Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 42, P. 102426 - 102426
Published: Dec. 1, 2024
Language: Английский
Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)
Published: April 18, 2024
Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose eventually falling out. Timely identification has crucial role preventing controlling its progression. Clinical measures are used to diagnose periodontitis. However, now, there is hunt for alternative diagnostic monitoring methods due progress technology. Various biomarkers have been assessed using multiple bodily fluids sample sources. Furthermore, conventional categorization factors do not provide significant insights into present disease activity, severity amount tissue damage, future development, responsiveness treatment. In recent times, growing utilization nanoparticle (NP)-based detection strategies create quick efficient assays. Every single one these platforms leverages distinct characteristics NPs identify Plasmonic include metal NPs, quantum dots (QDs), carbon base nanozymes, exceptionally potent light absorbers scatterers. These find application labeling, surface-enhanced spectroscopy, color-changing sensors. Fluorescent function photostable sensitive instruments capable labeling various biological targets. article presents comprehensive summary latest developments effective detect
Language: Английский
Citations
27
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(3)
Published: Jan. 30, 2025
Language: Английский
Citations
1
Japanese Journal of Clinical Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: March 13, 2025
Abstract Precision medicine based on biomarkers, such as genetic abnormalities and PD-L1 expression, has been established for the treatment of nonsmall cell lung cancer. Recently, liquid biopsy emerged a valuable minimally invasive alternative. This method analyzes blood other bodily fluids to detect cancer-related molecular residual disease (MRD). Liquid biopsy, which includes testing circulating tumor cells, DNA (ctDNA), microRNA (miRNA), offers several advantages over conventional methods. It is invasive, can be performed repeatedly, provides crucial information early cancer diagnosis, genotyping, monitoring. Elevated ctDNA levels miRNA markers show promise diagnosis. complements traditional tissue during particularly when samples are insufficient. Tests Cobas® EGFR Mutation Test v2 Guardant360® CDx have shown effective in detecting mutations guiding decisions. Although accuracy still lower than that its clinical utility continues improve. For prediction recurrence monitoring, analysis MRD earlier imaging, offering potential benefits adjustment relapse detection. The continuous development validation methods essential improving personalized strategies.
Language: Английский
Citations
1
Biogerontology, Journal Year: 2024, Volume and Issue: 25(4), P. 583 - 613
Published: March 11, 2024
Language: Английский
Citations
7
Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)
Published: June 26, 2024
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, affects large regions of Asia, Southwestern Southeastern Europe, Africa. CCHFV can produce symptoms, including no specific clinical mild to severe or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, cheap technology, biosensors, must be designed developed detect The goal this article offer overview modern laboratory available as well other innovative detection methods such biosensors CCHFV, the benefits limits assays. confirmed cases CCHF managed with symptomatic assistance general supportive care. This study examined various treatment modalities, their respective limitations developments, immunotherapy antivirals. Recent biotechnology advancements availability suitable animal models have accelerated development vaccines by substantial margin. We range potential in research, comprising nucleic acid, viral particles, inactivated, multi-epitope vaccines, present obstacles developments field. Thus, purpose review comprehensive summary endeavors dedicated advancing diagnostic, therapeutic, preventive strategies infection anticipation forthcoming hazards.
Language: Английский
Citations
7
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: June 17, 2024
The substantial heterogeneity exhibited by head and neck cancer (HNC), encompassing diverse cellular origins, anatomical locations, etiological contributors, combined with the prevalent late-stage diagnosis, poses significant challenges for clinical management. Genomic sequencing endeavors have revealed extensive alterations in key signaling pathways that regulate proliferation survival. Initiatives to engineer therapies targeting these dysregulated are underway, several candidate molecules progressing evaluation phases, including FDA approval agents like EGFR-targeting monoclonal antibody cetuximab K-RAS wild-type, EGFR-mutant HNSCC treatment. Non-coding RNAs (ncRNAs), owing their enhanced stability biological fluids important roles intracellular intercellular within HNC contexts, now recognized as potent biomarkers disease management, catalyzing further refined diagnostic therapeutic strategies, edging closer personalized medicine desideratum. Enhanced comprehension of genomic immunological landscapes characteristic is anticipated facilitate a more rigorous assessment targeted benefits limitations, optimize deployment, foster innovative advancements treatment approaches. This review presents an update on molecular mechanisms mutational spectrum driving oncogenesis malignancies explores implications advancing methodologies precision therapeutics.
Language: Английский
Citations
4
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 3, 2025
Lung cancer (LC) is the second most commonly diagnosed among both men and women, it stands as leading cause of cancer-related mortality, characterized by high rates morbidity mortality. Among its subtypes, non-small cell lung (NSCLC) prevalent one challenging malignant tumors to treat. To date, various therapeutic approaches, including surgery, radiotherapy, chemotherapy, have been employed in management cancer; however, due aggressive nature, survival remain low. Consequently, exploring novel treatment strategies paramount importance. MicroRNAs (miRNAs), a large family non-coding RNAs, play crucial roles regulating several key biological processes, proliferation, differentiation, inflammation, apoptosis. these, microRNA155(miR-155) conserved versatile miRNAs, predominantly overexpressed diseases, tumors. This review elucidates functions miR-155 NSCLC discusses potential significance target for future research directions clinical applications.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 3, 2025
Immunotherapy for cancer has made significant strides in the last several years. The prognosis patients significantly improved as a result, particularly hematological diseases. However, it was discovered that translating these achievements to solid tumors proved challenging. peptide-loading complex (PLC), temporary multisubunit membrane assembly endoplasmic reticulum (ER), is crucial initiating hierarchical immune response. Chaperones calreticulin and tapasin make up PLC, unique class I glycoproteins, thiooxido-reductase ERp57, transporter associated with antigen processing. loading editing of major histocompatibility (MHC-I) molecules peptide translocation into ER are synchronized by PLC. One escape strategies revealed so far changes expression MHC molecules. This because antigens presenting T-lymphocytes controlling NK cell activity. Furthermore, decreased MHC-I been linked malignancies resistant T-cell-based immunotherapies (adoptive transfer antitumor CD8 T-cells or checkpoint inhibition). PLC essential T-cell priming, differentiation, tumor growth control can bind wide range allomorphs. In this review, we have looked PLC’s function effects all forms improve therapy techniques.
Language: Английский
Citations
0
Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2003 - 2003
Published: March 15, 2025
Preeclampsia (PE) is a multifactorial hypertensive disorder that typically manifests after the twentieth week of pregnancy, significantly impacting perinatal mortality and neonatal morbidity. Its development influenced by immunological components, systemic inflammation, genetic factors, with placental malfunction playing crucial role. While many aspects its pathophysiology have been elucidated, key mechanisms remain incompletely understood. MicroRNAs (miRNAs), small noncoding RNA molecules regulate gene expression, emerged as promising biomarkers therapeutic targets in PE. Dysregulated miRNAs identified pregnant PE patients, highlighting their role disease onset. Placenta-specific miRNAs, such miR-210 miR-155, influence endothelial function, hypoxia responses, which are closely associated development. These play regulating trophoblast invasion, angiogenesis, immune modulation, further linking dysregulation to This review aims provide comprehensive overview PE, focusing on potential diagnostic targets. By integrating recent advancements molecular research, we explore implications clinical practice, particularly risk assessment, early detection, novel treatment strategies.
Language: Английский
Citations
0