Shining a Spotlight on RNA m6A Modifications and Potential Targeted Immunotherapy in Ovarian Cancer DOI Creative Commons

Huishen Pang,

Weiping Zheng,

Qiyun Lu

et al.

Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 51(12)

Published: Dec. 23, 2024

Objective: Ovarian cancer is one of the major gynecologic malignancies worldwide. Evidence indicates that N6-methyladenosine (m6A) modification strongly related to immunity. This review aims demonstrate role and function m6A in ovarian tumorigenesis its potential targeted immunotherapy. Mechanism: Searching literature for articles Conducting a comprehensive analysis summarizing content logically. Findings Brief: In this review, we summarized latest research on regulators Firstly, found underlying molecular mechanism (writers, erasers readers) development progress cancer. Then, discovered play pivotal immune responses efficacy, serving as therapeutic targets Additionally, long noncoding RNAs (lncRNAs) have strong impact survival Finally, deeply analyzing genes are needed improve immunotherapy Conclusions: has carcinogenesis

Language: Английский

Epigenetic regulation in female reproduction: the impact of m6A on maternal-fetal health DOI Creative Commons
Peipei Li,

Yumeng Lin,

Hongyun Ma

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 4, 2025

Language: Английский

Citations

1
Emerging role of m6A modification in ovarian cancer: progression, drug resistance, and therapeutic prospects DOI Creative Commons

Shahil Alam,

P. Giri

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: March 13, 2024

Ovarian Cancer (OC) ranks as a prominent contributor to mortality among female reproductive system associated cancers, particularly the prevalent subtype epithelial (EOC). Despite advancements in treatment modalities, prognosis for OC patients remains grim due limitation of current therapeutic methodology such high cytotoxicity chemotherapeutic agents and tumor relapse making existing chemotherapy ineffective. Recognizing limitations broad-spectrum approach treating OC, shift toward targeted therapies aligning with unique molecular features is imperative. This stems from an incomplete understanding OC’s origin, distinguishing it extensively researched malignancies cervical or colon cancer. At level, postsynthetic modifications—DNA, RNA, protein—shape transcriptional, posttranscriptional, posttranslational processes. Posttranscriptional regulatory mechanisms, including RNA modifications are termed epitranscriptomic play critical roles this process. For more than five decades, 100+ post-synthetic modifications, notably N6-methyladenosine (m6A), most modification mammals, dynamically regulate messenger (mRNA), non-coding (ncRNA) life orchestrated via writers, erasers, readers. The disruption m6A found several underscores pivotal role m6A. review focused on coding RNAs, emphasizing their prognostic markers impact development, migration, invasion, drug resistance. Additionally, RNA-modified regulators have been explored potential targets, offering innovative combatting challenging malignancy.

Language: Английский

Citations

5
Peroxiredoxin-1 as a molecular chaperone that regulates glutathione S-transferase P1 activity and drives mutidrug resistance in ovarian cancer cells DOI Creative Commons

Chengling Fan,

Shubin Yuan,

Yuemei Zhang

et al.

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 37, P. 101639 - 101639

Published: Jan. 14, 2024

Ovarian cancer is among the most prevalent gynecological malignancies around globe. Nonetheless, chemoresistance continues to be one of greatest obstacles in treatment ovarian cancer. Therefore, understanding mechanisms and identifying new options for patients urgently required. In this study, we found that mRNA protein expression levels PRDX1 were significantly increased cisplatin resistant A2780/CDDP cells. Cell survival assays revealed depletion substantially cell sensitivity cisplatin, docetaxel, doxorubicin. Additionally, GSTP1 activity, resulting multidrug resistance. Biochemical experiments showed interacted with through Cysteine 83, which regulated activity as well chemotherapy resistance Our findings indicate molecular chaperone a promising therapeutic target

Language: Английский

Citations

3
LncRNA16 inhibits pyroptosis and promotes platinum resistance in non-small cell lung cancer by sponging miRNA1827 to regulate MBD3/GSDME expression DOI Creative Commons
Yanfang Liu, Yuanjun Zeng,

Sikai Wang

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 24, 2025

Platinum-based chemotherapy is the standard first-line cancer treatment. However, patients experience relapses due to chemoresistance. We found that long non-coding RNA 16 (lncRNA16) promotes platinum resistance and inhibits cell death in non-small lung (NSCLC). type of inhibited by lncRNA16 remains unknown. The biological roles microRNA 1827 (miRNA1827) proliferation colony formation were determined using functional experiments. Dual-luciferase reporter immunoprecipitation assays performed confirm interactions between miRNA1827. In vivo patient-derived tumor xenograft (PDX) models used investigate effects miRNA1827 agomir on resistance. Pyroptosis was platinum-resistant NSCLC cells. LncRNA16 contributed expression methyl-CpG binding domain protein 3 (MBD3) sponging miRNA1827, thereby inhibiting gasdermin E (GSDME) expression, which pyroptosis NSCLC. repressed vitro experiments PDX models. identified a novel function proposed an effective therapeutic drug, agomir, for chemosensitization. This study offers potential strategy treating with NSCLC, especially those

Language: Английский

Citations

0
Exploratory analysis on the relationship between dietary live microbe intake and arthritis: a national population based cross-sectional study DOI Creative Commons
Yiping Liu,

Yida Xing,

Xiaodan Kong

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 4, 2024

The pathogenesis of arthritis such as rheumatoid (RA) and osteoarthritis (OA) remains unclear. This study aims to investigate whether the intake live dietary microbes can be used an auxiliary means for treatment arthritis.Methods: Data in present research were originated from US National Health Nutrition Examination Survey (NHANES) 2003-2018. Participants involved categorized into three groups based on microbe classification system, namely low, medium, high groups. analyses utilized weighted univariate multivariate logistic regression. restricted cubic spline plot was explore relationship between group odds arthritis.Results: 12844 participants included study. RA lower than that healthy control OA group. proportion patients low medium Following comprehensive adjustment covariates, it observed both exhibited compared those (High OR: 0.71, 95% CI: 0.53-0.96; Medium 0.77, 0.59-1.00, p =0.02). A indicates a negative correlation quantity occurrence within group.The results our revealed significant difference patients. Higher correlated with decreased RA. However, no association found microbes.

Language: Английский

Citations

2
Fatty Acid Metabolism-Related lncRNA Prognostic Signature for Serous Ovarian Carcinoma DOI
Lele Ye,

Zhuofeng Jiang,

Mengxia Zheng

et al.

Epigenomics, Journal Year: 2024, Volume and Issue: 16(5), P. 309 - 329

Published: Feb. 15, 2024

Background: To explore the role of fatty acid metabolism (FAM)-related lncRNAs in prognosis and antitumor immunity serous ovarian cancer (SOC). Materials & methods: A SOC FAM-related lncRNA risk model was developed evaluated by a series analyses. Additional immune-related analyses were performed to further assess associations between immune state, tumor microenvironment prognostic model. Results: Five associated with FAM genes found used create predictive The patients low-risk profile exhibited favorable outcomes. Conclusion: established exhibits better capabilities for offers novel potential therapy targets SOC.

Language: Английский

Citations

2
Long non‐coding RNA TPT1‐AS1 inhibits ferroptosis in ovarian cancer by regulating GPX4 via CREB1 regulation DOI
Lei Cao, Yan Wang,

Juanni Liu

et al.

American Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 92(2)

Published: Aug. 1, 2024

Long non-coding RNAs (lncRNAs) play crucial roles in cellular processes, with dysregulation implicated various diseases, including cancers. The lncRNA TPT1-AS1 (TPT1 Antisense RNA 1) promotes tumor progression several cancers, ovarian cancer (OC), but its influence on ferroptosis and interaction other proteins remains underexplored.

Language: Английский

Citations

2
Research Advances in the Roles of N6-Methyladenosine Modification in Ovarian Cancer DOI Creative Commons
Y Zhang,

Yufeng Ling,

Ying Zhou

et al.

Cancer Control, Journal Year: 2024, Volume and Issue: 31

Published: Jan. 1, 2024

Ovarian cancer (OC) is the most lethal gynecological tumor, characterized by its insidious and frequently recurring metastatic progression. Owing to limited early screening methods, over 70% of OC cases are diagnosed at advanced stages, typically stage III or IV. Recently, N6-methyladenosine (m6A) modification has emerged as a hotspot epigenetic research, representing significant endogenous RNA in higher eukaryotes. Numerous studies have reported that m6A-related regulatory factors play pivotal roles tumor development through diverse mechanisms. Moreover, recent indicated aberrant expression multiple OC. Therefore, this paper comprehensively reviews research advancements concerning m6A OC, aiming elucidate mechanism m6A-associated regulators on aspects, such proliferation, invasion, metastasis, drug resistance, Furthermore, it discusses potential diagnostic markers therapeutic targets, thus contributing diagnosis treatment

Language: Английский

Citations

1
A comprehensive study on epigenetic signatures to monitor disease progression and the response to therapy in breast cancer DOI Creative Commons
Dhruv Parikh, Manan Shah

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(3), P. 205 - 217

Published: Aug. 6, 2024

Breast cancer is the single most complex type, affecting thousands around globe annually. With recent studies highlighting epigenetic signatures in breast detection, this landscape can be exploited to inhibit potentially. This paper comprehensively explores cancer, elucidating their impact on disease progression and therapeutic responses. The objective unravel intricate interplay of different biomarkers shaping cancer's molecular landscape. We delve into diverse manifestations alterations, particularly context heterogeneity, offering insights early diagnosis, prognosis assessment, targeted strategies. discussion encompasses dynamic role changes influencing gene expression, tumor characteristics, treatment outcomes across various subtypes. underscores transformative power incorporating evaluations clinical care, facilitating a personalized approach. Notably, emphasizing need for precision, combination therapies, development robust biomarkers. By examining technological advancements, such as single-cell RNA sequencing next-generation sequencing, we uncover landscapes underpinning heterogeneity resistance mechanisms. also address challenges faced by current DNA methyltransferase inhibitors histone deacetylase inhibitors, precision application. In summary, unfolds compelling narrative that advances our understanding beacon hope improved patient through interventions.

Language: Английский

Citations

1
The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth DOI Creative Commons
Hyun‐Jin Kim, Don Carlo Batara, Young-Jun Jeon

et al.

Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 93 - 109

Published: March 13, 2024

Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that highly upregulated GSCs compared normal, differentiated counterparts. Inhibition expression by shRNA significantly reduced GSC growth both vitro vivo experiments. On other hand, integrated transcriptomics analyses datasets revealed correlated cell cycle-related genes. Clinical data analysis elevated high-grade gliomas, patients with high levels have poorer overall survival outcomes. The findings suggest prognostic biomarker possible target developing novel therapeutic strategies against GBM.

Language: Английский

Citations

0