detection
treatment
tract-associated
pathologies
indispensable
innovative.
Of
late,
several
clinical
trials
also
been
conducted
using
nanoparticles
for
tract
infections
targeted
drug
delivery,
cellular
therapeutics.
However,
these
nanoparticle
nascent
due
body's
delicate
complex
system.
The
present
review
comprehensively
focuses
on
emerging
applications,
which
hold
promise
improved
diagnosis
effective
treatments
various
organ
diseases.
Journal of Ovarian Research,
Journal Year:
2023,
Volume and Issue:
16(1)
Published: Sept. 6, 2023
Abstract
Tumor-associated
lncRNAs
regulated
by
epigenetic
modification
switches
mediate
immune
escape
and
chemoresistance
in
ovarian
cancer
(OC).
However,
the
underlying
mechanisms
concrete
targets
have
not
been
systematically
elucidated.
Here,
we
discovered
that
methylation
modifications
played
a
significant
role
regulating
cell
infiltration
sensitizing
OC
to
chemotherapy
modulating
immune-related
(irlncRNAs),
which
represent
tumor
status.
Through
deep
analysis
of
TCGA
database,
prognostic
risk
model
incorporating
four
methylation-related
(mrlncRNAs)
irlncRNAs
was
constructed.
Twenty-one
mrlncRNA/irlncRNA
pairs
were
identified
significantly
related
overall
survival
(OS)
patients.
Subsequently,
selected
construct
signature
predictive
OS
indicative
infiltration,
verified
robustness
an
internal
validation
set.
The
score
independent
factor
for
prognosis,
demonstrated
via
multifactorial
Cox
regression
nomogram.
Moreover,
scores
negatively
expression
CD274,
CTLA4,
ICOS,
LAG3,
PDCD1,
PDCD1LG2
correlated
with
CD8
+
,
CD4
Treg
tumor-infiltrating
cells.
In
addition,
high-risk
associated
higher
IC50
value
cisplatin,
worse
clinical
outcome.
Next,
competing
endogenous
RNA
(ceRNA)
network
signaling
pathway
controlling
T
cells
explored
based
on
lncRNA
model,
suggested
potential
therapeutic
target
immunotherapy.
Overall,
this
study
constructed
pairing
mrlncRNAs
revealed
critical
FTO/RP5-991G20.1/hsa-miR-1976/MEIS1
function
enhancing
anticancer
therapy.
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: Jan. 28, 2022
Gynecological
cancers
seriously
affect
the
reproductive
system
of
females;
diseases
include
ovarian
tumors,
uterine
endometrial
cancers,
cervical
and
vulva
vaginal
tumors.
At
present,
diagnosis
methods
gynecological
cancer
are
insufficiently
sensitive
specific,
leading
to
failure
early
disease
detection.
N6-methyladenosine
(m6A)
plays
various
biological
functions
in
RNA
modification
is
currently
studied
extensively.
m6A
controls
fate
transcripts
regulates
metabolism
processes
through
interaction
methyltransferase
("writer")
demethylase
("erasers")
binding
protein
decoding
methylation
("readers").
In
field
epigenetics,
a
dynamic
process
reversible
regulation
target
its
regulatory
factors.
It
an
important
role
many
diseases,
especially
cancer.
However,
gynecologic
has
not
been
fully
investigated.
Thus,
we
review
mechanism,
functions,
therapeutic
prospects
regulators
cancers.