A novel cuproptosis-related LncRNA signature predicts prognosis inpatients with esophageal carcinoma DOI Creative Commons

Shang Peng,

LI Hai-peng,

Jingting Min

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 10, 2023

Abstract Background: Esophageal cancer (ESCA) is a significant cause of tumor-related mortality worldwide. Cuproptosis novel cell death which different from other regulate death, including ferroptosis, pyroptosis and apoptosis. However, the role cuproptosis in initiation progression ESCA remains unknown. Methods: The transcriptome data clinical 173 patients with esophageal TCGA database were sorted extracted Perl software. Pearson correlation analysis was performed on related genes all lncRNAs. prognostic lncRNAs determined by univariate multivariate Cox regression analysis, new model constructed to calculate risk score each patient. C-Index curve, PCA ROC curve used evaluate prognosis prediction performance 3- (CRLs) model. In addition, assess value entire cohort subgroups. Results: 3-CRLs scoring criteria EWSAT1, AC125437.1 GK-IT1 established overall survival (OS) ESCA. Survival showed that had good train group test group. coefficients analyzed using Lasso lambda values determined. principal component determine whether can clearly distinguish gap between high low samples. Multivariate characteristics independent factors OS. Norman map robust effectiveness prediction. Conclusion: based may be predict carcinoma

Language: Английский

Advances in HPV‐associated tumor management: Therapeutic strategies and emerging insights DOI

Xiangjin Gong,

Hao Chi, Zhijia Xia

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(7)

Published: July 1, 2023

Abstract With the rapid increase in incidence of cervical cancer, anal cancer and other cancers, human papillomavirus (HPV) infection has become a growing concern. Persistent with high‐risk HPV is major cause malignant tumors. In addition, microbiota viruses such as immunodeficiency virus, herpes simplex Epstein–Barr virus are closely associated infection. The limited effectiveness existing treatments for HPV‐associated tumors high rates recurrence metastasis patients create an urgent need novel effective approaches. recent years, vaccine coverage increased can reduce serious adverse events. Overall, this article provides comprehensive overview biology, microbiome, viral interactions development, highlighting more approach to prevention treatment. Current emerging HPV‐related control treatment strategies also further explored.

Language: Английский

Citations

41
The Various Roles of PEDF in Cancer DOI Open Access
Mitra Elmi, Joshua Dass, Crispin R. Dass

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 510 - 510

Published: Jan. 24, 2024

Pigment epithelium-derived factor (PEDF) is a natural immunomodulator, anti-inflammatory, anti-angiogenic, anti-tumour growth and anti-metastasis factor, which can enhance tumour response to PEDF but also conversely have pro-cancerous effects. Inflammation major cause of cancer, it has been proven that anti-inflammatory properties. PEDF’s functional activity be investigated through measuring metastatic metabolic biomarkers will discussed in this review.

Language: Английский

Citations

4
Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma DOI

Ze-Jun Xu,

Min Zhang, Zhiqiang Guo

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(5-6), P. 860 - 880

Published: March 30, 2023

Language: Английский

Citations

11
The therapeutic and prognostic role of cuproptosis-related genes in triple negative breast cancer DOI Creative Commons

Bingye Shi,

Wei Zhang, Tao Wang

et al.

BMC Bioinformatics, Journal Year: 2023, Volume and Issue: 24(1)

Published: May 31, 2023

Abstract Background This study aimed to observe the potential impact of known cuproptosis-related genes (CRGs) on triple negative breast cancer (TNBC) development, as well their associated molecular mechanisms, immune infiltration mechanisms and therapeutic agents. Results Based Cox Proportional Hazard Model, 11 CRGs may be especially important in TNBC development progression (considered Key-TNBC-CRGs). The expression several Key-TNBC-CRGs (e.g., ATP7A, PIK3CA, LIAS, LIPT ) are with common mutations. SCNA variation related differences profiles. In particular, depletion ATP7A , ATP7B CLS LIAS SCL31A1 while high amplification NLRP3 LIPT2 correlated decreased infiltration. our proportional hazards regression model, there is a significant difference overall survival between high-risk low-risk groups. HR group 3.891 versus group. And this model has satisfactory performance Prediction 5–15-year survival, particular 10-year (AUC = 0.836). Finally, we discovered some drugs for treatment based strategy targeting Key-TNBC-CRGs, such Dasatinib combined ABT-737, Erastin or Methotrexate, Docetaxel/Ispinesib combination. Conclusion conclusion, play roles they can tumor microenvironment patient survival. interact mutually influenced by BC-related Additionally, established 11-gene risk robust prediction As well, new proposed potentially effective CRG strategy.

Language: Английский

Citations

11
Cuproptosis Regulation by Long Noncoding RNAs: Mechanistic Insights and Clinical Implications in Cancer DOI

Nahla E. El‐Ashmawy,

Eman G. Khedr, Mariam A. Abo-Saif

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324

Published: Feb. 1, 2025

Language: Английский

Citations

0
Developing four cuproptosis-related lncRNAs signature to predict prognosis and immune activity in ovarian cancer DOI Creative Commons

Li Liu,

Qing Wang, Jiayun Zhou

et al.

Journal of Ovarian Research, Journal Year: 2023, Volume and Issue: 16(1)

Published: April 30, 2023

Abstract Background There has been a recent discovery of new type cell death produced by copper-iron ions, called Cuproptosis (copper death). The purpose this study was to identify LncRNA signatures associated with in ovarian cancer that could be used as prognostic indicators. Methods RNA sequencing (RNA-seq) profiles clinicopathological data from TCGA database were select CRLs and then constructed risk model using multivariate regression analysis LASSO algorithms. An independent dataset GEO validate the performance. Combined clinical factors, we further nomogram. In addition, tumor immune microenvironment, somatic mutation drug sensitivity analyzed ssGSEA, GSVA, ESTIMATE CIBERSORT Result A total 129 selected whose expression levels significantly related 10 cuproptosis-related genes. univariate Cox showed 12 overall survival (OS). Using algorithms analysis, four-CRLs signature training dataset. Patients classified into high- or low-risk subgroups different OS (log-rank p < 0.001). performance confirmed TCGA-OC cohort 0.001) an = 0.023). Multivariate cox proved factor for OC. Additionally, subtypes cells, signal pathways, response. Conclusion We established based on lncRNAs OC patients, which will great value predicting prognosis patients may provide perspective research individualized treatment.

Language: Английский

Citations

9
ALMS1-IT1: A Key Player in the Novel Disulfidptosis-Related LncRNA Prognostic Signature for Head and Neck Squamous Cell Carcinoma DOI Creative Commons
Xin-Yi Sun,

Mian Xiao,

Min Fu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 266 - 266

Published: Feb. 23, 2024

Disulfidptosis is a newly discovered form of programmed cell death that induced by disulfide stress. It closely associated with various cancers, including head and neck squamous carcinoma (HNSCC). However, the factors involved in modulation disulfidptosis-related genes (DRGs) still remain unknown. In this study, we established validated novel risk score model composed 11 lncRNAs (DRLs) based on 24 DRGs HNSCC. The results revealed strong correlations between 11-DRL prognostic signature clinicopathological features, immune infiltration, immune-related functions, disulfidptosis-associated pathways, NADPH oxidoreductase activities. Furthermore, studied verified involvement ALMS1-IT1, one DRLs, disulfidptosis HNSCC lines. A series assays demonstrated ALMS1-IT1 modulated under starvation conditions pentose phosphate pathway (PPP)-dependent manner. Knockdown inhibited PPP, contributing to decline levels, which resulted formation multiple intermolecular bonds actin cytoskeleton proteins collapse F-actin cytoplasm. Therefore, highly expressed SLC7A11high cells, can be considered promising therapeutic target for disulfidptosis-focused treatment strategies cancer other diseases.

Language: Английский

Citations

2
Bioinformatic analysis and experimental validation of cuproptosis-related LncRNA as a novel biomarker for prognosis and immunotherapy of oral squamous cell carcinoma DOI Creative Commons
Shuang Liang,

Lanting Ji,

Zhenyuan Yu

et al.

Hereditas, Journal Year: 2024, Volume and Issue: 161(1)

Published: Feb. 27, 2024

Abstract Background The novel form of regulatory cell death, cuproptosis, is characterized by proteotoxicity, which ultimately leads to death. Its targeting has emerged as a promising therapeutic approach for oral squamous carcinoma (OSCC). Long noncoding RNAs (lncRNAs) participate in epigenetic regulation and have been linked the progression, prognosis, treatment OSCC. Thus, this study aimed identify new cuproptosis-related lncRNAs (CRLs), establish predictive models clinical immune response, drug sensitivity, provide insights into escape tumor resistance. Methods present screened eight CRLs (THAP9-AS1, STARD4-AS1, WDFY3-AS2, LINC00847, CDKN2A-DT, AL132800.1, GCC2-AS1, AC005746.1) using Lasso Cox regression analysis develop an eight-CRL prognostic model. Patients were categorized high- low-risk groups risk scores. To evaluate ability model, Kaplan-Meier analysis, ROC curves, nomograms employed. Furthermore, investigated differences function anticancer sensitivity between groups. validate expression OSCC lines subjected quantitative real-time fluorescence PCR (qRT-PCR). Results results showed that high-risk group had shorter overall survival (OS) time patients. demonstrated score was independent factor poor prognosis. validity model confirmed curve nomogram developed predict prognosis patients with high TMB poorer responded better immunotherapy than those group. Additionally, scores significantly associated Finally, findings qRT-PCR supported reliability proposed Conclusion identified established 8-CRL represents pathway lncRNA cuproptosis This provides guidance offers insight

Language: Английский

Citations

2
Copper homeostasis and cuproptosis in gynecological cancers DOI Creative Commons
Xiaodi Huang,

Mengyi Lian,

Changzhong Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 25, 2024

Copper (Cu) is an essential trace element involved in a variety of biological processes, such as antioxidant defense, mitochondrial respiration, and bio-compound synthesis. In recent years, novel theory called cuproptosis has emerged to explain how Cu induces programmed cell death. targets lipoylated enzymes the tricarboxylic acid cycle subsequently triggers oligomerization dihydrolipoamide S-acetyltransferase, leading loss Fe–S clusters induction heat shock protein 70. Gynecological malignancies including cervical cancer, ovarian cancer uterine corpus endometrial carcinoma significantly impact women’s quality life even pose threat their lives. Excessive can promote progression by enhancing tumor growth, proliferation, angiogenesis metastasis through multiple signaling pathways. However, there are few studies investigating gynecological cancers relation cuproptosis. Therefore, this review discusses homeostasis while exploring potential use for prognosis prediction well its implications treatment cancers. Additionally, we explore application ionophore therapy treating malignancies.

Language: Английский

Citations

1
5-Methylcytosine-related lncRNAs: predicting prognosis and identifying hot and cold tumor subtypes in head and neck squamous cell carcinoma DOI Creative Commons
Juntao Huang, Ziqian Xu, Chongchang Zhou

et al.

World Journal of Surgical Oncology, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 14, 2023

5-Methylcytosine (m5C) methylation is recognized as an mRNA modification that participates in biological progression by regulating related lncRNAs. In this research, we explored the relationship between m5C-related lncRNAs (mrlncRNAs) and head neck squamous cell carcinoma (HNSCC) to establish a predictive model.RNA sequencing information were obtained from TCGA database, patients divided into two sets verify risk model while identifying prognostic mrlncRNAs. Areas under ROC curves assessed evaluate effectiveness, nomogram was constructed for further prediction. Subsequently, tumor mutation burden (TMB), stemness, functional enrichment analysis, microenvironment, immunotherapeutic chemotherapeutic responses also based on novel model. Moreover, regrouped subtypes according expression of mrlncRNAs.Assessed model, distinguished low-MLRS high-MLRS groups, showing satisfactory effects with AUCs 0.673, 0.712, 0.681 ROCs, respectively. Patients groups exhibited better survival status, lower mutated frequency, stemness but more sensitive response, whereas group appeared have higher sensitivity chemotherapy. clusters: cluster 1 displayed immunosuppressive 2 behaved hot response.Referring above results, established lncRNA prognosis, TME, TMB, clinical treatments HNSCC patients. This assessment system able precisely predict patients' prognosis identify cold clearly patients, providing ideas treatment.

Language: Английский

Citations

3