Pathology - Research and Practice, Journal Year: 2022, Volume and Issue: 239, P. 154146 - 154146
Published: Sept. 29, 2022
Language: Английский
Frontiers in Bioscience-Scholar, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 22, 2025
Background: Cryopreservation cannot be widely used for rooster sperm due to high incidences of cryoinjury, including damage membranes. Thus, cryopreserved has limited use low motility and reduced fertilizing ability, which disrupts the mechanisms involved in sperm–egg interactions. Previously, we an Illumina 60K single-nucleotide polymorphism (SNP) array search genes associated with quality, before after freeze–thawing. As a continuation these genome-wide association studies (GWAS), present investigation denser 600K SNP chip. Consequently, screen depth was expanded by many markers cryo-resistance while more candidate were identified. our study aimed identify associations ejaculate quality indicators, those concerning membrane damage. Methods: We selected indicators freezing–thawing using samples from proprietary cryobank collection created preserve generative germ cells rare endangered breeds chickens other animal species. A total 258 ejaculates 96 roosters 16 different analyzed. Moreover, respective DNA isolated genotyping Affymetrix® Axiom® high-density array. Results: In total, 31 SNPs 26 characteristics damage, progressive motility, cell respiration induction 2,4-dinitrophenol. particular, identified ENSGALG00000029931 gene as PHF14 ARID1B damaged membranes, KDELR3, DDX17, DMD, CDKL5, DGAT2, ST18, FAM150A, DIAPH2, MTMR7, NAV2, RAG2, PDE11A, IFT70A, AGPS, WDFY1, DEPDC5, TSC1, CASZ1, PLEKHM2 induction. Conclusions: Our findings provide important information understanding genetic basis integrity traits that can potentially compromise These are relevant persistence fertility thawing previously frozen semen.
Language: Английский
Citations
1
Frontiers in Chemistry, Journal Year: 2022, Volume and Issue: 10
Published: Sept. 19, 2022
Breast cancer (BC) is one of the most common cancers in women worldwide; however, successful treatment BC, especially triple-negative breast (TNBC), remains a significant clinical challenge. Recently, photothermal therapy (PTT), which involves generation heat under irradiation to achieve ablation BC with minimal invasiveness and outstanding spatial–temporal selectivity, has been demonstrated as novel that can overcome drawbacks chemotherapy or surgery. Significantly, when combining PTT and/or photodynamic therapy, an enhanced synergistic therapeutic effect be achieved both primary metastatic tumors. Thus, this review discusses recent developments nanotechnology-based for its metastasis provide potential strategies future treatment.
Language: Английский
Citations
33
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131075 - 131075
Published: March 24, 2024
Language: Английский
Citations
7
Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14
Published: April 14, 2023
Long Intergenic Non-Protein Coding RNA 511 (LINC00511) is an gene being mostly associated with lung cancer. Further assessments have shown dysregulation of this lncRNA in a variety cancers. LINC00511 has interactions hsa-miR-29b-3p, hsa-miR-765, hsa-mir-150, miR-1231, TFAP2A-AS2, hsa-miR-185-3p, hsa-miR-29b-1-5p, hsa-miR-29c-3p, RAD51-AS1 and EZH2. A number transcription factors been identified that regulate expression LINC00511. The current narrative review summarizes the role different cancers especial focus on its prognostic impact human
Language: Английский
Citations
11
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 195, P. 104271 - 104271
Published: Jan. 23, 2024
RNA-binding proteins (RBPs) refer to a class of that participate in alternative splicing, RNA stability, polyadenylation, localization and translation RNAs, thus regulating gene expression post-transcriptional manner. Dysregulation RNA-RBP interaction contributes various diseases, including cancer. In breast cancer, disorders RBP function influence the biological characteristics tumor cells. Targeting RBPs has fostered development innovative therapies for However, RBP-related mechanisms cancer are not completely clear. this review, we summarize regulatory their signaling crosstalk Specifically, emphasize potential certain as prognostic factors due effects on proliferation, invasion, apoptosis, therapy resistance Most importantly, present comprehensive overview latest therapeutic strategies novel targets have proven be useful treatment
Language: Английский
Citations
4
Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 23(7), P. 3179 - 3188
Published: May 19, 2023
Abstract HAND2 antisense RNA 1 (HAND2-AS1) is a newly recognized lncRNA encoded by gene on 4q34.1. This has 10 exons and predicted to have positive effect expression of certain genes. HAND2-AS1 mainly considered as tumor suppressive in different tissues. Moreover, been shown regulate several targets with possible roles the carcinogenesis through serving sponge for miRNAs. can also influence activity BMP, TGF-β1, JAK/STAT PI3K/Akt pathways. Down-regulation tissues associated larger size, higher grade, chance metastasis poor clinical outcome. The present study aims at summarization impact its potential cancer diagnosis or prediction prognosis.
Language: Английский
Citations
8
Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 244, P. 154420 - 154420
Published: March 17, 2023
Long Intergenic Non-Protein Coding RNA, Regulator Of Reprogramming (LINC-ROR) is a long non-coding RNA with diverse physiological functions. The gene encoding this transcript resides on 18q21.31. Expression levels of LINC-ROR have been reported to be dysregulated in patients disorders, including cancer, autoimmune disorders and neurodegenerative neurodevelopmental disorders. Moreover, polymorphisms within lncRNA shown associated variety such as some kinds cancer aspects systemic lupus erythematous. Abnormal expression other human not yet understood. Emerging evidence suggests that exerts pivotal roles most types an oncogene. Differentially expressed contributes the development diseases by changing genes control cell cycle. It can also exert its role affecting activity cancer-related signaling pathways sponging tumor suppressor miRNAs. Expanding our understanding functions will pave way for developing efficient therapeutic strategies against related current review aims at providing concise overview through summary association studies assays.
Language: Английский
Citations
6
Cytokine, Journal Year: 2023, Volume and Issue: 170, P. 156351 - 156351
Published: Aug. 30, 2023
The cytokine known as transforming growth factor (TGF) is essential for cell development, differentiation, and apoptosis in BC. TGF-β dysregulation can either promote or inhibit tumor it a key signaling pathway BC spread. A recently identified family of ncRNAs lncRNAs has received great deal effort an important regulator many cellular processes, including transcription genes, chromatin remodeling, progression the cycle, posttranscriptional processing. Furthermore, both serve early-stage biomarkers diagnosis prognosis also play significant role drug resistance. According to recent studies, regulate by modulating its cofactors However, particular functions controlling are not well understood yet. This review explores lncRNAs' functional properties suppressors oncogenes regulation with focus on dysregulated signaling. Further, we emphasize roles discover new treatment strategies better comprehend fundamental pathways.
Language: Английский
Citations
6
Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 245, P. 154458 - 154458
Published: April 8, 2023
Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding that has physiological roles in epithelial and muscle satellite cells. This lncRNA been reported to be over-expressed variety of cancer cell lines. Its silencing attenuated tumor growth animal models cancers. SNHG8 can served as molecular sponge for some miRNAs regulate their target genes. miR-634/ZBTB20, miR-335–5p/PYGO2, miR588/ATG7, miR-152/c-MET, miR-1270/BACH1, miR-491/PDGFRA, miR-512–5p/TRIM28, miR-149–5p/PPM1F, miR-542–3p/CCND1/CDK6, miR-656–3p/SERBP1, miR-656–3p/SATB1, miR-1270/S100A11 miR-384/HOXB7 are examples axes being regulated by the context cancer. Moreover, it affect pathogenesis atherosclerosis, chronic cerebral ischemia, acute gouty arthritis, ischemic stroke myocardial infarction through modulation number such SNHG8/miR-384/Hoxa13/FAM3A miR-335/RASA1 well NF-κB signaling pathway. The current review aims at summarization role diverse human disorders.
Language: Английский
Citations
4
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: Feb. 15, 2023
LncRNA prostate androgen-regulated transcript 1 (PART1) is an important lncRNA in the carcinogenesis whose role has been firstly unraveled cancer. Expression of this activated by androgen cancer cells. In addition, a pathogenesis intervertebral disc degeneration, myocardial ischemia-reperfusion injury, osteoarthritis, osteoporosis and Parkinson’s disease. Diagnostic PART1 assessed some types cancers. Moreover, dysregulation expression regarded as prognostic factor variety The current review provides concise but comprehensive summary different cancers non-malignant disorders.
Language: Английский
Citations
4